Enhanced siRNA delivery into cells by exploiting the synergy between targeting ligands and cell-penetrating peptides

Biomaterials

Volumn 32, Issue 26, 2011, Pages 6194-6203

  Cheng, Christopher J ^a,b   Saltzman, W Mark ^a  

^a Yale University   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

Controlled drug release; Copolymer; Drug delivery; Gene therapy; Nanoparticle; Phospholipid

Indexed keywords

CELL BINDING; CELL SURFACE RECEPTORS; CELL SURFACES; CELL-PENETRATING PEPTIDE; CONTROLLED DRUG RELEASE; GENE SILENCING; HIGH DENSITY; INTRACELLULAR DELIVERY; MULTIPLE LIGANDS; NANO SCALE; NANOVEHICLES; PARTICULATE SYSTEMS; PENETRATIN; POLYMER NANOPARTICLES; SIRNA DELIVERY; SURFACE BINDING; SURFACE COVERAGES; TUMOR MODELS;

CELL CULTURE; CELL MEMBRANES; CONTROLLED DRUG DELIVERY; GENES; GENETIC ENGINEERING; MERGERS AND ACQUISITIONS; NANOPARTICLES; PEPTIDES; PHOSPHOLIPIDS; PLASTIC COATINGS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; RNA; SURFACE MORPHOLOGY;

LIGANDS;

CELL SURFACE RECEPTOR; FOLIC ACID; NANOPARTICLE; PENETRATIN; PHOSPHOLIPID; POLYMER; SMALL INTERFERING RNA; WATER;

ARTICLE; CELL MEMBRANE; CELL SURFACE; DENSITY; DRUG POTENTIATION; ENCAPSULATION; GENE DELIVERY SYSTEM; GENE SILENCING; GENE TARGETING; INTERNALIZATION; MORPHOLOGY; NANOFABRICATION; PARTICLE SIZE; PARTICULATE MATTER; PRIORITY JOURNAL; PROTEIN TARGETING; SUSTAINED DRUG RELEASE;

ANIMALS; CELL-PENETRATING PEPTIDES; FLOW CYTOMETRY; GENE SILENCING; MICE; MICE, NUDE; MODELS, THEORETICAL; NANOPARTICLES; PHOSPHOLIPIDS; POLYMERS; RNA, SMALL INTERFERING;

EID: 79959870154     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.04.053     Document Type: Article

References (51)

