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Volumn 29, Issue , 2016, Pages 71-81

The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses

Author keywords

Alternative interferon response pathway; Cytokines interferon; Host pathogen interactions; ISGF3; Signal transduction; STAT2 transcription factor; STAT2 IRF9

Indexed keywords

INTERFERON; INTERFERON REGULATORY FACTOR 9; INTERFERON STIMULATED GENE FACTOR 3; STAT1 PROTEIN; STAT2 PROTEIN; IRF9 PROTEIN, HUMAN; STAT2 PROTEIN, HUMAN;

EID: 84971232255     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2016.02.010     Document Type: Short Survey
Times cited : (107)

References (88)
  • 1
    • 65549165903 scopus 로고    scopus 로고
    • Interferons and viral infections
    • Fensterl V., Sen G.C. Interferons and viral infections. Biofactors 2009, 35:14-20.
    • (2009) Biofactors , vol.35 , pp. 14-20
    • Fensterl, V.1    Sen, G.C.2
  • 2
    • 34547108380 scopus 로고    scopus 로고
    • JAK-STAT signaling: from interferons to cytokines
    • Schindler C., Levy D.E., Decker T. JAK-STAT signaling: from interferons to cytokines. J. Biol. Chem. 2007, 282:20059-20063.
    • (2007) J. Biol. Chem. , vol.282 , pp. 20059-20063
    • Schindler, C.1    Levy, D.E.2    Decker, T.3
  • 3
    • 84873083416 scopus 로고    scopus 로고
    • A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
    • Prokunina-Olsson L., Muchmore B., Tang W., Pfeiffer R.M., Park H., Dickensheets H., et al. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. Nat. Genet. 2013, 45:164-171.
    • (2013) Nat. Genet. , vol.45 , pp. 164-171
    • Prokunina-Olsson, L.1    Muchmore, B.2    Tang, W.3    Pfeiffer, R.M.4    Park, H.5    Dickensheets, H.6
  • 4
    • 17644372733 scopus 로고    scopus 로고
    • IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    • Liu Y.J. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol. 2005, 23:275-306.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 275-306
    • Liu, Y.J.1
  • 5
    • 51349087106 scopus 로고    scopus 로고
    • Innate immune response to viral infection
    • Koyama S., Ishii K.J., Coban C., Akira S. Innate immune response to viral infection. Cytokine 2008, 43:336-341.
    • (2008) Cytokine , vol.43 , pp. 336-341
    • Koyama, S.1    Ishii, K.J.2    Coban, C.3    Akira, S.4
  • 6
    • 34548694962 scopus 로고    scopus 로고
    • Innate recognition of viruses
    • Pichlmair A., Reis e Sousa C. Innate recognition of viruses. Immunity 2007, 27:370-383.
    • (2007) Immunity , vol.27 , pp. 370-383
    • Pichlmair, A.1    Reis e Sousa, C.2
  • 7
    • 0023788435 scopus 로고
    • Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements
    • Miyamoto M., Fujita T., Kimura Y., Maruyama M., Harada H., Sudo Y., et al. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell 1988, 54:903-913.
    • (1988) Cell , vol.54 , pp. 903-913
    • Miyamoto, M.1    Fujita, T.2    Kimura, Y.3    Maruyama, M.4    Harada, H.5    Sudo, Y.6
  • 8
    • 84875065899 scopus 로고    scopus 로고
    • IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling
    • Lazear H.M., Lancaster A., Wilkins C., Suthar M.S., Huang A., Vick S.C., et al. IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling. PLoS Pathog. 2013, 9:e1003118.
    • (2013) PLoS Pathog. , vol.9
    • Lazear, H.M.1    Lancaster, A.2    Wilkins, C.3    Suthar, M.S.4    Huang, A.5    Vick, S.C.6
  • 9
    • 79953089398 scopus 로고    scopus 로고
    • IRF8 and IRF3 cooperatively regulate rapid interferon-beta induction in human blood monocytes
    • Li P., Wong J.J., Sum C., Sin W.X., Ng K.Q., Koh M.B., et al. IRF8 and IRF3 cooperatively regulate rapid interferon-beta induction in human blood monocytes. Blood 2011, 117:2847-2854.
    • (2011) Blood , vol.117 , pp. 2847-2854
    • Li, P.1    Wong, J.J.2    Sum, C.3    Sin, W.X.4    Ng, K.Q.5    Koh, M.B.6
  • 10
    • 33748475531 scopus 로고    scopus 로고
    • Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors
    • Honda K., Takaoka A., Taniguchi T. Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity 2006, 25:349-360.
