Evolution of functionally diverse alleles associated with PTC bitter taste sensitivity in Africa

Molecular Biology and Evolution

Volumn 29, Issue 4, 2012, Pages 1141-1153

  Campbell, Michael C ^a   Ranciaro, Alessia ^a   Froment, Alain ^b   Hirbo, Jibril ^a   Omar, Sabah ^c   Bodo, Jean Marie ^d   Nyambo, Thomas ^a   Lema, Godfrey ^a   Zinshteyn, Daniel ^e   Drayna, Dennis ^f   Breslin, Paul A S ^g   Tishkoff, Sarah A ^a,e  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^c INSTITUTE OF AGRICULTURAL RESEARCH FOR DEVELOPMENT IRAD   (Cameroon)

^d MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^e NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^f MONELL CHEMICAL SENSES CENTER   (United States)

^g RUTGERS UNIVERSITY   (United States)

Author keywords

adaptive evolution; African genetic diversity; excess of rare mutations; genotype phenotype association

Indexed keywords

PHENYLTHIOUREA;

AFRICA; ALLELE; ARTICLE; BITTER TASTE; CLINICAL EXAMINATION; CONTROLLED STUDY; EVOLUTION; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC TRAIT; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; TASTE ACUITY; TASTE BUD;

ADAPTATION, BIOLOGICAL; AFRICA; AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; EVOLUTION, MOLECULAR; GENETIC VARIATION; HAPLOTYPES; HUMANS; MUTATION; PHENOTYPE; RECEPTORS, G-PROTEIN-COUPLED; TASTE;

EID: 84858379651     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msr293     Document Type: Article

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