1. Tong R., Cheng J. Anticancer polymeric nanomedicines. Polym Rev 2007, 47:345-381.
2. Cartiera M.S., Johnson K.M., Rajendran V., Caplan M.J., Saltzman W.M. The uptake and intracellular fate of PLGA nanoparticles in epithelial cells. Biomaterials 2009, 30:2790-2798.
3. Andersen MØ, Lichawska A., Arpanaei A., Rask Jensen S.M., Kaur H., Oupicky D., et al. Surface functionalisation of PLGA nanoparticles for gene silencing. Biomaterials 2010, 31:5671-5677.
4. Fahmy T.M., Fong P.M., Goyal A., Saltzman W.M. Targeted for drug delivery. Mater Today 2005, 8:18-26.
5. Cu Y., LeMoëllic C., Caplan M.J., Saltzman W.M. Ligand-modified gene carriers increased uptake in target cells but reduced DNA release and transfection efficiency. Nanomedicine 2010, 6:334-343.
6. Keegan M.E., Saltzman W.M. Surface-modified biodegradable microspheres for DNA vaccine delivery. Methods Mol Med 2006, 127:107-113.
7. Allen T.M. Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2002, 2:750.
8. Gu F., Karnik R., Wang A., Alexis F., Levy-Nissenbaum E., Hong S., et al. Targeted nanoparticles for cancer therapy. Nano Today 2007, 2:14-21.
9. Zureikat A.H., McKee M.D. Targeted therapy for solid tumors: current status. Surg Oncol Clin N Am 2008, 17:279-301.
10. Low P.S., Antony A.C. Folate receptor-targeted drugs for cancer and inflammatory diseases. Adv Drug Deliv Rev 2004, 56:1055-1058.
11. Salazar M., Ratnam M. The folate receptor: what does it promise in tissue-targeted therapeutics?. Cancer Metastasis Rev 2007, 26:141-152.
12. Hong S., Leroueil P.R., Majoros I.J., Orr B.G., Baker J.R., Banaszak Holl M.M. The binding avidity of a nanoparticle-based multivalent targeted drug delivery platform. Chem Biol 2007, 14:107-115.
13. Simnick A.J., Valencia C.A., Liu R., Chilkoti A. Morphing low-affinity ligands into high-avidity nanoparticles by thermally triggered self-assembly of a genetically encoded polymer. ACS Nano. 2010, 4:2217-2227.
14. Tseng Y., Liu J., Hong R. Translocation of liposomes into cancer cells by cell-penetrating peptides penetratin and TAT: a kinetic and efficacy study. Mol Pharmacol 2002, 62:864-872.
15. Console S., Marty C., Garcia-Echeverria C., Schwendener R., Ballmer-Hofer K. Antennapedia and HIV transactivator of transcription (TAT) "Protein transduction domains" promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans. J Biol Chem 2003, 278:35109-35114.
16. Sugita T., Yoshikawa T., Mukai Y., Yamanada N., Imai S., Nagano K., et al. Improved cytosolic translocation and tumor-killing activity of TAT-shepherdin conjugates mediated by co-treatment with TAT-fused endosome-disruptive HA2 p.ptide. Biochem Biophys Res Commun 2007, 363:1027-1032.
17. Pirollo K.F., Rait A., Zhou Q., Hwang S.H., Dagata J.A., Zon G., et al. Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system. Cancer Res 2007, 67:2938-2943.
18. Zhao P., Wang H., Yu M., Cao S., Zhang F., Chang J., et al. Paclitaxel-loaded, folic-acid-targeted and TAT-peptide-conjugated polymeric liposomes: in vitro and in vivo evaluation. Pharm Res 2010, 27:1914-1926.
19. Thorén P.E., Persson D., Karlsson M., Nordén B. The antennapedia peptide penetratin translocates across lipid bilayers - the first direct observation. FEBS Lett 2000, 482:265-268.
20. Ziegler A., Seelig J. Binding and clustering of glycosaminoglycans: a common property of mono- and multivalent cell-penetrating compounds. Biophys J 2008, 94:2142-2149.
21. Takeshita F., Ochiya T. Therapeutic potential of RNA interference against cancer. Cancer Sci 2006, 97:689-696.
22. Woodrow K.A., Cu Y., Booth C.J., Saucier-Sawyer J.K., Wood M.J., Saltzman W.Mark Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA. Nat Mater 2009, 8:526-533.
23. Vauthier C., Schmidt C., Couvreur P. Measurement of the density of polymeric nanoparticulate drug carriers by isopycnic centrifugation. J Nanopart Res 1999, 1:411-418.
24. Goodson H.V., Dzurisin J.S., Wadsworth P. Generation of stable cell lines expressing GFP-tubulin and photoactivatable-GFP-tubulin and characterization of clones. Cold Spring Harb Protoc 2010, 2010:pdb.prot5480.
25. Uster P.S., Allen T.M., Daniel B.E., Mendez C.J., Newman M.S., Zhu G.Z. Insertion of poly(ethylene glycol) derivatized phospholipid into pre-formed liposomes results in prolonged in vivo circulation time. FEBS Lett 1996, 386:243-246.
