A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity

Journal of Medicinal Chemistry

Volumn 55, Issue 11, 2012, Pages 5642-5646

  Xia, Yi ^a   Wang, Menghua ^a,b   Demaria, Olivier ^c,e   Tang, Jingjie ^b   Rocchi, Palma ^d   Qu, Fanqi ^b   Iovanna, Juan L ^d   Alexopoulou, Lena ^c   Peng, Ling ^a  

^a AIX MARSEILLE UNIVERSITÉ   (France)

^b WUHAN UNIVERSITY   (China)

^c CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^d AIX MARSEILLE UNIVERSITY   (France)

^e LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACYCLIC NUCLEOSIDE; ANTINEOPLASTIC AGENT; BITRIAZOLYL ACYCLONUCLEOSIDE DERIVATIVE; GEMCITABINE; IMMUNOMODULATING AGENT; INTERLEUKIN 6; TOLL LIKE RECEPTOR 7; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; DENDRITIC CELL; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DENDRITIC CELLS; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-6; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; NUCLEOSIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 7; TRIAZOLES;

EID: 84862289176     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300534u     Document Type: Article

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