New chemosensory component in the U.S. National Health and Nutrition Examination Survey (NHANES): first-year results for measured olfactory dysfunction

Reviews in Endocrine and Metabolic Disorders

Volumn 17, Issue 2, 2016, Pages 221-240

  Hoffman, Howard J ^a   Rawal, Shristi ^b,c   Li, Chuan Ming ^a   Duffy, Valerie B ^c  

^a NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Epidemiology; Health status; Olfaction disorders; Public health surveillance; Risk factors; Taste

Indexed keywords

ADULT; AGED; FEMALE; HEALTH SURVEY; HUMAN; MALE; MIDDLE AGED; NUTRITION; OLFACTION DISORDERS; PATHOPHYSIOLOGY; STATISTICS AND NUMERICAL DATA; UNITED STATES; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HEALTH SURVEYS; HUMANS; MALE; MIDDLE AGED; NUTRITION SURVEYS; OLFACTION DISORDERS; UNITED STATES;

EID: 84973651828     PISSN: 13899155     EISSN: 15732606     Source Type: Journal    
DOI: 10.1007/s11154-016-9364-1     Document Type: Review

References (101)

1. National Health and Nutrition Examination Survey: Plan and Operations, 1999–2010. Centers for Disease Control and Prevention (CDC), National Center for Health Statistics (NCHS). Available from: http://www.cdc.gov/nchs/data/series/sr_01/sr01_056.pdf. Accessed May 20, 2016.
2. National Institutes on Deafness and Other Communication Disorders. NIDCD Workshop on Epidemiology of Communication Disorders. 2005. Available from: http://www.nidcd.nih.gov/funding/programs/pages/episummary.aspx. Accessed May 20, 2016.
3. Healthy People 2020 Topics & Objectives: Hearing and Other Sensory or Communication Disorders. U.S. Department of Health and Human Services, Office of Disease Prevention and Health Promotion. Available from: http://www.healthypeople.gov/2020/topicsobjectives2020/objectiveslist.aspx?topicId=20. Accessed May 20, 2016.
4. National Health and Nutrition Examination Survey (NHANES) Taste and Smell Examination Component Manual. CDC, NCHS. Available from: http://www.cdc.gov/nchs/data/nhanes/nhanes_13_14/Taste_Smell.pdf. Accessed May 20, 2016.
5. NIH Toolbox For the Assessment of Neurological and Behavioral Function. NIH Blueprint for Neuroscience Research. Available from: http://www.nihtoolbox.org/WhatAndWhy/Sensation. Accessed May 20, 2016.
6. Coldwell SE, Mennella JA, Duffy VB, Pelchat ML, Griffith JW, Smutzer G, et al. Gustation assessment using the NIH Toolbox. Neurology. 2013;80(11 Suppl 3):S20–4.
7. Dalton P, Doty RL, Murphy C, Frank R, Hoffman HJ, Maute C, et al. Olfactory assessment using the NIH Toolbox. Neurology. 2013;80(11 Suppl 3):S32–6.
8. NHANES. 2011–2012 Data Documentation, Codebook, and Frequencies: Taste and Smell Disorders [internet]. CDC, NCHS. Available from: http://www.cdc.gov/nchs/nhanes/nhanes2011-2012/CSQ_G.htm. Accessed May 20, 2016.
9. Rawal S, Hoffman HJ, Bainbridge KE, Huedo-Medina TB, Duffy VB. Prevalence and risk factors of self-reported smell and taste alterations: results from the 2011-2012 US National Health and Nutrition Examination Survey (NHANES). Chem Senses. 2016;41(1):69–76.
10. Rawal S, Hoffman HJ, Chapo AK, Duffy VB. Sensitivity and specificity of self-reported olfactory dysfunction in a home-based study of independent-living. Healthy Older Women Chemosens Percept. 2014;7(304):108–16.