    • (2006) Immunity , vol.25 , pp. 349-360
    • Honda, K.1    Takaoka, A.2    Taniguchi, T.3
  • 11
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell J.E., Kerr I.M., Stark G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994, 264:1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell, J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 12
    • 0037138370 scopus 로고    scopus 로고
    • Signaling through the JAK/STAT pathway, recent advances and future challenges
    • Kisseleva T., Bhattacharya S., Braunstein J., Schindler C.W. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 2002, 285:1-24.
    • (2002) Gene , vol.285 , pp. 1-24
    • Kisseleva, T.1    Bhattacharya, S.2    Braunstein, J.3    Schindler, C.W.4
  • 13
    • 0029052176 scopus 로고
    • Ligand-induced association of the type I interferon receptor components
    • Cohen B., Novick D., Barak S., Rubinstein M. Ligand-induced association of the type I interferon receptor components. Mol. Cell. Biol. 1995, 15:4208-4214.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4208-4214
    • Cohen, B.1    Novick, D.2    Barak, S.3    Rubinstein, M.4
  • 14
    • 84867411811 scopus 로고    scopus 로고
    • Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation
    • Piehler J., Thomas C., Garcia K.C., Schreiber G. Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation. Immunol. Rev. 2012, 250:317-334.
    • (2012) Immunol. Rev. , vol.250 , pp. 317-334
    • Piehler, J.1    Thomas, C.2    Garcia, K.C.3    Schreiber, G.4
  • 15
    • 4344656346 scopus 로고    scopus 로고
    • Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals
    • Luker K.E., Smith M.C., Luker G.D., Gammon S.T., Piwnica-Worms H., Piwnica-Worms D. Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:12288-12293.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 12288-12293
    • Luker, K.E.1    Smith, M.C.2    Luker, G.D.3    Gammon, S.T.4    Piwnica-Worms, H.5    Piwnica-Worms, D.6
  • 17
    • 0028349904 scopus 로고
    • Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
    • Shuai K., Horvath C.M., Huang L.H., Qureshi S.A., Cowburn D., Darnell J.E. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 1994, 76:821-828.
    • (1994) Cell , vol.76 , pp. 821-828
    • Shuai, K.1    Horvath, C.M.2    Huang, L.H.3    Qureshi, S.A.4    Cowburn, D.5    Darnell, J.E.6
  • 18
    • 0036731485 scopus 로고    scopus 로고
    • Stats: transcriptional control and biological impact
    • Levy D.E., Darnell J.E. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 2002, 3:651-662.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell, J.E.2
  • 19
    • 0027933635 scopus 로고
    • Identification and characterization of an interferon (IFN)-stimulated response element-IFN-stimulated gene factor 3-independent signaling pathway for IFN-alpha
    • Haque S.J., Williams B.R. Identification and characterization of an interferon (IFN)-stimulated response element-IFN-stimulated gene factor 3-independent signaling pathway for IFN-alpha. J. Biol. Chem. 1994, 269:19523-19529.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19523-19529
    • Haque, S.J.1    Williams, B.R.2
  • 20
    • 0028913109 scopus 로고
    • A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain
    • Horvath C.M., Wen Z., Darnell J.E. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 1995, 9:984-994.
    • (1995) Genes Dev. , vol.9 , pp. 984-994
    • Horvath, C.M.1    Wen, Z.2    Darnell, J.E.3
  • 21
    • 0029739627 scopus 로고    scopus 로고
    • Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
    • Xu X., Sun Y.L., Hoey T. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science 1996, 273:794-797.
    • (1996) Science , vol.273 , pp. 794-797
    • Xu, X.1    Sun, Y.L.2    Hoey, T.3
  • 22
    • 16844375566 scopus 로고    scopus 로고
    • Functional relevance of the conserved DNA-binding domain of STAT2
    • Brierley M.M., Fish E.N. Functional relevance of the conserved DNA-binding domain of STAT2. J. Biol. Chem. 2005, 280:13029-13036.
    • (2005) J. Biol. Chem. , vol.280 , pp. 13029-13036
    • Brierley, M.M.1    Fish, E.N.2
  • 23
    • 0034919802 scopus 로고    scopus 로고
    • The interferon-inducible Stat2:Stat1 heterodimer preferentially binds in vitro to a consensus element found in the promoters of a subset of interferon-stimulated genes
    • Ghislain J.J., Wong T., Nguyen M., Fish E.N. The interferon-inducible Stat2:Stat1 heterodimer preferentially binds in vitro to a consensus element found in the promoters of a subset of interferon-stimulated genes. J. Interferon Cytokine Res. 2001, 21:379-388.