26. Silvander M., Johnsson M., Edwards K. Effects of PEG-lipids on permeability of phosphatidylcholine/cholesterol liposomes in buffer and in human serum. Chem Phys Lipids 1998, 97:15-26.
27. Fahmy T.M., Samstein R.M., Harness C.C., Saltzman W.Mark Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting. Biomaterials 2005, 26:5727-5736.
28. Duncanson W.J., Figa M.A., Hallock K., Zalipsky S., Hamilton J.A., Wong J.Y. Targeted binding of PLA microparticles with lipid-PEG-tethered ligands. Biomaterials 2007, 28:4991-4999.
29. Moghimi S. The effect of methoxy-PEG chain length and molecular architecture on lymph node targeting of immuno-PEG liposomes. Biomaterials 2006, 27:136-144.
30. Li S., Huang L. Nanoparticles evading the reticuloendothelial system: role of the supported bilayer. BBA Biomembranes 2009, 1788:2259-2266.
31. Tirosh O., Barenholz Y., Katzhendler J., Priev A. Hydration of polyethylene glycol-grafted liposomes. Biophys J 1998, 74:1371-1379.
32. Avgoustakis K. Pegylated poly(lactide) and poly(lactide-co-glycolide) nanoparticles: preparation, properties and possible applications in drug delivery. Curr Drug Deliv 2004, 1:321-333.
33. Conner S.D., Schmid S.L. Regulated portals of entry into the cell. Nature 2003, 422:37-44.
34. Rejman J., Oberle V., Zuhorn I.S., Hoekstra D. Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem J 2004, 377:159-169.
35. Gindy M.E., Ji S., Hoye T.R., Panagiotopoulos A.Z., Prud'homme R.K. Preparation of poly(ethylene glycol) protected nanoparticles with variable bioconjugate ligand density. Biomacromolecules 2008, 9:2705-2711.
36. Rux Gref R, Couvreur P., Barratt G., Mysiakine E. Surface-engineered nanoparticles for multiple ligand coupling. Biomaterials 2003, 24:4529-4537.
37. Garbuzenko O., Barenholz Y., Priev A. Effect of grafted PEG on liposome size and on compressibility and packing of lipid bilayer. Chem Phys Lipids 2005, 135:117-129.
38. Zhang L., Chan J.M., Gu F.X., Rhee J., Wang A.Z., Radovic-Moreno A.F., et al. Self-assembled lipid-polymer hybrid nanoparticles: a robust drug delivery platform. ACS Nano. 2008, 2:1696-1702.
39. Liu Y., Li K., Pan J., Liu B., Feng S. Folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core for targeted delivery of Docetaxel. Biomaterials 2010, 31:330-338.
40. Torchilin V.P., Rammohan R., Weissig V., Levchenko T.S. TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc Natl Acad Sci U S A 2001, 98:8786-8791.
41. Ashok B., Arleth L., Hjelm R.P., Rubinstein I., Onyüksel H. In vitro characterization of PEGylated phospholipid micelles for improved drug solubilization: effects of PEG chain length and PC incorporation. J Pharm Sci 2004, 93:2476-2487.
42. Anderson M.T., Martin J.E., Odinek J.G., Newcomer P.P. Effect of methanol concentration on CTAB micellization and on the formation of surfactant-templated silica (STS). Chem Mater 1998, 10:1490-1500.
43. Akhter M.S., Alawi S.M. The effect of organic additives on critical micelle concentration of non-aqueous micellar solutions. Colloids Surf A Physicochem Eng Asp 2000, 175:311-320.
44. MacKay J.A., Li W., Huang Z., Dy E.E., Huynh G., Tihan T., et al. HIV TAT peptide modifies the distribution of DNA nanolipoparticles following convection-enhanced delivery. Mol Ther 2008, 16:893-900.
45. Lorenz C., Hadwiger P., John M., Vornlocher H., Unverzagt C. Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells. Bioorg Med Chem Lett 2004, 14:4975-4977.
46. Sabharanjak S., Mayor S. Folate receptor endocytosis and trafficking. Adv Drug Deliv Rev 2004, 56:1099-1109.
47. Richard J.P., Melikov K., Vives E., Ramos C., Verbeure B., Gait M.J., et al. Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake. J Biol Chem 2003, 278:585-590.
48. Lee R.J., Low P.S. Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro. BBA Biomembranes 1995, 1233:134-144.
49. Wan C.P., Park C.S., Lau B.H. A rapid and simple microfluorometric phagocytosis assay. J Immunol Methods 1993, 162:1-7.
50. Haigler H.T., Maxfield F.R., Willingham M.C., Pastan I. Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells. J Biol Chem 1980, 255:1239-1241.
51. Zolnik B.S., Burgess D.J. Effect of acidic pH on PLGA microsphere degradation and release. J Control Release 2007, 122:338-344.