A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo

Cell Research

Volumn 22, Issue 2, 2012, Pages 333-345

  Chen, Yanqun ^a,b   Wu, Bin ^a,b   Xu, Liangliang ^a   Li, Huapeng ^a   Xia, Jianhong ^a   Yin, Wenguang ^a   Li, Zhuo ^a   Shi, Dawei ^a,c   Li, Song ^d   Lin, Shuo ^d   Shu, Xiaodong ^a   Pei, Duanqing ^a  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^c FUJIAN AGRICULTURE AND FORESTRY UNIVERSITY   (China)

^d PEKING UNIVERSITY   (China)

Author keywords

Ciliogenesis; SNX10; V ATPase; Zebrafish

Indexed keywords

PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RAB PROTEIN; RAB8A PROTEIN, HUMAN; SMALL INTERFERING RNA; SORTING NEXIN; ZEBRAFISH PROTEIN;

ANIMAL; ARTICLE; CELL VACUOLE; CENTROSOME; DRUG ANTAGONISM; EMBRYO DEVELOPMENT; EUKARYOTIC FLAGELLUM; GENETICS; HUMAN; METABOLISM; MORPHOGENESIS; PHYSIOLOGY; PROTEIN BINDING; RNA INTERFERENCE; TUMOR CELL LINE; ZEBRA FISH;

ANIMALS; BODY PATTERNING; CELL LINE, TUMOR; CENTROSOME; CILIA; EMBRYONIC DEVELOPMENT; HUMANS; MORPHOGENESIS; PROTEIN BINDING; RAB GTP-BINDING PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SORTING NEXINS; VACUOLAR PROTON-TRANSLOCATING ATPASES; VACUOLES; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO; EUKARYOTA;

EID: 84856607538     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2011.134     Document Type: Article

References (39)