11. Murphy C, Schubert C, Cruickshanks K, Klein B, Klein R, Nondahl D. Prevalence of olfactory impairment in older adults. J Am Med Assoc. 2002;288(18):2307–12.
12. Schubert CR, Cruickshanks KJ, Fischer ME, Huang GH, Klein BE, Klein R, et al. Olfactory impairment in an adult population: the Beaver Dam Offspring Study. Chem Senses. 2012;37(4):325–34.
13. Hoffman H, Ishii E, MacTurk R. Age-related changes in the prevalence of smell/taste problems among the United States adult population. Results of the 1994 Disability Supplement to the National Health Interview Survey (NHIS). Ann N Y Acad Sci. 1998;855:716–22.
14. Rawal S, Hoffman HJ, Honda M, Huedo-Medina TB, Duffy VB. The taste and smell protocol in the 2011-2014 U.S. National Health and Nutrition Examination Survey (NHANES): test-retest reliability and validity testing. Chemosens Percept. 2015;8(3):138–48.
15. Wehling E, Nordin S, Espeseth T, Reinvang I, Lundervold AJ. Unawareness of olfactory dysfunction and its association with cognitive functioning in middle aged and old adults. Arch Clin Neuropsychol. 2011;26(3):260–9.
16. Bramerson A, Johansson L, Ek L, Nordin S, Bende M. Prevalence of olfactory dysfunction: the Skovde population-based study. Laryngoscope. 2004;114(4):733–7.
17. Shu CH, Hummel T, Lee PL, Chiu CH, Lin SH, Yuan BC. The proportion of self-rated olfactory dysfunction does not change across the life span. Am J Rhinol Allergy. 2009;23(4):413–6.
18. Lee WH, Wee JH, Kim DK, Rhee CS, Lee CH, Ahn S, et al. Prevalence of subjective olfactory dysfunction and its risk factors: Korean National Health and Nutrition Examination Survey. PLoS One. 2013;8(5):e62725.
19. Michikawa T, Nishiwaki Y, Takebayashi T. Are you conscious of any age-related taste impairment? Prevalence of and factors associated with taste impairment in Japan. J Am Geriatr Soc. 2011;59(5):951–3.
20. Welge-Lussen A, Dorig P, Wolfensberger M, Krone F, Hummel T. A study about the frequency of taste disorders. J Neurol. 2011;258(3):386–92.
21. Bartoshuk LM, Duffy VB, Green BG, Hoffman HJ, Ko CW, Lucchina LA, et al. Valid across-group comparisons with labeled scales: the gLMS versus magnitude matching. Physiol Behav. 2004;82(1):109–14.
22. Galindo-Cuspinera V, Waeber T, Antille N, Hartmann C, Stead N, Martin N. Reliability of threshold and suprathreshold methods for taste phenotyping: characterization with PROP and sodium chloride. Chemosens Percept. 2009;2(4):214–28.
23. Pepino MY, Bradley D, Eagon JC, Sullivan S, Abumrad NA, Klein S. Changes in taste perception and eating behavior after bariatric surgery-induced weight loss in women. Obesity (Silver Spring). 2014;22(5):E13–20.
24. Pelletier CA, Steele CM. Influence of the perceived taste intensity of chemesthetic stimuli on swallowing parameters given age and genetic taste differences in healthy adult women. J Speech Lang Hear Res. 2014;57(1):46–56.
25. McAnally HM, Poulton R, Hancox RJ, Prescott J, Welch D. Psychosocial correlates of 6-n-propylthiouracil (PROP) ratings in a birth cohort. Appetite. 2007;49(3):700–3.
26. Cruickshanks KJ, Schubert CR, Snyder DJ, Bartoshuk LM, Huang GH, Klein BE, et al. Measuring taste impairment in epidemiologic studies: the Beaver Dam Offspring Study. Ann N Y Acad Sci. 2009;1170:543–52.
27. Dias AG, Rousseau D, Duizer L, Cockburn M, Chiu W, Nielsen D, et al. Genetic variation in putative salt taste receptors and salt taste perception in humans. Chem Senses. 2013;38(2):137–45.
