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Volumn 52, Issue 2, 2017, Pages 194-201

Regulatory T Cells in Systemic Sclerosis: a Comprehensive Review

Author keywords

Regulatory T cells; Skin resident regulatory T cells; Systemic sclerosis

Indexed keywords

ILOPROST;

EID: 84975155671     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-016-8563-6     Document Type: Review
Times cited : (44)

References (72)
  • 1
    • 84856929470 scopus 로고    scopus 로고
    • Epidemiology of systemic sclerosis: incidence, prevalence, survival, risk factors, malignancy, and environmental triggers
    • PID: 22269658
    • Barnes J, Mayes MD (2012) Epidemiology of systemic sclerosis: incidence, prevalence, survival, risk factors, malignancy, and environmental triggers. Curr Opin Rheumatol 24(2):165–170
    • (2012) Curr Opin Rheumatol , vol.24 , Issue.2 , pp. 165-170
    • Barnes, J.1    Mayes, M.D.2
  • 2
    • 84954240890 scopus 로고    scopus 로고
    • A gender gap in primary and secondary heart dysfunctions in systemic sclerosis: a EUSTAR prospective study
    • PID: 25342760
    • Elhai M, Avouac J, Walker UA et al (2016) A gender gap in primary and secondary heart dysfunctions in systemic sclerosis: a EUSTAR prospective study. Ann Rheum Dis 75(1):163–169
    • (2016) Ann Rheum Dis , vol.75 , Issue.1 , pp. 163-169
    • Elhai, M.1    Avouac, J.2    Walker, U.A.3
  • 3
    • 84953343033 scopus 로고    scopus 로고
    • Systemic sclerosis: from pathogenesis to targeted therapy
    • PID: 26457375
    • Denton CP (2015) Systemic sclerosis: from pathogenesis to targeted therapy. Clin Exp Rheumatol 33(4 Suppl 92):S3–S7
    • (2015) Clin Exp Rheumatol , vol.33 , pp. S3-S7
    • Denton, C.P.1
  • 4
    • 67649666863 scopus 로고    scopus 로고
    • Skin disease: a cardinal feature of systemic sclerosis
    • Krieg T, Takehara K (2009) Skin disease: a cardinal feature of systemic sclerosis. Rheumatology (Oxford) 48(Suppl 3):iii14–iii18
    • (2009) Rheumatology (Oxford) , vol.48 , pp. iii14-iii18
    • Krieg, T.1    Takehara, K.2
  • 5
    • 77957286169 scopus 로고    scopus 로고
    • Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database
    • PID: 20551155
    • Tyndall AJ, Bannert B, Vonk M et al (2010) Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. Ann Rheum Dis 69(10):1809–1815
    • (2010) Ann Rheum Dis , vol.69 , Issue.10 , pp. 1809-1815
    • Tyndall, A.J.1    Bannert, B.2    Vonk, M.3
  • 6
    • 84971282268 scopus 로고    scopus 로고
    • Systemic sclerosis: an update in 2016
    • PID: 26802722
    • Desbois AC, Cacoub P (2016) Systemic sclerosis: an update in 2016. Autoimmun Rev 15:417–426
    • (2016) Autoimmun Rev , vol.15 , pp. 417-426
    • Desbois, A.C.1    Cacoub, P.2
  • 7
    • 84863857123 scopus 로고    scopus 로고
    • Update on the profile of the EUSTAR cohort: an analysis of the EULAR Scleroderma Trials and Research group database
    • PID: 22615460
    • Meier FM, Frommer KW, Dinser R et al (2012) Update on the profile of the EUSTAR cohort: an analysis of the EULAR Scleroderma Trials and Research group database. Ann Rheum Dis 71:1355–1360
    • (2012) Ann Rheum Dis , vol.71 , pp. 1355-1360
    • Meier, F.M.1    Frommer, K.W.2    Dinser, R.3
  • 8
    • 84902249499 scopus 로고    scopus 로고
    • Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study
    • PID: 23687283
    • Coghlan JG, Denton CP, Grunig E et al (2014) Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study. Ann Rheum Dis 73:1340–1349
    • (2014) Ann Rheum Dis , vol.73 , pp. 1340-1349
    • Coghlan, J.G.1    Denton, C.P.2    Grunig, E.3
  • 9
    • 84889561159 scopus 로고    scopus 로고
    • Neurologic involvement in scleroderma: a systematic review
    • PID: 23827688
    • Amaral TN, Peres FA, Lapa AT et al (2013) Neurologic involvement in scleroderma: a systematic review. Semin Arthritis Rheum 43:335–347
    • (2013) Semin Arthritis Rheum , vol.43 , pp. 335-347
    • Amaral, T.N.1    Peres, F.A.2    Lapa, A.T.3
  • 10
    • 84882464963 scopus 로고    scopus 로고
    • Vascular endothelial growth factor aggravates fibrosis and vasculopathy in experimental models of systemic sclerosis
