Antihypertensive and vasorelaxant effects of tilianin isolated from Agastache mexicana are mediated by NO/cGMP pathway and potassium channel opening

Biochemical Pharmacology

Volumn 78, Issue 1, 2009, Pages 54-61

  Hernández Abreu, Oswaldo ^a   Castillo España, Patricia ^a   León Rivera, Ismael ^b   Ibarra Barajas, Maximiliano ^c   Villalobos Molina, Rafael ^c   González Christen, Judith ^a   Vergara Galicia, Jorge ^a   Estrada Soto, Samuel ^a  

^a UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

^b CENTRO DE INVESTIGACIONES QUÍMICAS   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Agastache mexicana; Antihypertensive; cGMP; Nitric oxide; Tilianin

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 AMINOPYRIDINE; ATROPINE; CARBACHOL; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLAVONOID; GUANYLATE CYCLASE; INDOMETACIN; MUSCARINIC RECEPTOR; N(G) NITROARGININE METHYL ESTER; NIFEDIPINE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; NORADRENALIN; POTASSIUM CHANNEL; PROSTAGLANDIN SYNTHASE; SEROTONIN; TETRYLAMMONIUM; TILIANIN; UNCLASSIFIED DRUG;

AGASTACHE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; AORTA; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; ENDOTHELIUM; HEART RATE; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SPONTANEOUSLY HYPERTENSIVE HEART FAILURE RAT; VASODILATATION;

AGASTACHE; ANTIHYPERTENSIVE AGENTS; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; GLYCOSIDES; HUMANS; ION CHANNEL GATING; MEDICINE, TRADITIONAL; METHANOL; MEXICO; NITRIC OXIDE; PLANT EXTRACTS; PLANTS, MEDICINAL; POTASSIUM CHANNELS; VASODILATOR AGENTS;

EID: 67349281691     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.03.016     Document Type: Article

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