Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak-Stat signaling and inhibits HCV RNA replication

Virology Journal

Volumn 7, Issue , 2010, Pages

  Poat, Bret ^a   Hazari, Sidhartha ^a   Chandra, Partha K ^a   Gunduz, Feyza ^a   Alvarez, Xavier ^b   Balart, Luis A ^a   Garry, Robert F ^a   Dash, Srikanta ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CELL PROTEIN; CELL SURFACE RECEPTOR; CHIMERIC PROTEIN; GENOMIC RNA; GREEN FLUORESCENT PROTEIN; HLA ANTIGEN CLASS 1; HYBRID PROTEIN; INITIATION FACTOR 2ALPHA; INTERFERON REGULATORY FACTOR 9; INTERFERON REGULATORY FACTOR 9 STAT1 FUSION PROTEIN; INTERFERON REGULATORY FACTOR 9 STAT2 FUSION PROTEIN; INTERFERON STIMULATED GENE FACTOR 3; JANUS KINASE; LUCIFERASE; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 5B; PLASMID DNA; RECOMBINANT PROTEIN; STAT1 PROTEIN; STAT2 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA; IRF9 PROTEIN, HUMAN; STAT1 PROTEIN, HUMAN; STAT2 PROTEIN, HUMAN;

ANTIVIRAL ACTIVITY; ARTICLE; CELL NUCLEUS; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; FLOW CYTOMETRY; GENE CONSTRUCT; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; NONHUMAN; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REPLICON; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA REPLICATION; SIGNAL TRANSDUCTION; TRANSIENT TRANSFECTION; VIRUS INHIBITION; VIRUS RESISTANCE; WESTERN BLOTTING; CELL LINE; GENETICS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; REPORTER GENE; VIRUS REPLICATION;

HEPATITIS C VIRUS;

CELL LINE; GENES, REPORTER; HEPACIVIRUS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INTERFERON-ALPHA; INTERFERON-STIMULATED GENE FACTOR 3, GAMMA SUBUNIT; LUCIFERASES; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; VIRUS REPLICATION;

EID: 77957741169     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-7-265     Document Type: Article

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