17beta-Estradiol, Its Metabolites, and Progesterone Inhibit Cardiac Fibroblast Growth

Hypertension

Volumn 31, Issue 1, 1998, Pages 522-528

  Dubey, Raghvendra K ^a   Gillespie, Delbert G ^a   Jackson, Edwin K ^a   Keller, Paul J ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYESTRADIOL; 2 METHOXYESTRADIOL; 2-HYDROXYESTRADIOL; 2-METHOXYESTRADIOL; 4 HYDROXYTAMOXIFEN; 4-HYDROXYTAMOXIFEN; ANTIESTROGEN; CATECHOL ESTROGEN; COLLAGEN; DNA; DRUG DERIVATIVE; ESTRADIOL; ESTROGEN RECEPTOR; PROGESTERONE; PROLINE; TAMOXIFEN; ESTRADIOL DERIVATIVE; ESTRIOL; ESTRONE; PHYTOESTROGEN;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; FEMALE; FIBROBLAST; HEART MUSCLE; HUMAN; KINETICS; MALE; METABOLISM; RAT; SEXUAL DEVELOPMENT; SPRAGUE DAWLEY RAT; ANIMAL TISSUE; CELL PROLIFERATION; CONTROLLED STUDY; FIBROBLAST CULTURE; GROWTH INHIBITION; HEART HYPERTROPHY; HEART PROTECTION; HORMONAL REGULATION; NONHUMAN; POSTMENOPAUSE; PRIORITY JOURNAL;

ANIMALS; CELL DIVISION; CELLS, CULTURED; COLLAGEN; DNA; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGENS, CATECHOL; FEMALE; FIBROBLASTS; HUMANS; KINETICS; MALE; MYOCARDIUM; PROGESTERONE; PROLINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; SEX CHARACTERISTICS; TAMOXIFEN;

EID: 0031606441     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/01.HYP.31.1.522     Document Type: Article

References (21)

1. Kalin MF, Zumoff and coronary disease: a review of the clinical studies. Steroids. 1990;55:330-352.
2. Heart, and Stroke Facts. Dallas: American Heart Association, 1992.
3. Oparil S, Levine RL, Chen YF. Sex hormones and the vasculature. In: Sowers JR, Walsh M, eds. Endocrinology of the Vasculature. Totwa, N.J.: Humana Press; 1996:225-237.
4. Krasinski K, Spyridopoulos I, Asahara T, van der Zee R, Isner JM, Losordo DW. Estradiol accelerates functional endothelial recovery after arterial injury. Circulation. 1997;95:1768-1772.
5. Rosselli M, Keller PJ, Kern F, Hahn AWA, Dubey RK. Estradiol inhibits mitogen-induced proliferation and migration of human aortic smooth muscle cells: implications for cardiovascular disease in women (abstract). Circulation. 1994;90:1-87.
6. Dubey RK, Jackson EK, Rupprecht H, Sterzel RB. Factors controlling growth and matrix production in vascular smooth muscle and glomerular mesangial cells. Curr Opin Nephrol Hypertens. 1997;6:88-105.
7. Oparil S, Levine R, Chen S-J, Durand J, Chen YF. Sexually dimorphic response of the balloon-injured rat carotid artery to hormone treatment. Circulation. 1997;95:1301-1307.
8. Foegh ML, Asotra S, Howell MH, Ramwell PW. Estradiol inhibition of arterial neointimal hyperplasia after balloon injury. J Vasc Surg. 1994;19:722-726.
9. 2B receptors. Circulation. 1997;96:2656-2666.
10. Grohe C, Kahlert S, Lobbert K, Meyer R, Linz KW, Karas RH, Vetter H. Modulation of hypertensive heart disease by estrogen. Steroids. 1996;61:201-204.
11. Nishigaki I, Sasaguri Y, Yagi K. Anti-proliferative effect of 2-methoxyestradiol on cultured smooth muscle cells from rabbit aorta. Atherosclerosis. 1995;113:167-170.
12. Honore EK, Williams JK, Anthony MS, Clarkson TB. Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques. Fertil Ster. 1997;67:148-154.
13. Imthurn B, Rosselli M, Jaeger AW, Keller PJ, Dubey RK. Differential effects of hormone-replacement therapy on endogenous nitric oxide (nitrite/nitrate) levels in postmenopausal women substituted with 17beta-estradiol valerate and cyproterone acetate or medroxyprogesterone acetate. J Clin Endocrinol Metab. 1997;82:388-394.
14. Shwaery GT, Vita JA, Keaney JF. Antioxidant protection of LDL by physiological concentrations of 17beta-estradiol: requirement for estradiol modification. Circulation. 1997;95:1378-1385.
15. Liehr JG, Ricci MJ. 4-Hydroxylation of estrogens as marker of human mammary tumors. Proc Natl Acad Sci U S A. 1996;93:3294-3296.
16. Levine RL, Chen SJ, Durand J, Chen YF, Oparil S. Medroxyprogesterone attenuates estrogen-mediated inhibition of neointima formation after balloon injury of the rat carotid artery. Circulation. 1996;94:2221-2227.
17. Rosselli M, Imthurn B, Keller PJ, Jackson EK, Dubey RK. Circulating nitric oxide (nitrite/nitrate) levels in postmenopausal women substituted with 17beta-estradiol and norethisterone acetate: a two year follow-up study. Hypertension. 1995;25:848-853.
18. Grainger DJ, Metcalfe JC. Tamoxifen: teaching an old drug new tricks? Nature Med. 1996;2:381-385.
19. Iafrati MD, Karas RH, Aronovitz M, Kim S, Sullivan TR Jr, Lubahn DB, O'Donell Jr. TF, Korach KS, Mendelsohn ME. Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice. Nature Med. 1997;3:545-548.
20. Judd HL. Hormonal dynamics associated with the menopause. Clin Obstet Gynecol. 1976;19:775-788.
21. Caulin-Glaser T, Watson CA, Pardi R, Bender JR. Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression. J Clin Invest. 1996;98:36-42.