Histone deacetylase inhibitors suppress mechanical stress-induced expression of RUNX-2 and ADAMTS-5 through the inhibition of the MAPK signaling pathway in cultured human chondrocytes

Osteoarthritis and Cartilage

Volumn 21, Issue 1, 2013, Pages 165-174

  Saito, T ^a   Nishida, K ^a   Furumatsu, T ^a   Yoshida, A ^a   Ozawa, M ^a   Ozaki, T ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

ADAMTS; Aggrecanase; Chondrocyte; Histone deacetylase inhibitor; Mechanical stress; RUNX 2

Indexed keywords

AGGRECANASE 2; COLLAGENASE 3; ENTINOSTAT; HISTONE DEACETYLASE INHIBITOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; STROMELYSIN; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR RUNX2; TRICHOSTATIN A;

ADULT; ARTICLE; CARTILAGE CELL; DOWN REGULATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LABORATORY DEVICE; MALE; MECHANICAL STRESS; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION TIME; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STRETCH CHAMBER; WESTERN BLOTTING;

ADAM PROTEINS; BLOTTING, WESTERN; CHONDROCYTES; CORE BINDING FACTOR ALPHA 1 SUBUNIT; GENE EXPRESSION; HISTONE DEACETYLASE INHIBITORS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 3; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REAL-TIME POLYMERASE CHAIN REACTION; STRESS, MECHANICAL;

EID: 84871921066     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2012.09.003     Document Type: Article

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