Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

Nature

Volumn 517, Issue 7536, 2015, Pages 635-639

  Freudenthal, Bret D ^a   Beard, William A ^a   Perera, Lalith ^a   Shock, David D ^a   Kim, Taejin ^b,c   Schlick, Tamar ^b,c   Wilson, Samuel H ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b NEW YORK UNIVERSITY SHANGHAI   (China)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ADENINE; CYTOSINE; NUCLEOTIDE; 8-HYDROXYGUANINE; 8-OXODEOXYGUANOSINE TRIPHOSPHATE; CYTOTOXIN; DEOXYGUANOSINE PHOSPHATE; DNA; DNA DIRECTED DNA POLYMERASE BETA; GUANINE;

ANTIBIOTIC SENSITIVITY; ARTICLE; CANCER CELL; CATALYSIS; CELL SURVIVAL; CRYSTALLOGRAPHY; CYTOTOXICITY; DNA REPAIR; ESCHERICHIA COLI; HUMAN; HYDROGEN BOND; KINETICS; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; BASE PAIRING; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DNA DAMAGE; DNA REPLICATION; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; MUTAGENESIS; NEOPLASM; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; STATIC ELECTRICITY; TIME FACTOR; X RAY CRYSTALLOGRAPHY;

ADENINE; BASE PAIRING; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYTOSINE; CYTOTOXINS; DEOXYGUANINE NUCLEOTIDES; DNA; DNA DAMAGE; DNA POLYMERASE BETA; DNA REPAIR; DNA REPLICATION; GUANINE; HUMANS; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTAGENESIS; NEOPLASMS; OXIDATION-REDUCTION; OXIDATIVE STRESS; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 84925461150     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13886     Document Type: Article

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