Simultaneous determination of calycosin-7-O-β-d-glucoside, calycosin, formononetin, astragaloside IV and schisandrin in rat plasma by LC-MS/MS: Application to a pharmacokinetic study after oral administration of shenqi wuwei chewable tablets

Biomedical Chromatography

Volumn 28, Issue 8, 2014, Pages 1118-1125

  Sun, Xuehui ^a   Zhang, Pingping ^a   Wu, Xiujun ^b   Wu, Qiong ^a   Zhang, Mengmeng ^a   An, Ye ^a   Shi, Guobing ^a  

^a GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

^b LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

LC MS MS; Pharmacokinetic; Rat plasma; Shenqi wuwei chewable tablets

Indexed keywords

BODY FLUIDS; CARBOHYDRATES; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PHASE SEPARATION;

ASTRAGALOSIDE IV; FORMONONETIN; LC-MS-MS; LC.MS/MS; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; RAT PLASMA; SCHISANDRIN; SHENQI WUWEI CHEWABLE TABLET; SIMULTANEOUS DETERMINATIONS;

RATS;

ASTRAGALOSIDE IV; CALYCOSIN; CALYCOSIN 7 O BETA DEXTRO GLUCOSIDE; CHINESE DRUG; FORMONONETIN; HERBACEOUS AGENT; SCHISANDRIN; SHENQI WUWEI; UNCLASSIFIED DRUG; 7,3'-DIHYDROXY-4'-METHOXYISOFLAVONE; ASTRAGALOSIDE A; CALYCOSIN-7-O-BETA-D-GLUCOSIDE; CYCLOOCTANE DERIVATIVE; GLUCOSIDE; ISOFLAVONE DERIVATIVE; LIGNAN; POLYCYCLIC HYDROCARBON; SAPONIN; SCHIZANDRIN; TABLET; TRITERPENE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG HALF LIFE; ELECTROSPRAY MASS SPECTROMETRY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MEASUREMENT PRECISION; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BLOOD; CHEMISTRY; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ORAL DRUG ADMINISTRATION; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL; TABLET;

RATTUS;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOCTANES; DRUG STABILITY; DRUGS, CHINESE HERBAL; GLUCOSIDES; ISOFLAVONES; LIGNANS; LINEAR MODELS; MALE; POLYCYCLIC COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SAPONINS; SENSITIVITY AND SPECIFICITY; TABLETS; TANDEM MASS SPECTROMETRY; TRITERPENES;

EID: 84904469857     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3128     Document Type: Article

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