The thumb domain mediates acid-sensing ion channel desensitization

Journal of Biological Chemistry

Volumn 291, Issue 21, 2016, Pages 11407-11419

  Krauson, Aram J ^a   Carattino, Marcelo D ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CHEMICAL REACTIONS;

ACID-SENSING ION CHANNELS; CONTINUOUS EXPOSURE; COVALENT MODIFICATIONS; EXTRACELLULAR ACIDIFICATIONS; EXTRACELLULAR LOOPS; PHYSIOLOGICAL PROCESS; SYNAPTIC PLASTICITY; TRANS-MEMBRANE DOMAINS;

ENZYME ACTIVITY;

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 1A; ACID SENSING ION CHANNEL 2A; CYSTEINE; THIOL REAGENT; UNCLASSIFIED DRUG; ACCN1 PROTEIN, MOUSE; ACCN2 PROTEIN, MOUSE; HYBRID PROTEIN; PROTEIN SUBUNIT;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; COVALENT BOND; DESENSITIZATION; FEMALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; THUMB DOMAIN; VOLTAGE CLAMP TECHNIQUE; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; ELECTROCHEMICAL ANALYSIS; GENETICS; METABOLISM; MOLECULAR MODEL; OOCYTE; PROTEIN DOMAIN; PROTEIN SUBUNIT; SITE DIRECTED MUTAGENESIS; XENOPUS LAEVIS;

ACID SENSING ION CHANNELS; AMINO ACID SUBSTITUTION; ANIMALS; ELECTROCHEMICAL TECHNIQUES; FEMALE; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN SUBUNITS; RECOMBINANT FUSION PROTEINS; XENOPUS LAEVIS;

EID: 84971659162     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.702316     Document Type: Article

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