Androgen receptor (AR) in cardiovascular diseases

Journal of Endocrinology

Volumn 229, Issue 1, 2016, Pages R1-R16

  Huang, Chiung Kuei ^a   Lee, Soo Ok ^a   Chang, Eugene ^a,c   Pang, Haiyan ^a   Chang, Chawnshang ^a,b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Androgen; Castration; Gender difference; Male hormone

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANTIANDROGEN; LIPID;

ABDOMINAL AORTA ANEURYSM; ANDROGEN BLOOD LEVEL; ANDROGEN DEFICIENCY; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; DIABETES MELLITUS; DISEASE COURSE; DISEASE EXACERBATION; HEART FAILURE; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; LIPID STORAGE; METABOLIC SYNDROME X; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE; ANIMAL; METABOLISM;

ANIMALS; CARDIOVASCULAR DISEASES; HUMANS; RECEPTORS, ANDROGEN;

EID: 84973575513     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-15-0518     Document Type: Review

References (191)

1. Alexandersen P, Haarbo J, Byrjalsen I, Lawaetz H & Christiansen C 1999 Natural androgens inhibit male atherosclerosis: a study in castrated, cholesterol-fed rabbits. Circulation Research 84 813-819. (doi:10.1161/01.RES.84.7.813)
2. Alimurung MM, Joseph LG, Craige E & Massell BF 1950 The Q-T interval in normal infants and children. Circulation 1 1329-1337. (doi:10.1161/01.CIR.1.6.1329)
3. Alva JA, Zovein AC, Monvoisin A, Murphy T, Salazar A, Harvey NL, Carmeliet P & Iruela-Arispe ML 2006 VE-cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells. Developmental Dynamics 235 759-767. (doi:10.1002/dvdy.20643)
4. Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, Bonds D, Brunner R, Brzyski R, Caan B, et al. 2004 Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 291 1701-1712. (doi:10.1001/jama.291.14.1701)
5. Annambhotla S, Bourgeois S, Wang X, Lin PH, Yao Q & Chen C 2008 Recent advances in molecular mechanisms of abdominal aortic aneurysm formation. World Journal of Surgery 32 976-986. (doi:10.1007/s00268-007-9456-x)
6. Appelros P, Stegmayr B & Terent A 2009 Sex differences in stroke epidemiology: a systematic review. Stroke 40 1082-1090. (doi:10.1161/STROKEAHA.108.540781)
7. Ashton N & Balment RJ 1991 Sexual dimorphism in renal function and hormonal status of New Zealand genetically hypertensive rats. Acta Endocrinologica 124 91-97. (doi:10.1530/acta.0.1240091)
8. Azoulay L, Yin H, Benayoun S, Renoux C, Boivin JF & Suissa S 2011 Androgen-deprivation therapy and the risk of stroke in patients with prostate cancer. European Urology 60 1244-1250. (doi:10.1016/j.eururo.2011.08.041)
9. Baltatu O, Cayla C, Iliescu R, Andreev D, Jordan C & Bader M 2002 Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 gene. Journal of the American Society of Nephrology 13 2681-2687. (doi:10.1097/01.ASN.0000033327.65390.CA)
10. Banos G, Guarner V & Perez-Torres I 2011 Sex steroid hormones, cardiovascular diseases and the metabolic syndrome. Cardiovascular & Hematological Agents in Medicinal Chemistry 9 137-146. (doi:10.2174/187152511797037547)
11. Barrett-Connor E & Khaw KT 1988 Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study. Circulation 78 539-545. (doi:10.1161/01.CIR.78.3.539)
12. Bialek M, Zaremba P, Borowicz KK & Czuczwar SJ 2004 Neuroprotective role of testosterone in the nervous system. Polish Journal of Pharmacology 56 509-518.
13. Bourghardt J 2010 Actions of androgens and estrogens in experimental models of cardiovascular disease. Doctoral Thesis, University of Gothenburg.
14. Bruck B, Brehme U, Gugel N, Hanke S, Finking G, Lutz C, Benda N, Schmahl FW, Haasis R & Hanke H 1997 Gender-specific differences in the effects of testosterone and estrogen on the development of atherosclerosis in rabbits. Arteriosclerosis, Thrombosis, and Vascular Biology 17 2192-2199. (doi:10.1161/01.ATV.17.10.2192)
15. Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, Horan MJ & Labarthe D 1995 Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension 25 305-313. (doi:10.1161/01.HYP.25.3.305)
16. Cabral AM, Vasquez EC, Moyses MR & Antonio A 1988 Sex hormone modulation of ventricular hypertrophy in sinoaortic denervated rats. Hypertension 11 I93-I97.