    • PID: 23918036
    • Maurer B, Distler A, Suliman YA et al (2014) Vascular endothelial growth factor aggravates fibrosis and vasculopathy in experimental models of systemic sclerosis. Ann Rheum Dis 73:1880–1887
    • (2014) Ann Rheum Dis , vol.73 , pp. 1880-1887
    • Maurer, B.1    Distler, A.2    Suliman, Y.A.3
  • 11
    • 0028074746 scopus 로고
    • Increased endothelin-1 production in fibroblasts derived from patients with systemic sclerosis
    • COI: 1:STN:280:DyaK2M%2FjtFehsw%3D%3D, PID: 7944634
    • Kawaguchi Y, Suzuki K, Hara M et al (1994) Increased endothelin-1 production in fibroblasts derived from patients with systemic sclerosis. Ann Rheum Dis 53(8):506–510
    • (1994) Ann Rheum Dis , vol.53 , Issue.8 , pp. 506-510
    • Kawaguchi, Y.1    Suzuki, K.2    Hara, M.3
  • 12
    • 84936858751 scopus 로고    scopus 로고
    • Enhanced chemokine-receptor expression, function, and signaling in healthy African American and scleroderma-patient monocytes are regulated by caveolin-1
    • PID: 26322128
    • Lee R, Reese C, Perry B et al (2015) Enhanced chemokine-receptor expression, function, and signaling in healthy African American and scleroderma-patient monocytes are regulated by caveolin-1. Fibrogenesis Tissue Repair 8:11. doi:10.1186/s13069-015-0028-7
    • (2015) Fibrogenesis Tissue Repair , vol.8 , pp. 11
    • Lee, R.1    Reese, C.2    Perry, B.3
  • 13
    • 84893081873 scopus 로고    scopus 로고
    • Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis
    • PID: 24350901
    • Van Bon L, Affandi AJ, Broen J et al (2014) Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med 370:433–443
    • (2014) N Engl J Med , vol.370 , pp. 433-443
    • Van Bon, L.1    Affandi, A.J.2    Broen, J.3
  • 14
    • 33745168605 scopus 로고    scopus 로고
    • Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication
    • COI: 1:CAS:528:DC%2BD28XlsFeqtb4%3D, PID: 16709748
    • Pisitkun P, Deane JA, Difilippantonio MJ et al (2006) Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 312(5780):1669–1672
    • (2006) Science , vol.312 , Issue.5780 , pp. 1669-1672
    • Pisitkun, P.1    Deane, J.A.2    Difilippantonio, M.J.3
  • 15
    • 77954965596 scopus 로고    scopus 로고
    • Type I interferon system activation and association with disease manifestations in systemic sclerosis
    • COI: 1:CAS:528:DC%2BC3cXhtVSlur7F, PID: 20472592
    • Eloranta ML, Franck-Larsson K, Lövgren T et al (2010) Type I interferon system activation and association with disease manifestations in systemic sclerosis. Ann Rheum Dis 69(7):1396–1402
    • (2010) Ann Rheum Dis , vol.69 , Issue.7 , pp. 1396-1402
    • Eloranta, M.L.1    Franck-Larsson, K.2    Lövgren, T.3
  • 16
    • 84931274690 scopus 로고    scopus 로고
    • Molecular and cellular pathways as treatment targets for biologic therpaies in systemic sclerosis
    • COI: 1:CAS:528:DC%2BC2MXpsVWhtL0%3D, PID: 25850767
    • Dimitroulas T, Daoussis D, Garyfallos A, Sfikakis PP, Kitas GD (2015) Molecular and cellular pathways as treatment targets for biologic therpaies in systemic sclerosis. Curr Med Chem 22(16):1943–1955
    • (2015) Curr Med Chem , vol.22 , Issue.16 , pp. 1943-1955
    • Dimitroulas, T.1    Daoussis, D.2    Garyfallos, A.3    Sfikakis, P.P.4    Kitas, G.D.5
  • 17
    • 34347366358 scopus 로고    scopus 로고
    • Dendritic cells and interferon-mediated autoimmunity
    • COI: 1:CAS:528:DC%2BD2sXnsFKrurs%3D, PID: 17562353
    • Gottenberg JE, Chiocchia G (2007) Dendritic cells and interferon-mediated autoimmunity. Biochimie 89(6-7):856–871
    • (2007) Biochimie , vol.89 , Issue.6-7 , pp. 856-871
    • Gottenberg, J.E.1    Chiocchia, G.2
  • 18
    • 84925501437 scopus 로고    scopus 로고
    • Role of anti-inflammatory cytokines IL-4 and IL-13 in systemic sclerosis
    • COI: 1:CAS:528:DC%2BC2MXjs1Sitrw%3D, PID: 25725697
    • Huang XL, Wang YJ, Yan JW et al (2015) Role of anti-inflammatory cytokines IL-4 and IL-13 in systemic sclerosis. Inflamm Res 64(3-4):151–159
    • (2015) Inflamm Res , vol.64 , Issue.3-4 , pp. 151-159
    • Huang, X.L.1    Wang, Y.J.2    Yan, J.W.3