1. Gerdes JM, Davis EE, Katsanis N. The vertebrate primary cilium in development, homeostasis, and disease. Cell 2009; 137:32-45.
2. Satir P, Christensen ST. Overview of structure and function of mammalian cilia. Annu Rev Physiol 2007; 69:377-400. (Pubitemid 46457649)
3. Fliegauf M, Benzing T, Omran H. When cilia go bad: cilia defects and ciliopathies. Nat Rev Mol Cell Biol 2007; 8:880-893. (Pubitemid 47622564)
4. Singla V, Reiter JF. The primary cilium as the cell's antenna: signaling at a sensory organelle. Science 2006; 313:629-633. (Pubitemid 44201133)
5. Nachury MV, Loktev AV, Zhang Q, et al. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 2007; 129:1201-1213. (Pubitemid 46891037)
6. Spektor A, Tsang WY, Khoo D, Dynlacht BD. Cep97 and CP110 suppress a cilia assembly program. Cell 2007; 130:678-690. (Pubitemid 47268052)
7. Tsang WY, Bossard C, Khanna H, et al. CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease. Dev Cell 2008; 15:187-197.
8. Sorokin S. Centrioles and the formation of rudimentary cilia by fibroblasts and smooth muscle cells. J Cell Biol 1962; 15:363-377.
9. Pedersen LB, Veland IR, Schroder JM, Christensen ST. Assembly of primary cilia. Dev Dyn 2008; 237:1993-2006.
10. Silverman MA, Leroux MR. Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia. Trends Cell Biol 2009; 19:306-316.
11. Yoshimura S, Egerer J, Fuchs E, Haas AK, Barr FA. Functional dissection of Rab GTPases involved in primary cilium formation. J Cell Biol 2007; 178:363-369. (Pubitemid 47196146)
12. Gray RS, Abitua PB, Wlodarczyk BJ, et al. The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. Nat Cell Biol 2009; 11:1225-1232.
13. Kim J, Lee JE, Heynen-Genel S, et al. Functional genomic screen for modulators of ciliogenesis and cilium length. Nature 2010; 464:1048-1051.
14. Cullen PJ. Endosomal sorting and signalling: an emerging role for sorting nexins. Nat Rev Mol Cell Biol 2008; 9:574-582. (Pubitemid 351881840)
15. Kurten RC, Cadena DL, Gill GN. Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Science 1996; 272:1008-1010. (Pubitemid 26259317)
16. Seet LF, Hong W. The Phox (PX) domain proteins and membrane traffic. Biochim Biophys Acta 2006; 1761:878-896. (Pubitemid 44348964)
17. Schwarz DG, Griffin CT, Schneider EA, Yee D, Magnuson T. Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice. Mol Biol Cell 2002; 13:3588-3600. (Pubitemid 35191377)
18. Zheng B, Tang T, Tang N, et al. Essential role of RGSPX1/ sorting nexin 13 in mouse development and regulation of endocytosis dynamics. Proc Natl Acad Sci USA 2006; 103:16776-16781. (Pubitemid 44737329)
19. Cai L, Loo LS, Atlashkin V, Hanson BJ, Hong W. Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C). Mol Cell Biol 2011; 31:1734-1747.
20. Qin B, He M, Chen X, Pei D. Sorting nexin 10 induces giant vacuoles in mammalian cells. J Biol Chem 2006; 281:36891-36896. (Pubitemid 46042157)
21. Long S, Ahmad N, Rebagliati M. The zebrafish nodal-related gene southpaw is required for visceral and diencephalic leftright asymmetry. Development 2003; 130:2303-2316. (Pubitemid 36722383)
22. Essner JJ, Vogan KJ, Wagner MK, Tabin CJ, Yost HJ, Brueckner M. Conserved function for embryonic nodal cilia. Nature 2002; 418:37-38. (Pubitemid 34742562)
23. Essner JJ, Amack JD, Nyholm MK, Harris EB, Yost HJ. Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. Development 2005; 132:1247-1260. (Pubitemid 40528785)
24. Esteban MA, Harten SK, Tran MG, Maxwell PH. Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein. J Am Soc Nephrol 2006; 17:1801-1806. (Pubitemid 44036164)
25. Ullrich O, Reinsch S, Urbe S, Zerial M, Parton RG. Rab11 regulates recycling through the pericentriolar recycling endosome. J Cell Biol 1996; 135:913-924. (Pubitemid 26403768)
26. Forgac M. Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Nat Rev Mol Cell Biol 2007; 8:917-929. (Pubitemid 47622561)
27. Marshansky V, Futai M. The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function. Curr Opin Cell Biol 2008; 20:415-426.
28. Nuckels RJ, Ng A, Darland T, Gross JM. The vacuolar- ATPase complex regulates retinoblast proliferation and survival, photoreceptor morphogenesis, and pigmentation in the zebrafish eye. Invest Ophthalmol Vis Sci 2009; 50:893-905.
29. Adams DS, Robinson KR, Fukumoto T, et al. Early, H+-VATPase- dependent proton flux is necessary for consistent leftright patterning of non-mammalian vertebrates. Development 2006; 133:1657-1671. (Pubitemid 43810973)
30. Drummond IA, Majumdar A, Hentschel H, et al. Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development 1998; 125:4655-4667. (Pubitemid 29027196)
31. Sun Z, Amsterdam A, Pazour GJ, Cole DG, Miller MS, Hopkins N. A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development 2004; 131:4085-4093. (Pubitemid 39232166)
32. Nicolson T. The genetics of hearing and balance in zebrafish. Annu Rev Genet 2005; 39:9-22. (Pubitemid 43011105)
33. Edge AS, Chen ZY. Hair cell regeneration. Curr Opin Neurobiol 2008; 18:377-382.
34. Li Y, Hu J. Small GTPases and cilia. Protein Cell 2011; 2:13-25.
35. Omori Y, Zhao C, Saras A, et al. Elipsa is an early determinant of ciliogenesis that links the IFT particle to membraneassociated small GTPase Rab8. Nat Cell Biol 2008; 10:437-444.
36. Kim J, Krishnaswami SR, Gleeson JG. CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium. Hum Mol Genet 2008; 17:3796-3805.
37. Bieber T, Elsasser HP. Preparation of a low molecular weight polyethylenimine for efficient cell transfection. Biotechniques 2001; 30:74-77, 80-81.
38. Nifontova IN, Sats NV, Surin VL, Svinareva DA, Gasparian ME, Drize NJ. Infection of stromal and hemopoietic precursor cells with lentivirus vector in vivo and in vitro. Bull Exp Biol Med 2008; 145:133-136.
39. Westerfield M. The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio). Eugene: University of Oregon, 1995.