Epigenetics of cartilage diseases

Joint Bone Spine

Volumn 83, Issue 5, 2016, Pages 491-494

  Gabay, Odile ^a   Clouse, Kathleen A ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Arthritis; Cartilage; DNA methylation; Epigenetics; Histone deacetylases; miRNA

Indexed keywords

HISTONE DEACETYLASE; METALLOPROTEINASE; MICRORNA; MICRORNA 140; SIRTUIN 1; UNCLASSIFIED DRUG; HISTONE;

CARTILAGE MATRIX; CHONDROPATHY; EPIGENETICS; GENE EXPRESSION; HISTONE METHYLATION; HUMAN; NEXT GENERATION SEQUENCING; NONHUMAN; OSTEOARTHRITIS; PATHOPHYSIOLOGY; SHORT SURVEY; AGING; ARTHRITIS; DNA METHYLATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; PHYSIOLOGY;

AGING; ARTHRITIS; CARTILAGE DISEASES; DNA METHYLATION; EPIGENESIS, GENETIC; HISTONE DEACETYLASES; HISTONES; HUMANS; MICRORNAS;

EID: 84973163223     PISSN: 1297319X     EISSN: 17787254     Source Type: Journal    
DOI: 10.1016/j.jbspin.2015.10.004     Document Type: Short Survey

References (36)

