Androgen receptors mediate hypertrophy in cardiac myocytes

Circulation

Volumn 98, Issue 3, 1998, Pages 256-261

  Marsh, James D ^a,d   Lehmann, Michael H ^a,c   Ritchie, Rebecca H ^a   Gwathmey, Judith K ^a,b   Green, Glenn E ^a   Schiebinger, Rick J ^a  

^a HARPER UNIVERSITY HOSPITAL   (United States)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^c SINAI GRACE HOSPITAL   (United States)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hormones; Hypertrophy; Myocytes

Indexed keywords

ANDROGEN RECEPTOR;

ANIMAL CELL; ARTICLE; ELECTROCARDIOGRAPHY; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART REPOLARIZATION; MUSCLE STRENGTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; QT INTERVAL; RAT; RECEPTOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 0032555171     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.98.3.256     Document Type: Article

References (50)

1. Silver MD. Cardiovascular Pathology. 2nd ed. New York, NY: Churchill Livingstone; 1991.
2. Bazett H. An analysis of the time-relations of electrocardiograms. Heart. 1920;7:353-357.
3. Lepeschkin E, Surawicz B. The duration of the Q-U interval and its components in electrocardiograms of normal persons. Am Heart J. 1953; 46:9-20.
4. Moss AJ, Schwanz P, Crampton R, Tzivoni D, Locati EH, MacCluer J, Hall WJ, Weitkamp L, Vincent GM, Garson A Jr. The long QT syndrome: prospective longitudinal study of 328 families. Circulation. 1991; 84:1136-1144.
5. Hashiba K. Sex differences in phenotypic manifestation and gene transmission in the Romano-Ward syndrome. Ann N Y Acad Sci. 1992;644: 142-156.
6. Lehmann MH, Hardy S, Archibald D, Quart B, MacNeil DJ. Sex difference in risk of torsade de pointes with d,l-sotalol. Circulation. 1996; 94:2535-2541.
7. Zareba W, Moss A, le Cessie S, Locati E, Robinson J, Hall W, Andrews M. Risk of cardiac events in family members of patients with long QT syndrome. J Am Coll Cardiol. 1995;26:1685-1691.
8. Makkar R, Fromm B, Steinman R, Meissner M, Lehmann M. Female gender as a risk factor for torsade de pointes associated with cardiovascular drugs. JAMA. 1993;270:2590-2597.
9. Kawasaki R, Machado C, Baga J, Reinoehl J, Steinman R, Fromm B, Lehmann M. Torsade de pointes in complete heart block: evidence for increased female susceptibility. J Cardiovasc Electrophysiol. 1995;6: 1032-1038.
10. Stramba-Badial M, Spagnolo D, Bosi G, Schwartz P, MISNES Investigators. Are gender differences in QTc present at birth? Am J Cardiol. 1995;75:1277-1278.
11. Alimurung M, Joseph L, Craige E, Massel B. The QT interval in normal infants and children. Circulation. 1950;1:1329-1337.
12. Rautaharju PM, Zhou S, Wong S, Calhoun H, Berenson G, Prineas RDA. Sex differences in the evolution of the electrocardiographic QT interval with age. Can J Cardiol. 1992;8:690-695.
13. Schaible TF, Malhotra A, Ciambrone G, Scheuer J. The effect of gonadectomy on left ventricular function and cardiac contractile proteins in male and female rats. Circ Res. 1984;54:38-49.
14. Malhotra A, Buttrick P, Scheuer J. Effects of sex hormones on development of physiological and pathological hypertrophy in male and female rats. Am J Physiol. 1990;259:H866-H871.
15. Scheuer JMA, Schaible T, Capasso J. Effects of gonadectomy and hormonal replacement on rat hearts. Circ Res. 1987;61:12-19.
16. Melchert R, Herron T, Welder A. The effect of anabolic-androgenic steroids on primary myocardial cell cultures. Med Sci Sports Exerc. 1992;24:206-212.
17. Campbell S, Farb A, Weber K. Pathologic remodeling of the myocardium in a weightlifter taking anabolic steroids. Blood Press. 1993;2:213-216.
18. Bhasin S, Storer T, Berman N, Caggegari C, Clevenger B, Phillips J, Bunnell T, Tricker R, Shirazi A, Casaburi R. The effects of supraphysiologic doses of testosterone on the muscle size and strength in normal men. N Engl J Med. 1996;335:1-7.
19. Sadoshima J, Izumo S. Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Circ Res. 1993;73:413-423.
20. Lin AL, McGill HC, Shain SA. Hormone receptors of the baboon cardiovascular system: biochemical characterization of aortic and myocardial cytoplasmic androgen receptors. Circ Res. 1981;49:1010-1016.
21. Lin AL, Schultz JJ, Brenner RM, Shain SA. Sexual dimorphism characterizes baboon myocardial androgen receptors but not myocardial estrogen and progesterone receptors. J Steroid Biochem Mol Biol. 1990; 37:85-95.
22. Simpson P, Savion S. Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells: cross striations, ultrastructure, and chronotropic responses to isoproterenol. Circ Res. 1982;50:101-116.
23. Maki TM, Gruver EJ, Davidoff AJ, Izzo N, Toupin D, Colucci W, Marks A, Marsh JD. Regulation of calcium channel expression in neonatal myocytes by catecholamines. J Clin Invest. 1996;97:656-663.
