Autologous stem cell transplantation AIDS autoimmune patients by functional renewal and TCR diversification of regulatory T cells

Blood

Volumn 127, Issue 1, 2016, Pages 91-101

  Delemarre, Eveline M ^a   Van Den Broek, Theo ^a   Mijnheer, Gerdien ^a   Meerding, Jenny ^a   Wehrens, Ellen J ^a   Olek, Sven ^b   Boes, Marianne ^a   Van Herwijnen, Martijn J C ^c   Broere, Femke ^c   Van Royen, Annet V ^a   Wulffraat, Nico M ^a   Prakken, Berent J ^a   Spierings, Eric ^d   Van Wijk, Femke ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b EPIONTIS GMBH   (Germany)

^c UTRECHT UNIVERSITY   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Adding regulatory t cells to the graft does not lead to additional clinical improvement but results in delayed donor t cell reconstitution; Autologous HSCT induces functional renewal of regulatory t cells as well as a strong treg TCR diversification in autoimmune patients

Indexed keywords

CDR3 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; LYMPHOCYTE ANTIGEN; MESSENGER RNA; NEUROPILIN 1; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BONE MARROW TRANSPLANTATION; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL COMPARTMENTALIZATION; CELL RENEWAL; CELL STIMULATION; CONGENIC BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; INFLAMMATION; JUVENILE DERMATOMYOSITIS; JUVENILE RHEUMATOID ARTHRITIS; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; RELAPSE; REMISSION; SEQUENCE ANALYSIS; SPLEEN CELL; THYMUS; TREATMENT OUTCOME; ANIMAL; AUTOIMMUNE DISEASES; AUTOTRANSPLANTATION; BAGG ALBINO MOUSE; CELL CULTURE; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; AUTOIMMUNE DISEASES; BLOTTING, WESTERN; BONE MARROW TRANSPLANTATION; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNE TOLERANCE; INFLAMMATION; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION, AUTOLOGOUS;

EID: 84955505585     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-06-649145     Document Type: Article

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