17. Carwile E, Wagner AK, Crago E & Alexander SA 2009 Estrogen and stroke: a review of the current literature. Journal of Neuroscience Nursing 41 18-25. (doi:10.1097/JNN.0b013e31819345f8)
18. Cavasin MA, Sankey SS, Yu AL, Menon S & Yang XP 2003 Estrogen and testosterone have opposing effects on chronic cardiac remodeling and function in mice with myocardial infarction. American Journal of Physiology: Heart and Circulatory Physiology 284 H1560-H1569. (doi:10.1152/ajpheart.01087.2002)
19. Chen YF & Meng QC 1991 Sexual dimorphism of blood pressure in spontaneously hypertensive rats is androgen dependent. Life Sciences 48 85-96. (doi:10.1016/0024-3205(91)90428-E)
20. Chen SJ, Li H, Durand J, Oparil S & Chen YF 1996 Estrogen reduces myointimal proliferation after balloon injury of rat carotid artery. Circulation 93 577-584. (doi:10.1161/01.CIR.93.3.577)
21. Cheng J, Alkayed NJ & Hurn PD 2007 Deleterious effects of dihydrotestosterone on cerebral ischemic injury. Journal of Cerebral Blood Flow & Metabolism 27 1553-1562. (doi:10.1038/sj.jcbfm.9600457)
22. Cho BS, Woodrum DT, Roelofs KJ, Stanley JC, Henke PK & Upchurch GR Jr 2009 Differential regulation of aortic growth in male and female rodents is associated with AAA development. Journal of Surgical Research 155 330-338. (doi:10.1016/j.jss.2008.07.027)
23. Chung SD, Chen YK, Wu FJ & Lin HC 2011 Hormone therapy for prostate cancer and the risk of stroke: a 5-year follow-up study. BJU International 109 1001-1005. (doi:10.1111/j.1464-410X.2011.10459.x)
24. Clegg DJ, Brown LM, Woods SC & Benoit SC 2006 Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes 55 978-987. (doi:10.2337/diabetes.55.04.06.db05-1339)
25. Collier A, Ghosh S, McGlynn B & Hollins G 2011 Prostate cancer, androgen deprivation therapy, obesity, the metabolic syndrome, type 2 diabetes, and cardiovascular disease: a review. American Journal of Clinical Oncology 35 504-509. (doi:10.1097/COC.0b013e318201a406)
26. Collier A, Ghosh S, McGlynn B & Hollins G 2012 Prostate cancer, androgen deprivation therapy, obesity, the metabolic syndrome, type 2 diabetes, and cardiovascular disease: a review. American Journal of Clinical Oncology 35 504-509. (doi:10.1097/COC.0b013e318201a406)
27. Crabbe DL, Dipla K, Ambati S, Zafeiridis A, Gaughan JP, Houser SR & Margulies KB 2003 Gender differences in post-infarction hypertrophy in end-stage failing hearts. Journal of the American College of Cardiology 41 300-306. (doi:10.1016/S0735-1097(02)02710-9)
28. Daugherty A, Manning MW & Cassis LA 2001 Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis. British Journal of Pharmacology 134 865-870. (doi:10.1038/sj.bjp.0704331)
29. Devereux RB, Pickering TG, Alderman MH, Chien S, Borer JS & Laragh JH 1987 Left ventricular hypertrophy in hypertension. Prevalence and relationship to pathophysiologic variables. Hypertension 9 II53-II60.
30. Dubey RK, Gillespie DG, Jackson EK & Keller PJ 1998 17Beta-estradiol, its metabolites, and progesterone inhibit cardiac fibroblast growth. Hypertension 31 522-528. (doi:10.1161/01.HYP.31.1.522)
31. Dunajska K, Milewicz A, Szymczak J, Jedrzejuk D, Kuliczkowski W, Salomon P & Nowicki P 2004 Evaluation of sex hormone levels and some metabolic factors in men with coronary atherosclerosis. Aging Male 7 197-204. (doi:10.1080/13685530400004181)
32. Egan BM, Zhao Y & Axon RN 2010 US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. JAMA 303 2043-2050. (doi:10.1001/jama.2010.650)
33. Ely DL, Salisbury R, Hadi D, Turner M & Johnson ML 1991 Androgen receptor and the testes influence hypertension in a hybrid rat model. Hypertension 17 1104-1110. (doi:10.1161/01.HYP.17.6.1104)
34. Fairweather D, Frisancho-Kiss S & Rose NR 2008 Sex differences in autoimmune disease from a pathological perspective. American Journal of Pathology 173 600-609. (doi:10.2353/ajpath.2008.071008)
35. Fiebach NH, Viscoli CM & Horwitz RI 1990 Differences between women and men in survival after myocardial infarction. Biology or methodology? JAMA 263 1092-1096. (doi:10.1001/jama.1990.03440080070026)
36. Foradori CD, Weiser MJ & Handa RJ 2008 Non-genomic actions of androgens. Frontiers in Neuroendocrinology 29 169-181. (doi:10.1016/j.yfrne.2007.10.005)
37. Forbes TL, Lawlor DK, DeRose G & Harris KA 2006 Gender differences in relative dilatation of abdominal aortic aneurysms. Annals of Vascular Surgery 20 564-568. (doi:10.1007/S10016-006-9079-y)
38. Forger NG, Hodges LL, Roberts SL & Breedlove SM 1992 Regulation of motoneuron death in the spinal nucleus of the bulbocavernosus. Journal of Neurobiology 23 1192-1203.
39. Fujimoto R, Morimoto I, Morita E, Sugimoto H, Ito Y & Eto S 1994 Androgen receptors, 5 alpha-reductase activity and androgen-dependent proliferation of vascular smooth muscle cells. Journal of Steroid Biochemistry and Molecular Biology 50 169-174. (doi:10.1016/0960-0760(94)90025-6)
40. Ganten U, Schroder G, Witt M, Zimmermann F, Ganten D & Stock G 1989 Sexual dimorphism of blood pressure in spontaneously hypertensive rats: effects of anti-androgen treatment. Journal of Hypertension 7 721-726.
41. Gaziano TA, Bitton A, Anand S, Abrahams-Gessel S & Murphy A 2010 Growing epidemic of coronary heart disease in low- and middle-income countries. Current Problems in Cardiology 35 72-115. (doi:10.1016/j.cpcardiol.2009.10.002)
42. Goodall S, Crowther M, Hemingway DM, Bell PR & Thompson MM 2001 Ubiquitous elevation of matrix metalloproteinase-2 expression in the vasculature of patients with abdominal aneurysms. Circulation 104 304-309. (doi:10.1161/01.CIR.104.3.304)
43. Grange JJ, Davis V & Baxter BT 1997 Pathogenesis of abdominal aortic aneurysm: an update and look toward the future. Cardiovascular Surgery 5 256-265. (doi:10.1016/S0967-2109(97)00018-5)
44. Greenhalgh RM & Powell JT 2008 Endovascular repair of abdominal aortic aneurysm. New England Journal of Medicine 358 494-501. (doi:10.1056/NEJMct0707524)
45. Haarbo J & Christiansen C 1996 The impact of female sex hormones on secondary prevention of atherosclerosis in ovariectomized cholesterol-fed rabbits. Atherosclerosis 123 139-144. (doi:10.1016/0021-9150(96)05798-X)
46. Habashi JP, Doyle JJ, Holm TM, Aziz H, Schoenhoff F, Bedja D, Chen Y, Modiri AN, Judge DP & Dietz HC 2011 Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism. Science 332 361-365. (doi:10.1126/science.1192152)
47. Hanke H, Lenz C, Hess B, Spindler KD & Weidemann W 2001 Effect of testosterone on plaque development and androgen receptor expression in the arterial vessel wall. Circulation 103 1382-1385. (doi:10.1161/01.CIR.103.10.1382)
48. Hannawa KK, Eliason JL & Upchurch GR Jr 2009 Gender differences in abdominal aortic aneurysms. Vascular 17 (Supplement 1) S30-S39. (doi:10.2310/6670.2008.00092)
49. Hawk T, Zhang YQ, Rajakumar G, Day AL & Simpkins JW 1998 Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats. Brain Research 796 296-298. (doi:10.1016/S0006-8993(98)00327-8)
50. Heinlein CA & Chang C 2002 The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Molecular Endocrinology 16 2181-2187. (doi:10.1210/me.2002-0070)
51. Heinlein CA & Chang C 2004 Androgen receptor in prostate cancer. Endocrine Reviews 25 276-308. (doi:10.1210/er.2002-0032)
52. Henriques TA, Huang J, D'Souza SS, Daugherty A & Cassis LA 2004 Orchidectomy, but not ovariectomy, regulates angiotensin II-induced vascular diseases in apolipoprotein E-deficient mice. Endocrinology 145 3866-3872. (doi:10.1210/en.2003-1615)
53. Henriques T, Zhang X, Yiannikouris FB, Daugherty A & Cassis LA 2008 Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology 28 1251-1256. (doi:10.1161/ATVBAHA.107.160382)
54. Hoesche C, Sauerwald A, Veh RW, Krippl B & Kilimann MW 1993 The 5'-flanking region of the rat synapsin I gene directs neuron-specific and developmentally regulated reporter gene expression in transgenic mice. Journal of Biological Chemistry 268 26494-26502.