  • 19
    • 84924336809 scopus 로고    scopus 로고
    • Interleukin-17A promotes functional activation of systemic sclerosis patient-derived dermal vascular smooth muscle cells by extracellular-regulated protein kinases signalling pathway
    • PID: 25551434
    • Liu M, Yang J, Xing X et al (2014) Interleukin-17A promotes functional activation of systemic sclerosis patient-derived dermal vascular smooth muscle cells by extracellular-regulated protein kinases signalling pathway. Arthritis Res Ther 16(6):4223
    • (2014) Arthritis Res Ther , vol.16 , Issue.6 , pp. 4223
    • Liu, M.1    Yang, J.2    Xing, X.3
  • 20
    • 0034513819 scopus 로고    scopus 로고
    • Derangement of apoptosis-related lymphocyte homeostasis in systemic sclerosis
    • COI: 1:STN:280:DC%2BD3M7gtFajug%3D%3D
    • Stummvoll GH, Aringer M, Smolen JS et al (2000) Derangement of apoptosis-related lymphocyte homeostasis in systemic sclerosis. Rheumatology (Oxford) 39(12):1341–1350
    • (2000) Rheumatology (Oxford) , vol.39 , Issue.12 , pp. 1341-1350
    • Stummvoll, G.H.1    Aringer, M.2    Smolen, J.S.3
  • 21
    • 84946545254 scopus 로고    scopus 로고
    • FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases
    • PID: 26441996
    • Nie J, Li YY, Zheng SG et al (2015) FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases. Front Immunol 6:493. doi:10.3389/fimmu.2015.00493
    • (2015) Front Immunol , vol.6 , pp. 493
    • Nie, J.1    Li, Y.Y.2    Zheng, S.G.3
  • 22
    • 84896704750 scopus 로고    scopus 로고
    • Homeostatic control of regulatory T cell diversity
    • COI: 1:CAS:528:DC%2BC2cXhs1Smtb4%3D, PID: 24481337
    • Liston A, Gray DH (2014) Homeostatic control of regulatory T cell diversity. Nat Rev Immunol 14(3):154–165
    • (2014) Nat Rev Immunol , vol.14 , Issue.3 , pp. 154-165
    • Liston, A.1    Gray, D.H.2
  • 23
    • 84940890201 scopus 로고    scopus 로고
    • The role of the acquired immune response in systemic sclerosis
    • COI: 1:CAS:528:DC%2BC2MXhtFyqsL3F, PID: 26152639
    • Chizzolini C, Boin F (2015) The role of the acquired immune response in systemic sclerosis. Semin Immunopathol 37(5):519–528
    • (2015) Semin Immunopathol , vol.37 , Issue.5 , pp. 519-528
    • Chizzolini, C.1    Boin, F.2
  • 24
    • 84869148187 scopus 로고    scopus 로고
    • T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development
    • COI: 1:CAS:528:DC%2BC38Xhs1Wjs77N, PID: 23123060
    • Ohkura N, Hamaguchi M, Morikawa H et al (2012) T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity 37(5):785–799
    • (2012) Immunity , vol.37 , Issue.5 , pp. 785-799
    • Ohkura, N.1    Hamaguchi, M.2    Morikawa, H.3
  • 25
    • 84888092265 scopus 로고    scopus 로고
    • IL-2 coordinates IL-2-producing and regulatory T cell interplay
    • COI: 1:CAS:528:DC%2BC3sXhvVKjtr7M, PID: 24249704
    • Amado IF, Berges J, Luther RJ et al (2013) IL-2 coordinates IL-2-producing and regulatory T cell interplay. J Exp Med 210(12):2707–2720
    • (2013) J Exp Med , vol.210 , Issue.12 , pp. 2707-2720
    • Amado, I.F.1    Berges, J.2    Luther, R.J.3
  • 26
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
    • COI: 1:CAS:528:DC%2BD1MXpsFCnurk%3D, PID: 19464196
    • Miyara M, Yoshioka Y, Kitoh A et al (2009) Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 30(6):899–911
    • (2009) Immunity , vol.30 , Issue.6 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3
  • 27
    • 84923107503 scopus 로고    scopus 로고
    • Control of tissue-localized immune responses by human regulatory T cells
    • PID: 25378065
    • Pesenacker AM, Broady R, Levings MK (2014) Control of tissue-localized immune responses by human regulatory T cells. Eur J Immunol 45(2):333–343
    • (2014) Eur J Immunol , vol.45 , Issue.2 , pp. 333-343
    • Pesenacker, A.M.1    Broady, R.2    Levings, M.K.3
  • 28
    • 84896786878 scopus 로고    scopus 로고
    • Memory regulatory T cells reside in human skin
    • PID: 24509084
    • Sanchez Rodriguez R, Pauli ML, Neuhaus IM et al (2014) Memory regulatory T cells reside in human skin. J Clin Invest 124(3):1027–1036
