Poly(amidoamine) dendrimer-based multifunctional engineered nanodevice for cancer therapy

Journal of Medicinal Chemistry

Volumn 48, Issue 19, 2005, Pages 5892-5899

  Majoros, István J ^a   Thomas, Thommey P ^a   Mehta, Chandan B ^a   Baker Jr , James R ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ANTINEOPLASTIC AGENT; DENDRIMER; DRUG CARRIER; FLUORESCEIN ISOTHIOCYANATE; FOLATE RECEPTOR; FOLIC ACID; GLYCIDOL; METHOTREXATE; POLYAMIDOAMINE; POLYAMINE; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CANCER THERAPY; CHEMICAL STRUCTURE; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; GEL PERMEATION CHROMATOGRAPHY; NANODEVICE; NANOTECHNOLOGY; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET SPECTROPHOTOMETRY;

ACETYLATION; ANTINEOPLASTIC AGENTS; DRUG CARRIERS; EPOXY COMPOUNDS; FLUORESCEIN-5-ISOTHIOCYANATE; FOLIC ACID; METHOTREXATE; NANOSTRUCTURES; POLYAMINES; PROPANOLS;

EID: 24944531237     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0401863     Document Type: Article

References (29)

1. Quintana, A.; Raczka, E.; Piehler, L.; Lee, I.; Myc, A.; Majoros, I. J.; Patri, A.; Thomas, T.; Mulé, J.; Baker, J. R., Jr. Design and Function of Dendrimer-Based Therapeutic Nanodevice Targeted to Tumor Cells Through the Folate Receptor. Pharm. Res. 2002, 19 (9), 1310-1316.
2. Tomalia, D. A.; Taylor A. M.; Goddard, W. A., III. Starburst dendrimers: Control of size, shape, surface chemistry, and topology. Angew. Chem., Int. Ed. Engl. 1990, 102, 119-157.
3. Esfand, R.; Tomalia, D. A. Poly(amidoamine) (PAMAM) dendrimers: From biomimicry to drug delivery and biomedical application. Drug Discovery Today 2001, 6 (8), 427-436.
4. Stiribara, S. E.; Frey, H.; Haag, R. Dendritic polymers in biomedical applications: From potential to clinical use in diagnosis and therapy. Angew. Chem., Int. Ed. 2002, 41, 1329-1334.
5. Patri, A. K.; Majoros, I.; Baker, J. R., Jr. Dendritic polymer macromolecular carriers for drug delivery. Curr. Opin. Chem. Biol. 2002, 6, 466-471.
6. Majoros, I. J.; Thomas, T. P.; Baker, J. R., Jr. Molecular Engineering in Nanotechnology: Engineered Drug Delivery. 2004 Handbook of Theoretical and Computational Nanotechnology; in press.
7. Malik, N.; Wiwattanapatapee, R.; Klopsch, R.; Lorenz, K.; Frey, H.; Weener, J. W.; Meijer, E. W.; Paulus, W.; Duncan, R. Dendrimers: Relationship Between Structure And Biocompatibility In Vitro, and Preliminary Studies on the Biodistribution of 1251-Labelled Poly(amidoamine) Dendrimers In Vivo. J. Controlled Release 2000, 65 (1-2), 133-148.
8. Erratum in: J. Controlled Release 2000, 68 (2), 299-302.
9. Tomalia, D. A.; Baker, H.; Dewald, J.; Hall, M.; Kallos, G.; Martin, S.; Roeck, J.; Ryder, J.; Smith, P. A New Class of Polymers: Starburst-Dendritic Macromolecules. Polym. J. 1985, 17 (1), 117-132.
10. Majoros, I. J.; Mehta, C. B.; Baker, J. R., Jr. Mathematical Description of Dendrimer Structure. J. Comput. Theor. Nanosci. 2004, 1, 193-198.
11. Tomalia, D. A.; Majoros, I. J. Dendrimeric Supramolecular and Supramacromolecular Assemblies. In Supramolecular Polymers; Ciferri, A., Ed.; Marcel Dekker Inc.: New York, 2000; pp 359-434.
12. Paleos, C. M.; Tsiourvas, D.; Sideratou, Z.; Tziveleka, L. Acid- and Salt-Triggered Multifunctional Poly(propyleneimine) Dendrimer as a Prospective Drug Delivery System. Biomacromolecules 2004, 5, 524-529.