55. Holm TM, Habashi JP, Doyle JJ, Bedja D, Chen Y, van Erp C, Lindsay ME, Kim D, Schoenhoff F, Cohn RD, et al. 2011 Noncanonical TGFbeta signaling contributes to aortic aneurysm progression in Marfan syndrome mice. Science 332 358-361. (doi:10.1126/science.1192149)
56. Hu G, Qiao Q, Tuomilehto J, Balkau B, Borch-Johnsen K & Pyorala K 2004 Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women. Archives of Internal Medicine 164 1066-1076. (doi:10.1001/archinte.164.10.1066)
57. Hu X, Rui L, Zhu T, Xia H, Yang X, Wang X, Liu H, Lu Z & Jiang H 2011 Low testosterone level in middle-aged male patients with coronary artery disease. European Journal of Internal Medicine 22 e133-e136. (doi:10.1016/j.ejim.2011.08.016)
58. Hu JC, Williams SB, O'Malley AJ, Smith MR, Nguyen PL & Keating NL 2012 Androgen-deprivation therapy for nonmetastatic prostate cancer is associated with an increased risk of peripheral arterial disease and venous thromboembolism. European Urology 61 1119-1128. (doi:10.1016/j.eururo.2012.01.045)
59. Huang CK, Pang H, Wang L, Niu Y, Luo J, Chang E, Sparks JD, Lee SO & Chang C 2014 New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis. Hypertension 63 1345-1353. (doi:10.1161/HYPERTENSIONAHA.113.02804)
60. Huang CK, Luo J, Lai KP, Wang R, Pang H, Chang E, Yan C, Sparks J, Lee SO, Cho J, et al. 2015 Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1alpha and transforming growth factor-beta1 expression. Hypertension 66 881-891. (doi:10.1161/HYPERTENSIONAHA.115.05654)
61. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B & Vittinghoff E 1998 Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA 280 605-613. (doi:10.1001/jama.280.7.605)
62. Iams SG, McMurthy JP & Wexler BC 1979 Aldosterone, deoxycorticosterone, corticosterone, and prolactin changes during the lifespan of chronically and spontaneously hypertensive rats. Endocrinology 104 1357-1363. (doi:10.1210/endo-104-5-1357)
63. Ikeda Y, Aihara K, Yoshida S, Sato T, Yagi S, Iwase T, Sumitomo Y, Ise T, Ishikawa K, Azuma H, et al. 2009 Androgen-androgen receptor system protects against angiotensin II-induced vascular remodeling. Endocrinology 150 2857-2864. (doi:10.1210/en.2008-1254)
64. Izumi K, Fang LY, Mizokami A, Namiki M, Li L, Lin WJ & Chang C 2013 Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation. EMBO Molecular Medicine 5 1383-1401. (doi:10.1002/emmm.201202367)
65. Jeppesen LL, Jorgensen HS, Nakayama H, Raaschou HO, Olsen TS & Winther K 1996 Decreased serum testosterone in men with acute ischemic stroke. Arteriosclerosis, Thrombosis, and Vascular Biology 16 749-754. (doi:10.1161/01.ATV.16.6.749)
66. Johnston SC, Higashida RT, Barrow DL, Caplan LR, Dion JE, Hademenos G, Hopkins LN, Molyneux A, Rosenwasser RH, Vinuela F, et al. 2002 Recommendations for the endovascular treatment of intracranial aneurysms: a statement for healthcare professionals from the Committee on Cerebrovascular Imaging of the American Heart Association Council on Cardiovascular Radiology. Stroke 33 2536-2544. (doi:10.1161/01.STR.0000034708.66191.7D)
67. Julius U, Leonhardt W, Schulze J, Schollberg K, Hanefeld M & Haller H 1981 Hyperinsulinemia in patients with low fractional catabolic rate of triglycerides. Acta Diabetologica Latina 18 217-223. (doi:10.1007/BF02047893)
68. Kang HY, Cho CL, Huang KL, Wang JC, Hu YC, Lin HK, Chang C & Huang KE 2004 Nongenomic androgen activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts. Journal of Bone and Mineral Research 19 1181-1190. (doi:10.1359/JBMR.040306)
69. Kang NN, Fu L, Xu J, Han Y, Cao JX, Sun JF & Zheng M 2012 Testosterone improves cardiac function and alters angiotensin II receptors in isoproterenol-induced heart failure. Archives of Cardiovascular Diseases 105 68-76. (doi:10.1016/j.acvd.2011.12.002)
70. Kannel WB 2000 Elevated systolic blood pressure as a cardiovascular risk factor. American Journal of Cardiology 85 251-255. (doi:10.1016/S0002-9149(99)00635-9)
71. Kaplinsky E 1994 Significance of left ventricular hypertrophy in cardiovascular morbidity and mortality. Cardiovascular Drugs and Therapy 8 (Supplement 3) 549-556. (doi:10.1007/BF00877223)
72. Katz DJ, Stanley JC & Zelenock GB 1997 Gender differences in abdominal aortic aneurysm prevalence, treatment, and outcome. Journal of Vascular Surgery 25 561-568. (doi:10.1016/S0741-5214(97)70268-4)
73. Kaufman JM & Vermeulen A 2005 The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocrine Reviews 26 833-876. (doi:10.1210/er.2004-0013)
74. Keating NL, O'Malley AJ & Smith MR 2006 Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer. Journal of Clinical Oncology 24 4448-4456. (doi:10.1200/JCO.2006.06.2497)
75. Keating NL, O'Malley AJ, Freedland SJ & Smith MR 2010 Diabetes and cardiovascular disease during androgen deprivation therapy: observational study of veterans with prostate cancer. Journal of the National Cancer Institute 102 39-46. (doi:10.1093/jnci/djp404)
76. Khaw KT & Barrett-Connor E 1988 Blood pressure and endogenous testosterone in men: an inverse relationship. Journal of Hypertension 6 329-332.
