Gender-related differences in the burden of non-motor symptoms in Parkinson's disease

Journal of Neurology

Volumn 259, Issue 8, 2012, Pages 1639-1647

  Martinez Martin, Pablo ^a   Pecurariu, Cristian Falup ^b   Odin, Per ^c,d   Van Hilten, Jacobus J ^e   Antonini, Angelo ^f   Rojo Abuin, Jose M ^g   Borges, Vanderci ^h   Trenkwalder, Claudia ⁱ   Aarsland, Dag ^j,k   Brooks, David J ^l   Chaudhuri, Kallol Ray ^m  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b TRANSILVANIA UNIVERSITY OF BRASOV   (Romania)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d Central Hospital   (Germany)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^f IRCCS SAN CAMILLO HOSPITAL   (Italy)

^g CSIC   (Spain)

^h FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

ⁱ Paracelsus Elena Hospital   (Germany)

^j KAROLINSKA INSTITUTE   (Sweden)

^k STAVANGER UNIVERSITY HOSPITAL   (Norway)

^l IMPERIAL COLLEGE LONDON   (United Kingdom)

^m KING S COLLEGE HOSPITAL   (United Kingdom)

more..

Author keywords

Burden; Gender; Non motor symptoms; Parkinson's disease; Prevalence

Indexed keywords

ABNORMAL SENSATION; ADULT; AGED; APATHY; ARTICLE; CLINICAL ASSESSMENT; CLINICAL FEATURE; CONSTIPATION; CONTROLLED STUDY; DAYTIME SOMNOLENCE; DEMOGRAPHY; DISEASE DURATION; DISEASE SEVERITY; FATIGUE; FEMALE; HEALTH STATUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MOOD DISORDER; MOTOR DYSFUNCTION; NERVOUSNESS; NOCTURIA; NONMOTOR SYMPTOM; PAIN; PARKINSON DISEASE; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; RATING SCALE; RESTLESS LEGS SYNDROME; SADNESS; SALIVATION; SEX DIFFERENCE; SEXUAL DYSFUNCTION; SYMPTOM; TASTE AVERSION; WEIGHT CHANGE;

AGED; COST OF ILLNESS; CROSS-SECTIONAL STUDIES; FATIGUE; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MENTAL DISORDERS; MIDDLE AGED; PARKINSON DISEASE; SEX CHARACTERISTICS;

EID: 84867322109     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-011-6392-3     Document Type: Article

References (75)

