MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis

Journal of Bone and Mineral Metabolism

Volumn 33, Issue 1, 2015, Pages 1-8

  Jingsheng, Shi ^a   Yibing, Wei ^a   Jun, Xia ^a   Siqun, Wang ^a   Jianguo, Wu ^a   Feiyan, Chen ^a   Gangyong, Huang ^a   Jie, Chen ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

MicroRNA; Osteoarthritis chondrocyte; Type II diabetes

Indexed keywords

MICRORNA; MICRORNA 140; MICRORNA 146A; UNCLASSIFIED DRUG; MIRN140 MICRORNA, HUMAN; MIRN146 MICRORNA, HUMAN; MIRN34 MICRORNA, HUMAN;

3' UNTRANSLATED REGION; ARTICULAR CARTILAGE; BONE DEVELOPMENT; CARTILAGE CELL; DISEASE COURSE; EXTRACELLULAR MATRIX; HOMEOSTASIS; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OSTEOARTHRITIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVIEW; ANIMAL; BLOOD; CARTILAGE; COMPLICATION; DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PROGNOSIS; QUALITY OF LIFE;

ANIMALS; CARTILAGE; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; DISEASE PROGRESSION; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; MICRORNAS; OSTEOARTHRITIS; PROGNOSIS; QUALITY OF LIFE;

EID: 84922079078     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-014-0628-0     Document Type: Review

References (100)