77. Khoury S, Yarows SA, O'Brien TK & Sowers JR 1992 Ambulatory blood pressure monitoring in a nonacademic setting. Effects of age and sex. American Journal of Hypertension 5 616-623. (doi:10.1093/ajh/5.9.616)
78. King VL, Lin AY, Kristo F, Anderson TJ, Ahluwalia N, Hardy GJ, Owens AP III, Howatt DA, Shen D, Tager AM, et al. 2009 Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture. Circulation 119 426-435. (doi:10.1161/CIRCULATIONAHA.108.785949)
79. Klues HG, Schiffers A & Maron BJ 1995 Phenotypic spectrum and patterns of left ventricular hypertrophy in hypertrophic cardiomyopathy: morphologic observations and significance as assessed by two-dimensional echocardiography in 600 patients. Journal of the American College of Cardiology 26 1699-1708. (doi:10.1016/0735-1097(95)00390-8)
80. Kobayashi M, Kweon MN, Kuwata H, Schreiber RD, Kiyono H, Takeda K & Akira S 2003 Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. Journal of Clinical Investigation 111 1297-1308. (doi:10.1172/JCI17085)
81. Kushwaha RS & Hazzard WR 1981 Exogenous estrogens attenuate dietary hypercholesterolemia and atherosclerosis in the rabbit. Metabolism 30 359-366. (doi:10.1016/0026-0495(81)90116-5)
82. Kyle UG, Genton L, Hans D, Karsegard L, Slosman DO & Pichard C 2001 Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years. European Journal of Clinical Nutrition 55 663-672. (doi:10.1038/sj.ejcn.1601198)
83. Lai JJ, Lai KP, Chuang KH, Chang P, Yu IC, Lin WJ & Chang C 2009 Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression. Journal of Clinical Investigation 119 3739-3751. (doi:10.1172/JCI39335)
84. Lai KP, Huang CK, Chang YJ, Chung CY, Yamashita S, Li L, Lee SO, Yeh S & Chang C 2013 New therapeutic approach to suppress castration-resistant prostate cancer using ASC-J9 via targeting androgen receptor in selective prostate cells. American Journal of Pathology 182 460-473. (doi:10.1016/j.ajpath.2012.10.029)
85. Larsen BA, Nordestgaard BG, Stender S & Kjeldsen K 1993 Effect of testosterone on atherogenesis in cholesterol-fed rabbits with similar plasma cholesterol levels. Atherosclerosis 99 79-86. (doi:10.1016/0021-9150(93)90053-W)
86. Laughlin GA, Barrett-Connor E & Bergstrom J 2008 Low serum testosterone and mortality in older men. Journal of Clinical Endocrinology & Metabolism 93 68-75. (doi:10.1210/jc.2007-1792)
87. Lepeschkin E & Surawicz B 1953 The duration of the Q-U interval and its components in electrocardiograms of normal persons. American Heart Journal 46 9-20. (doi:10.1016/0002-8703(53)90237-3)
88. Li Y, Kishimoto I, Saito Y, Harada M, Kuwahara K, Izumi T, Hamanaka I, Takahashi N, Kawakami R, Tanimoto K, et al. 2004 Androgen contributes to gender-related cardiac hypertrophy and fibrosis in mice lacking the gene encoding guanylyl cyclase-A. Endocrinology 145 951-958. (doi:10.1210/en.2003-0816)
89. Liang L, Li L, Tian J, Lee SO, Dang Q, Huang CK, Yeh S, Erturk E, Bushinsky D, Chang LS, et al. 2014 Androgen receptor enhances kidney stone-CaOx crystal formation via modulation of oxalate biosynthesis & oxidative stress. Molecular Endocrinology 28 1291-1303. (doi:10.1210/me.2014-1047)
90. Lin HY, Xu Q, Yeh S, Wang RS, Sparks JD & Chang C 2005 Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor. Diabetes 54 1717-1725. (doi:10.2337/diabetes.54.6.1717)
91. Lin HY, Yu IC, Wang RS, Chen YT, Liu NC, Altuwaijri S, Hsu CL, Ma WL, Jokinen J, Sparks JD, et al. 2008 Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor. Hepatology 47 1924-1935. (doi:10.1002/hep.22252)
92. Lin TH, Yeh S & Chang C 2011 Tissue-specific knockout of androgen receptor in mice. Methods in Molecular Biology 776 275-293. (doi:10.1007/978-1-61779-243-4_16)
93. Liu PY, Death AK & Handelsman DJ 2003 Androgens and cardiovascular disease. Endocrine Reviews 24 313-340. (doi:10.1210/er.2003-0005)
94. Longo GM, Buda SJ, Fiotta N, Xiong W, Griener T, Shapiro S & Baxter BT 2005 MMP-12 has a role in abdominal aortic aneurysms in mice. Surgery 137 457-462. (doi:10.1016/j.surg.2004.12.004)
95. Lopez MJ, Wong SK, Kishimoto I, Dubois S, Mach V, Friesen J, Garbers DL & Beuve A 1995 Salt-resistant hypertension in mice lacking the guanylyl cyclase-A receptor for atrial natriuretic peptide. Nature 378 65-68. (doi:10.1038/378065a0)
96. MacTaggart JN, Xiong W, Knispel R & Baxter BT 2007 Deletion of CCR2 but not CCR5 or CXCR3 inhibits aortic aneurysm formation. Surgery 142 284-288. (doi:10.1016/j.surg.2007.04.017)
97. Malhotra A, Buttrick P & Scheuer J 1990 Effects of sex hormones on development of physiological and pathological cardiac hypertrophy in male and female rats. American Journal of Physiology 259 H866-H871.
