Gender differences in hypertension in spontaneously hypertensive rats: Role of androgens and androgen receptor

Hypertension

Volumn 34, Issue 4 II, 1999, Pages 920-923

  Reckelhoff, Jane F ^a,b   Zhang, Huimin ^a   Srivastava, Kumud ^a   Granger, Joey P ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Blood pressure; Finasteride; Flutamide; Gender

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; FINASTERIDE; FLUTAMIDE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; GLOMERULUS FILTRATION RATE; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0032735745     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.hyp.34.4.920     Document Type: Article

References (27)

1. Wiinberg N, Hoegholm A, Christensen HR, Bang LE, Mikkelsen KL, Nielsen PE, Svendsen TL, Kampmann JP, Madsen NH, Bentzon MW. 24-h Ambulatory blood pressure in 352 normal Danish subjects, related to age and gender. Am J Hypertens. 1995;8:978-986.
2. Khoury S, Yarows SA, O'Brien TK, Sowers JR. Ambulatory blood pressure monitoring in a nonacademic setting: effects of age and sex. Am J Hypertens. 1992;5:616-623.
3. Reckelhoff JF, Zhang H, Granger JP. Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats. Hypertension. 1998;31:435-439.
4. Masubuchi Y, Kumai T, Uematsu A, Komoriyama K, Hirai M. Gonadectomy-induced reduction in blood pressure in adult spontaneously hypertensive rats. Acta Endocrinol (Copenh). 1982;101:154-160.
5. Rowland NE, Fregly MJ. Role of gonadal hormones in hypertension in the Dahl salt-sensitive rat. Clin Exp Hypertens. 1992;A14:367-375.
6. Chen Y-F, Meng Q-M. Sexual dimorphism of blood pressure in spontaneously hypertensive rats is androgen dependent. Life Sci. 1991;48: 85-96.
7. Ashton N, Balment RJ. Sexual dimorphism in renal function and hormonal status of New Zealand genetically hypertensive rats. Acta Endocrinol (Copenh). 1991;124:91-97.
8. Ouchi Y, Share L, Crofton JT, Iitake K, Brooks DP. Sex difference in the development of deoxycorticosterone-salt hypertension in the rat. Hypertension. 1987;9:172-177.
9. Bachmann H, Horacek U, Leowsky M, Hirche H. Blood pressure in children and adolescents aged 4 to 18: correlation of blood pressure values with age, sex, body height, body weight, and skinfold thickness. Monatsschr Kinderheilkd. 1987;135:128-134.
10. Harshfield GA, Alpert BS, Pulliam DA, Somes GW, Wilson DK. Ambulatory blood pressure recordings in children and adolescents. Pediatrics. 1994;94:180-184.
11. Ganten U, Schroder G, Witt M, Zimmerman F, Ganten D, Stock G. Sexual dimorphism of blood pressure in spontaneously hypertensive rats: effects of anti- androgen treatment. J Hypertens. 1989;7:721-726.
12. Ilams SG, McMurtry JP, Wexler BC. Aldosterone, deoxycorticosterone, and prolactin changes during lifespan of chronically and spontaneously hypertensive rats. Endocrinology. 1979;104:1357-1363.
13. Rubio I, Yanez R, Gallo G, Almaguer G, Garcia A, Morato T, Chamorro G, Geballos G. Rapid and possibly nongenomic effects of testosterone on isolated and perfused rat heart. Proc West Pharmacol Soc. 1998;41: 131-132.
14. Chou TM, Sudhir K, Hutchinson SJ, Ko E, Amidon TM, Collins P, Chatterjee K. Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo. Circulation. 1996;4: 2614-2619.
15. Costarella CE, Stallone JN, Rutecki GW, Whittier FC. Testosterone causes direct relaxation of rat thoracic aorta. J Pharmacol Exp Ther. 1996;277:34-39.
16. Labrie F. Mechanisms of action and pure antiandrogenic properties of flutamide. Cancer. 1993;72:3816-3827.
17. Boccuzzi G, Tamagno E, Brignardello E, Di Monaco M, Aragno M, Danni O. Growth inhibition of DMBA-induced rat mammary carcinoma by the antiandrogen flutamide. Cancer Res Clin Oncol. 1995;121:150-154.
18. Imperato-McGinley J, Snachez RS, Spencer JR, Yee B, Vaughan ED. Comparison of the effects of the 5a-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: dose-response studies. Endocrinology. 1992;131:1149-1156.
19. Russo P, Warner JA, Huryk R, Perez G, Heston WDW. TRPM-2 gene expression in normal rat ventral prostate following castration and exposure to diethylstilbestrol, flutamide, MK-906 (finasteride), and coumarin. Prostate. 1994;24:237-243.
20. Ichikawa I, Maddox DA, Cogan MG, Brenner BM. Dynamics of glomerular ultrafiltration in euvolemic Munich Wistar rats. Renal Physiol. 1978; 1:121-131.
21. Reckelhoff JF, Manning RD Jr. Role of endothelial-derived nitric oxide in the control of the renal microvasculature in aging male rats. Am J Physiol. 1993;265:R1126-R1131.
22. Reckelhoff JF, Kellum JA Jr, Racusen LC, Hildebrandt DA. Long term dietary supplementation with L-arginine prevents age-related reduction in renal function. Am J Physiol. 1997;272:R1768-R1774.
23. Ely DL, Salisbury R, Hadi D, Turner M, Johnson ML. Androgen receptor and the testes influence hypertension in a hybrid rat model. Hypertension. 1991;17:1104-1110.
24. Marks LS, Partin AW, Dorey FJ, Gormley GJ, Epstein JI, Garris JB, Macairan ML, Shery ED, Santos PB, Stoner E, deKernion JB. Long-term effects of finasteride on prostate tissue composition. Urology. 1999;53: 574-580.
25. Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillex R, Bergfeld W, Price VH, Van Neste D, Roberts JL, Hordinsky M, Shapiro J, Binkowitz B, Gormley GJ. Finasteride in the treatment of men with androgenetic alopecia: Finasteride Male Pattern Hair Loss Study Group. J Am Acad Dermatol. 1998;39:578-589.
26. Guyton AC, Coleman TG, Cowley AW Jr, Scheel KW, Manning RD, Norman RA. Arterial pressure regulation: overriding dominance of the kidneys in long-term regulation and in hypertension. Am J Med. 1972; 52:584-594.
27. Hall JE, Mizelle HL, Hildebrandt DA, Brands MW. Abnormal pressure-natriuresis: a cause or a consequence of hypertension. Hypertension. 1990;15:547-559.