PPAR-αlpha activation as a preconditioning-like intervention in rats in vivo confers myocardial protection against acute ischaemia-reperfusion injury: Involvement of PI3K-Akt

Canadian Journal of Physiology and Pharmacology

Volumn 90, Issue 8, 2012, Pages 1135-1144

  Ravingerová, Táňa ^a   Čarnická, Slávka ^a   Nemčeková, Martina ^a   Ledvényiová, Veronika ^a   Adameová, Adriana ^b   Kelly, Tara ^c   Barlaka, Eleftheria ^c   Galatou, Eleftheria ^c   Khandelwal, Vinoth Kumar Megraj ^d,e   Lazou, Antigone ^c  

^a Institute for Heart Research   (Slovakia)

^b Faculty of Natural Sciences   (Slovakia)

^c ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

^e Laboratorio Angela Valenti dei Fattori Genetici e Ambientali di Rischio Trombotico   (Italy)

Author keywords

Cardioprotection; Metabolic genes; Myocardial ischaemia reperfusion; PI3K Akt; PPAR activation; WY 14643

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PIRINIXIC ACID; PROTEIN KINASE B; ANDROSTANE DERIVATIVE; CHYMASE; MCPT1 PROTEIN, RAT; PEROXISOME PROLIFERATOR; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; PYRUVATE DEHYDROGENASE KINASE 4; WORTMANNIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE FIBRILLATION; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; UPREGULATION; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; DRUG ANTAGONISM; HEART ARRHYTHMIA; HEART INFARCTION; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT;

ANDROSTADIENES; ANIMALS; ARRHYTHMIAS, CARDIAC; CHYMASES; DISEASE MODELS, ANIMAL; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PEROXISOME PROLIFERATORS; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PPAR ALPHA; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84864213086     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y2012-052     Document Type: Article

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