메뉴 건너뛰기




Volumn 4, Issue , 2015, Pages 1-13

Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12;

EID: 84970993205     PISSN: 20461402     EISSN: 1759796X     Source Type: Journal    
DOI: 10.12688/f1000research.7010.1     Document Type: Review
Times cited : (198)

References (151)
  • 1
    • 0024467154 scopus 로고
    • Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
    • 2504877, 2189443
    • Kobayashi M Fitz L Ryan M: Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med. 1989;170(3):827-45. 2504877 2189443
    • (1989) J Exp Med , vol.170 , Issue.3 , pp. 827-845
    • Kobayashi, M.1    Fitz, L.2    Ryan, M.3
  • 2
    • 0028043326 scopus 로고
    • Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
    • 7994020
    • Trinchieri G: Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood. 1994;84(12):4008-27. 7994020
    • (1994) Blood , vol.84 , Issue.12 , pp. 4008-4027
    • Trinchieri, G.1
  • 3
    • 0035399832 scopus 로고    scopus 로고
    • Positive regulatory role of IL-12 in macrophages and modulation by IFN-gamma
    • 11418652
    • Grohmann U Belladonna ML Vacca C: Positive regulatory role of IL-12 in macrophages and modulation by IFN-gamma. J Immunol. 2001;167(1):221-7. 11418652 10.4049/jimmunol.167.1.221
    • (2001) J Immunol , vol.167 , Issue.1 , pp. 221-227
    • Grohmann, U.1    Belladonna, M.L.2    Vacca, C.3
  • 4
    • 0030064148 scopus 로고    scopus 로고
    • The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells
    • 8551218, 2192398
    • Ma X Chow JM Gri G: The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J Exp Med. 1996;183(1):147-57. 8551218 10.1084/jem.183.1.147 2192398
    • (1996) J Exp Med , vol.183 , Issue.1 , pp. 147-157
    • Ma, X.1    Chow, J.M.2    Gri, G.3
  • 5
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • 11114383
    • Oppmann B Lesley R Blom B: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000;13(5):715-25. 11114383 10.1016/S1074-7613(00)00070-4
    • (2000) Immunity , vol.13 , Issue.5 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3
  • 6
    • 84936891385 scopus 로고    scopus 로고
    • IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases
    • 26121196
    • Teng MW Bowman EP McElwee JJ: IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med. 2015;21(7):719-29. 26121196 10.1038/nm.3895
    • (2015) Nat Med , vol.21 , Issue.7 , pp. 19-29
    • Teng, M.W.1    Bowman, E.P.2    McElwee, J.J.3
  • 7
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • 18033300, F1000 Recommendation
    • Collison LW Workman CJ Kuo TT: The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 2007;450(7169):566-9. 18033300 10.1038/nature06306 F1000 Recommendation
    • (2007) Nature , vol.450 , Issue.7169 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3
  • 8
    • 84937000772 scopus 로고    scopus 로고
    • Interleukin-35: Expanding Its Job Profile
    • 25919641, 4507123
    • Sawant DV Hamilton K Vignali DA: Interleukin-35: Expanding Its Job Profile. J Interferon Cytokine Res. 2015;35(7):499-512. 25919641 10.1089/jir.2015.0015 4507123
    • (2015) J Interferon Cytokine Res , vol.35 , Issue.7 , pp. 499-512
    • Sawant, D.V.1    Hamilton, K.2    Vignali, D.A.3
  • 9
    • 84930407196 scopus 로고    scopus 로고
    • Human tolerogenic dendritic cells produce IL-35 in the absence of other IL-12 family members
    • 25820702, 4617619