    • (2014) J Clin Invest , vol.124 , Issue.3 , pp. 1027-1036
    • Sanchez Rodriguez, R.1    Pauli, M.L.2    Neuhaus, I.M.3
  • 29
    • 84922335323 scopus 로고    scopus 로고
    • The panoply of αβT cells in the skin
    • COI: 1:CAS:528:DC%2BC2cXhtlCktbzK, PID: 25190363
    • Nomura T, Kabashima K, Miyachi Y (2014) The panoply of αβT cells in the skin. J Dermatol Sci 76(1):3–9
    • (2014) J Dermatol Sci , vol.76 , Issue.1 , pp. 3-9
    • Nomura, T.1    Kabashima, K.2    Miyachi, Y.3
  • 30
    • 84861462335 scopus 로고    scopus 로고
    • Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells
    • COI: 1:CAS:528:DC%2BC38XmsFCksb8%3D, PID: 22560445
    • Seneschal J, Clark RA, Gehad A et al (2012) Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity 36(5):873–884
    • (2012) Immunity , vol.36 , Issue.5 , pp. 873-884
    • Seneschal, J.1    Clark, R.A.2    Gehad, A.3
  • 31
    • 46949111560 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells maintain immune homeostasis in the skin
    • COI: 1:CAS:528:DC%2BD1cXosVKkt7w%3D, PID: 18573908
    • Dudda JC, Perdue N, Bachtanian E et al (2008) Foxp3+ regulatory T cells maintain immune homeostasis in the skin. J Exp Med 205(7):1559–1565
    • (2008) J Exp Med , vol.205 , Issue.7 , pp. 1559-1565
    • Dudda, J.C.1    Perdue, N.2    Bachtanian, E.3
  • 32
    • 79251577059 scopus 로고    scopus 로고
    • Glucocorticosteroids modify Langerhans cells to produce TGF-β and expand regulatory T cells
    • COI: 1:CAS:528:DC%2BC3cXhs1ajtL%2FK, PID: 21135170
    • Stary G, Klein I, Bauer W et al (2011) Glucocorticosteroids modify Langerhans cells to produce TGF-β and expand regulatory T cells. J Immunol 186(1):103–112
    • (2011) J Immunol , vol.186 , Issue.1 , pp. 103-112
    • Stary, G.1    Klein, I.2    Bauer, W.3
  • 33
    • 84863800955 scopus 로고    scopus 로고
    • Resident CD141 (BDCA3) + dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation
    • COI: 1:CAS:528:DC%2BC38Xmsl2itLk%3D, PID: 22547651
    • Chu CC, Ali N, Karagiannis P et al (2012) Resident CD141 (BDCA3) + dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation. J Exp Med 209(5):935–945
    • (2012) J Exp Med , vol.209 , Issue.5 , pp. 935-945
    • Chu, C.C.1    Ali, N.2    Karagiannis, P.3
  • 34
    • 77949747054 scopus 로고    scopus 로고
    • Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice
    • COI: 1:CAS:528:DC%2BC3cXjtV2nsLk%3D, PID: 20179354
    • Tomura M, Honda T, Tanizaki H et al (2010) Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. J Clin Invest 120(3):883–893
    • (2010) J Clin Invest , vol.120 , Issue.3 , pp. 883-893
    • Tomura, M.1    Honda, T.2    Tanizaki, H.3
  • 35
    • 84897946867 scopus 로고    scopus 로고
    • Once a Treg, always a Treg?
    • COI: 1:CAS:528:DC%2BC2cXmtV2ntb0%3D, PID: 24712466
    • Sawant DV, Vignali DA (2014) Once a Treg, always a Treg? Immunol Rev 259(1):173–191
    • (2014) Immunol Rev , vol.259 , Issue.1 , pp. 173-191
    • Sawant, D.V.1    Vignali, D.A.2
  • 36
    • 84877275454 scopus 로고    scopus 로고
    • CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines
    • COI: 1:CAS:528:DC%2BC3sXlvVOjs74%3D, PID: 23355538
    • Pesenacker AM, Bending D, Ursu S et al (2013) CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines. Blood 121(14):2647–2658
    • (2013) Blood , vol.121 , Issue.14 , pp. 2647-2658
    • Pesenacker, A.M.1    Bending, D.2    Ursu, S.3
  • 37
    • 84861039642 scopus 로고    scopus 로고
    • Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells
    • COI: 1:CAS:528:DC%2BC38Xnt1Gktrc%3D, PID: 22438251
    • Duhen T, Duhen R, Lanzavecchia A et al (2012) Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells. Blood 119(19):4430–4440
    • (2012) Blood , vol.119 , Issue.19 , pp. 4430-4440
    • Duhen, T.1    Duhen, R.2    Lanzavecchia, A.3
  • 38
    • 79955028001 scopus 로고    scopus 로고
    • Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
    • COI: 1:CAS:528:DC%2BC3MXjvVKmt7Y%3D, PID: 21368230
    • McClymont SA, Putnam AL, Lee MR et al (2011) Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol 186(7):3918–3926
