Tat-conjugated PAMAM dendrimers as delivery agents for antisense and siRNA oligonucleotides

Pharmaceutical Research

Volumn 22, Issue 12, 2005, Pages 2099-2106

  Kang, Hyunmin ^a   DeLong, Robert ^a,b   Fisher, Michael H ^a   Juliano, Rudolph L ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b Louisberg College   (United States)

Author keywords

Antisense; Cell penetrating peptide; Oligonucleotide; PAMAM dendrimer; siRNA; Tat

Indexed keywords

4,4 DIFLUORO 5,7 DIMETHYL 4 BORA 3A,4A DIAZA S INDACENE 3 PROPIONIC ACID SULFOSUCCIMIDYL ESTER SODIUM; ANTISENSE OLIGONUCLEOTIDE; CYSTEINE DERIVATIVE; DENDRIMER; HEXANOIC ACID DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN 1; PEPTIDE DERIVATIVE; POLYAMIDOAMINE; RNA DERIVATIVE; SODIUM DERIVATIVE; SULFOSUCCINIMIDYL 6 [ALPHA METHYL ALPHA (2 PYRIDYLDITHIO)TOLUAMIDO] HEXANOATE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL STRAIN 3T3; CELL VACUOLE; CONJUGATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; GENE EXPRESSION; INTRACELLULAR SPACE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING;

3T3 CELLS; ANIMALS; BORON COMPOUNDS; CELL SURVIVAL; CHROMATOGRAPHY, GEL; DENDRIMERS; DRUG DELIVERY SYSTEMS; FLUORESCENT DYES; GENE PRODUCTS, TAT; GENES, MDR; MICE; MICROSCOPY, CONFOCAL; OLIGONUCLEOTIDES; P-GLYCOPROTEIN; POLYAMINES; RIBONUCLEASES; RNA, ANTISENSE; RNA, SMALL INTERFERING;

EID: 29244459673     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-005-8330-5     Document Type: Article

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