4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from Amyotrophic Lateral Sclerosis Patient-Derived Induced Pluripotent Stem Cells

Stem Cells

Volumn 34, Issue 6, 2016, Pages 1563-1575

  Naujock, Maximilian ^a,b   Stanslowsky, Nancy ^a   Bufler, Sebastian ^a   Naumann, Marcel ^c   Reinhardt, Peter ^d   Sterneckert, Jared ^d   Kefalakes, Ekaterini ^a   Kassebaum, Carola ^a   Bursch, Franziska ^a   Lojewski, Xenia ^c   Storch, Alexander ^c,d,e,f   Frickenhaus, Marie ^g   Boeckers, Tobias M ^h   Putz, Stefan ^h   Demestre, Maria ^h   Liebau, Stefan ⁱ   Klingenstein, Moritz ⁱ   Ludolph, Albert C ^h   Dengler, Reinhard ^a   Kim, Kwang Soo ^b   Hermann, Andreas ^c,e   Wegner, Florian ^a   Petri, Susanne ^a   more..

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^e GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^f UNIVERSITY OF ROSTOCK   (Germany)

^g MAX PLANCK INSTITUTE FOR MOLECULAR BIOMEDICINE   (Germany)

^h UNIVERSITY OF ULM   (Germany)

ⁱ UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

4 Aminopyridine; Amyotrophic lateral sclerosis; Hypoexcitability; Induced pluripotent stem cells; Motor neurons

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CASPASE; COPPER ZINC SUPEROXIDE DISMUTASE; FAMPRIDINE; FUSED IN SARCOMA PROTEIN; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; NEUROPROTECTIVE AGENT; POTASSIUM CHANNEL; SODIUM CHANNEL; FUS PROTEIN, HUMAN; ION CHANNEL; RNA BINDING PROTEIN FUS; SUPEROXIDE DISMUTASE;

ACTION POTENTIAL; AMYOTROPHIC LATERAL SCLEROSIS; ANTIBODY LABELING; APOPTOSIS; ARTICLE; CELL STRESS; CONTROLLED STUDY; DEPOLARIZATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; MALE; MOTONEURON; NERVE CELL EXCITABILITY; NEUROPROTECTION; PHENOTYPE; POTASSIUM CURRENT; PROTEIN EXPRESSION; SODIUM CURRENT; UNFOLDED PROTEIN RESPONSE; UPREGULATION; CELL DIFFERENTIATION; DRUG EFFECTS; GENETICS; METABOLISM; MIDDLE AGED; MUTATION; PATHOLOGY; SYNAPSE;

4-AMINOPYRIDINE; AMYOTROPHIC LATERAL SCLEROSIS; CASPASES; CELL DIFFERENTIATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FEMALE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; ION CHANNELS; MALE; MIDDLE AGED; MOTOR NEURONS; MUTATION; NEUROPROTECTION; PHENOTYPE; RNA-BINDING PROTEIN FUS; SUPEROXIDE DISMUTASE; SYNAPSES;

EID: 84973109229     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2354     Document Type: Article

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