    • (2011) J Immunol , vol.186 , Issue.7 , pp. 3918-3926
    • McClymont, S.A.1    Putnam, A.L.2    Lee, M.R.3
  • 39
    • 67650128154 scopus 로고    scopus 로고
    • Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression
    • PID: 19543397
    • Radstake TR, van Bon L, Broen J et al (2009) Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression. PLoS One 4(6):e5981
    • (2009) PLoS One , vol.4 , Issue.6
    • Radstake, T.R.1    van Bon, L.2    Broen, J.3
  • 40
    • 77956475716 scopus 로고    scopus 로고
    • Increased CD127 expression on activated FOXP3 + CD4+ regulatory T cells
    • COI: 1:CAS:528:DC%2BC3cXhtV2gu7%2FN, PID: 20690182
    • Simonetta F, Chiali A, Cordier C et al (2010) Increased CD127 expression on activated FOXP3 + CD4+ regulatory T cells. Eur J Immunol 40(9):2528–2538
    • (2010) Eur J Immunol , vol.40 , Issue.9 , pp. 2528-2538
    • Simonetta, F.1    Chiali, A.2    Cordier, C.3
  • 41
    • 77956619921 scopus 로고    scopus 로고
    • Analyses of T cell phenotype and function reveal an altered T cell homeostasis in systemic sclerosis. Correlations with disease severity and phenotypes
    • COI: 1:CAS:528:DC%2BC3cXhtFyisr%2FP, PID: 20580318
    • Giovannetti A, Rosato E, Renzi C et al (2010) Analyses of T cell phenotype and function reveal an altered T cell homeostasis in systemic sclerosis. Correlations with disease severity and phenotypes. Clin Immunol 137(1):122–133
    • (2010) Clin Immunol , vol.137 , Issue.1 , pp. 122-133
    • Giovannetti, A.1    Rosato, E.2    Renzi, C.3
  • 42
    • 77649178968 scopus 로고    scopus 로고
    • Regulatory T cells (CD4(+)CD25(bright)FoxP3(+)) expansion in systemic sclerosis correlates with disease activity and severity
    • COI: 1:CAS:528:DC%2BC3cXhs1yisbs%3D, PID: 20096404
    • Slobodin G, Ahmad MS, Rosner I et al (2010) Regulatory T cells (CD4(+)CD25(bright)FoxP3(+)) expansion in systemic sclerosis correlates with disease activity and severity. Cell Immunol 261(2):77–80
    • (2010) Cell Immunol , vol.261 , Issue.2 , pp. 77-80
    • Slobodin, G.1    Ahmad, M.S.2    Rosner, I.3
  • 43
    • 84878922773 scopus 로고    scopus 로고
    • Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction
    • COI: 1:CAS:528:DC%2BC3sXhtVanurrK, PID: 23776439
    • Liu X, Gao N, Li M et al (2013) Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction. PLoS One 8(6):e64531
    • (2013) PLoS One , vol.8 , Issue.6
    • Liu, X.1    Gao, N.2    Li, M.3
  • 44
    • 84907990272 scopus 로고    scopus 로고
    • + regulatory T cells with clinical parameters in patients with systemic sclerosis
    • + regulatory T cells with clinical parameters in patients with systemic sclerosis. Chin Med J (Engl) 127(20):3557–3561
    • (2014) Chin Med J (Engl) , vol.127 , Issue.20 , pp. 3557-3561
    • Jiang, N.1    Li, M.2    Zeng, X.3
  • 45
    • 84866405411 scopus 로고    scopus 로고
    • Th17 peripheral cells are increased in diffuse cutaneous systemic sclerosis compared with limited illness: a cross-sectional study
    • PID: 21789610
    • Rodríguez-Reyna TS, Furuzawa-Carballeda J, Cabiedes J et al (2012) Th17 peripheral cells are increased in diffuse cutaneous systemic sclerosis compared with limited illness: a cross-sectional study. Rheumatol Int 32(9):2653–2660
    • (2012) Rheumatol Int , vol.32 , Issue.9 , pp. 2653-2660
    • Rodríguez-Reyna, T.S.1    Furuzawa-Carballeda, J.2    Cabiedes, J.3
  • 46
    • 75549091944 scopus 로고    scopus 로고
    • CD127(low/-) and FoxP3(+) expression levels characterize different regulatory T-cell populations in human peripheral blood
    • COI: 1:CAS:528:DC%2BC3cXntVahtw%3D%3D, PID: 19940860
    • Klein S, Kretz CC, Krammer PH et al (2010) CD127(low/-) and FoxP3(+) expression levels characterize different regulatory T-cell populations in human peripheral blood. J Invest Dermatol 130(2):492–499
    • (2010) J Invest Dermatol , vol.130 , Issue.2 , pp. 492-499
    • Klein, S.1    Kretz, C.C.2    Krammer, P.H.3
  • 47
    • 79959798607 scopus 로고    scopus 로고
    • Reduction of regulatory T cells in skin lesions but not in peripheral blood of patients with systemic scleroderma
