Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse Ren-2 gene

Journal of the American Society of Nephrology

Volumn 13, Issue 11, 2002, Pages 2681-2687

  Baltatu, Ovidiu ^a   Cayla, Cécile ^a   Iliescu, Radu ^a   Andreev, Dmitrii ^a   Jordan, Cynthia ^a   Bader, Michael ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ANDROGEN RECEPTOR; ANGIOTENSINOGEN; ESTROGEN; FLUTAMIDE; FOLLITROPIN; LUTEINIZING HORMONE; RENIN; RNA; SEX HORMONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CROSS BREEDING; FEMALE; GENE MUTATION; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; HYPOPHYSIS GONAD SYSTEM; KIDNEY FAILURE; MALE; MULTIPLE ORGAN FAILURE; NONHUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TESTICULAR FEMINIZATION; TRANSGENIC ANIMAL;

EID: 0036839381     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000033327.65390.CA     Document Type: Article

References (47)

1. Mendelsohn ME, Karas RH: The protective effects of estrogen on the cardiovascular system, N Engl J Med 340: 1801-1811, 1999
2. Chen YF: Sexual dimorphism of hypertension. Curr Opin Nephrol Hypertens 5: 181-185, 1996
3. Reckelhoff JF: Gender differences in the regulation of blood pressure. Hypertension 37: 1199-1208, 2001
4. Hayward CS, Webb CM, Collins P: Effect of sex hormones on cardiac mass. Lancet 357: 1354-1356, 2001
5. Reckelhoff JF, Granger JP: Role of androgens in mediating hypertension and renal injury. Clin Exp Pharmacol Physiol 26: 127-131, 1999
6. Reckelhoff JF, Zhang H, Granger JP: Decline in renal hemodynamic function in aging SHR: role of androgens. Hypertension 30: 677-681, 1997
7. Ely DL, Salisbury R, Hadi D, Turner M, Johnson ML: Androgen receptor and the testes influence hypertension in a hybrid rat model. Hypertension 17: 1104-1110, 1991
8. Ganten U, Schroder G, Witt M, Zimmermann F, Ganten D, Stock G: Sexual dimorphism of blood pressure in spontaneously hypertensive rats: Effects of anti-androgen treatment, J Hypertens 7: 721-726, 1989
9. Mullins JJ, Peters J, Ganten D: Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature 344: 541-544, 1990
10. Bader M, Peters J, Baltatu O, Muller DN, Luft FC, Ganten D: Tissue renin-angiotensin systems: New insights from experimental animal models in hypertension research. J Mol Med 79: 76-102, 2001
11. Kumai T, Tanaka M, Tateishi T, Watanabe M, Nakura H, Asoh M, Kobayashi S: Effects of anti-androgen treatment on the catecholamine synthetic pathway in the adrenal medulla of spontaneously hypertensive rats. Naunyn Schmiedebergs Arch Pharmacol 357: 620-624, 1998
12. Baltatu O, Janssen BJ, Bricca G, Plehm R, Monti J, Ganten D, Bader M: Alterations in blood pressure and heart rate variability in transgenic rats with low brain angiotensinogen. Hypertension 37: 408-413, 2001
13. Yarbrough WG, Quarmby VE, Simental JA, Joseph DR, Sar M, Lubahn DB, Olsen KL, French FS, Wilson EM: A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat. J Biol Chem 265: 8893-8900, 1990
14. Barberis C, Tribollet E: Vasopressin and oxytocin receptors in the central nervous system. Crit Rev Neurobiol 10: 119-154, 1996
15. Baltatu O, Lippoldt A, Hansson A, Ganten D, Bader M: Local renin-angiotensin system in the pineal gland. Brain Res Mol Brain Res 54: 237-242, 1998
16. Springate JE, Feld LG, Ganten D: Renal function in hypertensive rats transgenic for mouse renin gene. Am J Physiol 266: F731-F737, 1994
17. Van Liew JB, Davis FB, Davis PJ, Noble B, Bernardis LL: Calorie restriction decreases microalbuminuria associated with aging in barrier-raised Fischer 344 rats. Am J Physiol 263: F554-F561, 1992
18. Cerasola G, Cottone S, Mule G, Nardi E, Mangano MT, Andronico G, Contomo A, Li VM, Galione P, Renda F, Piazza G, Volpe V, Lisi A, Ferrara L, Panepinto N, Riccobene R: Microalbuminuria, renal dysfunction and cardiovascular complication in essential hypertension. J Hypertens 14: 915-920, 1996
19. Crofton JT, Ota M, Share L: Role of vasopressin, the renin-angiotensin system and sex in Dahl salt-sensitive hypertension. J Hypertens 11: 1031-1038, 1993
20. Crofton JT, Share L: Gonadal hormones modulate deoxycorticosterone-salt hypertension in male and female rats. Hypertension 29: 494-499, 1997
21. Ouchi Y, Share L, Crofton JT, Iitake K, Brooks DP: Sex difference in pressor responsiveness to vasopressin and baroreflex function in DOC-salt hypertensive rats. J Hypertens 6: 381-387, 1988