    • Dixon KO van der Kooij SW Vignali DA: Human tolerogenic dendritic cells produce IL-35 in the absence of other IL-12 family members. Eur J Immunol. 2015;45(6):1736-47. 25820702 10.1002/eji.201445217 4617619
    • (2015) Eur J Immunol , vol.45 , Issue.6 , pp. 1736-1747
    • Dixon, K.O.1    van der Kooij, S.W.2    Vignali, D.A.3
  • 10
    • 0032168336 scopus 로고    scopus 로고
    • IL-12 acts directly on DC to promote nuclear localization of NF-kappaB and primes DC for IL-12 production
    • 9768751
    • Grohmann U Belladonna ML Bianchi R: IL-12 acts directly on DC to promote nuclear localization of NF-kappaB and primes DC for IL-12 production. Immunity. 1998;9(3):315-23. 9768751 10.1016/S1074-7613(00)80614-7
    • (1998) Immunity , vol.9 , Issue.3 , pp. 315-323
    • Grohmann, U.1    Belladonna, M.L.2    Bianchi, R.3
  • 11
    • 0026605457 scopus 로고
    • IL-12 receptor. II. Distribution and regulation of receptor expression
    • 1578139
    • Desai BB Quinn PM Wolitzky AG: IL-12 receptor. II. Distribution and regulation of receptor expression. J Immunol. 1992;148(10):3125-32. 1578139
    • (1992) J Immunol , vol.148 , Issue.10 , pp. 3125-3132
    • Desai, B.B.1    Quinn, P.M.2    Wolitzky, A.G.3
  • 12
    • 9644257195 scopus 로고    scopus 로고
    • Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4
    • 15546391
    • Watford WT Hissong BD Bream JH: Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev. 2004;202(1):139-56. 15546391 10.1111/j.0105-2896.2004.00211.x
    • (2004) Immunol Rev , vol.202 , Issue.1 , pp. 139-156
    • Watford, W.T.1    Hissong, B.D.2    Bream, J.H.3
  • 13
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • 12563297
    • Trinchieri G: Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 2003;3(2):133-46. 12563297 10.1038/nri1001
    • (2003) Nat Rev Immunol , vol.3 , Issue.2 , pp. 133-146
    • Trinchieri, G.1
  • 14
    • 84857193362 scopus 로고    scopus 로고
    • The composition and signaling of the IL-35 receptor are unconventional
    • 22306691, 3529151, F1000 Recommendation
    • Collison LW Delgoffe GM Guy CS: The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol. 2012;13(3):290-9. 22306691 10.1038/ni.2227 3529151 F1000 Recommendation
    • (2012) Nat Immunol , vol.13 , Issue.3 , pp. 290-299
    • Collison, L.W.1    Delgoffe, G.M.2    Guy, C.S.3
  • 15
    • 0025875022 scopus 로고
    • Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
    • 1673147
    • Wolf SF Temple PA Kobayashi M: Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol. 1991;146(9):3074-81. 1673147
    • (1991) J Immunol , vol.146 , Issue.9 , pp. 3074-3081
    • Wolf, S.F.1    Temple, P.A.2    Kobayashi, M.3
  • 16
    • 0026701132 scopus 로고
    • Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
    • 1357073, 2119437
    • D'Andrea A Rengaraju M Valiante NM: Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med. 1992;176(5):1387-98. 1357073 2119437
    • (1992) J Exp Med , vol.176 , Issue.5 , pp. 1387-1398
    • D'Andrea, A.1    Rengaraju, M.2    Valiante, N.M.3
  • 17
    • 0030064036 scopus 로고    scopus 로고
    • Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit
    • 8557999
    • Snijders A Hilkens CM van der Pouw Kraan TC: Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J Immunol. 1996;156(3):1207-12. 8557999
    • (1996) J Immunol , vol.156 , Issue.3 , pp. 1207-1212
    • Snijders, A.1    Hilkens, C.M.2    van der Pouw Kraan, T.C.3
  • 18
    • 0035886848 scopus 로고    scopus 로고
    • + dendritic cells by specifically inducing p35 gene transcription
