The associations between 6-n-propylthiouracil (PROP) intensity and taste intensities differ by TAS2R38 haplotype

Journal of Nutrigenetics and Nutrigenomics

Volumn 7, Issue 3, 2014, Pages 143-152

  Fischer, Mary E ^a   Cruickshanks, Karen J ^a   Pankow, James S ^b   Pankratz, Nathan ^c   Schubert, Carla R ^a   Huang, Guan Hua ^d   Klein, Barbara E K ^a   Klein, Ronald ^a   Pinto, Alex ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

Author keywords

Population association study; Propylthiouracil; Taste

Indexed keywords

PROPYLTHIOURACIL; PROTEIN; PROTEIN TAS2R38; QUININE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; TASTE RECEPTORS, TYPE 2;

ADULT; AGED; ARTICLE; BITTER TASTE; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TASTE; DOSE RESPONSE; DRUG EFFECTS; GENETICS; MIDDLE AGED; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPYLTHIOURACIL; RECEPTORS, G-PROTEIN-COUPLED; TASTE; TASTE PERCEPTION; YOUNG ADULT;

EID: 84925383092     PISSN: 16616499     EISSN: 16616758     Source Type: Journal    
DOI: 10.1159/000371552     Document Type: Article

References (44)

1. Glanz K, Basil M, Maibach E, Goldberg J, Snyder D: Why Americans eat what they do: taste, nutrition, cost, convenience, and weight control concerns as influences on food consumption. J Am Diet Assoc 1998; 98: 1118-1126
2. Dressler H, Smith C: Food choice, eating behavior, and food liking differs between lean/normal and overweight/obese, low-income women. Appetite 2013; 65: 145-152
3. Peyrot des Gachons CP, Beauchamp GK, Breslin PA: The genetics of bitterness and pungency detection and its impact on phytonutrient evaluation. Ann NY Acad Sci 2009; 1170: 140-144
4. Blakeslee AF: Genetics of sensory thresholds: taste for phenylthiocarbamide. Proc Natl Acad Sci USA 1932; 18: 120-130
5. Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D: Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 2003; 299: 1221-1225
6. Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM: Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Alcohol Clin Exp Res 2004; 28: 1629-1637
7. Calo C, Padiglia A, Zonza A, Corrias L, Contu P, Tepper BJ, Barbarossa IT: Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype. Physiol Behav 2011; 104: 1065-1071
8. Reed DR, Nanthakumar E, North M, Bell C, Bartoshuk LM, Price RA: Localization of a gene for bitter-taste perception to human chromosome 5p15. Am J Hum Genet 1999; 64: 1478-1480
9. Bufe B, Breslin PA, Kuhn C, Reed DR, Tharp CD, Slack JP, Kim UK, Drayna D, Meyerhof W: The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol 2005; 15: 322-327
10. Bartoshuk LM, Duffy VB, Miller IJ: PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiol Behav 1994; 56: 1165-1171
11. Bartoshuk LM, Duffy VB, Lucchina LA, Prutkin J, Fast K: PROP (6-n-propylthiouracil) supertasters and the saltiness of NaCl. Ann NY Acad Sci 1998; 855: 793-796
12. Bartoshuk LM: Comparing sensory experiences across individuals: recent psychophysical advances illuminate genetic variation in taste perception. Chem Senses 2000; 25: 447-460
13. Delwiche JF, Buletic Z, Breslin PAS: Relationship of papillae number to bitter intensity of quinine and PROP within and between individuals. Physiol Behav 2001; 74: 329-337
14. Bajec MR, Pickering GJ: Thermal taste, PROP responsiveness, and perception of oral sensations. Physiol Behav 2008; 95: 581-590
15. Hayes JE, Bartoshuk LM, Kidd JK, Duffy VB: Supertasting and PROP bitterness depends on more than the TAS2R38 gene. Chem Senses 2008; 33: 255-265
16. Lucchina LA, Curtis OF 5th, Putnam P, Drewnowski A, Prutkin JM, Bartoshuk LM: Psychophysical measurement of 6-n-propylthiouracil (PROP) taste perception. Ann NY Acad Sci 1998; 855: 816-819
17. Hayes JE, Sullivan BS, Duffy VB: Explaining variability in sodium intake through oral sensory phenotype, salt sensation and liking. Physiol Behav 2010; 100: 369-380
18. Tepper BJ, Nurse RJ: PROP taster status is related to fat perception and preference. Ann NY Acad Sci 1998; 855: 802-804
19. Hayes JE, Duffy VB: Revisiting sugar-fat mixtures: sweetness and creaminess vary with phenotypic markers of oral sensation. Chem Senses 2007; 32: 225-236
20. Yackinous C, Guinard J-X: Relation between PROP taster status and fat perception, touch, and olfaction. Physiol Behav 2001; 72: 427-437
