Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

Immunity

Volumn 44, Issue 6, 2016, Pages 1392-1405

  Lassen, Kara G ^a,b   McKenzie, Craig I ^c   Mari, Muriel ^d,e   Murano, Tatsuro ^a,b   Begun, Jakob ^b,f   Baxt, Leigh A ^b   Goel, Gautam ^b   Villablanca, Eduardo J ^a,b   Kuo, Szu Yu ^a   Huang, Hailiang ^a,b   Macia, Laurence ^c   Bhan, Atul K ^b   Batten, Marcel ^g   Daly, Mark J ^a,b   Reggiori, Fulvio ^d,e   Mackay, Charles R ^c   Xavier, Ramnik J ^a,b  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f UNIVERSITY OF QUEENSLAND   (Australia)

^g UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FAT DROPLET; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 1BETA; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; G PROTEIN COUPLED RECEPTOR; GPR65 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BACTERIAL CLEARANCE; BIOACCUMULATION; CELL PH; COLITIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; FUNCTIONAL GENOMICS; GENE; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GPR65 GENE; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATORY BOWEL DISEASE; INTESTINE EPITHELIUM CELL; LYSOSOME; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; EPITHELIUM CELL; GENETIC PREDISPOSITION; GENETICS; HELA CELL LINE; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PHAGOSOME; PHYSIOLOGY; RISK; SALMONELLA ENTERICA; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SALMONELLOSIS;

ANIMALS; COLITIS; EPITHELIAL CELLS; GENETIC PREDISPOSITION TO DISEASE; HELA CELLS; HUMANS; INFLAMMATORY BOWEL DISEASES; LYSOSOMES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHAGOSOMES; POLYMORPHISM, GENETIC; RECEPTORS, G-PROTEIN-COUPLED; RISK; SALMONELLA ENTERICA; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM;

EID: 84973563174     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.05.007     Document Type: Article

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