    • (2001) J. Interferon Cytokine Res. , vol.21 , pp. 379-388
    • Ghislain, J.J.1    Wong, T.2    Nguyen, M.3    Fish, E.N.4
  • 24
    • 0033213949 scopus 로고    scopus 로고
    • IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells
    • Gupta S., Jiang M., Pernis A.B. IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells. J. Immunol. 1999, 163:3834-3841.
    • (1999) J. Immunol. , vol.163 , pp. 3834-3841
    • Gupta, S.1    Jiang, M.2    Pernis, A.B.3
  • 25
    • 0029923456 scopus 로고    scopus 로고
    • Stark GR. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha
    • Li X., Leung S., Qureshi S., Darnell J.E. Stark GR. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J. Biol. Chem. 1996, 271:5790-5794.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5790-5794
    • Li, X.1    Leung, S.2    Qureshi, S.3    Darnell, J.E.4
  • 26
    • 84934976197 scopus 로고    scopus 로고
    • STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1
    • Blaszczyk K., Olejnik A., Nowicka H., Ozgyin L., Chen Y.L., Chmielewski S., et al. STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1. Biochem. J. 2015, 466:511-524.
    • (2015) Biochem. J. , vol.466 , pp. 511-524
    • Blaszczyk, K.1    Olejnik, A.2    Nowicka, H.3    Ozgyin, L.4    Chen, Y.L.5    Chmielewski, S.6
  • 27
    • 84932177973 scopus 로고    scopus 로고
    • Different STAT transcription complexes drive early and delayed responses to type I IFNs
    • Abdul-Sater A.A., Majoros A., Plumlee C.R., Perry S., Gu A.D., Lee C., et al. Different STAT transcription complexes drive early and delayed responses to type I IFNs. J. Immunol. 2015, 195:210-216.
    • (2015) J. Immunol. , vol.195 , pp. 210-216
    • Abdul-Sater, A.A.1    Majoros, A.2    Plumlee, C.R.3    Perry, S.4    Gu, A.D.5    Lee, C.6
  • 28
    • 0033520422 scopus 로고    scopus 로고
    • Stat protein transactivation domains recruit p300/CBP through widely divergent sequences
    • Paulson M., Pisharody S., Pan L., Guadagno S., Mui A.L., Levy D.E. Stat protein transactivation domains recruit p300/CBP through widely divergent sequences. J. Biol. Chem. 1999, 274:25343-25349.
    • (1999) J. Biol. Chem. , vol.274 , pp. 25343-25349
    • Paulson, M.1    Pisharody, S.2    Pan, L.3    Guadagno, S.4    Mui, A.L.5    Levy, D.E.6
  • 29
    • 0033230707 scopus 로고    scopus 로고
    • Murine Stat2 is uncharacteristically divergent
    • Park C., Lecomte M.J., Schindler C. Murine Stat2 is uncharacteristically divergent. Nucleic Acids Res. 1999, 27:4191-4199.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 4191-4199
    • Park, C.1    Lecomte, M.J.2    Schindler, C.3
  • 30
    • 0034231339 scopus 로고    scopus 로고
    • Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2
    • Farrar J.D., Smith J.D., Murphy T.L., Leung S., Stark G.R., Murphy K.M. Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2. Nat. Immunol. 2000, 1:65-69.
    • (2000) Nat. Immunol. , vol.1 , pp. 65-69
    • Farrar, J.D.1    Smith, J.D.2    Murphy, T.L.3    Leung, S.4    Stark, G.R.5    Murphy, K.M.6
  • 31
    • 63449095005 scopus 로고    scopus 로고
    • STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response
    • Chen L.S., Wei P.C., Liu T., Kao C.H., Pai L.M., Lee C.K. STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response. J. Biomed. Sci. 2009, 16:22.
    • (2009) J. Biomed. Sci. , vol.16 , pp. 22
    • Chen, L.S.1    Wei, P.C.2    Liu, T.3    Kao, C.H.4    Pai, L.M.5    Lee, C.K.6
  • 32
    • 0029987787 scopus 로고    scopus 로고
    • Identification of alternative splicing form of Stat2
    • Sugiyama T., Nishio Y., Kishimoto T., Akira S. Identification of alternative splicing form of Stat2. FEBS Lett. 1996, 381:191-194.
    • (1996) FEBS Lett. , vol.381 , pp. 191-194
    • Sugiyama, T.1    Nishio, Y.2    Kishimoto, T.3    Akira, S.4
  • 33
    • 42649114059 scopus 로고    scopus 로고
    • The IRF family transcription factors in immunity and oncogenesis
    • Tamura T., Yanai H., Savitsky D., Taniguchi T. The IRF family transcription factors in immunity and oncogenesis. Annu. Rev. Immunol. 2008, 26:535-584.