1. Taylor AM (2013) Metabolic and endocrine diseases, cartilage calcification and arthritis. Curr Opin Rheumatol 25:198–203
2. Nukavarapu SP, Dorcemus DL (2013) Osteochondral tissue engineering: current strategies and challenges. Biotechnol Adv 31:706–721
3. Lotz MK, Kraus VB (2010) New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options. Arthritis Res Ther 12:211
4. Hashimoto M, Nakasa T, Hikata T, Asahara H (2008) Molecular network of cartilage homeostasis and osteoarthritis. Med Res Rev 28:464–481
5. Goldring MB, Marcu KB (2009) Cartilage homeostasis in health and rheumatic diseases. Arthritis Res Ther 11:224
6. Sandell LJ (2012) Etiology of osteoarthritis: genetics and synovial joint development. Nat Rev Rheumatol 8:77–89
7. Sowers MR, Karvonen-Gutierrez CA (2010) The evolving role of obesity in knee osteoarthritis. Curr Opin Rheumatol 22:533–537
8. Sulsky SI, Carlton L, Bochmann F, Ellegast R, Glitsch U, Hartmann B, Pallapies D, Seidel D, Sun Y (2012) Epidemiological evidence for work load as a risk factor for osteoarthritis of the hip: a systematic review. PLoS ONE 7:e31521
9. Yan W, Li X (2013) Impact of diabetes and its treatments on skeletal diseases. Front Med 7:81–90
10. Wen CY, Chen Y, Tang HL, Yan CH, Lu WW, Chiu KY (2013) Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus. Osteoarthritis Cartilage 21:1716–1723
11. Schett G, Kleyer A, Perricone C, Sahinbegovic E, Iagnocco A, Zwerina J, Lorenzini R, Aschenbrenner F, Berenbaum F, D’Agostino MA, Willeit J, Kiechl S (2013) Diabetes is an independent predictor for severe osteoarthritis: results from a longitudinal cohort study. Diabetes Care 36:403–409
12. Kussmann M, Morine MJ, Hager J, Sonderegger B, Kaput J (2013) Perspective: a systems approach to diabetes research. Front Genet 4:205
13. Berenbaum F (2011) Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype. Ann Rheum Dis 70:1354–1356
14. Rosa SC, Rufino AT, Judas F, Tenreiro C, Lopes MC, Mendes AF (2011) Expression and function of the insulin receptor in normal and osteoarthritic human chondrocytes: modulation of anabolic gene expression, glucose transport and GLUT-1 content by insulin. Osteoarthritis Cartilage 19:719–727
15. McNulty AL, Stabler TV, Vail TP, McDaniel GE, Kraus VB (2005) Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint. Arthritis Rheum 52:2676–2685
16. Henrotin YE, Bruckner P, Pujol JP (2003) The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthritis Cartilage 11:747–755
17. Verzijl N, DeGroot J, Ben ZC, Brau-Benjamin O, Maroudas A, Bank RA, Mizrahi J, Schalkwijk CG, Thorpe SR, Baynes JW, Bijlsma JW, Lafeber FP, TeKoppele JM (2002) Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis. Arthritis Rheum 46:114–123
18. Ramasamy R, Vannucci SJ, Yan SS, Herold K, Yan SF, Schmidt AM (2005) Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology 15:16R–28R
19. Steenvoorden MM, Huizinga TW, Verzijl N, Bank RA, Ronday HK, Luning HA, Lafeber FP, Toes RE, DeGroot J (2006) Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes. Arthritis Rheum 54:253–263
20. Cecil DL, Johnson K, Rediske J, Lotz M, Schmidt AM, Terkeltaub R (2005) Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products. J Immunol 175:8296–8302
21. Loeser RF, Yammani RR, Carlson CS, Chen H, Cole A, Im HJ, Bursch LS, Yan SD (2005) Articular chondrocytes express the receptor for advanced glycation end products: potential role in osteoarthritis. Arthritis Rheum 52:2376–2385
22. Rosa SC, Rufino AT, Judas FM, Tenreiro CM, Lopes MC, Mendes AF (2011) Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes. J Cell Biochem 112:2813–2824
23. Berezikov E (2011) Evolution of microRNA diversity and regulation in animals. Nat Rev Genet 12:846–860
24. Farh KK, Grimson A, Jan C, Lewis BP, Johnston WK, Lim LP, Burge CB, Bartel DP (2005) The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science 310:1817–1821
25. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281–297
26. Care A, Catalucci D, Felicetti F, Bonci D, Addario A et al (2007) MicroRNA-133 controls cardiac hypertrophy. Nat Med 13:613–618
27. Pandey AK, Agarwal P, Kaur K, Datta M (2009) MicroRNAs in diabetes: tiny players in big disease. Cell Physiol Biochem 23:221–232