21. Drewnowski A, Henderson SA, Cockroft JE: Genetic sensitivity to 6-n-propylthiouracil has no influence on dietary patterns, body mass indexes, or plasma lipid profiles of women. J Am Diet Assoc 2007; 107: 1340-1348
22. Lim J, Urban L, Green BG: Measures of individual differences in taste and creaminess perception. Chem Senses 2008; 33: 493-501
23. Essick GK, Chopra A, Guest S, McGlone F: Lingual tactile acuity, taste perception, and the density and diameter of fungiform papillae in female subjects. Physiol Behav 2003; 80: 289-302
24. Duffy VB, Hayes JE, Davidson AC, Kidd JR, Kidd KK, Bartoshuk LM: Vegetable intake in college-aged adults is explained by oral sensory phenotypes and TAS2R38 genotype. Chemosens Percept 2010; 3: 137-148
25. Fischer ME, Cruickshanks KJ, Schubert CR, Pinto A, Klein R, Pankratz N, Pankow JS, Huang GH: Factors related to fungiform papillae density: the Beaver Dam Offspring Study. Chem Senses 2013; 38: 669-677
26. Garneu NL, Nuessle TM, Sloan MM, Santorico SA, Coughlin BC, Hayes JE: Crowdsourcing taste research: genetic and phenotypic predictors of bitter taste perception as a model. Front Integr Neurosci 2014; 8: 33
27. Cruickshanks KJ, Wiley TL, Tweed TS, Klein BEK, Klein R, Mares-Perlman JA, Nondahl DM: Prevalence of hearing loss in older adults in Beaver Dam, Wisconsin. The Epidemiology of Hearing Loss Study. Am J Epidemiol 1998; 148: 879-886
28. Cruickshanks KJ, Schubert CR, Snyder DJ, Bartoshuk LM, Huang G-H, Klein BEK, Klein R, Nieto FJ, Pankow JS, Tweed TS, Krantz EM, Moy GS: Measuring taste impairment in epidemiologic studies. The Beaver Dam Offspring Study. Ann NY Acad Sci 2009; 1170: 543-552
29. Zhan W, Cruickshanks KJ, Klein BEK, Klein R, Huang GH, Pankow JS, Gangnon RE, Tweed TS: Generational differences in the prevalence of hearing impairment in older adults. Am J Epidemiol 2010; 171: 260-266
30. Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, et al: Concept, design and implementation of a cardiovascular gene-centric 50 K SNP array for large-scale genomic association studies. PLoS One 2008; 3:e3583
31. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, Maller J, Sklar P, de Bakker PIW, Daly MJ, Sham PC: PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575
32. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D: Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006; 38: 904-909
33. Patterson N, Price AL, Reich D: Population structure and eigenanalysis. PLoS Genet 2006; 2:e190
34. Bartoshuk LM, Duffy VB, Green BG, Hoffman HJ, Ko C-W, Lucchina LA, Marks LE, Snyder DJ, Weiffenbach JM: Valid across-group comparisons with labeled scales: the gLMS versus magnitude matching. Physiol Behav 2004; 82: 109-114
35. Drewnowski A, Kristal A, Cohen J: Genetic taste responses to 6-n-propylthiouracil among adults: a screening tool for epidemiological studies. Chem Senses 2001; 26: 483-489
36. Fischer ME, Cruickshanks KJ, Schubert CR, Pinto A, Klein BE, Klein R, Nieto FJ, Pankow JS, Huang GH, Snyder DJ: Taste intensity in the Beaver Dam Offspring Study. Laryngoscope 2013; 123: 1399-1404
37. Prutkin J, Duffy VB, Etter L, Fast K, Gardner E, Lucchina LA, Snyder DJ, Tie K, Weiffenbach J, Bartoshuk LM: Genetic variation and inferences about perceived taste intensity in mice and men. Physiol Behav 2000; 69: 161-173
38. Ohla K, Lundström JN: Sex differences in chemosensation: sensory or emotional? Front Hum Neurosci 2013; 7: 607
39. Duffy VB, Peterson JM, Bartoshuk LM: Associations between taste genetics, oral sensation and alcohol intake. Physiol Behav 2004; 82: 435-445
40. Drewnowski A, Henderson SA, Shore AB: Genetic sensitivity to 6-n-propylthiouracil (PROP) and hedonic responses to bitter and sweet tastes. Chem Senses 1997; 22: 27-37
41. Kaminski LC, Henderson SA, Drewnowski A: Young women's food preferences and taste responsiveness to 6-n-propylthiouracil (PROP). Physiol Behav 2000; 68: 691-697
42. Ly A, Drewnowski A: PROP (6-n-Propylthiouracil) tasting and sensory responses to caffeine, sucrose, neohesperidin dihydrochalcone and chocolate. Chem Senses 2001; 26: 41-47
43. Marks LE, Borg G, Westerlund J: Differences in taste perception assessed by magnitude matching and by category-ratio scaling. Chem Senses 1992; 17: 493-506
44. Hayes JE, Keast RS: Two decades of supertasting: where do we stand? Physiol Behav 2011; 104: 1072-1074.