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 535-584
    • Tamura, T.1    Yanai, H.2    Savitsky, D.3    Taniguchi, T.4
  • 34
    • 4544341121 scopus 로고    scopus 로고
    • STAT2 nuclear trafficking
    • Banninger G., Reich N.C. STAT2 nuclear trafficking. J. Biol. Chem. 2004, 279:39199-39206.
    • (2004) J. Biol. Chem. , vol.279 , pp. 39199-39206
    • Banninger, G.1    Reich, N.C.2
  • 35
    • 0028176452 scopus 로고
    • A novel interferon-alpha-regulated, DNA-binding protein participates in the regulation of the IFP53/tryptophanyl-tRNA synthetase gene
    • Seegert D., Strehlow I., Klose B., Levy D.E., Schindler C., Decker T. A novel interferon-alpha-regulated, DNA-binding protein participates in the regulation of the IFP53/tryptophanyl-tRNA synthetase gene. J. Biol. Chem. 1994, 269:8590-8595.
    • (1994) J. Biol. Chem. , vol.269 , pp. 8590-8595
    • Seegert, D.1    Strehlow, I.2    Klose, B.3    Levy, D.E.4    Schindler, C.5    Decker, T.6
  • 36
    • 0035844291 scopus 로고    scopus 로고
    • Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs
    • Melen K., Kinnunen L., Julkunen I. Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs. J. Biol. Chem. 2001, 276:16447-16455.
    • (2001) J. Biol. Chem. , vol.276 , pp. 16447-16455
    • Melen, K.1    Kinnunen, L.2    Julkunen, I.3
  • 37
    • 19044367766 scopus 로고    scopus 로고
    • Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5
    • Fagerlund R., Melen K., Kinnunen L., Julkunen I. Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5. J. Biol. Chem. 2002, 277:30072-30078.
    • (2002) J. Biol. Chem. , vol.277 , pp. 30072-30078
    • Fagerlund, R.1    Melen, K.2    Kinnunen, L.3    Julkunen, I.4
  • 38
    • 33845718240 scopus 로고    scopus 로고
    • Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain
    • Mertens C., Zhong M., Krishnaraj R., Zou W., Chen X., Darnell J.E. Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain. Genes Dev. 2006, 20:3372-3381.
    • (2006) Genes Dev. , vol.20 , pp. 3372-3381
    • Mertens, C.1    Zhong, M.2    Krishnaraj, R.3    Zou, W.4    Chen, X.5    Darnell, J.E.6
  • 39
    • 0030795422 scopus 로고    scopus 로고
    • Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3
    • Martinez-Moczygemba M., Gutch M.J., French D.L., Reich N.C. Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3. J. Biol. Chem. 1997, 272:20070-20076.
    • (1997) J. Biol. Chem. , vol.272 , pp. 20070-20076
    • Martinez-Moczygemba, M.1    Gutch, M.J.2    French, D.L.3    Reich, N.C.4
  • 40
    • 0030945179 scopus 로고    scopus 로고
    • Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling
    • Li X., Leung S., Kerr I.M., Stark G.R. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol. Cell. Biol. 1997, 17:2048-2056.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2048-2056
    • Li, X.1    Leung, S.2    Kerr, I.M.3    Stark, G.R.4
  • 41
    • 0029655971 scopus 로고    scopus 로고
    • Function of Stat2 protein in transcriptional activation by alpha interferon
    • Qureshi S.A., Leung S., Kerr I.M., Stark G.R., Darnell J.E. Function of Stat2 protein in transcriptional activation by alpha interferon. Mol. Cell. Biol. 1996, 16:288-293.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 288-293
    • Qureshi, S.A.1    Leung, S.2    Kerr, I.M.3    Stark, G.R.4    Darnell, J.E.5
  • 42
    • 0027434082 scopus 로고
    • Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways
    • Muller M., Laxton C., Briscoe J., Schindler C., Improta T., Darnell J.E., et al. Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways. EMBO J. 1993, 12:4221-4228.
    • (1993) EMBO J. , vol.12 , pp. 4221-4228
    • Muller, M.1    Laxton, C.2    Briscoe, J.3    Schindler, C.4    Improta, T.5    Darnell, J.E.6
  • 43
    • 0024721567 scopus 로고
    • Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro
    • Levy D.E., Kessler D.S., Pine R., Darnell J.E. Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro. Genes Dev. 1989, 3:1362-1371.
    • (1989) Genes Dev. , vol.3 , pp. 1362-1371
    • Levy, D.E.1    Kessler, D.S.2    Pine, R.3    Darnell, J.E.4
  • 44
    • 0025084603 scopus 로고
    • Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator
    • Kessler D.S., Veals S.A., Fu X.Y., Levy D.E. Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator. Genes Dev. 1990, 4:1753-1765.