98. Malkin CJ, Pugh PJ, Jones RD, Jones TH & Channer KS 2003 Testosterone as a protective factor against atherosclerosis - immunomodulation and influence upon plaque development and stability. Journal of Endocrinology 178 373-380. (doi:10.1677/joe.0.1780373)
99. Malkin CJ, Jones RD, Jones TH & Channer KS 2006a Effect of testosterone on ex vivo vascular reactivity in man. Clinical Science 111 265-274. (doi:10.1042/CS20050354)
100. Malkin CJ, Pugh PJ, West JN, van Beek EJ, Jones TH & Channer KS 2006b Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial. European Heart Journal 27 57-64.
101. Malkin CJ, Jones TH & Channer KS 2009 Testosterone in chronic heart failure. Frontiers of Hormone Research 37 183-196. (doi:10.1159/000176053)
102. Malyusz M & Ehrens HJ 1983 Effect of castration and testosterone substitution on the urinary output of gamma-glutamyl transpeptidase and of N-acetyl-beta-D-glucosaminidase of male rats with renovascular hypertension. Enzyme 29 93-99.
103. Malyusz M, Ehrens HJ & Wrigge P 1985 Effect of castration on the experimental renal hypertension of the rat. Blood pressure, nephrosclerosis, long-chain fatty acids, and N-acetylation of PAH in the kidney. Nephron 40 96-99. (doi:10.1159/000183437)
104. Manzano-Fernandez S, Pastor-Perez FJ, Barquero-Perez O, Pascual-Figal DA, Goya-Esteban R, Rojo-Alvarez JL, Caamano-Fernandez A, Martinez Martinez-Espejo MD, Januzzi JL, Valdes M, et al. 2011 Short-term variability of heart rate turbulence in chronic heart failure. Journal of Cardiac Failure 17 735-741. (doi:10.1016/j.cardfail.2011.05.007)
105. Maron BJ, Casey SA, Hurrell DG & Aeppli DM 2003 Relation of left ventricular thickness to age and gender in hypertrophic cardiomyopathy. American Journal of Cardiology 91 1195-1198. (doi:10.1016/S0002-9149(03)00266-2)
106. Marsh JD, Lehmann MH, Ritchie RH, Gwathmey JK, Green GE & Schiebinger RJ 1998 Androgen receptors mediate hypertrophy in cardiac myocytes. Circulation 98 256-261. (doi:10.1161/01.CIR.98.3.256)
107. Martin-Merino E, Johansson S, Morris T & Garcia Rodriguez LA 2011 Androgen deprivation therapy and the risk of coronary heart disease and heart failure in patients with prostate cancer: a nested case-control study in UK primary care. Drug Safety 34 1061-1077. (doi:10.2165/11594540-000000000-00000)
108. Matsumoto A 1997 Hormonally induced neuronal plasticity in the adult motoneurons. Brain Research Bulletin 44 539-547. (doi:10.1016/S0361-9230(97)00240-2)
109. Meusburger SM & Keast JR 2001 Testosterone and nerve growth factor have distinct but interacting effects on structure and neurotransmitter expression of adult pelvic ganglion cells in vitro. Neuroscience 108 331-340. (doi:10.1016/S0306-4522(01)00420-1)
110. Meyer R, Linz KW, Surges R, Meinardus S, Vees J, Hoffmann A, Windholz O & Grohe C 1998 Rapid modulation of L-type calcium current by acutely applied oestrogens in isolated cardiac myocytes from human, guinea-pig and rat. Experimental Physiology 83 305-321. (doi:10.1113/expphysiol.1998.sp004115)
111. Miyamoto H, Rahman M, Takatera H, Kang HY, Yeh S, Chang HC, Nishimura K, Fujimoto N & Chang C 2002 A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth. Journal of Biological Chemistry 277 4609-4617. (doi:10.1074/jbc.M108312200)
112. Miyamoto H, Yang Z, Chen YT, Ishiguro H, Uemura H, Kubota Y, Nagashima Y, Chang YJ, Hu YC, Tsai MY, et al. 2007 Promotion of bladder cancer development and progression by androgen receptor signals. Journal of the National Cancer Institute 99 558-568. (doi:10.1093/jnci/djk113)
113. Morales A 2010 Words of wisdom. Re: lower testosterone levels predict incident stroke and transient ischemic attack in older men. European Urology 58 182-183. (doi:10.1016/j.eururo.2010.04.017)
114. Morano I, Gerstner J, Ruegg JC, Ganten U, Ganten D & Vosberg HP 1990 Regulation of myosin heavy chain expression in the hearts of hypertensive rats by testosterone. Circulation Research 66 1585-1590. (doi:10.1161/01.RES.66.6.1585)
115. Nettleship JE, Jones TH, Channer KS & Jones RD 2007 Physiological testosterone replacement therapy attenuates fatty streak formation and improves high-density lipoprotein cholesterol in the Tfm mouse: an effect that is independent of the classic androgen receptor. Circulation 116 2427-2434. (doi:10.1161/CIRCULATIONAHA.107.708768)
116. Neyses L & T Pelzer 1995 The biological cascade leading to cardiac hypertrophy. European Heart Journal 16 (Supplement N) 8-11. (doi:10.1093/eurheartj/16.suppl_N.8)
117. Nguyen CT, Aaronson A, Morrissey RP, Agarwal M, Willix RD & Schwarz ER 2011 Myths and truths of growth hormone and testosterone therapy in heart failure. Expert Review of Cardiovascular Therapy 9 711-720. (doi:10.1586/erc.11.25)