    • 11602633, 2193517, F1000 Recommendation
    • Grumont R Hochrein H O'Keeffe M: c-Rel regulates interleukin 12 p70 expression in CD8 + dendritic cells by specifically inducing p35 gene transcription. J Exp Med. 2001;194(8):1021-32. 11602633 10.1084/jem.194.8.1021 2193517 F1000 Recommendation
    • (2001) J Exp Med , vol.194 , Issue.8 , pp. 1021-1032
    • Grumont, R.1    Hochrein, H.2    O'Keeffe, M.3
  • 19
    • 34748818985 scopus 로고    scopus 로고
    • The Th2 transcription factor c-Maf inhibits IL-12p35 gene expression in activated macrophages by targeting NF-kappaB nuclear translocation
    • 17892401
    • Homma Y Cao S Shi X: The Th2 transcription factor c-Maf inhibits IL-12p35 gene expression in activated macrophages by targeting NF-kappaB nuclear translocation. J Interferon Cytokine Res. 2007;27(9):799-808. 17892401 10.1089/jir.2007.0006
    • (2007) J Interferon Cytokine Res , vol.27 , Issue.9 , pp. 799-808
    • Homma, Y.1    Cao, S.2    Shi, X.3
  • 20
    • 0142156744 scopus 로고    scopus 로고
    • Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1
    • 14568984, 2194226
    • Liu J Cao S Herman LM: Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. J Exp Med. 2003;198(8):1265-76. 14568984 10.1084/jem.20030026 2194226
    • (2003) J Exp Med , vol.198 , Issue.8 , pp. 1265-1276
    • Liu, J.1    Cao, S.2    Herman, L.M.3
  • 21
    • 0038115124 scopus 로고    scopus 로고
    • Human IL-12(p35) gene activation involves selective remodeling of a single nucleosome within a region of the promoter containing critical Sp1-binding sites
    • 12576336, F1000 Recommendation
    • Goriely S Demonté D Nizet S: Human IL-12(p35) gene activation involves selective remodeling of a single nucleosome within a region of the promoter containing critical Sp1-binding sites. Blood. 2003;101(12):4894-902. 12576336 10.1182/blood-2002-09-2851 F1000 Recommendation
    • (2003) Blood , vol.101 , Issue.12 , pp. 4894-4902
    • Goriely, S.1    Demonté, D.2    Nizet, S.3
  • 22
    • 31544456342 scopus 로고    scopus 로고
    • Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation
    • 16219795, F1000 Recommendation
    • Goriely S Molle C Nguyen M: Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation. Blood. 2006;107(3):1078-84. 16219795 10.1182/blood-2005-06-2416 F1000 Recommendation
    • (2006) Blood , vol.107 , Issue.3 , pp. 1078-1084
    • Goriely, S.1    Molle, C.2    Nguyen, M.3
  • 23
    • 8444251663 scopus 로고    scopus 로고
    • Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells
    • 15539151, F1000 Recommendation
    • Kim S Elkon KB Ma X: Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells. Immunity. 2004;21(5):643-53. 15539151 10.1016/j.immuni.2004.09.009 F1000 Recommendation
    • (2004) Immunity , vol.21 , Issue.5 , pp. 643-653
    • Kim, S.1    Elkon, K.B.2    Ma, X.3
  • 24
    • 37049031230 scopus 로고    scopus 로고
    • Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1
    • 18093541, 2194654
    • Chung EY Liu J Homma Y: Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. Immunity. 2007;27(6):952-64. 18093541 10.1016/j.immuni.2007.11.014 2194654
    • (2007) Immunity , vol.27 , Issue.6 , pp. 952-964
    • Chung, E.Y.1    Liu, J.2    Homma, Y.3
  • 25
    • 0030872393 scopus 로고    scopus 로고
    • Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins
    • 9234715, 232311