28. Rawal S, Hayes JE, Wallace MR, Bartoshuk LM, Duffy VB. Do polymorphisms in the TAS1R1 gene associate with broader differences in human taste intensity? Chem Senses. 2013;38(8):719–28.
29. Fischer ME, Cruickshanks KJ, Pankow JS, Pankratz N, Schubert CR, Huang GH, et al. The associations between 6-n-propylthiouracil (PROP) intensity and taste intensities differ by TAS2R38 haplotype. J Nutrigenet Nutrigenomics. 2014;7(3):143–52.
30. Dinehart ME, Hayes JE, Bartoshuk LM, Lanier SL, Duffy VB. Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake. Physiol Behav. 2006;87(2):304–13.
31. Hayes JE, Sullivan BS, Duffy VB. Explaining variability in sodium intake through oral sensory phenotype, salt sensation and liking. Physiol Behav. 2010;100(4):369–80.
32. Fischer ME, Cruickshanks KJ, Schubert CR, Pinto A, Huang GH, Klein BE, et al. The association of taste with change in adiposity-related health measures. J Acad Nutr Diet. 2014;114(8):1195–202.
33. Simchen U, Koebnick C, Hoyer S, Issanchou S, Zunft HJ. Odour and taste sensitivity is associated with body weight and extent of misreporting of body weight. Eur J Clin Nutr. 2006;60(6):698–705.
34. Kveton J, Bartoshuk L. The effect of unilateral chorda tympani damage on taste. Laryngoscope. 1994;104(1):25–9.
35. Yanagisawa K, Bartoshuk LM, Catalanotto FA, Karrer TA, Kveton JF. Anesthesia of the chorda tympani nerve and taste phantoms. Physiol Behav. 1997;63(3):329–35.
36. Sipiora ML, Murtaugh MA, Gregoire MB, Duffy VB. Bitter taste perception and severe vomiting in pregnancy. Physiol Behav. 2000;69(3):259–67.
37. Bartoshuk LM, Catalanotto F, Hoffman H, Logan H, Snyder DJ. Taste damage (otitis media, tonsillectomy and head and neck cancer), oral sensations and BMI. Physiol Behav. 2012;107(4):516–26.
38. Duffy VB, Peterson J, Bartoshuk LM. Associations between taste genetics, oral sensations and alcohol intake. Physiol Behav. 2004;82(2–3):435–45.
39. Reed DR, Zhu G, Breslin PA, Duke FF, Henders AK, Campbell MJ, et al. The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12. Hum Mol Genet. 2010;19(21):4278–85.
40. Cowart B, Yokomukai Y, Beauchamp G. Bitter taste in aging: compound-specific decline in sensitivity. Physiol Behav. 1994;56(6):1237–41.
41. Campbell MC, Ranciaro A, Froment A, Hirbo J, Omar S, Bodo JM, et al. Evolution of functionally diverse alleles associated with PTC bitter taste sensitivity in Africa. Mol Biol Evol. 2012;29(4):1141–53.
42. Bartoshuk LM, Duffy VB, Miller Jr IJ. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiol Behav. 1994;56(6):1165–71.
43. Tepper BJ. Nutritional implications of genetic taste variation: the role of PROP sensitivity and other taste phenotypes. Annu Rev Nutr. 2008;28:367–88.
44. Akmal A, Kung J. Propylthiouracil, and methimazole, and carbimazole-related hepatotoxicity. Expert Opin Drug Saf. 2014;13(10):1397–406.
45. Coldwell S, Duffy V, Bartoshuk L, Griffith J, Hoffman H. The NIH Toolbox brief gustation assessment protocol (abstract). 2013;Abstracts from the 35th Annual Meeting of AChemS—Chem Senses:A114.
