Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress

PLoS Genetics

Volumn 12, Issue 5, 2016, Pages

  Wilhelm, Therese ^a,g   Ragu, Sandrine ^a   Magdalou, Indiana ^a   Machon, Christelle ^b,c   Dardillac, Elodie ^a   Técher, Hervé ^d,e,f   Guitton, Jérôme ^b,c   Debatisse, Michelle ^d,e,f   Lopez, Bernard S ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b CENTRE HOSPITALIER LYON SUD   (France)

^c UNIVERSITÉ LYON 1   (France)

^d INSTITUT CURIE   (France)

^e SORBONNE UNIVERSITÉ   (France)

^f Institut Curie   (France)

^g UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BRCA2 PROTEIN; CHECKPOINT KINASE 1; HISTONE H2AX; HYDROGEN PEROXIDE; RAD51 PROTEIN; REACTIVE OXYGEN METABOLITE; RIBONUCLEOTIDE REDUCTASE; XRCC1 PROTEIN; DNA BINDING PROTEIN; HISTONE; X-RAY REPAIR CROSS COMPLEMENTING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARCINOGENESIS; CELL AGING; CELL DIVISION; CELL METABOLISM; CENTROSOME; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DECELERATION; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; ENZYME PHOSPHORYLATION; EXPRESSION VECTOR; GENE CONVERSION; GENOMIC INSTABILITY; HAMSTER; HOMOLOGOUS RECOMBINATION; IMMUNOFLUORESCENCE; LOSS OF FUNCTION MUTATION; MITOSIS; MOLECULAR COMBING; MOLECULAR DYNAMICS; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; SACCHAROMYCES CEREVISIAE; SINGLE STRANDED DNA BREAK; ANIMAL; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; GENE REGULATORY NETWORK; GENETICS; METABOLISM; SINGLE MOLECULE IMAGING;

ACETYLCYSTEINE; ANIMALS; CENTROSOME; CHO CELLS; CRICETULUS; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA-BINDING PROTEINS; GENE REGULATORY NETWORKS; HISTONES; HOMOLOGOUS RECOMBINATION; HYDROGEN PEROXIDE; MITOSIS; OXIDATIVE STRESS; SINGLE MOLECULE IMAGING;

EID: 84974577769     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1006007     Document Type: Article

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