1. Chaudhuri KR, Yates L, Martinez-Martin P (2005) The nonmotor symptom complex of Parkinson's disease: time for a comprehensive assessment. Curr Neurol Neurosci Rep 5:275-283
2. Hely MA, Morris JGL, Reid WGJ, Trafficante R (2005) Sydney multicenter study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years. Mov Disord 20:190-199
3. Chaudhuri KR, Healy D, Schapira AHV (2006) The non-motor symptoms of Parkinson's disease. Diagnosis and management. Lancet Neurol 5:235-245
4. Martinez-Martin P, Schapira AH, Stocchi F, Sethi K, Odin P, Macphee G et al (2007) Prevalence of nonmotor symptoms in Parkinson's disease in an international setting: Study using nonmotor symptoms questionnaire in 545 patients. Mov Disord 22:1623-1629
5. Shulman LM, Taback RL, Rabinstein AA, Weiner WJ (2002) Non-recognition of depression and other non-motor symptoms in Parkinson's disease. Parkinsonism Relat Disord 8:193-197
6. Chaudhuri KR, Prieto-Jurcynska C, Naidu Y, Mitra T, Frades-Payo B, Tluk S et al (2010) The non declaration of non motor symptoms of Parkinson's disease to health care professionals: an international study using the non motor symptoms questionnaire. Mov Disord 25:704-709
7. Martinez-Martin P, Marinus J, van Hilten B (2009) Assessment tools for non-motor symptoms of Parkinson's disease. In: Chaudhuri KR, Tolosa E, Schapira A, Poewe W (eds) Non-motor symptoms of Parkinson's disease. Oxford University Press, Oxford, pp 47-58
8. Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P et al (2008) Movement disorder societysponsored revision of the unified Parkinson's disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord 23:2129-2170
9. Martinez-Martin P, Rodriguez-Blazquez C, Abe K, Bhattacharyya KB, Bloem BR, Carod-Artal FJ et al (2009) International study on the psychometric attributes of the non-motor symptoms scale in Parkinson disease. Neurology 73:1584-1591
10. Chaudhuri KR, Martinez-Martin P, Brown RG, Sethi K, Stocchi F, Odin P et al (2007) The metric properties of a novel non-motor symptoms scale for Parkinson's disease: results from an international pilot study. Mov Disord 22:1901-1911
11. Kasten M, Chade A, Tanner CM (2007) Epidemiology of Parkinson's disease. In: Koller WC, Melamed E (eds) Parkinson's Disease and Related Disorders. Part I. Handbook of Clinical Neurology vol. 83, 3rd edn. Elsevier BV, Amsterdam, pp 129-151
12. Lyons K, Hubble J, Tröster A, Pahwa R, Koller WC (1998) Gender differences in Parkinson's disease. Clin Neuropharmacol 21:118-121
13. Scott B, Borgman A, Engler H, Johnels B, Aquilonius SM (2000) Gender differences in Parkinson's disease symptom profile. Acta Neurol Scand 102:37-43
14. Van Den Eeden SK, Tanner CM, Bernstein AL, Fross RD, Leimpeter A, Bloch DA et al (2003) Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity. Am J Epidemiol 157:1015-1022
15. Baba Y, Putzke JD, Whaley NR, Wszolek ZK, Uitti RJ (2005) Gender and the Parkinson's disease phenotype. J Neurol 252:1201-1205
16. Haaxma CA, Bloem BR, Borm GF, Oyen WJ, Leenders KL, Eshuis S et al (2007) Gender differences in Parkinson's disease. J Neurol Neurosurg Psychiatry 78:819-824
17. Ehrt U, Brønnick K, De Deyn PP, Emre M, Tekin S, Lane R et al (2007) Subthreshold depression in patients with Parkinson's disease and dementia-clinical and demographic correlates. Int J Geriatr Psychiatry 22:980-985
18. Celikel E, Ozel-Kizil ET, Akbostanci MC, Cevik A (2008) Assessment of sexual dysfunction in patients with Parkinson's disease: a case-control study. Eur J Neurol 15:1168-1172
19. Solimeo S (2008) Sex and gender in older adults' experience of Parkinson's disease. J Gerontol Soc Sci 63 B: S42-S48
20. Miller IN, Cronin-Golomb A (2010) Gender differences in Parkinson's disease: clinical characteristics and cognition. Mov Disord 25:2695-2703
21. Krishnan S, Sarma G, Sarma S, Kishore A (2011) Do Nonmotor Symptoms in Parkinson's disease differ from normal aging? Mov Disord. doi:10.1002/mds.23826
22. Lees AJ, Hardy J, Revesz T (2009) Parkinson's disease. Lancet 373:2055-2066
23. Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression, and mortality. Neurology 17:427-442
24. Marinus J, Visser M, Stiggelbout AM, Martin Rabey J, Martinez-Martin P, Bonuccelli U et al (2004) A short scale for the assessment of motor impairments and disabilities in Parkinson's disease: the SPES/SCOPA. J Neurol Neurosurg Psychiatry 75:388-395
25. Martinez-Martin P, Benito-Leon J, Burguera JA, Castro A, Linazasoro G, Martinez-Castrillo JC et al (2005) The SCOPAMotor Scale for assessment of Parkinson's disease is a consistent and valid measure. J Clin Epidemiol 58:674-679
26. Martinez-Martin P, Forjaz MJ, Cubo E, Frades B, de Pedro Cuesta J, Project Members ELEP (2006) Global versus factorrelated impression of severity in Parkinson's disease: A new clinimetric index (CISI-PD). Mov Disord 21:208-214
27. Martinez-Martin P, Rodriguez-Blazquez C, Forjaz MJ, de Pedro J, Longitudinal PD, Group Patient Study (2009) The clinical impression of severity index for Parkinson's disease: international validation study. Mov Disord 24:211-217
28. Group EuroQol (1990) EuroQol-a new facility for the measurement of health related quality of life. Health Policy 16:199-208
29. Jenkinson C, Fitzpatrick R, Peto V, Greenhall R, Hyman N (1997) The PDQ-8: development and validation of a short-form Parkinson's disease questionnaire. Psychol Health 12:805-814
30. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc 57:289-300
31. Friedman JH, Friedman H (1993) Fatigue in Parkinson's disease. Neurology 43:2016-2018
32. Martinez-Martin P, Catalan MJ, Benito-Leon J et al (2006) Impact of fatigue in Parkinson's disease: the fatigue impact scale for daily use (D-FIS). Qual Life Res 15:597-606
33. Friedman JH, Brown RG, Comella C et al (2007) Fatigue in Parkinson's disease: a review. Mov Disord 22:297-308
34. Barone P, Antonini A, Colosimo C, Marconi R, Morgante L, Avarello TP et al (2009) The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease. Mov Disord 24:1641-1649
35. Beiske AG, Loge JH, Hjermstad MJ, Svensson E (2010) Fatigue in Parkinson's disease: prevalence and associated factors. Mov Disord 25:2456-2460
36. Stein MB, Heuser IJ, Juncos JL, Uhde TW (1990) Anxiety disorders in patients with Parkinson's disease. Am J Psychiatry 147:217-220
37. Richard IH (2005) Anxiety disorders in Parkinson's disease. Adv Neurol 96:42-55
38. Weintraub D, Burn DJ (2011) Parkinson's disease: the quintessential neuropsychiatric disorder. Mov Disord 26:1022-1031
39. Blonder LX, Slevin JT (2011) Emotional dysfunction in Parkinson's disease. Behav Neurol 24:201-217
40. Martinez-Martin P, Damian J (2010) Depression and anxiety in Parkinson's disease. Nature Rev Neurol 6:243-245
41. Leentjens AF, Dujardin K, Marsh L, Martinez-Martin P, Richard IH, Starkstein SE (2011) Symptomatology and markers of anxiety disorders in Parkinson's disease: a cross-sectional study. Mov Disord 26:484-492
42. Carod-Artal FJ, Vargas AP, Martínez-Martín P (2007) Determinants of quality of life in Brazilian patients with Parkinson's disease. Mov Disord 22:1408-1415
43. Kulisevsky J, Pagonabarraga J, Pascual-Sedano B, García- Sánchez C, Gironell A, Study Trapecio Group (2008) Prevalence and correlates of neuropsychiatric symptoms in Parkinson's disease without dementia. Mov Disord 23:1889-1896
44. Reijnders JSAM, Ehrt U, Weber WEJ, Aarsland D, Leentjens AFG (2008) A systematic review of prevalence studies of depression in Parkinson's disease. Mov Disord 23:183-189
45. Rojo A, Aguilar M, Garolera MT, Cubo E, Navas I, Quintana S (2003) Depression in Parkinson's disease: clinical correlates and outcome. Parkinsonism Relat Disord 10:23-28
46. Krogh K, Ostergaard K, Sabroe S, Laurberg S (2008) Clinical aspects of bowel symptoms in Parkinson's disease. Acta Neurol Scand 117:60-64
47. Kamm MA (2003) Constipation and its management. Br Med J 327:459-460
48. Goetz CG, Tanner CM, Levy M, Wilson RS, Garron DC (1986) Pain in Parkinson's disease. Mov Disord 1:45-49
49. Defazio G, Berardelli A, Fabbrini G, Martino D, Fincati E, Fiaschi A et al (2008) Pain as a nonmotor symptom of Parkinson disease. Arch Neurol 65:1191-1194