28. Mishra PK, Tyagi N, Kumar M, Tyagi SC (2009) MicroRNAs as a therapeutic target for cardiovascular diseases. J Cell Mol Med 13:778–789
29. Rottiers V, Naar AM (2012) MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol 13:239–250
30. Cheng Q, Yi B, Wang A, Jiang X (2013) Exploring and exploiting the fundamental role of microRNAs in tumor pathogenesis. Onco Targets Ther 6:1675–1684
31. Le LT, Swingler TE, Clark IM (2013) Review: the role of microRNAs in osteoarthritis and chondrogenesis. Arthritis Rheum 65:1963–1974
32. Hong E, Reddi AH (2012) MicroRNAs in chondrogenesis, articular cartilage, and osteoarthritis: implications for tissue engineering. Tissue Eng Part B Rev 18:445–453
33. Baxter D, McInnes IB, Kurowska-Stolarska M (2012) Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA. Immunol Cell Biol 90:288–292
34. Kobayashi T, Lu J, Cobb BS, Rodda SJ, McMahon AP, Schipani E, Merkenschlager M, Kronenberg HM (2008) Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci USA 105:1949–1954
35. Dykxhoorn DM (2010) MicroRNAs and metastasis: little RNAs go a long way. Cancer Res 70:6401–6406
36. Singh PK, Brand RE, Mehla K (2012) MicroRNAs in pancreatic cancer metabolism. Nat Rev Gastroenterol Hepatol 9:334–344
37. Kumar M, Nath S, Prasad HK, Sharma GD, Li Y (2012) MicroRNAs: a new ray of hope for diabetes mellitus. Protein Cell 3:726–738
38. McClelland AD, Kantharidis P (2014) MicroRNA in the development of diabetic complications. Clin Sci (Lond) 126:95–110
39. Goldring MB, Marcu KB (2012) Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis. Trends Mol Med 18:109–118
40. Kumar M, Nath S, Prasad HK, Sharma GD, Li Y (2012) MicroRNAs: a new ray of hope for diabetes mellitus. Protein Cell 3:726–738
41. McClelland AD, Kantharidis P (2014) MicroRNA in the development of diabetic complications. Clin Sci 126:95–110
42. Long J, Wang Y, Wang W, Chang BH, Danesh FR (2010) Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions. J Biol Chem 285:23457–23465
43. Attur M, Krasnokutsky-Samuels S, Samuels J, Abramson SB (2013) Prognostic biomarkers in osteoarthritis. Curr Opin Rheumatol 25:136–144
44. Murata K, Yoshitomi H, Tanida S, Ishikawa M, Nishitani K, Ito H, Nakamura T (2010) Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Res Ther 12:R86
45. Tuddenham L, Wheeler G, Ntounia-Fousara S, Waters J, Hajihosseini MK, Clark I, Dalmay T (2006) The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells. FEBS Lett 580:4214–4217
46. Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, Kato Y, Takemoto F, Nakasa T, Yamashita S, Takada S, Lotz MK, Ueno-Kudo H, Asahara H (2010) MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev 24:1173–1185
47. Miyaki S, Nakasa T, Otsuki S, Grogan SP, Higashiyama R, Inoue A, Kato Y, Sato T, Lotz MK, Asahara H (2009) MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum 60:2723–2730
48. Tardif G, Hum D, Pelletier JP, Duval N, Martel-Pelletier J (2009) Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes. BMC Musculoskelet Disord 10:148
49. Wang M, Sampson ER, Jin H, Li J, Ke QH, Im HJ, Chen D (2013) MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther 15:R5
50. Pais H, Nicolas FE, Soond SM, Swingler TE, Clark IM, Chantry A, Moulton V, Dalmay T (2010) Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level. RNA 16:489–494
51. Wan R, Hu J, Zhou Q, Wang J, Liu P, Wei Y (2012) Application of co-expressed genes to articular cartilage: new hope for the treatment of osteoarthritis (review). Mol Med Rep 6:16–18
52. Nakamura Y, He X, Kato H, Wakitani S, Kobayashi T, Watanabe S, Iida A, Tahara H, Warman ML, Watanapokasin R, Postlethwait JH (2012) Sox9 is upstream of microRNA-140 in cartilage. Appl Biochem Biotechnol 166:64–71
53. Yang J, Qin S, Yi C, Ma G, Zhu H, Zhou W, Xiong Y, Zhu X, Wang Y, He L, Guo X (2011) MiR-140 is co-expressed with Wwp2-C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation. FEBS Lett 585:2992–2997
54. Yamashita S, Miyaki S, Kato Y, Yokoyama S, Sato T, Barrionuevo F, Akiyama H, Scherer G, Takada S, Asahara H (2012) L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity. J Biol Chem 287:22206–22215