46. Doty R, Frye R. Influence of nasal obstruction on smell function. Otolaryngol Clin N Am. 1989;22:397–441.
47. Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G. 'Sniffin' sticks': olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses. 1997;22(1):39–52.
48. Cain WS, Rabin MD. Comparability of two tests of olfactory functioning. Chem Senses. 1989;14(4):479–85.
49. Doty R, Shaman P, Dann M. Development of the University of Pennsylvania smell identification test: a standardized microencapsulated test of olfactory function. Physiol Behav. 1984;34:489–502.
50. Schumm LP, McClintock M, Williams S, Leitsch S, Lundstrom J, Hummel T, et al. Assessment of sensory function in the National Social Life, Health, and Aging Project. J Gerontol B Psychol Sci Soc Sci. 2009;64(Suppl 1):i76–85.
51. NHANES 2011–2012 Overview. 2015. CDC, NCHS Available at: http://www.cdc.gov/nchs/nhanes/nhanes2011-2012/overview_g.htm. Accessed May 20, 2016.
52. CDC. 2011-2012 National Health and Nutrition Examination Survey (NHANES): Survey Operations Manuals. Available from URL: http://www.cdc.gov/nchs/nhanes/nhanes2011-2012/manuals11_12.htm. Accessed May 20, 2016.
53. U.S. Census. Poverty-Definitions. Available at: https://www.census.gov/hhes/www/poverty/methods/definitions.html. Accessed May 20, 2016.
54. Sabanayagam C, Shankar A. Income is a stronger predictor of mortality than education in a national sample of US adults. J Health Popul Nutr. 2012;20:82–6.
55. Doty RL, Shaman P, Applebaum SL, Giberson R, Siksorski L, Rosenberg L. Smell identification ability: changes with age. Science. 1984;226(4681):1441–2.
56. Ship J, Weiffenbach J. Age, gender, medical treatment and medication effects on smell identification. J Gerontol. 1993;48:M26–32.
57. Wysocki CJ, Gilbert AN. The National Geographic Smell Survey: effects of age are heterogeneous. Ann N Y Acad Sci. 1989;561:12–28.
58. Schubert CR, Cruickshanks KJ, Fischer ME, Huang GH, Klein R, Tsai MY, et al. Carotid intima media thickness, atherosclerosis, and 5-year decline in odor identification: the Beaver Dam Offspring Study. J Gerontol A Biol Sci Med Sci. 2015;70(7):879–84.
59. Vennemann M, Hummel T, Berger K. The association between smoking and smell and taste impairment in the general population. J Neurol. 2008;255(8):1121–6.
60. Mullol J, Alobid I, Marino-Sanchez F, Quinto L, de Haro J, Bernal-Sprekelsen M et al. Furthering the understanding of olfaction, prevalence of loss of smell and risk factors: a population-based survey (OLFACAT study). BMJ Open. 2012;2(6).
61. Wilson RS, Arnold SE, Tang Y, Bennett DA. Odor identification and decline in different cognitive domains in old age. Neuroepidemiology. 2006;26(2):61–7.
62. Roberts RO, Christianson TJ, Kremers WK, Mielke MM, Machulda MM, Vassilaki M, et al. Association between olfactory dysfunction and amnestic mild cognitive impairment and Alzheimer disease dementia. JAMA Neurol. 2016;73(1):93–101.
63. Pinto JM, Wroblewski KE, Kern DW, Schumm LP, McClintock MK. The rate of age-related olfactory decline among the general population of older U.S. adults. J Gerontol A Biol Sci Med Sci. 2015;70(11):1435–41.
64. Pence TS, Reiter ER, DiNardo LJ, Costanzo RM. Risk factors for hazardous events in olfactory-impaired patients. JAMA Otolaryngol Head Neck Surg. 2014;140(10):951–5.
65. Suchowersky O, Reich S, Perlmutter J, Zesiewicz T, Gronseth G, Weiner WJ, et al. Practice parameter: diagnosis and prognosis of new onset Parkinson disease (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2006;66(7):968–75.