118. Normann S, de Veber G, Fobker M, Langer C, Kenet G, Bernard TJ, Fiedler B, Strater R, Goldenberg NA & Nowak-Gottl U 2009 Role of endogenous testosterone concentration in pediatric stroke. Annals of Neurology 66 754-758. (doi:10.1002/ana.21840)
119. Obici S & Rossetti L 2003 Minireview: nutrient sensing and the regulation of insulin action and energy balance. Endocrinology 144 5172-5178. (doi:10.1210/en.2003-0999)
120. Ouchi Y, Share L, Crofton JT, Iitake K & Brooks DP 1987 Sex difference in the development of deoxycorticosterone-salt hypertension in the rat. Hypertension 9 172-177. (doi:10.1161/01.HYP.9.2.172)
121. Pan Y, Zhang H, Acharya AB, Patrick PH, Oliver D & Morley JE 2005 Effect of testosterone on functional recovery in a castrate male rat stroke model. Brain Research 1043 195-204. (doi:10.1016/j.brainres.2005.02.078)
122. Pastor-Perez FJ, Manzano-Fernandez S, Garrido Bravo IP, Nicolas F, Tornel PL, Lax A, de la Morena G, Valdes M & Pascual-Figal DA 2011 Anabolic status and functional impairment in men with mild chronic heart failure. American Journal of Cardiology 108 862-866. (doi:10.1016/j.amjcard.2011.05.016)
123. Pearce WH & Shively VP 2006 Abdominal aortic aneurysm as a complex multifactorial disease: interactions of polymorphisms of inflammatory genes, features of autoimmunity, and current status of MMPs. Annals of the New York Academy of Sciences 1085 117-132. (doi:10.1196/annals.1383.025)
124. PEPI Trial Writing Group 1995 Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. The Writing Group for the PEPI Trial. JAMA 273 199-208. (doi:10.1001/jama.1995.03520270033028)
125. Pugh PJ, Jones TH & Channer KS 2003 Acute haemodynamic effects of testosterone in men with chronic heart failure. European Heart Journal 24 909-915. (doi:10.1016/S0195-668X(03)00083-6)
126. Pugh PJ, Jones RD, West JN, Jones TH & Channer KS 2004 Testosterone treatment for men with chronic heart failure. Heart 90 446-447. (doi:10.1136/hrt.2003.014639)
127. Qiu Y, Yanase T, Hu H, Tanaka T, Nishi Y, Liu M, Sueishi K, Sawamura T & Nawata H 2010 Dihydrotestosterone suppresses foam cell formation and attenuates atherosclerosis development. Endocrinology 151 3307-3316. (doi:10.1210/en.2009-1268)
128. Rautaharju PM, Zhou SH, Wong S, Calhoun HP, Berenson GS, Prineas R & Davignon A 1992 Sex differences in the evolution of the electrocardiographic QT interval with age. Canadian Journal of Cardiology 8 690-695.
129. Razzak M 2012 Prostate cancer: cardiovascular risk and androgen deprivation therapy. Nature Reviews Urology 9 61.
130. Reckelhoff JF 2001 Gender differences in the regulation of blood pressure. Hypertension 37 1199-1208. (doi:10.1161/01.HYP.37.5.1199)
131. Reckelhoff JF, Zhang H, Srivastava K & Granger JP 1999 Gender differences in hypertension in spontaneously hypertensive rats: role of androgens and androgen receptor. Hypertension 34 920-923. (doi:10.1161/01.HYP.34.4.920)
132. Reckelhoff JF, Yanes LL, Iliescu R, Fortepiani LA & Granger JP 2005 Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease. American Journal of Physiology: Renal Physiology 289 F941-F948. (doi:10.1152/ajprenal.00034.2005)
133. Regitz-Zagrosek V, Oertelt-Prigione S, Seeland U & Hetzer R 2010 Sex and gender differences in myocardial hypertrophy and heart failure. Circulation Journal 74 1265-1273. (doi:10.1253/circj.CJ-10-0196)
134. Rosano GM, Leonardo F, Pagnotta P, Pelliccia F, Panina G, Cerquetani E, della Monica PL, Bonfigli B, Volpe M & Chierchia SL 1999 Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation 99 1666-1670. (doi:10.1161/01.CIR.99.13.1666)
135. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, et al. 2002 Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288 321-333.
136. Rowell KO, Hall J, Pugh PJ, Jones TH, Channer KS & Jones RD 2009 Testosterone acts as an efficacious vasodilator in isolated human pulmonary arteries and veins: evidence for a biphasic effect at physiological and supra-physiological concentrations. Journal of Endocrinological Investigation 32 718-723. (doi:10.1007/BF03346526)
137. Rowland NE & Fregly MJ 1992 Role of gonadal hormones in hypertension in the Dahl salt-sensitive rat. Clinical and Experimental Hypertension. Part A 14 367-375. (doi:10.3109/10641969209036195)
138. Sadoshima J & Izumo S 1993 Molecular characterization of angiotensin II - induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circulation Research 73 413-423. (doi:10.1161/01.RES.73.3.413)
139. Sakalihasan N, Delvenne P, Nusgens BV, Limet R & Lapiere CM 1996 Activated forms of MMP2 and MMP9 in abdominal aortic aneurysms. Journal of Vascular Surgery 24 127-133. (doi:10.1016/S0741-5214(96)70153-2)
140. Schulze J, Julius U, Hanefeld M, Haller H & Leonhardt W 1981 [Therapy of hypertriglyceridemia from a pathophysiological viewpoint]. Zeitschrift fur die Gesamte Innere Medizin 36 304-305.