22. Haywood JR, Hinojosa LC: Sexual dimorphism of sodium-sensitive renal-wrap hypertension. Hypertension 30: 667-671, 1997
23. Guo GB, Abboud FM: Impaired central mediation of the arterial baroreflex in chronic renal hypertension. Am J Physiol 246: H720-H727, 1984
24. Bohm M, Lee M, Kreutz R, Kim S, Schinke M, Djavidani B, Wagner J, Kaling M, Wienen W, Bader M, Ganten D: Angiotensin II receptor blockade in TGR(mREN2)27: Effects of renin-angiotensin-system gene expression and cardiovascular functions. J Hypertens 13: 891-899, 1995
25. Teisman AC, Pinto YM, Buikema H, Flesch M, Bohm M, Paul M, van GW: Dissociation of blood pressure reduction from end-organ damage in TGR(mREN2)27 transgenic hypertensive rats. J Hypertens 16: 1759-1765, 1998
26. Kon Y, Endoh D, Murakami K, Yamashita T, Watanabe T, Hashimoto Y, Sugimura M: Expression of renin in coagulating glands is regulated by testosterone. Anat Rec 241: 451-460, 1995
27. Chen YF, Naftilan AJ, Oparil S: Androgen-dependent angiotensinogen and renin messenger RNA expression in hypertensive rats. Hypertension 19: 456-463, 1992
28. Caplea A, Seachrist D, Dunphy G, Ely D: Sodium-induced rise in blood pressure is suppressed by androgen receptor blockade. Am J Physiol Heart Circ Physiol 280: H1793-H1801, 2001
29. Reckelhoff JF, Zhang H, Srivastava K: Gender differences in development of hypertension in spontaneously hypertensive rats: Role of the renin-angiotensin system. Hypertension 35: 480-483, 2000
30. Brogden RN, Chrisp P: Flutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in advanced prostatic cancer. Drugs Aging 1: 104-115, 1991
31. Goldspiel BR, Kohler DR: Flutamide: An antiandrogen for advanced prostate cancer. DICP 24: 616-623, 1990
32. Marchetti B, Labrie F: Characteristics of flutamide action on prostatic and testicular functions in the rat. J Steroid Biochem 29: 691-698, 1988
33. Crews JK, Khalil RA: Gender-specific inhibition of Ca2+ entry mechanisms of arterial vasoconstriction by sex hormones. Clin Exp Pharmacol Physiol 26: 707-715, 1999
34. Costarella CE, Stallone JN, Rutecki GW, Whittier FC: Testosterone causes direct relaxation of rat thoracic aorta. J Pharmacol Exp Ther 277: 34-39, 1996
35. Yue P, Chatterjee K, Beale C, Poole WP, Collins P: Testosterone relaxes rabbit coronary arteries and aorta. Circulation 91: 1154-1160, 1995
36. Ceballos G, Figueroa L, Rubio I, Gallo G, Garcia A, Martinez A, Yanez R, Perez J, Morato T, Chamorro G: Acute and nongenomic effects of testosterone on isolated and perfused rat heart. J Cardiovasc Pharmacol 33: 691-697, 1999
37. Matsuda K, Ruff A, Morinelli TA, Mathur RS, Halushka PV: Testosterone increases thromboxane A2 receptor density and responsiveness in rat aortas and platelets. Am J Physiol 267: H887-H893, 1994
38. Wilson JD, Griffin JE, George FW, Leshin M: The endocrine control of male phenotypic development. Aust J Biol Sci 36: 101-128, 1983
39. Stanley AJ, Gumbreck LG, Allison JE, Easley RB: Male pseudohermaphroditism in the laboratory Norway rat. Recent Prog Horm Res 29: 43-64, 1973
40. Yamada K, Iyer SN, Chappell MC, Brosnihan KB, Fukuhara M, Ferrario CM: Differential response of angiotensin peptides in the urine of hypertensive animals. Regul Pept 80: 57-66, 1999
41. Farhat MY, Lavigne MC, Ramwell PW: The vascular protective effects of estrogen. FASEB J 10: 615-624, 1996
42. Silberberg SD, Magleby KL: Beating the odds with Big K. Science 285: 1859-1860, 1999
43. Valverde MA, Rojas P, Amigo J, Cosmelli D, Orio P, Bahamonde MI, Mann GE, Vergara C, Latorre R: Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit [see comments]. Science 285: 1929-1931, 1999
44. Schunkert H, Danser AH, Hense HW, Derkx FH, Kurzinger S, Riegger GA: Effects of estrogen replacement therapy on the renin-angiotensin system in postmenopausal women. Circulation 95: 39-45, 1997
45. He XR, Wang W, Crofton JT, Share L: Effects of 17beta-estradiol on sympathetic activity and pressor response to phenylephrine in ovariectomized rats. Am J Physiol 275: R1202-R1208, 1998
46. Fischer M, Baessler A, Schunkert H: Renin angiotensin system and gender differences in the cardiovascular system. Cardiovasc Res 53: 672-677, 2002
47. Reinhart GA, Lohmeier TE, Hord CE, Jr: Hypertension induced by chronic renal adrenergic stimulation is angiotensin dependent. Hypertension 25: 940-949, 1995