    • (1990) Genes Dev. , vol.4 , pp. 1753-1765
    • Kessler, D.S.1    Veals, S.A.2    Fu, X.Y.3    Levy, D.E.4
  • 45
    • 0026778338 scopus 로고
    • Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins
    • Veals S.A., Schindler C., Leonard D., Fu X.Y., Aebersold R., Darnell J.E., et al. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Mol. Cell. Biol. 1992, 12:3315-3324.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 3315-3324
    • Veals, S.A.1    Schindler, C.2    Leonard, D.3    Fu, X.Y.4    Aebersold, R.5    Darnell, J.E.6
  • 46
    • 0034691151 scopus 로고    scopus 로고
    • Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors
    • Lau J.F., Parisien J.P., Horvath C.M. Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:7278-7283.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 7278-7283
    • Lau, J.F.1    Parisien, J.P.2    Horvath, C.M.3
  • 47
    • 79957999601 scopus 로고    scopus 로고
    • Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2
    • Testoni B., Vollenkle C., Guerrieri F., Gerbal-Chaloin S., Blandino G., Levrero M. Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2. J. Biol. Chem. 2011, 286:20217-20227.
    • (2011) J. Biol. Chem. , vol.286 , pp. 20217-20227
    • Testoni, B.1    Vollenkle, C.2    Guerrieri, F.3    Gerbal-Chaloin, S.4    Blandino, G.5    Levrero, M.6
  • 48
    • 67249144899 scopus 로고    scopus 로고
    • Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes
    • Cheon H., Stark G.R. Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:9373-9378.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 9373-9378
    • Cheon, H.1    Stark, G.R.2
  • 49
    • 65949099540 scopus 로고    scopus 로고
    • IRF-9/STAT2 [corrected] functional interaction drives retinoic acid-induced gene G expression independently of STAT1
    • Lou Y.J., Pan X.R., Jia P.M., Li D., Xiao S., Zhang Z.L., et al. IRF-9/STAT2 [corrected] functional interaction drives retinoic acid-induced gene G expression independently of STAT1. Cancer Res. 2009, 69:3673-3680.
    • (2009) Cancer Res. , vol.69 , pp. 3673-3680
    • Lou, Y.J.1    Pan, X.R.2    Jia, P.M.3    Li, D.4    Xiao, S.5    Zhang, Z.L.6
  • 51
    • 0030032755 scopus 로고    scopus 로고
    • Preassociation of STAT1 with STAT2 and STAT3 in separate signalling complexes prior to cytokine stimulation
    • Stancato L.F., David M., Carter-Su C., Larner A.C., Pratt W.B. Preassociation of STAT1 with STAT2 and STAT3 in separate signalling complexes prior to cytokine stimulation. J. Biol. Chem. 1996, 271:4134-4137.
    • (1996) J. Biol. Chem. , vol.271 , pp. 4134-4137
    • Stancato, L.F.1    David, M.2    Carter-Su, C.3    Larner, A.C.4    Pratt, W.B.5
  • 52
    • 0041344551 scopus 로고    scopus 로고
    • Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein
    • Melen K., Fagerlund R., Franke J., Kohler M., Kinnunen L., Julkunen I. Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein. J. Biol. Chem. 2003, 278:28193-28200.
    • (2003) J. Biol. Chem. , vol.278 , pp. 28193-28200
    • Melen, K.1    Fagerlund, R.2    Franke, J.3    Kohler, M.4    Kinnunen, L.5    Julkunen, I.6
  • 53
    • 84885869823 scopus 로고    scopus 로고
    • IFNbeta-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage
    • Cheon H., Holvey-Bates E.G., Schoggins J.W., Forster S., Hertzog P., Imanaka N., et al. IFNbeta-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage. EMBO J. 2013, 32:2751-2763.
    • (2013) EMBO J. , vol.32 , pp. 2751-2763
    • Cheon, H.1    Holvey-Bates, E.G.2    Schoggins, J.W.3    Forster, S.4    Hertzog, P.5    Imanaka, N.6
  • 54
    • 84918515178 scopus 로고    scopus 로고
    • Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs
    • Kolosenko I., Fryknas M., Forsberg S., Johnsson P., Cheon H., Holvey-Bates E.G., et al. Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs. Int. J. Cancer 2015, 136:E51-61.