55. Martinez-Sanchez A, Dudek KA, Murphy CL (2012) Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145). J Biol Chem 287:916–924
56. Yamasaki K, Nakasa T, Miyaki S, Ishikawa M, Deie M, Adachi N, Yasunaga Y, Asahara H, Ochi M (2009) Expression of MicroRNA-146a in osteoarthritis cartilage. Arthritis Rheum 60:1035–1041
57. Rong Y, Bao W, Shan Z, Liu J, Yu X, Xia S, Gao H, Wang X, Yao P, Hu FB, Liu L (2013) Increased microRNA-146a levels in plasma of patients with newly diagnosed type 2 diabetes mellitus. PLoS ONE 8:e73272
58. Oehler S, Neureiter D, Meyer-Scholten C, Aigner T (2002) Subtyping of osteoarthritic synoviopathy. Clin Exp Rheumatol 20:633–640
59. Taganov KD, Boldin MP, Chang KJ, Baltimore D (2006) NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 103:12481–12486
60. Wang JH, Shih KS, Wu YW, Wang AW, Yang CR (2013) Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1beta signaling in osteoarthritis fibroblast-like synoviocytes. Osteoarthritis Cartilage 21:1987–1996
61. Schulte LN, Westermann AJ, Vogel J (2013) Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing. Nucleic Acids Res 41:542–553
62. Corral-Fernandez NE, Salgado-Bustamante M, Martinez-Leija ME, Cortez-Espinosa N, Garcia-Hernandez MH, Reynaga-Hernandez E, Quezada-Calvillo R, Portales-Perez DP (2013) Dysregulated miR-155 expression in peripheral blood mononuclear cells from patients with type 2 diabetes. Exp Clin Endocrinol Diabetes 121:347–353
63. Liu-Bryan R, Terkeltaub R (2010) Chondrocyte innate immune myeloid differentiation factor 88-dependent signaling drives procatabolic effects of the endogenous Toll-like receptor 2/Toll-like receptor 4 ligands low molecular weight hyaluronan and high mobility group box chromosomal protein 1 in mice. Arthritis Rheum 62:2004–2012
64. Aldrich BT, Frakes EP, Kasuya J, Hammond DL, Kitamoto T (2009) Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation. Neuroscience 164:711–723
65. Nakagawa T, Kaneko S (2010) Spinal astrocytes as therapeutic targets for pathological pain. J Pharmacol Sci 114:347–353
66. Li X, Gibson G, Kim JS, Kroin J, Xu S, van Wijnen AJ, Im HJ (2011) MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis. Gene 480:34–41
67. Lisse TS, Chun RF, Rieger S, Adams JS, Hewison M (2013) Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts. J Bone Miner Res 28:1478–1488
68. Castro RE, Ferreira DM, Afonso MB, Borralho PM, Machado MV, Cortez-Pinto H, Rodrigues CM (2013) miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. J Hepatol 58:119–125
69. Choi SE, Fu T, Seok S, Kim DH, Yu E, Lee KW, Kang Y, Li X, Kemper B, Kemper JK (2013) Elevated microRNA-34a in obesity reduces NAD(+) levels and SIRT1 activity by directly targeting NAMPT. Aging Cell 12:1062–1072
70. Imai S (2011) Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis. FEBS Lett 585:1657–1662
71. Fu T, Choi SE, Kim DH, Seok S, Suino-Powell KM, Xu HE, Kemper JK (2012) Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor beta-Klotho. Proc Natl Acad Sci USA 109:16137–16142
72. El Tamer MK, Reis RL (2009) Progenitor and stem cells for bone and cartilage regeneration. J Tissue Eng Regen Med 3:327–337
73. Getgood A, Brooks R, Fortier L, Rushton N (2009) Articular cartilage tissue engineering: today’s research, tomorrow’s practice? J Bone Joint Surg Br 91:565–576
74. Vinatier C, Mrugala D, Jorgensen C, Guicheux J, Noel D (2009) Cartilage engineering: a crucial combination of cells, biomaterials and biofactors. Trends Biotechnol 27:307–314
75. Mason R, Tennekes H, Sánchez-Bayo F, Jepsen PU (2013) Immune suppression by neonicotinoid insecticides at the root of global wildlife declines. J Environ Immunol Toxicol 1:3–12
76. Petroianu GA, Lorke DE, Athauda G, Darvas F, Kalasz H (2013) Pralidoxime and obidoxime: phosphylationinduced changes in logP (partition coefficient). J Environ Immunol Toxicol 1:35–40
77. Flynt AS, Lai EC (2008) Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nat Rev Genet 9:831–842
78. Hobert O (2008) Gene regulation by transcription factors and microRNAs. Science 319:1785–1786
79. Kong XJ, Liu XW, Li JY, Yang YJ (2014) Advances in pharmacological research of Eugenol. Curr Opin Complement Alternat Med 1:e00003