    • Plevy SE Gemberling JH Hsu S: Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol Cell Biol. 1997;17(8):4572-88. 9234715 10.1128/MCB.17.8.4572 232311
    • (1997) Mol Cell Biol , vol.17 , Issue.8 , pp. 4572-4588
    • Plevy, S.E.1    Gemberling, J.H.2    Hsu, S.3
  • 26
    • 0029143632 scopus 로고
    • Regulation of interleukin 12 p40 expression through an NF-kappa B half-site
    • 7565674, 230773
    • Murphy TL Cleveland MG Kulesza P: Regulation of interleukin 12 p40 expression through an NF-kappa B half-site. Mol Cell Biol. 1995;15(10):5258-67. 7565674 10.1128/MCB.15.10.5258 230773
    • (1995) Mol Cell Biol , vol.15 , Issue.10 , pp. 5258-5267
    • Murphy, T.L.1    Cleveland, M.G.2    Kulesza, P.3
  • 27
    • 0033748023 scopus 로고    scopus 로고
    • Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages
    • 11058167, 18828
    • Sanjabi S Hoffmann A Liou HC: Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. Proc Natl Acad Sci U S A. 2000;97(23):12705-10. 11058167 10.1073/pnas.230436397 18828
    • (2000) Proc Natl Acad Sci U S A , vol.97 , Issue.23 , pp. 12705-12710
    • Sanjabi, S.1    Hoffmann, A.2    Liou, H.C.3
  • 28
    • 0035451798 scopus 로고    scopus 로고
    • 2
    • 11509602
    • 2. J Immunol. 2001;167(5):2608-18. 11509602 10.4049/jimmunol.167.5.2608
    • (2001) J Immunol , vol.167 , Issue.5 , pp. 2608-2618
    • Becker, C.1    Wirtz, S.2    Ma, X.3
  • 29
    • 0037438455 scopus 로고    scopus 로고
    • Identification of IFN regulatory factor-1 binding site in IL-12 p40 gene promoter
    • 12517966
    • Maruyama S Sumita K Shen H: Identification of IFN regulatory factor-1 binding site in IL-12 p40 gene promoter. J Immunol. 2003;170(2):997-1001. 12517966 10.4049/jimmunol.170.2.997
    • (2003) J Immunol , vol.170 , Issue.2 , pp. 997-1001
    • Maruyama, S.1    Sumita, K.2    Shen, H.3
  • 30
    • 0141960262 scopus 로고    scopus 로고
    • Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP
    • 12876285
    • Zhu C Rao K Xiong H: Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP. J Biol Chem. 2003;278(41):39372-82. 12876285 10.1074/jbc.M306441200
    • (2003) J Biol Chem , vol.278 , Issue.41 , pp. 39372-39382
    • Zhu, C.1    Rao, K.2    Xiong, H.3
  • 31
    • 0034235928 scopus 로고    scopus 로고
    • An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages
    • 10861061
    • Wang IM Contursi C Masumi A: An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages. J Immunol. 2000;165(1):271-9. 10861061 10.4049/jimmunol.165.1.271
    • (2000) J Immunol , vol.165 , Issue.1 , pp. 271-279
    • Wang, I.M.1    Contursi, C.2    Masumi, A.3
  • 32
    • 0035947732 scopus 로고    scopus 로고
    • Characterization of an activation protein-1-binding site in the murine interleukin-12 p40 promoter. Demonstration of novel functional elements by a reductionist approach
    • 11279072
    • Zhu C Gagnidze K Gemberling JH: Characterization of an activation protein-1-binding site in the murine interleukin-12 p40 promoter. Demonstration of novel functional elements by a reductionist approach. J Biol Chem. 2001;276(21):18519-28. 11279072 10.1074/jbc.M100440200
    • (2001) J Biol Chem , vol.276 , Issue.21 , pp. 18519-18528
    • Zhu, C.1    Gagnidze, K.2    Gemberling, J.H.3
  • 33
    • 3442889057 scopus 로고    scopus 로고
    • 2 derived from mammary carcinomas
    • 15123779, 2965202
    • Mitsuhashi M Liu J Cao S: Regulation of interleukin-12 gene expression and its anti-tumor activities by prostaglandin E 2 derived from mammary carcinomas. J Leukoc Biol. 2004;76(2):322-32. 15123779 10.1189/jlb.1203641 2965202
