Correlation of th17 cells and CD4+CD25+ regulatory T cells with clinical parameters in patients with systemic sclerosis

Chinese Medical Journal

Volumn 127, Issue 20, 2014, Pages 3557-3561

  Nan, Jiang ^a   Li, Meng Tao ^b   Zeng, Xiao Feng ^b  

^a Department of Internal Medicine ^*  (China)

^b PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

Regulatory; Scleroderma; Systemic; T lymphocytes; Th17 cells

Indexed keywords

CARBON MONOXIDE; CD4 ANTIGEN; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; RIBONUCLEOPROTEIN ANTIBODY; TRANSCRIPTION FACTOR FOXP3;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL CULTURE; CELL PROLIFERATION; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE DURATION; FEMALE; FIBROSIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INFLAMMATION; INTERSTITIAL LUNG DISEASE; LUNG DIFFUSION CAPACITY; LUNG FUNCTION TEST; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEDICAL PARAMETERS; MIDDLE AGED; MODIFIED RODNAN SKIN SCORE; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; REGULATORY T LYMPHOCYTE; SCORING SYSTEM; STAINING; SYSTEMIC SCLEROSIS; T LYMPHOCYTE SUBPOPULATION; TH17 CELL; CD4+ T LYMPHOCYTE; IMMUNOLOGY; METABOLISM;

CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; SCLERODERMA, SYSTEMIC; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84907990272     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20141395     Document Type: Article

References (18)

1. Prescott RJ, Freemont AJ, Jones CJ, Hoyland J, Fielding P. Sequential dermal microvascular and perivascular changes in the development of scleroderma. J Pathol 1992; 166: 255-263.
2. Miossec P. Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy. Arthritis Rheum 2003; 48: 594-601.
3. Wong CK, Ho CY, Li EK, Lam CW. El eva t ion of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus. Lupus 2000; 9: 589-593.
4. Kurasawa K, Hirose K, Sano H, Endo H, Shinkai H, Nawata Y, et al. Increased interleukin-17 production in patients with systemic sclerosis. Arthritis Rheum 2000; 43: 2455-2463.
5. Fossiez F, Djossou O, Chomarat P, Flores-Romo L, Ait-Yahia S, Maat C, et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med 1996; 183: 2593-2603.
6. Afzali B, Lombardi G, Lechler RI, Lord GM. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol 2007; 148: 32-46.
7. Sakkas L., Platsoucas CD. Is systemic sclerosis an antigen-driven T cell disease? Arthritis Rheum 2004; 50: 1721-1733.
8. Fiocco U, Rosada M, Cozzi L, Ortolani C, De Silvestro G, Ruffatti A, et al. Early phenotypic activation of circulating helper memory T cells in scleroderma: correlation with disease activity. Ann Rheum Dis 1993; 52: 272-277.
9. Slobodin G, Ahmad MS, Rosner I, Peri R, Rozenbaum M, Kessel A, et al. Regulatory T cells (CD4(+)CD25(bright) FoxP3(+)) expansion in systemic sclerosis correlates with disease activity and severity. Cell Immunol 2010; 261: 77-80.
10. Radstake TR, van Bon L, Broen J, Wenink M, Santegoets K, Deng Y, et al. Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression. PloS one 2009; 4: e5981.
11. Cordiali-Fei P, Mussi A, D'Agosto G, Trento E, Bordignon V, Trincone S, et al. Assessment of T regulatory cells and expanded profiling of autoantibodies may offer novel biomarkers for the clinical management of systemic sclerosis and undifferentiated connective tissue disease. Clin Dev Immunol 2013; 2013: 390563.
12. Antiga E, Quaglino P, Bellandi S, Volpi W, Del Bianco E, Comessatti A, et al. Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea. Br J Dermatol 2010; 162: 1056-1063.
13. Kalogerou A, Gelou E, Mountantonakis S, Settas L, Zafiriou E, Sakkas L. Early T cell activation in the skin from patients with systemic sclerosis. Ann Rheum Dis 2005; 64: 1233-1235.
14. Fukasawa C, Kawaguchi Y, Harigai M, Sugiura T, Takagi K, Kawamoto M, et al. Increased CD40 expression in skin fibroblasts from patients with systemic sclerosis (SSc): role of CD40-CD154 in the phenotype of SSc fibroblasts. Eur J Immunol 2003; 33: 2792-2800.
15. Sakkas L., Chikanza IC, Platsoucas CD. Mechanisms of Disease: the role of immune cells in the pathogenesis of systemic sclerosis. Nat Clin Pract Rheumatol 2006; 2: 679-685.
16. Sonnylal S, Denton CP, Zheng B, Keene DR, He R, Adams HP, et al. Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum 2007; 56: 334-344.
17. Kawakami T, Ihn H, Xu W, Smith E, LeRoy C, Trojanowska M. Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype. J Invest Dermatol 1998; 110: 47-51.
18. Crispin JC, Martinez A, Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 2003; 21: 273-276.