    • (2015) Int. J. Cancer , vol.136 , pp. E51-61
    • Kolosenko, I.1    Fryknas, M.2    Forsberg, S.3    Johnsson, P.4    Cheon, H.5    Holvey-Bates, E.G.6
  • 55
    • 0028242693 scopus 로고
    • Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein
    • Improta T., Schindler C., Horvath C.M., Kerr I.M., Stark G.R., Darnell J.E. Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:4776-4780.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 4776-4780
    • Improta, T.1    Schindler, C.2    Horvath, C.M.3    Kerr, I.M.4    Stark, G.R.5    Darnell, J.E.6
  • 56
    • 0028798823 scopus 로고
    • Stark GR. Role of STAT2 in the alpha interferon signaling pathway
    • Leung S., Qureshi S.A., Kerr I.M., Darnell J.E. Stark GR. Role of STAT2 in the alpha interferon signaling pathway. Mol. Cell. Biol. 1995, 15:1312-1317.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1312-1317
    • Leung, S.1    Qureshi, S.A.2    Kerr, I.M.3    Darnell, J.E.4
  • 57
    • 0031048046 scopus 로고    scopus 로고
    • Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA
    • Bluyssen H.A., Levy D.E. Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA. J. Biol. Chem. 1997, 272:4600-4605.
    • (1997) J. Biol. Chem. , vol.272 , pp. 4600-4605
    • Bluyssen, H.A.1    Levy, D.E.2
  • 58
    • 0038644820 scopus 로고    scopus 로고
    • A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response
    • Kraus T.A., Lau J.F., Parisien J.P., Horvath C.M. A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response. J. Biol. Chem. 2003, 278:13033-13038.
    • (2003) J. Biol. Chem. , vol.278 , pp. 13033-13038
    • Kraus, T.A.1    Lau, J.F.2    Parisien, J.P.3    Horvath, C.M.4
  • 59
    • 77957741169 scopus 로고    scopus 로고
    • Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak-Stat signaling and inhibits HCV RNA replication
    • Poat B., Hazari S., Chandra P.K., Gunduz F., Alvarez X., Balart L.A., et al. Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak-Stat signaling and inhibits HCV RNA replication. Virol. J. 2010, 7:265.
    • (2010) Virol. J. , vol.7 , pp. 265
    • Poat, B.1    Hazari, S.2    Chandra, P.K.3    Gunduz, F.4    Alvarez, X.5    Balart, L.A.6
  • 60
    • 84903904112 scopus 로고    scopus 로고
    • STAT2 and IRF9: beyond ISGF3
    • Fink K., Grandvaux N. STAT2 and IRF9: beyond ISGF3. JAKSTAT 2013, 2:e27521.
    • (2013) JAKSTAT , vol.2
    • Fink, K.1    Grandvaux, N.2
  • 61
    • 84857818989 scopus 로고    scopus 로고
    • The role of signal transducer and activator of transcription-2 in the interferon response
    • Steen H.C., Gamero A.M. The role of signal transducer and activator of transcription-2 in the interferon response. J. Interferon Cytokine Res. 2012, 32:103-110.
    • (2012) J. Interferon Cytokine Res. , vol.32 , pp. 103-110
    • Steen, H.C.1    Gamero, A.M.2
  • 62
    • 84929283755 scopus 로고    scopus 로고
    • STAT2 phosphorylation and signaling
    • Steen H.C., Gamero A.M. STAT2 phosphorylation and signaling. JAKSTAT 2013, 2:e25790.
    • (2013) JAKSTAT , vol.2
    • Steen, H.C.1    Gamero, A.M.2
  • 63
    • 0030183109 scopus 로고    scopus 로고
    • ISGF3 gamma p48, a specificity switch for interferon activated transcription factors
    • Bluyssen A.R., Durbin J.E., Levy D.E. ISGF3 gamma p48, a specificity switch for interferon activated transcription factors. Cytokine Growth Factor Rev. 1996, 7:11-17.
    • (1996) Cytokine Growth Factor Rev. , vol.7 , pp. 11-17
    • Bluyssen, A.R.1    Durbin, J.E.2    Levy, D.E.3
  • 64
    • 33947583705 scopus 로고    scopus 로고
    • STAT activation and differential complex formation dictate selectivity of interferon responses
    • Wesoly J., Szweykowska-Kulinska Z., Bluyssen H.A. STAT activation and differential complex formation dictate selectivity of interferon responses. Acta Biochim. Pol. 2007, 54:27-38.
    • (2007) Acta Biochim. Pol. , vol.54 , pp. 27-38
    • Wesoly, J.1    Szweykowska-Kulinska, Z.2    Bluyssen, H.A.3
  • 65
    • 33749122058 scopus 로고    scopus 로고
    • STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-alpha
    • Sarkis P.T., Ying S., Xu R., Yu X.F. STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-alpha. J. Immunol. 2006, 177:4530-4540.
