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Volumn 33, Issue 2, 2014, Pages 317-324

Acacetin (5,7-dihydroxy-4'-methoxyflavone) exhibits in vitro and in vivo anticancer activity through the suppression of NF-?B/Akt signaling in prostate cancer cells

Author keywords

Acacetin; Akt; Apoptosis; Human prostate cancer cells; Nuclear factor ?B

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ACACETIN; ANTINEOPLASTIC AGENT; CYCLOOXYGENASE 2; GLYCOGEN SYNTHASE KINASE 3BETA; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; X LINKED INHIBITOR OF APOPTOSIS;

EID: 84893732777     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1571     Document Type: Article
Times cited : (82)

References (39)
  • 3
    • 84862501584 scopus 로고    scopus 로고
    • Carnosic acid modulates Akt/IKK/NF-?B signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells
    • Kar S, Palit S, Ball WB and Das PK: Carnosic acid modulates Akt/IKK/NF-?B signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells. Apoptosis 17: 735-747, 2012.
    • (2012) Apoptosis , vol.17 , pp. 735-747
    • Kar, S.1    Palit, S.2    Ball, W.B.3    Das, P.K.4
  • 4
    • 55949129696 scopus 로고    scopus 로고
    • Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of
    • Kim EJ, Lim SS, Park SY, Shin HK, Kim JS and Park JH: Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. Food Chem Toxicol 46: 3651-3658, 2008.
    • (2008) Saussurea lappa. Food Chem Toxicol , vol.46 , pp. 3651-3658
    • Kim, E.J.1    Lim, S.S.2    Park, S.Y.3    Shin, H.K.4    Kim, J.S.5    Park, J.H.6
  • 7
    • 80053097574 scopus 로고    scopus 로고
    • Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1a pathway
    • Liu LZ, Jing Y, Jiang LL, et al: Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1a pathway. Biochem Biophys Res Commun 413: 299-305, 2011.
    • (2011) Biochem Biophys Res Commun , vol.413 , pp. 299-305
    • Liu, L.Z.1    Jing, Y.2    Jiang, L.L.3
  • 8
    • 17844364904 scopus 로고    scopus 로고
    • Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: Structure-activity relationship with linarin and linarin acetate
    • Singh RP, Agrawal P, Yim D, Agarwal C and Agarwal R: Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: Structure-activity relationship with linarin and linarin acetate. Carcinogenesis 26: 845-854, 2005.
    • (2005) Carcinogenesis , vol.26 , pp. 845-854
    • Singh, R.P.1    Agrawal, P.2    Yim, D.3    Agarwal, C.4    Agarwal, R.5
  • 9
    • 26444483911 scopus 로고    scopus 로고
    • Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia
    • Schuier M, Sies H, lllek B and Fischer H: Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia. J Nutr 135: 2320-2325, 2005.
    • (2005) J Nutr , vol.135 , pp. 2320-2325
    • Schuier, M.1    Sies, H.2    Lllek, B.3    Fischer, H.4
  • 10
    • 3142783843 scopus 로고    scopus 로고
    • Antimutagenic activity of flavonoids from Chrysanthemum morifolium
    • Miyazawa M and Hisama M: Antimutagenic activity of flavonoids from Chrysanthemum morifolium. Biosci Biotechnol Biochem 67: 2091-2099, 2003.
    • (2003) Biosci Biotechnol Biochem , vol.67 , pp. 2091-2099
    • Miyazawa, M.1    Hisama, M.2
  • 11
    • 0004340398 scopus 로고    scopus 로고
    • A comparative study of the analgesic and anti-inflammatory activities of pectolinarin isolated from Cirsium subcoriaceum and linarin isolated from Buddleia cordata
    • Martínez-Vázquez M, RamírezApan TO, Lastra AL and Bye R: A comparative study of the analgesic and anti-inflammatory activities of pectolinarin isolated from Cirsium subcoriaceum and linarin isolated from Buddleia cordata. Planta Med 64: 134-137, 1998.
    • (1998) Planta Med , vol.64 , pp. 134-137
    • Martínez-Vázquez, M.1    RamírezApan, T.O.2    Lastra, A.L.3    Bye, R.4
  • 12
    • 0037328535 scopus 로고    scopus 로고
    • In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe
    • Kraft C, Jenett-Siems K, Siems K, et al: In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe. Phytother Res 17: 123-128, 2003.
    • (2003) Phytother Res , vol.17 , pp. 123-128
    • Kraft, C.1    Jenett-Siems, K.2    Siems, K.3
  • 13
    • 0026060983 scopus 로고
    • Inhibitory effects of phenolic compounds on CC14-induced micresomal lipid peroxidation
    • Cholbi MR, Paya M and Alcaraz MJ: Inhibitory effects of phenolic compounds on CC14-induced micresomal lipid peroxi-dation. Experientia 47: 195-199, 1991.
    • (1991) Experientia , vol.47 , pp. 195-199
    • Cholbi, M.R.1    Paya, M.2    Alcaraz, M.J.3
  • 14
    • 53649111736 scopus 로고    scopus 로고
    • Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita
