Nucleotide supply, not local histone acetylation, sets replication origin usage in transcribed regions

EMBO Reports

Volumn 11, Issue 9, 2010, Pages 698-704

  Gay, Sophie ^a,b,c   Lachages, Anne Marie ^a,b,c   Millot, Gael A ^a,b,c   Courbet, Sylvain ^a,b,c   Letessier, Anne ^a,b,c   Debatisse, Michelle ^a,b,c   Brison, Olivier ^a,b,c  

^a INSTITUT CURIE   (France)

^b CNRS   (France)

^c SORBONNE UNIVERSITÉ   (France)

Author keywords

CTP synthetase; molecular combing; replication dynamics; thymidylate synthase; trichostatin A

Indexed keywords

ADENOSINE MONOPHOSPHATE DEAMINASE; ADENOSINE MONOPHOSPHATE DEAMINASE 2; HISTONE; HISTONE DEACETYLASE INHIBITOR; NUCLEOTIDE; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; FIBROBLAST; GENE REPLICATION; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS;

ACETYLATION; ANIMALS; CELLS, CULTURED; DNA REPLICATION; FIBROBLASTS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HISTONES; HUMANS; HYDROXAMIC ACIDS; NUCLEOTIDES; REPLICATION ORIGIN; TRANSCRIPTION, GENETIC;

EUKARYOTA; MAMMALIA;

EID: 77956225395     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2010.112     Document Type: Article

References (23)

1. Aggarwal BD, Calvi BR (2004) Chromatin regulates origin activity in Drosophila follicle cells. Nature 430: 372-376
2. Anglana M, Apiou F, Bensimon A, Debatisse M (2003) Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing. Cell 114: 385-394
3. Cadoret JC, Meisch F, Hassan-Zadeh V, Luyten I, Guillet C, Duret L, Quesneville H, Prioleau MN (2008) Genome-wide studies highlight indirect links between human replication origins and gene regulation. Proc Natl Acad Sci USA 105: 15837-15842
4. Courbet S, Gay S, Arnoult N, Wronka G, Anglana M, Brison O, Debatisse M (2008) Replication fork movement sets chromatin loop size and origin choice in mammalian cells. Nature 455: 557-560
5. Dazy S, Gandrillon O, Hyrien O, Prioleau MN (2006) Broadening of DNA replication origin usage during metazoan cell differentiation. EMBO Rep 7: 806-811
6. Debatisse M, Berry M, Buttin G (1982) Stepwise isolation and properties of unstable Chinese hamster cell variants that overproduce adenylate deaminase. Mol Cell Biol 2: 1346-1353
7. Glaser KB, Staver MJ, Waring JF, Stender J, Ulrich RG, Davidsen SK (2003) Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. Mol Cancer Ther 2: 151-163
8. Gregoire D, Brodolin K, Mechali M (2006) HoxB domain induction silences DNA replication origins in the locus and specifies a single origin at its boundary. EMBO Rep 7: 812-816
9. Iizuka M, Matsui T, Takisawa H, Smith MM (2006) Regulation of replication licensing by acetyltransferase Hbo1. Mol Cell Biol 26: 1098-1108
10. Karnani N, Taylor CM, Malhotra A, Dutta A (2010) Genomic study of replication initiation in human chromosomes reveals the influence of transcription regulation and chromatin structure on origin selection. Mol Biol Cell 21: 393-404
11. Kemp MG, Ghosh M, Liu G, Leffak M (2005) The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells. Nucleic Acids Res 33: 325-336
12. Labit H, Goldar A, Guilbaud G, Douarche C, Hyrien O, Marheineke K (2008) A simple and optimized method of producing silanized surfaces for FISH and replication mapping on combed DNA fibers. Biotechniques 45: 649-652, 654, 656-648
13. Mathews CK (2006) DNA precursor metabolism and genomic stability. FASEB J 20: 1300-1314
14. Miotto B, Struhl K (2010) HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin. Mol Cell 37: 57-66
15. +-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication. Genes Dev 18: 769-781
16. Pasero P, Bensimon A, Schwob E (2002) Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locus. Genes Dev 16: 2479-2484
17. A-globin genes show opposite epigenetic modifications. Mol Cell Biol 23: 3536-3549
18. Sclafani RA, Holzen TM (2007) Cell cycle regulation of DNA replication. Annu Rev Genet 41: 237-280
19. Sherman PA, Fyfe JA (1989) Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers. Anal Biochem 180: 222-226
20. Svetlova EY, Razin SV, Debatisse M (2001) Mammalian recombination hot spot in a DNA loop anchorage region: a model for the study of common fragile sites. J Cell Biochem Suppl 36: 170-178
21. Tabancay AP Jr, Forsburg SL (2006) Eukaryotic DNA replication in a chromatin context. Curr Top Dev Biol 76: 129-184
22. Wu JR, Gilbert DM (2000) Lovastatin arrests CHO cells between the origin decision point and the restriction point. FEBS Lett 484: 108-112
23. Zhao X, Muller EG, Rothstein R (1998) A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol Cell 2: 329-340