P-glycoprotein-mediated efflux of indinavir metabolites in Caco-2 cells expressing cytochrome P450 3A4

Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 1, 2001, Pages 323-330

  Hochman, Jerome H ^a,b   Chiba, Masato ^a   Yamazaki, Masayo ^a   Tang, Cuyue ^a   Lin, Jiunn H ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Department of Drug Metabolism WP 75 200 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; CYTOCHROME P450 3A4; DRUG METABOLITE; GLYCOPROTEIN P; INDINAVIR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY C219; MONOCLONAL ANTIBODY UIC2; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL CELL; ARTICLE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ELIMINATION; DRUG INHIBITION; DRUG METABOLISM; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ARYL HYDROCARBON HYDROXYLASES; CACO-2 CELLS; CYCLOSPORINE; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HIV PROTEASE INHIBITORS; HUMANS; INDINAVIR; OXIDOREDUCTASES, N-DEMETHYLATING; P-GLYCOPROTEIN;

EID: 0034978263     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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