    • Yin Y, Gong FY, Wu XX, et al: Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita. J Ethnopharmacol 120: 1-6, 2008.
    • (2008) J Ethnopharmacol , vol.120 , pp. 1-6
    • Yin, Y.1    Gong, F.Y.2    Wu, X.X.3
  • 15
    • 74249121743 scopus 로고    scopus 로고
    • Acacetin inhibits TPA-induced MMP-2 and u-PA expressions of human lung cancer cells through inactivating JNK signaling pathway and reducing binding activities of NF-kappaB and AP-1
    • Fong Y, Shen KH, Chiang TA and Shih YW: Acacetin inhibits TPA-induced MMP-2 and u-PA expressions of human lung cancer cells through inactivating JNK signaling pathway and reducing binding activities of NF-kappaB and AP-1. J Food Sci 75: H30-H38, 2010.
    • (2010) J Food Sci , vol.75
    • Fong, Y.1    Shen, K.H.2    Chiang, T.A.3    Shih, Y.W.4
  • 16
    • 73449134066 scopus 로고    scopus 로고
    • Acacetin, a flavonoid, inhibits the invasion and migration of human prostate cancer DU145 cells via inactivation of the p38 MAPK signaling pathway
    • Shen KH, Hung SH, Yin LT, et al: Acacetin, a flavonoid, inhibits the invasion and migration of human prostate cancer DU145 cells via inactivation of the p38 MAPK signaling pathway. Mol Cell Biochem 333: 279-291, 2010.
    • (2010) Mol Cell Biochem , vol.333 , pp. 279-291
    • Shen, K.H.1    Hung, S.H.2    Yin, L.T.3
  • 17
    • 1042275543 scopus 로고    scopus 로고
    • Acacetin inhibits the proliferation of Hep G2 by blocking cell cycle progression and inducing apoptosis
    • Hsu YL, Kuo PL and Lin CC: Acacetin inhibits the proliferation of Hep G2 by blocking cell cycle progression and inducing apoptosis. Biochem Pharmacol 67: 823-829, 2004.
    • (2004) Biochem Pharmacol , vol.67 , pp. 823-829
    • Hsu, Y.L.1    Kuo, P.L.2    Lin, C.C.3
  • 18
    • 79953729368 scopus 로고    scopus 로고
    • Anti-cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF-?B
    • Park MH, Choi MS, Kwak DH, et al: Anti-cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF-?B. Prostate 71: 801-812, 2011.
    • (2011) Prostate , vol.71 , pp. 801-812
    • Park, M.H.1    Choi, M.S.2    Kwak, D.H.3
  • 19
    • 0034745420 scopus 로고    scopus 로고
    • NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100
    • Xiao G, Harhaj EW and Sun SC: NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 7: 401-409, 2001.
    • (2001) Mol Cell , vol.7 , pp. 401-409
    • Xiao, G.1    Harhaj, E.W.2    Sun, S.C.3
  • 20
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
    • Senftleben U, Cao Y, Xiao G, et al: Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293: 1495-1499, 2001.
    • (2001) Science , vol.293 , pp. 1495-1499
    • Senftleben, U.1    Cao, Y.2    Xiao, G.3
  • 21
    • 84861549757 scopus 로고    scopus 로고
    • Retigeric acid B exhibits antitumor activity through suppression of nuclear factor-?B signaling in prostate cancer cells in vitro and in vivo
    • Liu YQ, Hu XY, Lu T, et al: Retigeric acid B exhibits antitumor activity through suppression of nuclear factor-?B signaling in prostate cancer cells in vitro and in vivo. PLoS One 7: E38000, 2012.
    • (2012) PLoS One , vol.7
    • Liu, Y.Q.1    Hu, X.Y.2    Lu, T.3
  • 22
    • 0035137882 scopus 로고    scopus 로고
    • Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB
    • Baldwin AS: Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J Clin Invest 107: 241-246, 2001.
    • (2001) J Clin Invest , vol.107 , pp. 241-246
    • Baldwin, A.S.1
  • 23
    • 0036196320 scopus 로고    scopus 로고
    • NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer
    • Chen CD and Sawyers CL: NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer. Mol Cell Biol 22: 2862-2870, 2002.
    • (2002) Mol Cell Biol , vol.22 , pp. 2862-2870
    • Chen, C.D.1    Sawyers, C.L.2
  • 24
    • 0033517999 scopus 로고    scopus 로고
    • Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen
    • Palayoor ST, Youmell MY, Calderwood SK, Coleman CN and Price BD: Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene 18: 7389-7394, 1999.
    • (1999) Oncogene , vol.18 , pp. 7389-7394
    • Palayoor, S.T.1    Youmell, M.Y.2    Calderwood, S.K.3    Coleman, C.N.4    Price, B.D.5
  • 25
    • 79953293746 scopus 로고    scopus 로고
    • Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway
    • Boreddy SR, Pramanik KC and Srivastava SK: Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway. Clin Cancer Res 17: 1784-1795, 2011.
    • (2011) Clin Cancer Res , vol.17 , pp. 1784-1795
    • Boreddy, S.R.1    Pramanik, K.C.2    Srivastava, S.K.3
  • 26
    • 56049126878 scopus 로고    scopus 로고
    • Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: An in vitro and in vivo study
