Pharmacokinetics and metabolism of the putative cancer chemopreventive agent cyanidin-3-glucoside in mice

Cancer Chemotherapy and Pharmacology

Volumn 64, Issue 6, 2009, Pages 1261-1268

  Marczylo, Timothy H ^a   Cooke, Darren ^a   Brown, Karen ^a   Steward, William P ^a   Gescher, Andreas J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Anthocyanins; Cancer chemoprevention; Drug development

Indexed keywords

ANTHOCYANIN; CYANIDIN 3 GLUCOSIDE; DRUG METABOLITE; FLAVONOID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BODY FLUID; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG ELIMINATION; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG LIVER LEVEL; DRUG METABOLISM; DRUG TISSUE LEVEL; DRUG URINE LEVEL; GASTROINTESTINAL MUCOSA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY PARENCHYMA; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE;

ANIMAL STRUCTURES; ANIMALS; ANTHOCYANINS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL AVAILABILITY; BODY FLUIDS; GLUCOSIDES; MICE; MICE, INBRED C57BL;

EID: 69049110877     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-0996-7     Document Type: Article

References (20)

1. D Cooke WP Steward AJ Gescher T Marczylo 2005 Anthocyans from fruits and vegetables-does bright colour signal cancer chemopreventive activity? Eur J Cancer 41 1931 1940
2. LS Wang GD Stoner 2008 Anthocyanins and their role in cancer prevention Cancer Lett 269 281 290
3. M Ding RT Feng SY Wang L Bowman YJ Lu Y Qian V Castranova BH Jiang XL Shi 2006 Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity J Biol Chem 281 17359 17368
4. Min mouse model of intestinal carcinogenesis-relationship with tissue anthocyanin levels Int J Cancer 119 2213 2220
5. TY Ichiyanagi MM Shida Y Rahman H Hatano M Matsumoto KonishiT Hirayama 2005 Metabolic pathway of cyanidin 3-O-beta-d-glucopyranoside in rats J Agric Food Chem 53 145 150
6. TY Ichiyanagi MM Shida Y Rahman H Hatano T Konishi 2005 Extended glucuronidation is another major path of cyanidin 3-O-beta-d-glucopyranoside metabolism in rats J Agric Food Chem 53 7312 7319
7. M Schwarz S Hillebrand S Habben A Degenhardt P Winterhalter 2003 Application of high-speed countercurrent chromatography to the large-scale isolation of anthocyanins Biochem Eng J 14 179 189
8. P Workman P Twentyman F Balkwill A Balmain D Chaplin J Double J Embleton D Newell R Raymond J Stables T Stephens J Wallace 1998 United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) guidelines for the welfare of animals in experimental neoplasia (second edition) Br J Cancer 77 1 10
9. TK McGhie MC Walton 2007 The bioavailability and absorption of anthocyanins: towards a better understanding Molec Nutr Food Res 51 702 713
10. H Matsumoto H Inaba M Kishi S Tominaga M Hirayama T Tsuda 2001 Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms J Agric Food Chem 49 1546 1551
11. TY Ichiyanagi MM Shida Y Rahman H Hatano T Konishi 2006 Bioavailability and tissue distribution of anthocyanins in bilberry (Vaccinium myrtillus L.) extract in rats J Agric Food Chem 54 6578 6587
12. G Borges S Roowi JM Rouanet GG Duthie MEJ Lean A Crozier 2007 The bioavailability of raspberry anthocyanins and ellagitannins in rats Molec Nutr Food Res 51 714 725
13. C Manach G Williamson C Morand A Scalbert C Remesy 2005 Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies Am J Clin Nutr 81 230S 242S
14. F Galvano L La Fauci G Lazzarino V Fogliano A Ritieni S Ciappellano NC Battistini B Tavazzi G Galvano 2004 Cyanidins: metabolism and biological properties J Nutr Biochem 15 2 11
15. C Felgines S Talavera O Texier A Gil-Izquierdo JL Lamaison C Remesy 2005 Blackberry anthocyanins are mainly recovered from urine as methylated and glucuronidated conjugates in humans J Agric Food Chem 53 7721 7727
16. S Meiers M Kemeny U Weyand R Gastpar E von Angerer D Marko 2001 The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor J Agric Food Chem 49 958 962
17. J Fleschhut F Kratzer G Rechkemmer SE Kulling 2006 Stability and biotransformation of various dietary anthocyanins in vitro Eur J Nutr 45 1 7
18. P Vitaglione G Donnarumma A Napolitano F Galvano A Gallo L Scalfi V Foglian 2007 Protocatechuic acid is the major human metabolite of cyanidin-glucosides J Nutr 37 2043 2048
19. T Ichiyanagi MM Rahman Y Hatano T Konishi Y Ikeshiro 2007 Protocatechuic acid is not the major metabolite in rat blood plasma after oral administration of cyanidin 3-O-beta-d-glucopyranoside Food Chem 105 1032 1039
20. M Kern D Fridrich J Reichert S Skrbek A Nussher S Hofem S Vatter G Pahlke C Rufer D Marko 2007 Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid Molec Nutr Food Res 51 1163 1172