66. Aetna. Smell and Taste Disorders: Diagnosis. 2015 Available at: http://www.aetna.com/cpb/medical/data/300_399/0390.html. Accessed May 20, 2016.
67. ICD10Data.com. Symptoms and signs involving cognition, perception, emotional state and behavior. In: ICD-10-CM Diagnosis Codes. 2016. Available at: http://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R43-. Accessed May 20, 2016.
68. Malaty J, Malaty IA. Smell and taste disorders in primary care. Am Fam Physician. 2013;88(12):852–9.
69. Eekhof JA, De Bock GH, Schaapveld K, Springer MP. Screening for hearing and visual loss among elderly with questionnaires and tests: which method is the most convincing for action? Scand J Prim Health Care. 2000;18(4):203–7.
70. Nguyen AD, Shenton ME, Levitt JJ. Olfactory dysfunction in schizophrenia: a review of neuroanatomy and psychophysiological measurements. Harv Rev Psychiatry. 2010;18(5):279–92.
71. Knaapila A, Tuorila H, Kyvik KO, Wright MJ, Keskitalo K, Hansen J, et al. Self-ratings of olfactory function reflect odor annoyance rather than olfactory acuity. Laryngoscope. 2008;118(12):2212–7.
72. Kuk JL, Ardern CI. The influence of ethnicity and gender on the association between measured obesity and cardiorespiratory fitness with self-rated overweight, physical activity and health. Perspect Public Health. 2014;134(1):38–43.
73. Schubert CR, Cruickshanks KJ, Nondahl DM, Klein BE, Klein R, Fischer ME. Association of exercise with lower long-term risk of olfactory impairment in older adults. JAMA Otolaryngol Head Neck Surg. 2013;139(10):1061–6.
74. Menon C, Westervelt HJ, Jahn DR, Dressel JA, O'Bryant SE. Normative performance on the brief smell identification test (BSIT) in a multi-ethnic bilingual cohort: a project FRONTIER study. Clin Neuropsychol. 2013;27(6):946–61.
75. Boesveldt S, Lindau ST, McClintock MK, Hummel T, Lundstrom JN. Gustatory and olfactory dysfunction in older adults: a national probability study. Rhinology. 2011;49(3):324–30.
76. Doty RL, Petersen I, Mensah N, Christensen K. Genetic and environmental influences on odor identification ability in the very old. Psychol Aging. 2011;26(4):864–71.
77. Martinez-Martin P, Falup Pecurariu C, Odin P, van Hilten JJ, Antonini A, Rojo-Abuin JM, et al. Gender-related differences in the burden of non-motor symptoms in Parkinson's disease. J Neurol. 2012;259(8):1639–47.
78. Krantz EM, Schubert CR, Dalton DS, Zhong W, Huang GH, Klein BE, et al. Test-retest reliability of the San Diego odor identification test and comparison with the brief smell identification test. Chem Senses. 2009;34(5):435–40.
79. Doty RL, Applebaum S, Zusho H, Settle RG. Sex differences in odor identification ability: a cross-cultural analysis. Neuropsychologia. 1985;23(5):667–72.
80. Pinto JM, Schumm LP, Wroblewski KE, Kern DW, McClintock MK. Racial disparities in olfactory loss among older adults in the United States. J Gerontol A Biol Sci Med Sci. 2014;69(3):323–9.
81. Ross GW, Petrovitch H, Abbott RD, Tanner CM, Popper J, Masaki K, et al. Association of olfactory dysfunction with risk for future Parkinson's disease. Ann Neurol. 2008;63(2):167–73.
82. Shiga H, Yamamoto J, Kitamura M, Nakagawa H, Matsubasa T, Seo A, et al. Combinations of two odorants of smell identification test for screening of olfactory impairment. Auris Nasus Larynx. 2014;41(6):523–7.