141. Schwartz MW & Porte D Jr 2005 Diabetes, obesity, and the brain. Science 307 375-379. (doi:10.1126/science.1104344)
142. Shahani S, Braga-Basaria M & Basaria S 2008 Androgen deprivation therapy in prostate cancer and metabolic risk for atherosclerosis. Journal of Clinical Endocrinology & Metabolism 93 2042-2049. (doi:10.1210/jc.2007-2595)
143. Simon JA 2001 Safety of estrogen/androgen regimens. Journal of Reproductive Medicine 46 (3 Supplement) 281-290.
144. Sinning C, Wild PS, Echevarria FM, Wilde S, Schnabel R, Lubos E, Herkenhoff S, Bickel C, Klimpe S, Gori T, et al. 2011 Sex differences in early carotid atherosclerosis (from the community-based Gutenberg-Heart Study). American Journal of Cardiology 107 1841-1847. (doi:10.1016/j.amjcard.2011.02.318)
145. Smith MR 2008 Androgen deprivation therapy and risk for diabetes and cardiovascular disease in prostate cancer survivors. Current Urology Reports 9 197-202. (doi:10.1007/s11934-008-0035-y)
146. Somjen D, Kohen F, Jaffe A, Amir-Zaltsman Y, Knoll E & Stern N 1998 Effects of gonadal steroids and their antagonists on DNA synthesis in human vascular cells. Hypertension 32 39-45. (doi:10.1161/01.HYP.32.1.39)
147. Stramba-Badiale M, Spagnolo D, Bosi G & Schwartz PJ 1995 Are gender differences in QTc present at birth? MISNES Investigators. Multicenter Italian study on neonatal electrocardiography and sudden infant death syndrome. American Journal of Cardiology 75 1277-1278. (doi:10.1016/S0002-9149(99)80781-4)
148. Sugita S, Kawashima H, Tanaka T, Kurisu T, Sugimura K & Nakatani T 2004 Effect of type I growth factor receptor tyrosine kinase inhibitors on phosphorylation and transactivation activity of the androgen receptor in prostate cancer cells: ligand-independent activation of the N-terminal domain of the androgen receptor. Oncology Reports 11 1273-1279.
149. Svartberg J, von Muhlen D, Schirmer H, Barrett-Connor E, Sundfjord J & Jorde R 2004 Association of endogenous testosterone with blood pressure and left ventricular mass in men. The Tromso Study. European Journal of Endocrinology 150 65-71. (doi:10.1530/eje.0.1500065)
150. Svartberg J, von Muhlen D, Mathiesen E, Joakimsen O, Bonaa KH & Stensland-Bugge E 2006 Low testosterone levels are associated with carotid atherosclerosis in men. Journal of Internal Medicine 259 576-582. (doi:10.1111/j.1365-2796.2006.01637.x)
151. Taggart H, Sheridan B & Stout RW 1980 Sex hormone levels in younger male stroke survivors. Atherosclerosis 35 123-125. (doi:10.1016/0021-9150(80)90034-9)
152. Tangredi JF & Buxton IL 2001 Hypertension as a complication of topical testosterone therapy. Annals of Pharmacotherapy 35 1205-1207. (doi:10.1345/aph.1A020)
153. Thompson RW & Baxter BT 1999 MMP inhibition in abdominal aortic aneurysms. Rationale for a prospective randomized clinical trial. Annals of the New York Academy of Sciences 878 159-178. (doi:10.1111/j.1749-6632.1999.tb07682.x)
154. Tirassa P, Thiblin I, Agren G, Vigneti E, Aloe L & Stenfors C 1997 High-dose anabolic androgenic steroids modulate concentrations of nerve growth factor and expression of its low affinity receptor (p75-NGFr) in male rat brain. Journal of Neuroscience Research 47 198-207.
155. Toh S, Hernandez-Diaz S, Logan R, Rossouw JE & Hernan MA 2010 Coronary heart disease in postmenopausal recipients of estrogen plus progestin therapy: does the increased risk ever disappear? A randomized trial. Annals of Internal Medicine 152 211-217. (doi:10.7326/0003-4819-152-4-201002160-00005)
156. Towbin JA & Lipshultz SE 1999 Genetics of neonatal cardiomyopathy. Current Opinion in Cardiology 14 250-262. (doi:10.1097/00001573-199905000-00010)
157. Tsai HK, D'Amico AV, Sadetsky N, Chen MH & Carroll PR 2007 Androgen deprivation therapy for localized prostate cancer and the risk of cardiovascular mortality. Journal of the National Cancer Institute 99 1516-1524.
158. Turhan S, Tulunay C, Gulec S, Ozdol C, Kilickap M, Altin T, Gerede M & Erol C 2007 The association between androgen levels and premature coronary artery disease in men. Coronary Artery Disease 18 159-162. (doi:10.1097/MCA.0b013e328012a928)
159. Uchida M, Palmateer JM, Herson PS, DeVries AC, Cheng J & Hurn PD 2009 Dose-dependent effects of androgens on outcome after focal cerebral ischemia in adult male mice. Journal of Cerebral Blood Flow & Metabolism 29 1454-1462. (doi:10.1038/jcbfm.2009.60)
160. Vicencio JM, Ibarra C, Estrada M, Chiong M, Soto D, Parra V, Diaz-Araya G, Jaimovich E & Lavandero S 2006 Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes. Endocrinology 147 1386-1395. (doi:10.1210/en.2005-1139)
161. Vigna GB & Bergami E 2005 Testosterone replacement, cardiovascular system and risk factors in the aging male. Journal of Endocrinological Investigation 28 (11 Supplement Proceedings) 69-74.
162. Walker WH 2003 Nongenomic actions of androgen in Sertoli cells. Current Topics in Developmental Biology 56 25-53. (doi:10.1016/S0070-2153(03)01006-8)
163. Wang X, Yeh S, Wu G, Hsu CL, Wang L, Chiang T, Yang Y, Guo Y & Chang C 2001 Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells. Journal of Biological Chemistry 276 40417-40423. (doi:10.1074/jbc.M104765200)
164. Wang M, Baker L, Tsai BM, Meldrum KK & Meldrum DR 2005a Sex differences in the myocardial inflammatory response to ischemia-reperfusion injury. American Journal of Physiology: Endocrinology and Metabolism 288 E321-E326. (doi:10.1152/ajpendo.00278.2004)
165. Wang M, Tsai BM, Kher A, Baker LB, Wairiuko GM & Meldrum DR 2005b Role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusion. American Journal of Physiology: Heart and Circulatory Physiology 288 H221-H226.
166. Wang M, Crisostomo PR, Markel TA, Wang Y & Meldrum DR 2008 Mechanisms of sex differences in TNFR2-mediated cardioprotection. Circulation 118 (14 Supplement) S38-S45.