50. Beiske AG, Loge JH, Rønningen A, Svensson E (2009) Pain in Parkinson's disease: prevalence and characteristics. Pain 141:173-177
51. Zambito Marsala S, Tinazzi M, Vitaliani R, Recchia S, Fabris F, Marchini C et al (2011) Spontaneous pain, pain threshold, and pain tolerance in Parkinson's disease. J Neurol 258:627-633
52. Hanagasi HA, Akat S, Gurvit H, Yazici J, Emre M (2011) Pain is common in Parkinson's disease. Clin Neurol Neurosurg 113:11-13
53. Gomez-Esteban JC, Zarranz JJ, Tijero B, Velasco F, Barcena J, Rouco I et al (2007) Restless legs syndrome in Parkinson's disease. Mov Disord 22:1912-1916
54. Peralta CM, Frauscher B, Seppi K, Wolf E, Wenning GK, Högl B et al (2009) Restless legs syndrome in Parkinson's disease. Mov Disord 24:2076-2080
55. Verbaan D, van Rooden SM, van Hilten JJ, Rijsman RM (2010) Prevalence and clinical profile of restless legs syndrome in Parkinson's disease. Mov Disord 25:2142-2147
56. Ondo WG, Dat Vuong K, Khan H, Atassi F, Kwak C, Jankovic J (2001) Daytime sleepiness and other sleep disorders in Parkinson's disease. Neurology 57:1392-1396
57. Gjerstad MD, Alves G, Wentzel-Larsen T, Aarsland A, Larsen JP (2006) Excessive daytime sleepiness in Parkinson disease. Is it the drugs or the disease? Neurology 67:853-858
58. Stavitsky K, Cronin-Golomb A (2011) Sleep quality in Parkinson disease: an examination of clinical variables. Cogn Behav Neurol 24:43-49
59. Merello M (2008) Sialorrhoea and drooling in patients with Parkinson's disease: epidemiology and management. Drugs Aging 25:1007-1019
60. Wüllner U, Schmitz-Hübsch T, Antony G, Fimmers R, Spottke A, Oertel WH et al (2007) Autonomic dysfunction in 3414 Parkinson's disease patients enrolled in the German Network on Parkinson's disease (KNP e. V.): the effect of ageing. Eur J Neurol 14:1405-1408
61. Mshana G, Dotchin CL, Walker RW (2011) We call it the shaking illness: perceptions and experiences of Parkinson's disease in rural northern Tanzania. BMC Public Health 11:219
62. Chaudhuri KR, Schapira AHV (2009) Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. Lancet Neurol 8:464-474
63. Gillies GE, McArthur S (2010) Estrogen actions in the brain and the basis for differential action in men and women: a case for sexspecific medicines. Pharmacol Rev 62:155-198
64. Fuhrer R, Wessely S (1995) The epidemiology of fatigue and depression: a French primary-care study. Psychol Med 25:895-905
65. Sharpe M, Wilks D (2002) Fatigue. Br Med J 325:480-483
66. Howell HB, Brawman-Mintzer O, Monnier J, Yonkers KA (2001) Generalized anxiety disorder in women. Psychiatr Clin North Am 24:165-178
67. Tyrer P, Baldwin D (2006) Generalised anxiety disorder. Lancet 368:2156-2166
68. Djernes JK (2006) Prevalence and predictors of depression in populations of elderly: a review. Acta Psychiatr Scand 113:372-387
69. Vink D, Aartsen MJ, Comijs HC, Heymans MW, Penninx BW, Stek ML et al (2009) Onset of anxiety and depression in the aging population: comparison of risk factors in a 9-year prospective study. Am J Geriatr Psychiatry 17:642-652
70. Mourão AF, Blyth FM, Branco JC (2010) Generalised musculoskeletal pain syndromes. Best Pract Res Clin Rheumatol 24:829-840
71. Leresche L (2011) Defining gender disparities in pain management. Clin Orthop Relat Res 469:1871-1877
72. Yeh P, Walters AS, Tsuang JW (2011) Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment. Sleep Breath. doi:10.1007/s11325-011-0606-x
73. Krishnan V, Collop NA (2006) Gender differences in sleep disorders. Curr Opin Pulm Med 12:383-389
74. Honig H, Antonini A, Martinez-Martin P, Forgacs I, Faye GC, Fox T et al (2009) Intrajejunal levodopa infusion in Parkinson's disease: a pilot multicenter study of effects on nonmotor symptoms and quality of life. Mov Disord 24:1468-1474
75. Reddy P, Martinez-Martin P, Antonini A, Odin P, Martin A, Calandrella D (2011) Comparison of non-motor effects of subcutaneous apomorphine infusion and intrajejunal levodopa infusion in advanced Parkinson's disease. Eur J Neurol 18(Suppl 2):242