Glucuronidation of capsaicin by liver microsomes and expressed UGT enzymes: Reaction kinetics, contribution of individual enzymes and marked species differences

Expert Opinion on Drug Metabolism and Toxicology

Volumn 10, Issue 10, 2014, Pages 1325-1336

  Sun, Hua ^a   Wang, Huan ^a   Liu, Hongming ^a   Zhang, Xingwang ^a   Wu, Baojian ^a  

^a JINAN UNIVERSITY   (China)

Author keywords

Activity correlation; Capsaicin; Glucuronidation; Relative activity factor; UDP glucuronosyltransferase

Indexed keywords

CAPSAICIN; CAPSAICIN GLUCURONIDE; ESTRADIOL; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A4; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B7; PROPOFOL; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCURONIC ACID; ZIDOVUDINE;

ANIMAL CELL; ARTICLE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG GLUCURONIDATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HUMAN CELL; LIVER MICROSOME; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RAT; SPECIES DIFFERENCE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; DOG; ENZYMOLOGY; GUINEA PIG; HAPLORHINI; METABOLISM; SCANDENTIA; THEORETICAL MODEL;

ANIMALS; CAPSAICIN; DOGS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; GUINEA PIGS; HAPLORHINI; HUMANS; MICE; MICROSOMES, LIVER; MODELS, THEORETICAL; RATS; SPECIES SPECIFICITY; TUPAIIDAE; ZIDOVUDINE;

EID: 84907184180     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2014.954548     Document Type: Article

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