    • COI: 1:STN:280:DC%2BC3Mnkt1Kqug%3D%3D, PID: 21097800
    • Klein S, Kretz CC, Ruland V et al (2011) Reduction of regulatory T cells in skin lesions but not in peripheral blood of patients with systemic scleroderma. Ann Rheum Dis 70(8):1475–1481
    • (2011) Ann Rheum Dis , vol.70 , Issue.8 , pp. 1475-1481
    • Klein, S.1    Kretz, C.C.2    Ruland, V.3
  • 48
    • 58149485202 scopus 로고    scopus 로고
    • Quantification and molecular characterization of regulatory T cells in connective tissue diseases
    • COI: 1:CAS:528:DC%2BD1MXjtFyrtQ%3D%3D, PID: 18800250
    • Banica L, Besliu A, Pistol G et al (2009) Quantification and molecular characterization of regulatory T cells in connective tissue diseases. Autoimmunity 42(1):41–49
    • (2009) Autoimmunity , vol.42 , Issue.1 , pp. 41-49
    • Banica, L.1    Besliu, A.2    Pistol, G.3
  • 49
    • 77951238591 scopus 로고    scopus 로고
    • Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea
    • COI: 1:CAS:528:DC%2BC3cXnsVejsLY%3D, PID: 20105169
    • Antiga E, Quaglino P, Bellandi S et al (2010) Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea. Br J Dermatol 162(5):1056–1063
    • (2010) Br J Dermatol , vol.162 , Issue.5 , pp. 1056-1063
    • Antiga, E.1    Quaglino, P.2    Bellandi, S.3
  • 50
    • 79955618079 scopus 로고    scopus 로고
    • Altered T-cell and regulatory cell repertoire in patients with diffuse cutaneous systemic sclerosis
    • COI: 1:CAS:528:DC%2BC3MXlsVGmsLs%3D, PID: 21366383
    • Papp G, Horvath IF, Barath S et al (2011) Altered T-cell and regulatory cell repertoire in patients with diffuse cutaneous systemic sclerosis. Scand J Rheumatol 40(3):205–210
    • (2011) Scand J Rheumatol , vol.40 , Issue.3 , pp. 205-210
    • Papp, G.1    Horvath, I.F.2    Barath, S.3
  • 51
    • 79955974107 scopus 로고    scopus 로고
    • Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis
    • COI: 1:CAS:528:DC%2BC3MXmtFGgtrk%3D, PID: 21419712
    • Fenoglio D, Battaglia F, Parodi A et al (2011) Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis. Clin Immunol 139(3):249–257
    • (2011) Clin Immunol , vol.139 , Issue.3 , pp. 249-257
    • Fenoglio, D.1    Battaglia, F.2    Parodi, A.3
  • 52
    • 84879298388 scopus 로고    scopus 로고
    • Assessment of T regulatory cells and expanded profiling of autoantibodies may offer novel biomarkers for the clinical management of systemic sclerosis and undifferentiated connective tissue disease
    • PID: 23818915
    • Cordiali-Fei P, Mussi A, D’Agosto G et al (2013) Assessment of T regulatory cells and expanded profiling of autoantibodies may offer novel biomarkers for the clinical management of systemic sclerosis and undifferentiated connective tissue disease. Clin Dev Immunol 2013:390563
    • (2013) Clin Dev Immunol , vol.2013 , pp. 390563
    • Cordiali-Fei, P.1    Mussi, A.2    D’Agosto, G.3
  • 53
    • 84883230402 scopus 로고    scopus 로고
    • T lymphocyte abnormalities in juvenile systemic sclerosis patients
    • COI: 1:CAS:528:DC%2BC3sXhsVOktL7J, PID: 23994768
    • Reiff A, Weinberg KI, Triche T et al (2013) T lymphocyte abnormalities in juvenile systemic sclerosis patients. Clin Immunol 149(1):146–155
    • (2013) Clin Immunol , vol.149 , Issue.1 , pp. 146-155
    • Reiff, A.1    Weinberg, K.I.2    Triche, T.3
  • 54
    • 84862565756 scopus 로고    scopus 로고
    • Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions
    • COI: 1:CAS:528:DC%2BC38Xht1Ogtb7L, PID: 22696687
    • Mathian A, Parizot C, Dorgham K et al (2012) Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions. Ann Rheum Dis 71(7):1227–1234
    • (2012) Ann Rheum Dis , vol.71 , Issue.7 , pp. 1227-1234
    • Mathian, A.1    Parizot, C.2    Dorgham, K.3
  • 55
    • 84983434044 scopus 로고    scopus 로고
    • + regulatory T cells in systemic sclerosis
    • COI: 1:CAS:528:DC%2BC2cXitFCmt7nP, PID: 24716598
    • + regulatory T cells in systemic sclerosis. Mod Rheumatol 25(1):90–95
    • (2015) Mod Rheumatol , vol.25 , Issue.1 , pp. 90-95
    • Kataoka, H.1    Yasuda, S.2    Fukaya, S.3
  • 56
    • 79960912511 scopus 로고    scopus 로고