    • (2006) J. Immunol. , vol.177 , pp. 4530-4540
    • Sarkis, P.T.1    Ying, S.2    Xu, R.3    Yu, X.F.4
  • 66
    • 53249115175 scopus 로고    scopus 로고
    • Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5'-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon
    • George C.X., Das S., Samuel C.E. Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5'-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon. Virology 2008, 380:338-343.
    • (2008) Virology , vol.380 , pp. 338-343
    • George, C.X.1    Das, S.2    Samuel, C.E.3
  • 67
    • 84877101652 scopus 로고    scopus 로고
    • IFNbeta/TNFalpha synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH oxidase-mediated airway antiviral response
    • Fink K., Martin L., Mukawera E., Chartier S., De Deken X., Brochiero E., et al. IFNbeta/TNFalpha synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH oxidase-mediated airway antiviral response. Cell Res. 2013, 23:673-690.
    • (2013) Cell Res. , vol.23 , pp. 673-690
    • Fink, K.1    Martin, L.2    Mukawera, E.3    Chartier, S.4    De Deken, X.5    Brochiero, E.6
  • 68
    • 13844296660 scopus 로고    scopus 로고
    • Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling
    • Hahm B., Trifilo M.J., Zuniga E.I., Oldstone M.B. Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling. Immunity 2005, 22:247-257.
    • (2005) Immunity , vol.22 , pp. 247-257
    • Hahm, B.1    Trifilo, M.J.2    Zuniga, E.I.3    Oldstone, M.B.4
  • 69
    • 19944366634 scopus 로고    scopus 로고
    • Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection
    • Ousman S.S., Wang J., Campbell I.L. Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection. J. Virol. 2005, 79:7514-7527.
    • (2005) J. Virol. , vol.79 , pp. 7514-7527
    • Ousman, S.S.1    Wang, J.2    Campbell, I.L.3
  • 70
    • 34548167742 scopus 로고    scopus 로고
    • Radmacher MD, Ruppert A, Carson WE.;1;, 3rd. STAT1-dependent and STAT1-independent gene expression in murine immune cells following stimulation with interferon-alpha
    • Zimmerer J.M., Lesinski G.B. Radmacher MD, Ruppert A, Carson WE.;1;, 3rd. STAT1-dependent and STAT1-independent gene expression in murine immune cells following stimulation with interferon-alpha. Cancer Immunol. Immunother. 2007, 56:1845-1852.
    • (2007) Cancer Immunol. Immunother. , vol.56 , pp. 1845-1852
    • Zimmerer, J.M.1    Lesinski, G.B.2
  • 71
    • 79952237300 scopus 로고    scopus 로고
    • STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor
    • Perry S.T., Buck M.D., Lada S.M., Schindler C., Shresta S. STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor. PLoS Pathog. 2011, 7:e1001297.
    • (2011) PLoS Pathog. , vol.7
    • Perry, S.T.1    Buck, M.D.2    Lada, S.M.3    Schindler, C.4    Shresta, S.5
  • 72
    • 84862289065 scopus 로고    scopus 로고
    • Expression of interferon-induced antiviral genes is delayed in a STAT1 knockout mouse model of Crimean-Congo hemorrhagic fever
    • Bowick G.C., Airo A.M., Bente D.A. Expression of interferon-induced antiviral genes is delayed in a STAT1 knockout mouse model of Crimean-Congo hemorrhagic fever. Virol. J. 2012, 9:122.
    • (2012) Virol. J. , vol.9 , pp. 122
    • Bowick, G.C.1    Airo, A.M.2    Bente, D.A.3
  • 73
    • 0032731094 scopus 로고    scopus 로고
    • The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation
    • Didcock L., Young D.F., Goodbourn S., Randall R.E. The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation. J. Virol. 1999, 73:9928-9933.
    • (1999) J. Virol. , vol.73 , pp. 9928-9933
    • Didcock, L.1    Young, D.F.2    Goodbourn, S.3    Randall, R.E.4
  • 74
    • 70349239030 scopus 로고    scopus 로고
    • Paramyxovirus disruption of interferon signal transduction: sTATus report
    • Ramachandran A., Horvath C.M. Paramyxovirus disruption of interferon signal transduction: sTATus report. J. Interferon Cytokine Res. 2009, 29:531-537.
