Efficient siRNA delivery using PEG-conjugated PAMAM dendrimers targeting vascular endothelial growth factor in a CoCl2-induced neovascularization model in retinal endothelial cells

Current Drug Delivery

Volumn 13, Issue 4, 2016, Pages 590-599

  Xu, Lu ^a,b   Shen, Wenwen ^a,b   Wang, Bin ^c   Wang, Xinlei ^c   Liu, George ^a,b   Tao, Yong ^c   Qi, Rong ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

Choroidal neovascularization; Gene silencing efficacy; PEG conjugated PAMAM dendrimers; Retinal vascular endothelial cells; SiRNA; Vascular endothelial growth factor

Indexed keywords

COBALT CHLORIDE; DENDRIMER; MESSENGER RNA; POLYAMIDOAMINE; RIBONUCLEASE A; SMALL INTERFERING RNA; VASCULOTROPIN; COBALT; MACROGOL DERIVATIVE; PAMAM STARBURST; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFICACY; ENZYME DEGRADATION; FLUORESCENCE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RETINA NEOVASCULARIZATION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; MACACA; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; RETINA BLOOD VESSEL;

ANIMALS; CELLS, CULTURED; COBALT; DENDRIMERS; DISEASE MODELS, ANIMAL; MACACA; NEOVASCULARIZATION, PATHOLOGIC; POLYETHYLENE GLYCOLS; RETINAL VESSELS; RNA, SMALL INTERFERING; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84973630040     PISSN: 15672018     EISSN: 18755704     Source Type: Journal    
DOI: 10.2174/1567201812666150817123049     Document Type: Article

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