13. Malik, N.; Evagorou, E. G.; Duncan, R. Dendrimer-Platinate: A Novel Approach to Cancer Chemotherapy. Anti-Cancer Drugs 1999, 10 (8), 767-776.
14. Weitman, D.; Lark, R. H.; Coney, L. R.; Fort, D. W.; Frasca, V.; Surawski, V. R.; Kamen, B. A. Distance of the Folate Receptor GP38 in Normal and Malignant Cell Lines and Tissues. Cancer Res. 1992, 52, 3396-3401.
15. Ross, F.; Chaudhuri, P. K.; Ratnam, M. Differential Regulation of Folate Receptor Isoforms in Normal and Malignant Tissues In Vivo and in established cell lines. Physiologic and Clinical Implications. Cancer 1994, 73, 2432-2443.
16. Wang, X.; Frederick, G.; Ratnam, M. Differentiation-independent retinoid induction of folate receptor type β, a potential tumor target in myeloid leukemia. Blood 2000, 96, 3529-3536.
17. Badjic, J. D.; Cantrill, S. J.; Stoddart, J. F. Can Multivalency Be Expressed Kinetically? The Answer Is Yes. J. Am. Chem. Soc. 2004, 126, 2288-2289.
18. Santo, M.; Fox, M. A. Hydrogen bonding interactions between Starburst dendrimers and several molecules of biological interest. J. Phys. Org. Chem. 1999, 12, 293-307.
19. Mattei, S.; Wallimann, P.; Kenda, B.; Amrein, W.; Diederich, F. Dendrophanes: water-soluble dendritic receptors as models for buried recognition sites in globular proteins. Helv. Chim. Acta 1997, 80, 2391-2417.
20. Singh, P. Terminal Groups in Starburst Dendrimers: Activation and Reactions with Proteins. Bioconjugate Chem. 1998, 9, 54-63.
21. Pavlov, G. M.; Korneeva, E. V.; Roy, R.; Michailova, N. A.; Ortega, P. C.; Perez, M. A. Sedimentation, Translational Diffusion, and Viscosity of Lactosylated Poly(amidoamine) Dendrimers. Prog. Colloid Polym. Sci. 1999, 113, 150-157.
22. Genestier, L.; Paillot, R.; Quemeneur, L.; Izeradjene, K.; Revillard, J. P. Mechanisms of Action of Methotrexate. Immunopharmacology 2000, 47, 247-257.
23. Kono, K.; Liu, M.; Fréchet, J. M. J. Design of Dendritic Macromolecules Containing Folate or Methotrexate Residues. Bioconjugate Chem. 1999, 10, 1115-1121.
24. Majoros, I. J.; Keszler, B.; Woehler, S.; Bull, T.; Baker, J. R., Jr. Acetylation of Poly(amidoamine) Dendrimers. Macromolecules 2003, 36 (15), 5526-5529.
25. Diallo, M. S.; Christie, S.; Swaminathan, P.; Balogh, L.; Shi, X.; Um, W.; Papelis, C.; Goddard, W. A., III; Johnson, J. H., Jr. Dendritic Chelating Agents. 1. Cu(II) Binding to Ethylene Diamine Core Poly(amidoamine) Dendrimers in Aqueous Solutions. Langmuir 2004, 20 (7), 2640-2651.
26. Thomas, T. P.; Majoros, I. J.; Kotlyar, A.; Baker, J. R., Jr. Targeting and Cytotoxicity Studies of Engineered Dendritic Multifunctional Nanodevice. J. Med. Chem. 2005, 48, 3729-3735.
27. Kuwkowska-Latallo, J. F.; Candido, K. A.; Cao, Z.; Nigaveka, S. S.; Majoros, I. J.; Thomas, T. P.; Balogh, L. P.; Khan, M. K.; Baker, J. R., Jr. Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer. Cancer Res. 2005, 65, 5317-5324.
28. Islam, M. T.; Majoros, I. J.; Baker, J. R., Jr. HPLC Analysis of PAMAM Dendrimer Based Multifunctional Devices. J. Chromatogr., B, in press.
29. Majoros, I. J.; Chui, H. M.; Mehta, C. B.; Gopwani, S. R.; Baker, J. R., Jr. UV Properties of Dendrimer Based Multifunctional Devices. Unpublished data, 2004.