    • (2009) J. Interferon Cytokine Res. , vol.29 , pp. 531-537
    • Ramachandran, A.1    Horvath, C.M.2
  • 75
    • 0027498311 scopus 로고
    • Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity
    • Veals S.A., Santa Maria T., Levy D.E. Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity. Mol. Cell. Biol. 1993, 13:196-206.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 196-206
    • Veals, S.A.1    Santa Maria, T.2    Levy, D.E.3
  • 76
    • 29144475515 scopus 로고    scopus 로고
    • Global changes in STAT target selection and transcription regulation upon interferon treatments
    • Hartman S.E., Bertone P., Nath A.K., Royce T.E., Gerstein M., Weissman S., et al. Global changes in STAT target selection and transcription regulation upon interferon treatments. Genes Dev. 2005, 19:2953-2968.
    • (2005) Genes Dev. , vol.19 , pp. 2953-2968
    • Hartman, S.E.1    Bertone, P.2    Nath, A.K.3    Royce, T.E.4    Gerstein, M.5    Weissman, S.6
  • 78
    • 84864012520 scopus 로고    scopus 로고
    • Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus
    • Hofer M.J., Li W., Manders P., Terry R., Lim S.L., King N.J., et al. Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus. J. Virol. 2012, 86:6932-6946.
    • (2012) J. Virol. , vol.86 , pp. 6932-6946
    • Hofer, M.J.1    Li, W.2    Manders, P.3    Terry, R.4    Lim, S.L.5    King, N.J.6
  • 79
    • 84901989737 scopus 로고    scopus 로고
    • IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus
    • Li W., Hofer M.J., Jung S.R., Lim S.L., Campbell I.L. IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus. J. Virol. 2014, 88:7578-7588.
    • (2014) J. Virol. , vol.88 , pp. 7578-7588
    • Li, W.1    Hofer, M.J.2    Jung, S.R.3    Lim, S.L.4    Campbell, I.L.5
  • 80
    • 29244442569 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity
    • Fenner J.E., Starr R., Cornish A.L., Zhang J.G., Metcalf D., Schreiber R.D., et al. Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat. Immunol. 2006, 7:33-39.
    • (2006) Nat. Immunol. , vol.7 , pp. 33-39
    • Fenner, J.E.1    Starr, R.2    Cornish, A.L.3    Zhang, J.G.4    Metcalf, D.5    Schreiber, R.D.6
  • 84
    • 62549105364 scopus 로고    scopus 로고
    • Mutually exclusive STAT1 modifications identified by Ubc9/substrate dimerization-dependent SUMOylation
    • Zimnik S., Gaestel M., Niedenthal R. Mutually exclusive STAT1 modifications identified by Ubc9/substrate dimerization-dependent SUMOylation. Nucleic Acids Res. 2009, 37:e30.
    • (2009) Nucleic Acids Res. , vol.37
    • Zimnik, S.1    Gaestel, M.2    Niedenthal, R.3
  • 85
    • 84908332680 scopus 로고    scopus 로고
    • Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1
    • Xu W., Edwards M.R., Borek D.M., Feagins A.R., Mittal A., Alinger J.B., et al. Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1. Cell Host Microbe 2014, 16:187-200.
    • (2014) Cell Host Microbe , vol.16 , pp. 187-200
    • Xu, W.1    Edwards, M.R.2    Borek, D.M.3    Feagins, A.R.4    Mittal, A.5    Alinger, J.B.6
  • 86
    • 0036063662 scopus 로고    scopus 로고
    • All four Sendai Virus C proteins bind Stat1, but only the larger forms also induce its mono-ubiquitination and degradation
    • Garcin D., Marq J.B., Strahle L., le Mercier P., Kolakofsky D. All four Sendai Virus C proteins bind Stat1, but only the larger forms also induce its mono-ubiquitination and degradation. Virology 2002, 295:256-265.
    • (2002) Virology , vol.295 , pp. 256-265
    • Garcin, D.1    Marq, J.B.2    Strahle, L.3    le Mercier, P.4    Kolakofsky, D.5
  • 87
    • 0036891861 scopus 로고    scopus 로고
    • C-terminal region of STAT-1alpha is not necessary for its ubiquitination and degradation caused by mumps virus V protein
    • Yokosawa N., Yokota S., Kubota T., Fujii N. C-terminal region of STAT-1alpha is not necessary for its ubiquitination and degradation caused by mumps virus V protein. J. Virol. 2002, 76:12683-12690.
    • (2002) J. Virol. , vol.76 , pp. 12683-12690
    • Yokosawa, N.1    Yokota, S.2    Kubota, T.3    Fujii, N.4
  • 88
    • 84945143822 scopus 로고    scopus 로고
    • STAT2-directed pathogen responses
    • Bluyssen H. STAT2-directed pathogen responses. Oncotarget 2015, 6:28525-28526.
    • (2015) Oncotarget , vol.6 , pp. 28525-28526
    • Bluyssen, H.1


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