83. Ogihara H, Kobayashi M, Nishida K, Kitano M, Takeuchi K. Applicability of the cross-culturally modified University of Pennsylvania Smell Identification Test in a Japanese population. Am J Rhinol Allergy. 2011;25(6):404–10. doi:10.2500/ajra.2011.25.3658.
84. Patel HH, Straight CE, Lehman EB, Tanner M, Carr MM. Indications for tonsillectomy: a 10 year retrospective review. Int J Pediatr Otorhinolaryngol. 2014;78(12):2151–5.
85. Grob GN. The rise and decline of tonsillectomy in twentieth-century America. J Hist Med Allied Sci. 2007;62(4):383–421.
86. Holbrook EH, Leopold DA. An updated review of clinical olfaction. Curr Opin Otolaryngol Head Neck Surg. 2006;14(1):23–8.
87. Revai K, Dobbs LA, Nair S, Patel JA, Grady JJ, Chonmaitree T. Incidence of acute otitis media and sinusitis complicating upper respiratory tract infection: the effect of age. Pediatrics. 2007;119(6):e1408–12.
88. Linder JA, Singer DE. Health-related quality of life of adults with upper respiratory tract infections. J Gen Intern Med. 2003;18(10):802–7.
89. Takano K, Yamamoto M, Kondo A, Takahashi H, Himi T. A clinical study of olfactory dysfunction in patients with Mikulicz's disease. Auris Nasus Larynx. 2011;38(3):347–51.
90. Kamel UF, Maddison P, Whitaker R. Impact of primary Sjogren's syndrome on smell and taste: effect on quality of life. Rheumatology (Oxford). 2009;48(12):1512–4.
91. Coelho DH, Costanzo RM. Posttraumatic olfactory dysfunction. Auris Nasus Larynx. 2016 Apr;43(2):137–43.
92. Stuck BA, Hummel T. Olfaction in allergic rhinitis: a systematic review. J Allergy Clin Immunol. 2015;136(6):1460–70.
93. Schubert CR, Cruickshanks KJ, Klein BE, Klein R, Nondahl DM. Olfactory impairment in older adults: five-year incidence and risk factors. Laryngoscope. 2011;121(4):873–8.
94. Maurage P, Callot C, Chang B, Philippot P, Rombaux P, de Timary P. Olfactory impairment is correlated with confabulation in alcoholism: towards a multimodal testing of orbitofrontal cortex. PLoS One. 2011;6(8):e23190.
95. Pasala S, Barr T, Messaoudi I. Impact of alcohol abuse on the adaptive immune system. Alcohol Res. 2015;37(2):185–97.
96. Selya AS, Oancea SC, Thapa S. Time to first cigarette, a proxy of nicotine dependence, increases the risk of pulmonary impairment, independently of current and lifetime smoking behavior. Nicotine Tob Res. 2016;18(6):1431–9.
97. Glennon S-G, Litt M, Duffy VB. Olfactory but not taste dysfunction among chronic smokers: baseline results from an e-cigarette intervention. Association for Chemoreception Sciences Annual Meeting; Bonita Springs, FL: Chemical Senses; 2016. p. in press (abstract).
98. Glennon S-G, Rawal S, Hoffman H, Duffy V. Chronic cigarette exposure associates with self-reported smell alterations: findings from the U.S. National Health and nutrition examination survey (NHANES) 2011-2012. Association for Chemoreception Sciences Annual Meeting. Bonita Springs, FL: Chemical Senses. 2015;40(7):624–5.
99. Fishman EI, Steeves JA, Zipunnikov V, Koster A, Berrigan D, Harris TA et al. Association between objectively measured physical activity and mortality in NHANES. Med Sci Sports Exerc. 2016.
100. Cain WS, Gent JF, Goodspeed RB, Leonard G. Evaluation of olfactory dysfunction in the Connecticut chemosensory clinical research center. Laryngoscope. 1988;98:83–8.
101. Doty RL, Kamath V. The influences of age on olfaction: a review. Front Psychol. 2014;5:20.