    • CD4 + CD25+ regulatory T cells in systemic sclerosis and other rheumatic diseases
    • COI: 1:CAS:528:DC%2BC3MXhtFaiu7bP, PID: 21790293
    • Michels-van Amelsfort JM, Walter GJ, Taams LS (2011) CD4 + CD25+ regulatory T cells in systemic sclerosis and other rheumatic diseases. Expert Rev Clin Immunol 7(4):499–514
    • (2011) Expert Rev Clin Immunol , vol.7 , Issue.4 , pp. 499-514
    • Michels-van Amelsfort, J.M.1    Walter, G.J.2    Taams, L.S.3
  • 57
    • 77955096860 scopus 로고    scopus 로고
    • Immunosuppressive therapy may affect the number of circulating regulatory cells in systemic sclerosis: pay attention to the patient selection criteria
    • COI: 1:CAS:528:DC%2BC3cXpsFKqu74%3D, PID: 20619829
    • Antiga E, Fabbri P, Caproni M (2010) Immunosuppressive therapy may affect the number of circulating regulatory cells in systemic sclerosis: pay attention to the patient selection criteria. Cell Immunol 264(2):186
    • (2010) Cell Immunol , vol.264 , Issue.2 , pp. 186
    • Antiga, E.1    Fabbri, P.2    Caproni, M.3
  • 58
    • 78650036793 scopus 로고    scopus 로고
    • Iloprost modulates the immune response in systemic sclerosis
    • PID: 21159177
    • D’Amelio P, Cristofaro MA, D’Amico L et al (2010) Iloprost modulates the immune response in systemic sclerosis. BMC Immunol 11:62
    • (2010) BMC Immunol , vol.11 , pp. 62
    • D’Amelio, P.1    Cristofaro, M.A.2    D’Amico, L.3
  • 59
    • 84856550315 scopus 로고    scopus 로고
    • Immunomodulatory effects of extracorporeal photochemotherapy in systemic sclerosis
    • COI: 1:CAS:528:DC%2BC38XhvVGltbc%3D, PID: 22036269
    • Papp G, Horvath IF, Barath S et al (2012) Immunomodulatory effects of extracorporeal photochemotherapy in systemic sclerosis. Clin Immunol 142(2):150–159
    • (2012) Clin Immunol , vol.142 , Issue.2 , pp. 150-159
    • Papp, G.1    Horvath, I.F.2    Barath, S.3
  • 60
    • 84867890726 scopus 로고    scopus 로고
    • The effects of extracorporeal photochemotherapy on T cell activation and regulatory mechanisms in patients with systemic sclerosis
    • PID: 22706443
    • Papp G, Barath S, Szegedi A et al (2012) The effects of extracorporeal photochemotherapy on T cell activation and regulatory mechanisms in patients with systemic sclerosis. Clin Rheumatol 31(9):1293–1299
    • (2012) Clin Rheumatol , vol.31 , Issue.9 , pp. 1293-1299
    • Papp, G.1    Barath, S.2    Szegedi, A.3
  • 61
    • 79955133066 scopus 로고    scopus 로고
    • Analysis of immune reconstitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis: predominant reconstitution of Th1 CD4+ T cells
    • COI: 1:CAS:528:DC%2BC3MXkvFaiurY%3D
    • Tsukamoto H, Nagafuji K, Horiuchi T et al (2011) Analysis of immune reconstitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis: predominant reconstitution of Th1 CD4+ T cells. Rheumatology (Oxford) 50(5):944–952
    • (2011) Rheumatology (Oxford) , vol.50 , Issue.5 , pp. 944-952
    • Tsukamoto, H.1    Nagafuji, K.2    Horiuchi, T.3
  • 62
    • 84904240761 scopus 로고    scopus 로고
    • Peripheral blood regulatory T cells in patients with diffuse systemic sclerosis (SSc) before and after autologous hematopoietic SCT: a pilot study
    • COI: 1:CAS:528:DC%2BC2cXmsVGr, PID: 24362364
    • Baraut J, Grigore EI, Jean-Louis F et al (2014) Peripheral blood regulatory T cells in patients with diffuse systemic sclerosis (SSc) before and after autologous hematopoietic SCT: a pilot study. Bone Marrow Transplant 49(3):349–354
    • (2014) Bone Marrow Transplant , vol.49 , Issue.3 , pp. 349-354
    • Baraut, J.1    Grigore, E.I.2    Jean-Louis, F.3
  • 63
    • 84858402081 scopus 로고    scopus 로고
    • Immunological reconstitution after autologous stem cell transplantation in patients with refractory systemic autoimmune diseases
    • COI: 1:CAS:528:DC%2BC38XktFOns7Y%3D, PID: 21936606
    • Szodoray P, Varoczy L, Papp G et al (2012) Immunological reconstitution after autologous stem cell transplantation in patients with refractory systemic autoimmune diseases. Scand J Rheumatol 41(2):110–115
    • (2012) Scand J Rheumatol , vol.41 , Issue.2 , pp. 110-115
