Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2α

Journal of Orthopaedic Research

Volumn 33, Issue 7, 2015, Pages 1061-1070

  Li, Wuyin ^a   Cai, Litao ^a   Zhang, Yun ^b   Cui, Lei ^c   Shen, Gan ^d  

^a Henan Luoyang Orthopedic Traumatological Hospital   (China)

^b Guanghua Integrative Medicine Hospital   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

catabolic factor; HIF 2 ; osteoarthritis; resveratrol; SIRT1

Indexed keywords

COLLAGEN TYPE 2; COLLAGENASE 3; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; RESVERATROL; SIRTINOL; SIRTUIN 1; TRANSCRIPTION FACTOR RELA; ANTIOXIDANT; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; MMP13 PROTEIN, MOUSE; NOS2 PROTEIN, MOUSE; SIRT1 PROTEIN, MOUSE; STILBENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CHONDROCALCINOSIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; HISTOLOGY; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KNEE OSTEOARTHRITIS; LOW DRUG DOSE; MALE; MOUSE; MOUSE MODEL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; DRUG EFFECTS; DRUG SCREENING; INTRAARTICULAR DRUG ADMINISTRATION; METABOLISM; OSTEOARTHRITIS; PATHOLOGY; PHYTOTHERAPY; RANDOMIZATION;

ANIMALS; ANTIOXIDANTS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARTILAGE, ARTICULAR; COLLAGEN TYPE II; DRUG EVALUATION, PRECLINICAL; INJECTIONS, INTRA-ARTICULAR; MALE; MATRIX METALLOPROTEINASE 13; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE II; OSTEOARTHRITIS; PHYTOTHERAPY; RANDOM ALLOCATION; SIRTUIN 1; STILBENES;

EID: 84930090997     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22859     Document Type: Article

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