24. Ellingsen O, Davidoff AJ, Prasad SK, Berger HJ, Springhorn JP, Marsh JD, Kelly RA, Smith TW. Adult rat ventricular myocytes cultured in defined medium: phenotype and electromechanical function. Am J Physiol. 1993;265:H747-H754.
25. Farrell RE. RNA Methodologies: A Laboratory Guide for Isolation and Characterization. New York, NY: Academic Press; 1993.
26. Tan J, Joseph DR, Quarmby V, Lubahn D, Sar M, French F, Wilson E. The rat androgen receptor: primary structure, autoregulation of its messenger ribonucleic acid, and immunocytochemical localization of the receptor protein. Mol Endocrinol. 1988;2:1276-1285.
27. Taplin M-E, Bubley G, Shuster T, Frantz M, Spooner A, Ogata G, Keer H, Balk S. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N Engl J Med. 1995;332: 1393-1398.
28. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A. 1977;74:5463-5467.
29. Morgan H, Baker K. Cardiac hypertrophy: mechanical, neural, and endocrine dependence. Circulation. 1991;83:13-25.
30. Schiebinger R, Greening K. Interaction between stretch and hormonally stimulated atrial natriuretic peptide secretion. Am J Physiol. 1992;262: H78-H83.
31. Sheridan P, McGill J Jr, Aufdemorte T, Triplett R, Holt R. Heart contains receptors for dihydrotestosterone but not testosterone: possible role in the sex differential in coronary heart disease. Anat Rec. 1989;223:414-419.
32. Abdelgadir S, Connolly P, Resko J. Androgen binding in peripheral tissues of fetal rhesus macaques: effects of androgen metabolism in liver. J Steroid Biochem Mol Biol. 1990;37:545-551.
33. Kuipers H, Peeze Binkhorst F, Hartgens F, Wijnen J, Keizer H. Muscle ultrastructure after strength training with placebo or anabolic steroid. Can J Appl Physiol. 1993;18:189-196.
34. Bricout VA, Germain P, Serrurier BD, Guezennec CY. Changes in testosterone muscle receptors: effects of androgen treatment on physically trained rats. Cell Mol Biol (Noisy-le-grand). 1994;40:291-294.
35. Kuil C, Mulder E. Deoxyribonucleic acid-binding ability of androgen receptors in whole cells: implications for the action of androgens and antiandrogens. Endocrinology. 1996;137:1870-1877.
36. Ritchie RH, Marsh JD, Lancaster WD, Diglio CA, Schiebinger RJ. Bradykinin blocks angiotensin II-induced hypertrophy in the presence of endothelial cells. Hypertension. 1998;31:39-44.
37. Koenig H, Fan C, Goldstone A, Lu C, Trout J. Polyamines mediate androgenic stimulation of calcium fluxes and membrane transport in rat heart myocytes. Circ Res. 1989;64:415-426.
38. Melchert R, Welder A. Cardiovascular effects of androgenic-anabolic steroids. Med Sci Sports Exerc. 1995;27:1252-1262.
39. Welder A, Robertson J, Fugate R, Melchert R. Anabolic-androgenic steroid-induced toxicity in primary neonatal rat myocardial cell cultures. Toxicol Appl Pharmacol. 1995;133:328-342.
40. Feraudi M, Weicker H. Effects of training and methandrotestosterone (an anabolic steroid) on energy metabolism in the guinea pig: changes in enzyme activities in the gastrocnemius muscle and myocardium. Int J Biochem. 1985;17:1191-1205.
41. Deng Y, Kauffman S. The influence of reproductive hormones on ANF release by rat atria. Life Sci. 1993;53:689-696.
42. Kinson G, Layberry R, Hebert B. Influence of anabolic androgens on cardiac growth and metabolism in the rat. Can J Physiol Pharmacol. 1991;69:1698-1704.
43. Gillardon F, Morano I, Ganten U, Zimmerman M. Regulation of calcitonin gene-related peptide mRNA expression in the hearts of spontaneously hypertensive rats by testosterone. Neurosci Lett. 1991;125: 77-80.
44. Morano I, Gerstner J, Ruegg J, Ganten U, Ganten D, Vosberg H. Regulation of myosin heavy chain expression in the hearts of hypertensive rats by testosterone. Circ Res. 1990;66:1585-1590.
45. Culig Z, Hobisch A, Cronauer M, Hittmair A, Radmayer C, Bartsch G, Klocker H. Activation of the androgen receptor by polypeptide growth factors and cellular regulators. World J Urol. 1995;13:285-289.
46. Stumpf W, Sar M, Aumuller G. The heart: a target organ for estradiol. Science. 1977;196:319-321.
47. Trifunovic B, Norton G, Duffield M, Avraam P, Woodiwiss A. An androgenic steroid decreases left ventricular compliance in rats. Am J Physiol. 1995;268:H1096-H1105.
48. Thompson P, Sadaniantz A, Cullinane E, Bodziony K, Catlin D. Left ventricular function is not impaired in weight-lifters who use anabolic steroids. J Am Coll Cardiol. 1992;19:278-282.
49. Lehmann M, Timothy K, Frankovich D, Fromm B, Keating M, Locati EH, Taggart RT, Towbin JA, Moss AJ, Schwartz PJ, Vincent GM. Age-sex influence on QTc and the QT-heart rate relationship in genotypically characterized long QT syndrome families. J Am Coll Cardiol. 1997;29:93-99.
50. Drici M, Burklow T, Haridasse V, Glazer R, Woosley R. Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart. Circulation. 1996;94:1471-1474.