167. Wang RS, Yeh S, Tzeng CR & Chang C 2009 Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice. Endocrine Reviews 30 119-132. (doi:10.1210/er.2008-0025)
168. Webb CM, Adamson DL, de Zeigler D & Collins P 1999a Effect of acute testosterone on myocardial ischemia in men with coronary artery disease. American Journal of Cardiology 83 437-439, A439. (doi:10.1016/S0002-9149(98)00880-7)
169. Webb CM, McNeill JG, Hayward CS, de Zeigler D & Collins P 1999b Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation 100 1690-1696. (doi:10.1161/01.CIR.100.16.1690)
170. Weber KT & Brilla CG 1991 Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation 83 1849-1865. (doi:10.1161/01.CIR.83.6.1849)
171. Weinberg EO, Thienelt CD, Katz SE, Bartunek J, Tajima M, Rohrbach S, Douglas PS & Lorell BH 1999 Gender differences in molecular remodeling in pressure overload hypertrophy. Journal of the American College of Cardiology 34 264-273. (doi:10.1016/S0735-1097(99)00165-5)
172. Weintraub NL 2009 Understanding abdominal aortic aneurysm. New England Journal of Medicine 361 1114-1116. (doi:10.1056/NEJMcibr0905244)
173. Wexler RK, Elton T, Pleister A & Feldman D 2009 Cardiomyopathy: an overview. American Family Physician 79 778-784.
174. Wiinberg N, Hoegholm A, Christensen HR, Bang LE, Mikkelsen KL, Nielsen PE, Svendsen TL, Kampmann JP, Madsen NH & Bentzon MW 1995 24-h ambulatory blood pressure in 352 normal Danish subjects, related to age and gender. American Journal of Hypertension 8 978-986. (doi:10.1016/0895-7061(95)00216-2)
175. Wolf DA, Burke AP, Patterson KV & Virmani R 2002 Sudden death following rupture of a right ventricular aneurysm 9 months after ablation therapy of the right ventricular outflow tract. Pacing and Clinical Electrophysiology 25 1135-1137. (doi:10.1046/j.1460-9592.2002.01135.x)
176. Woods LL, Morgan TK & Resko JA 2010 Castration fails to prevent prenatally programmed hypertension in male rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 298 R1111-R1116. (doi:10.1152/ajpregu.00803.2009)
177. Wu FC & von Eckardstein A 2003 Androgens and coronary artery disease. Endocrine Reviews 24 183-217. (doi:10.1210/er.2001-0025)
178. Xin HB, Senbonmatsu T, Cheng DS, Wang YX, Copello JA, Ji GJ, Collier ML, Deng KY, Jeyakumar LH, Magnuson MA, et al. 2002 Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature 416 334-338. (doi:10.1038/416334a)
179. Xue B, Pamidimukkala J & Hay M 2005 Sex differences in the development of angiotensin II-induced hypertension in conscious mice. American Journal of Physiology: Heart and Circulatory Physiology 288 H2177-H2184. (doi:10.1152/ajpheart.00969.2004)
180. Yamashita S, Lai KP, Chuang KL, Xu D, Miyamoto H, Tochigi T, Pang ST, Li L, Arai Y, Kung HJ, et al. 2012 ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors. Neoplasia 14 74-83. (doi:10.1593/neo.111436)
181. Yang SH, Perez E, Cutright J, Liu R, He Z, Day AL & Simpkins JW 2002 Testosterone increases neurotoxicity of glutamate in vitro and ischemia-reperfusion injury in an animal model. Journal of Applied Physiology 92 195-201. (doi:10.1063/1.1486251)
182. Yang T, Huang YG, Ye W, Hansen P, Schnermann JB & Briggs JP 2005 Influence of genetic background and gender on hypertension and renal failure in COX-2-deficient mice. American Journal of Physiology: Renal Physiology 288 F1125-F1132. (doi:10.1152/ajprenal.00219.2004)
183. Yang Z, Chang YJ, Yu IC, Yeh S, Wu CC, Miyamoto H, Merry DE, Sobue G, Chen LM, Chang SS, et al. 2007 ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nature Medicine 13 348-353. (doi:10.1038/nm1547)
184. Yeap BB, Hyde Z, Almeida OP, Norman PE, Chubb SA, Jamrozik K, Flicker L & Hankey GJ 2009 Lower testosterone levels predict incident stroke and transient ischemic attack in older men. Journal of Clinical Endocrinology & Metabolism 94 2353-2359. (doi:10.1210/jc.2008-2416)
185. Yeh S, Tsai MY, Xu Q, Mu XM, Lardy H, Huang KE, Lin H, Yeh SD, Altuwaijri S, Zhou X, et al. 2002 Generation & characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. PNAS 99 13498-13503. (doi:10.1073/pnas.212474399)
186. Yoshimura K, Aoki H, Ikeda Y, Fujii K, Akiyama N, Furutani A, Hoshii Y, Tanaka N, Ricci R, Ishihara T, et al. 2005 Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Nature Medicine 11 1330-1338. (doi:10.1038/nm1335)
187. Yu IC, Lin HY, Liu NC, Wang RS, Sparks JD, Yeh S & Chang C 2008 Hyperleptinemia without obesity in male mice lacking androgen receptor in adipose tissue. Endocrinology 149 2361-2368. (doi:10.1210/en.2007-0516)
188. Yu S, Zhang C, Lin CC, Niu Y, Lai KP, Chang HC, Yeh SD, Chang C & Yeh S 2011 Altered prostate epithelial development and IGF-1 signal in mice lacking the androgen receptor in stromal smooth muscle cells. Prostate 71 517-524.
189. Yu IC, Lin HY, Liu NC, Sparks JD, Yeh S, Fang LY, Chen L & Chang C 2013 Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-kappaB-mediated PTP1B expression. Diabetes 62 411-423. (doi:10.2337/db12-0135)
190. Zhang Y, Naggar JC, Welzig CM, Beasley D, Moulton KS, Park HJ & Galper JB 2009 Simvastatin inhibits angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice: possible role of ERK. Arteriosclerosis, Thrombosis, and Vascular Biology 29 1764-1771. (doi:10.1161/ATVBAHA.109.192609)
191. Zimmerman FH 2012 Cardiovascular disease and risk factors in law enforcement personnel: a comprehensive review. Cardiology in Review 20 159-166. (doi:10.1097/CRD.0b013e318248d631)