1. [1] Roberts, S.B., Wooton, E., De Ferrari, L., et al. Epigenetics of osteoarticular diseases: recent developments. Rheumatol Int 35 (2015), 1293–1305.
2. [2] Gabay, O., Sanchez, C., Epigenetics, sirtuins and osteoarthritis. Joint Bone Spine 79 (2012), 570–573.
3. [3] Barter, M.J., Bui, C., Young, D.A., Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs. Osteoarthritis Cartilage 20 (2012), 339–349.
4. [4] Kim, H., Kang, D., Cho, Y., et al. Epigenetic regulation of chondrocyte catabolism and anabolism in osteoarthritis. Mol Cells 38 (2015), 677–684.
5. [5] Zhang, M., Egan, B., Wang, J., Epigenetic mechanisms underlying the aberrant catabolic and anabolic activities of osteoarthritic chondrocytes. Int J Biochem Cell Biol 67 (2015), 101–109.
6. [6] Toussirot, E., Wendling, D., Herbein, G., Biological treatments given in patients with rheumatoid arthritis or ankylosing spondylitis modify HAT/HDAC (histone acetyltransferase/histone deacetylase) balance. Joint Bone Spine 81 (2014), 544–545.
7. [7] Higashiyama, R., Miyaki, S., Yamashita, S., et al. Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. Mod Rheumatol 20 (2010), 11–17.
8. [8] Saito, T., Sishida, K., Furumatsu, T., et al. Histone deacetylase inhibitors suppress mechanical stress-induced expression of RUNX-2 and ADAM-TS5 through the inhibition of the MAPK signaling pathway in cultured human chondrocytes. Osteoarthritis Cartilage 21 (2013), 165–174.
9. [9] Huh, Y.H., Ryu, J.H., Chun, J.S., Regulation of type II collagen expression by histone deacetylase in articular chondrocytes. J Biol Chem 282 (2007), 17123–17131.
10. [10] Wendling, D., Vidon, C., Abbas, W., et al. Sirt1 activity in peripheral blood mononuclear cells from patients with rheumatoid arthritis. Joint Bone Spine 81 (2014), 462–463.
11. [11] Li, W., Cai, L., Zhang, Y., et al. Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2alpha. J Orthop Res 33 (2015), 1061–1070.
12. [12] Matsuzaki, T., Matsushita, T., Takayama, K., et al. Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice. Ann Rheum Dis 73 (2014), 1397–1404.
13. [13] Oppenheimer, H., Kumar, A., Meir, H., et al. Set7/9 impacts COL2A1 expression through binding and repression of SirT1 histone deacetylation. J Bone Miner Res 29 (2014), 348–360.
14. [14] Imai, S., Guarente, L., Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci 31 (2010), 212–220.
15. [15] Buhrmann, C., Busch, F., Shayan, P., et al. Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells. J Biol Chem 289 (2014), 22048–22062.
16. [16] Chen, Y., Zhang, J., Lin, Y., et al. Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep 12 (2011), 534–541.
17. [17] Mostoslavsky, R., Chua, K.F., Lombard, D.B., et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124 (2006), 315–329.
18. [18] Piao, J., Tssuji, K., Ochi, H., et al. Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling. Sci Rep, 3, 2013, 3022.
19. [19] Sesselmann, S., Soder, S., Voigt, R., et al. DNA methylation is not responsible for p21WAF1/CIP1 downregulation in osteoarthritic chondrocytes. Osteoarthritis Cartilage 17 (2009), 507–512.
20. [20] den Hollander, W., Ramos, Y.F., Bomer, N., et al. Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage. Arthritis Rheumatol 67 (2015), 2108–2116.
21. [21] Fernandez-Tajes, J., Soto-Hermida, A., Vazquez-Mosquera, M.E., et al. Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients. Ann Rheum Dis 73 (2014), 668–677.
22. [22] Rushton, M.D., Reynard, L.N., Barter, M.J., et al. Characterization of the cartilage DNA methylome in knee and hip osteoarthritis. Arthritis Rheumatol 66 (2014), 2450–2460.
23. [23] Hashimoto, K., Otero, M., Imagawa, K., et al. Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1beta (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites. J Biol Chem 288 (2013), 10061–10072.
24. [24] de Andres, M.C., Imagawa, K., Hashimoto, K., et al. Loss of methylation in CpG sites in the NF-kappaB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes. Arthritis Rheum 65 (2013), 732–742.
25. [25] Iliopoulos, D., Malizos, K.N., Oikonomou, P., et al. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PLoS One, 3, 2008, e3740.
26. [26] Diaz-Prado, S., Cicione, C., Muinos-Lopez, E., et al. Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes. BMC Musculoskelet Disord, 13, 2012, 144.
27. [27] Barter, M.J., Tselepi, M., Gomez, R., et al. Genome-wide MicroRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR-140-5p. Stem Cells 33 (2015), 3266–3280.
28. [28] Trzeciak, T., Czarny-Ratajczak, M., MicroRNAs: important epigenetic regulators in osteoarthritis. Curr Genomics 15 (2014), 481–484.
29. [29] Xie, Q., Wei, M., Kang, X., et al. Reciprocal inhibition between miR-26a and NF-κB regulates obesity-related chronic inflammation in chondrocytes. Biosci Rep, 35, 2015 [PMID: 25910954. Epub ahead of print].
30. [30] Hou, C., Yang, Z., Kang, Y., et al. MiR-193b regulates early chondrogenesis by inhibiting the TGF-beta2 signaling pathway. FEBS Lett 589 (2015), 1040–1047.
31. [31] Akhtar, N., Makki, M.S., Haqqi, T.M., MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes. Arthritis Rheumatol 67 (2015), 423–434.
32. [32] Gu, S.X., Li, X., Hamilton, J.L., et al. MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc. Gene 555 (2015), 80–87.
33. [33] Li, Z.C., Han, N., Li, X., et al. Decreased expression of microRNA-130a correlates with TNF-alpha in the development of osteoarthritis. Int J Clin Exp Pathol 8 (2015), 2555–2564.
34. [34] Yang, W.H., Tsai, C.H., Fong, Y.C., et al. Leptin induces oncostatin M production in osteoblasts by downregulating miR-93 through the Akt signaling pathway. Int J Mol Sci 15 (2014), 15778–15790.
35. [35] Jingsheng, S., Yibing, W., Jun, X., et al. MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis. J Bone Miner Metab 33 (2015), 1–8.
36. [36] Zhang, L., Yang, M., Marks, P., et al. Serum non-coding RNAs as biomarkers for osteoarthritis progression after ACL injury. Osteoarthritis Cartilage 20 (2012), 1631–1637.