Acacetin blocks Kv1.3 channels and inhibits human T cell activation

Cellular Physiology and Biochemistry

Volumn 34, Issue 4, 2014, Pages 1359-1372

  Zhao, Ning ^a   Dong, Qian ^a   Fu, Xiao Xing ^a   Du, Li Li ^a   Cheng, Xiang ^a   Du, Yi Mei ^a   Liao, Yu Hua ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Acacetin; Chemical blockade; Human T cells; Immunomodulatory; Kv1.3 potassium channel

Indexed keywords

ACACETIN; CALCIUM ACTIVATED POTASSIUM CHANNEL; CHOLECYSTOKININ OCTAPEPTIDE; FLUO 4; FLUORESCENT DYE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; POTASSIUM CHANNEL KV1.3; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT1; UNCLASSIFIED DRUG; ANILINE DERIVATIVE; ANTIINFLAMMATORY AGENT; CALCIUM; FLAVONE DERIVATIVE; NFATC2 PROTEIN, HUMAN; POTASSIUM CHANNEL BLOCKING AGENT; XANTHENE DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCIUM TRANSPORT; CELL PROLIFERATION; CONDUCTANCE; CURRENT CLAMP TECHNIQUE; CYTOKINE RELEASE; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; JURKAT CELL LINE; MEMBRANE POTENTIAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; LYMPHOCYTE ACTIVATION; METABOLISM; T LYMPHOCYTE; TUMOR CELL LINE;

ANILINE COMPOUNDS; ANTI-INFLAMMATORY AGENTS; CALCIUM; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; FLAVONES; HUMANS; INTERLEUKIN-2; JURKAT CELLS; KV1.3 POTASSIUM CHANNEL; LYMPHOCYTE ACTIVATION; MEMBRANE POTENTIALS; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; POTASSIUM CHANNEL BLOCKERS; SINCALIDE; T-LYMPHOCYTES; XANTHENES;

EID: 84908620746     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000366343     Document Type: Article

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