    • Szodoray, P.1    Varoczy, L.2    Papp, G.3
  • 64
    • 84955505585 scopus 로고    scopus 로고
    • Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells
    • COI: 1:CAS:528:DC%2BC28XhtVylt7vE, PID: 26480932
    • Delemarre EM, van den Broek T, Mijnheer G et al (2016) Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells. Blood 127(1):91–101
    • (2016) Blood , vol.127 , Issue.1 , pp. 91-101
    • Delemarre, E.M.1    van den Broek, T.2    Mijnheer, G.3
  • 65
    • 78649746433 scopus 로고    scopus 로고
    • Skewed X chromosomal inactivation impacts T regulatory cell function in systemic sclerosis
    • COI: 1:CAS:528:DC%2BC3cXhs1emsbzM, PID: 20699236
    • Broen JC, Wolvers-Tettero IL, Geurts-van Bon L et al (2010) Skewed X chromosomal inactivation impacts T regulatory cell function in systemic sclerosis. Ann Rheum Dis 69(12):2213–2216
    • (2010) Ann Rheum Dis , vol.69 , Issue.12 , pp. 2213-2216
    • Broen, J.C.1    Wolvers-Tettero, I.L.2    Geurts-van Bon, L.3
  • 66
    • 84905029354 scopus 로고    scopus 로고
    • DNA hypermethylation of the forkhead box protein 3 (FOXP3) promoter in CD4+ T cells of patients with systemic sclerosis
    • COI: 1:CAS:528:DC%2BC2cXht1Chs7fP, PID: 24641670
    • Wang YY, Wang Q, Sun XH et al (2014) DNA hypermethylation of the forkhead box protein 3 (FOXP3) promoter in CD4+ T cells of patients with systemic sclerosis. Br J Dermatol 171(1):39–47
    • (2014) Br J Dermatol , vol.171 , Issue.1 , pp. 39-47
    • Wang, Y.Y.1    Wang, Q.2    Sun, X.H.3
  • 67
    • 84884217070 scopus 로고    scopus 로고
    • Autoantibodies to estrogen receptor α in systemic sclerosis (SSc) as pathogenetic determinants and markers of progression
    • COI: 1:CAS:528:DC%2BC3sXhsFekt7rF, PID: 24058548
    • Giovannetti A, Maselli A, Colasanti T et al (2013) Autoantibodies to estrogen receptor α in systemic sclerosis (SSc) as pathogenetic determinants and markers of progression. PLoS One 8(9):e74332
    • (2013) PLoS One , vol.8 , Issue.9
    • Giovannetti, A.1    Maselli, A.2    Colasanti, T.3
  • 68
    • 84941996133 scopus 로고    scopus 로고
    • Semaphorin 3A: an immunoregulator in systemic sclerosis
    • COI: 1:CAS:528:DC%2BC2MXmvVSjt7c%3D, PID: 25895648
    • Rimar D, Nov Y, Rosner I et al (2015) Semaphorin 3A: an immunoregulator in systemic sclerosis. Rheumatol Int 35(10):1625–1630
    • (2015) Rheumatol Int , vol.35 , Issue.10 , pp. 1625-1630
    • Rimar, D.1    Nov, Y.2    Rosner, I.3
  • 69
    • 79955953491 scopus 로고    scopus 로고
    • Th17 and Treg balance in systemic sclerosis
    • COI: 1:CAS:528:DC%2BC3MXmtFGgtr0%3D, PID: 21482482
    • Khoury SJ (2011) Th17 and Treg balance in systemic sclerosis. Clin Immunol 139(3):231–232
    • (2011) Clin Immunol , vol.139 , Issue.3 , pp. 231-232
    • Khoury, S.J.1
  • 70
    • 84951852127 scopus 로고    scopus 로고
    • New insights into CD4(+) T cell abnormalities in systemic sclerosis
    • Liu M, Wu W, Sun X, et al. (2016) New insights into CD4(+) T cell abnormalities in systemic sclerosis. Cytokine Growth Factor Rev 28:31–36
    • (2016) Cytokine Growth Factor Rev , vol.28 , pp. 31-36
    • Liu, M.1    Wu, W.2    Sun, X.3
  • 71
    • 84892163120 scopus 로고    scopus 로고
    • Increased frequency of Th17 cells in systemic sclerosis is related to disease activity and collagen overproduction
    • PID: 24398084
    • Yang X, Yang J, Xing X et al (2014) Increased frequency of Th17 cells in systemic sclerosis is related to disease activity and collagen overproduction. Arthritis Res Ther 16(1):R4
    • (2014) Arthritis Res Ther , vol.16 , Issue.1 , pp. R4
    • Yang, X.1    Yang, J.2    Xing, X.3
  • 72
    • 84926249566 scopus 로고    scopus 로고
    • Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis
    • COI: 1:CAS:528:DC%2BC2MXisFChtLY%3D, PID: 25678090, e9
    • MacDonald KG, Dawson NA, Huang Q et al (2015) Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis. J Allergy Clin Immunol 135(4):946, e9
    • (2015) J Allergy Clin Immunol , vol.135 , Issue.4 , pp. 946
    • MacDonald, K.G.1    Dawson, N.A.2    Huang, Q.3


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