    • Kaur P, Shukla S and Gupta S: Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: An in vitro and in vivo study. Carcinogenesis 29: 2210-2217, 2008.
    • (2008) Carcinogenesis , vol.29 , pp. 2210-2217
    • Kaur, P.1    Shukla, S.2    Gupta, S.3
  • 27
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD and Cantley LC: AKT/PKB signaling: Navigating downstream. Cell 129: 1261-1274, 2007.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 28
    • 0033038491 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit
    • Sizemore N, Leung S and Stark GR: Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol Cell Biol 19: 4798-4805, 1999.
    • (1999) Mol Cell Biol , vol.19 , pp. 4798-4805
    • Sizemore, N.1    Leung, S.2    Stark, G.R.3
  • 29
    • 0037119428 scopus 로고    scopus 로고
    • Akt is a downstream target of NF-kappa B
    • Meng F, Liu L, Chin PC and D'Mello SR: Akt is a downstream target of NF-kappa B. J Biol Chem 277: 29674-29680, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 29674-29680
    • Meng, F.1    Liu, L.2    Chin, P.C.3    D'Mello, S.R.4
  • 30
    • 0033942505 scopus 로고    scopus 로고
    • Apoptosis in prostate carcinogenesis. A growth regulator and a therapeutic target
    • Bruckheimer EM and Kyprianou N: Apoptosis in prostate carcinogenesis. A growth regulator and a therapeutic target. Cell Tissue Res 301: 153-162, 2000.
    • (2000) Cell Tissue Res , vol.301 , pp. 153-162
    • Bruckheimer, E.M.1    Kyprianou, N.2
  • 31
    • 13244289838 scopus 로고    scopus 로고
    • Acacetin induces apoptosis in human gastric carcinoma cells accompanied by activation of caspase cascades and production of reactive oxygen species
    • Pan MH, Lai CS, Hsu PC and Wang YJ: Acacetin induces apoptosis in human gastric carcinoma cells accompanied by activation of caspase cascades and production of reactive oxygen species. J Agric Food Chem 53: 620-630, 2005.
    • (2005) J Agric Food Chem , vol.53 , pp. 620-630
    • Pan, M.H.1    Lai, C.S.2    Hsu, P.C.3    Wang, Y.J.4
  • 32
    • 77749234278 scopus 로고    scopus 로고
    • Antiproliferative activity of plant extracts used against cancer in traditional medicine
    • Talib WH and Mahasneh AM: Antiproliferative activity of plant extracts used against cancer in traditional medicine. Sci Pharm 78: 33-45, 2010.
    • (2010) Sci Pharm , vol.78 , pp. 33-45
    • Talib, W.H.1    Mahasneh, A.M.2
  • 33
    • 0029079275 scopus 로고
    • The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    • Franke TF, Yang SI, Chan TO, et al: The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81: 727-736, 1995.
    • (1995) Cell , vol.81 , pp. 727-736
    • Franke, T.F.1    Yang, S.I.2    Chan, T.O.3
  • 34
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I and Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 35
    • 79953324725 scopus 로고    scopus 로고
    • Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K/Akt/NF-?B pathway in human non-small cell lung cancer
    • Song L, Xiong H, Li J, et al: Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K/Akt/NF-?B pathway in human non-small cell lung cancer. Clin Cancer Res 17: 1839-1849, 2011.
    • (2011) Clin Cancer Res , vol.17 , pp. 1839-1849
    • Song, L.1    Xiong, H.2    Li, J.3
  • 36
    • 0031897632 scopus 로고    scopus 로고
    • NF-?B and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh S, May MJ and Kopp EB: NF-?B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16: 225-260, 1998.
    • (1998) Annu Rev Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 37
    • 0033596127 scopus 로고    scopus 로고
    • Control of apoptosis by Rel/NF-kappaB transcription factors
    • Barkett M and Gilmore TD: Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene 69: 6910-6924, 1999.
    • (1999) Oncogene , vol.69 , pp. 6910-6924
    • Barkett, M.1    Gilmore, T.D.2
  • 38
    • 0036009115 scopus 로고    scopus 로고
    • NF-kappaB at the crossroads of life and death
    • Karin M and Lin A: NF-kappaB at the crossroads of life and death. Nat Immunol 3: 221-227, 2002.
    • (2002) Nat Immunol , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 39
    • 84873715220 scopus 로고    scopus 로고
    • Antitumor effect and toxicity of free rhodium (II) citrate and rhodium (II) citrate-loaded maghemite nanoparticles in mice bearing breast cancer
    • Carneiro ML, Peixoto RC, Joanitti GA, et al: Antitumor effect and toxicity of free rhodium (II) citrate and rhodium (II) citrate-loaded maghemite nanoparticles in mice bearing breast cancer. J Nanobiotechnology 11: 4, 2013.
    • (2013) J Nanobiotechnology , vol.11 , pp. 4
    • Carneiro, M.L.1    Peixoto, R.C.2    Joanitti, G.A.3


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