80. Lee SY, Nakagawa T, Reddi AH (2010) Mesenchymal progenitor cells derived from synovium and infrapatellar fat pad as a source for superficial zone cartilage tissue engineering: analysis of superficial zone protein/lubricin expression. Tissue Eng Part A 16:317–325
81. Liu YM, Li ZY, Li XM, Pan RL (2014) Review on the Toxic Effects of Radix Bupleuri. Curr Opin Complement Alternat Med 1:e00002
82. Dowthwaite GP, Bishop JC, Redman SN, Khan IM, Rooney P, Evans DJ, Haughton L, Bayram Z, Boyer S, Thomson B, Wolfe MS, Archer CW (2004) The surface of articular cartilage contains a progenitor cell population. J Cell Sci 117:889–897
83. Yasuhara R, Ohta Y, Yuasa T, Kondo N, Hoang T, Addya S, Fortina P, Pacifici M, Iwamoto M, Enomoto-Iwamoto M (2011) Roles of beta-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells. Lab Invest 91:1739–1752
84. Gerada J, DeGaetano J, Sebire NJ, Hill S, Vassallo M, Attard TM (2013) Mucosal inflammation as a component of tufting enteropathy. Immunogastroenterology 2:62–67
85. Lv XY, Luo WZ, Wang YQ, Chen X, Tu ZL (2010) Bilateral thoracotomy for removal of uncommon postmediastinal multi-schwannomas. Thorac Cancer 3:130–132
86. Pretzel D, Linss S, Rochler S, Endres M, Kaps C, Alsalameh S, Kinne RW (2011) Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage. Arthritis Res Ther 13:R64
87. Fickert S, Fiedler J, Brenner RE (2004) Identification of subpopulations with characteristics of mesenchymal progenitor cells from human osteoarthritic cartilage using triple staining for cell surface markers. Arthritis Res Ther 6:R422–R432
88. Koelling S, Kruegel J, Irmer M, Path JR, Sadowski B, Miro X, Miosge N (2009) Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis. Cell Stem Cell 4:324–335
89. Murphy JM, Dixon K, Beck S, Fabian D, Feldman A, Barry F (2002) Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis. Arthritis Rheum 46:704–713
90. Ando W, Heard BJ, Chung M, Nakamura N, Frank CB, Hart DA (2012) Ovine synovial membrane-derived mesenchymal progenitor cells retain the phenotype of the original tissue that was exposed to in vivo inflammation: evidence for a suppressed chondrogenic differentiation potential of the cells. Inflamm Res 61:599–608
91. Osma U, Eyigor H, Yilmaz MD (2011) A fatal case of necrotizing fasciitis of the neck. J Ear Nose Throat (Kulak Burun Bogaz Ihtis Derg) 21:341–344
92. Hernández JR, Barlés GN, Eudaldo M, Fernández LT, Benítez VV, Jorge VN (2013) Fistula to the native esophagus after pharyngogastrostomy for malignant disease: a rare phenomenon in esophageal surgery. Thorac Cancer 4:71–74
93. Casillas-Ramírez A, Elias-Miró M, Jiménez-Castro MB, Massip-Salcedo M, Rimola A, Rodés J, Peralta C (2012) AICAR and Trimetazidine in University of Wisconsin Solution are Effective to Increase Survival in Recipients Transplanted with Steatotic Livers. Immunogastroenterology 1:58–68
94. Buechli ME, Lamarre J, Koch TG (2013) MicroRNA-140 expression during chondrogenic differentiation of equine cord blood-derived mesenchymal stromal cells. Stem Cells Dev 22:1288–1296
95. Jackson WM, Nesti LJ, Tuan RS (2012) Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells. Stem Cells Transl Med 1:44–50
96. Xu J, Wu W, Zhang L, Dorset-Martin W, Morris MW, Mitchell ME, Liechty KW (2012) The role of microRNA-146a in the pathogenesis of the diabetic wound-healing impairment: correction with mesenchymal stem cell treatment. Diabetes 61:2906–2912
97. Bawany MZ, Rafiq E, Thotakura R, McPhee MD, Nawras A (2012) Successful management of recurrent biliary colic caused by pancreatic stent migration after Whipple procedure. J Interv Gastroenterol 2:97–98
98. Reddy SB, Lee JG, Chang KJ, Muthusamy V (2013) The impact of diphenhydramine and promethazine in patients undergoing advanced upper endoscopic procedures. J Interv Gastroenterol 3:122–127
99. Kim D, Song J, Kim S, Chun CH, Jin EJ (2011) MicroRNA-34a regulates migration of chondroblast and IL-1beta-induced degeneration of chondrocytes by targeting EphA5. Biochem Biophys Res Commun 415:551–557
100. Kim D, Song J, Kim S, Park HM, Chun CH, Sonn J, Jin EJ (2012) MicroRNA-34a modulates cytoskeletal dynamics through regulating RhoA/Rac1 cross-talk in chondroblasts. J Biol Chem 287:12501–12509