    • (2004) J Leukoc Biol , vol.76 , Issue.2 , pp. 322-332
    • Mitsuhashi, M.1    Liu, J.2    Cao, S.3
  • 34
    • 0038127035 scopus 로고    scopus 로고
    • Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses
    • 12807488, 1782981, F1000 Recommendation
    • Goodridge HS Harnett W Liew FY: Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses. Immunology. 2003;109(3):415-25. 12807488 10.1046/j.1365-2567.2003.01689.x 1782981 F1000 Recommendation
    • (2003) Immunology , vol.109 , Issue.3 , pp. 415-425
    • Goodridge, H.S.1    Harnett, W.2    Liew, F.Y.3
  • 35
    • 84875323016 scopus 로고    scopus 로고
    • Involvement of DNA-PKcs in the IL-6 and IL-12 response to CpG-ODN is mediated by its interaction with TRAF6 in dendritic cells
    • 23533581, 3606245, F1000 Recommendation
    • Ma C Muranyi M Chu CH: Involvement of DNA-PKcs in the IL-6 and IL-12 response to CpG-ODN is mediated by its interaction with TRAF6 in dendritic cells. PLoS One. 2013;8(3):e58072. 23533581 10.1371/journal.pone.0058072 3606245 F1000 Recommendation
    • (2013) PLoS One , vol.8 , Issue.3
    • Ma, C.1    Muranyi, M.2    Chu, C.H.3
  • 36
    • 84877820210 scopus 로고    scopus 로고
    • Hepatitis B virus surface antigen selectively inhibits TLR2 ligand-induced IL-12 production in monocytes/macrophages by interfering with JNK activation
    • 23585678, F1000 Recommendation
    • Wang S Chen Z Hu C: Hepatitis B virus surface antigen selectively inhibits TLR2 ligand-induced IL-12 production in monocytes/macrophages by interfering with JNK activation. J Immunol. 2013;190(10):5142-51. 23585678 10.4049/jimmunol.1201625 F1000 Recommendation
    • (2013) J Immunol , vol.190 , Issue.10 , pp. 5142-5151
    • Wang, S.1    Chen, Z.2    Hu, C.3
  • 37
    • 0037090244 scopus 로고    scopus 로고
    • C/EBP beta gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL-12 p40 and p35 mRNAs in macrophages
    • 11937564, F1000 Recommendation
    • Gorgoni B Maritano D Marthyn P: C/EBP beta gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL-12 p40 and p35 mRNAs in macrophages. J Immunol. 2002;168(8):4055-62. 11937564 10.4049/jimmunol.168.8.4055 F1000 Recommendation
    • (2002) J Immunol , vol.168 , Issue.8 , pp. 4055-4062
    • Gorgoni, B.1    Maritano, D.2    Marthyn, P.3
  • 38
    • 0029040855 scopus 로고
    • Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes
    • 7605994
    • Hayes MP Wang J Norcross MA: Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. Blood. 1995;86(2):646-50. 7605994
    • (1995) Blood , vol.86 , Issue.2 , pp. 646-650
    • Hayes, M.P.1    Wang, J.2    Norcross, M.A.3
  • 39
    • 33750064259 scopus 로고    scopus 로고
    • Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program
    • 17018642, 1586247, F1000 Recommendation
    • Negishi H Fujita Y Yanai H: Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proc Natl Acad Sci U S A. 2006;103(41):15136-41. 17018642 10.1073/pnas.0607181103 1586247 F1000 Recommendation
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.41 , pp. 15136-15141
    • Negishi, H.1    Fujita, Y.2    Yanai, H.3
  • 40
    • 18644364701 scopus 로고    scopus 로고
    • A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells
    • 15851485, 2213193, F1000 Recommendation
    • Gautier G Humbert M Deauvieau F: A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J Exp Med. 2005;201(9):1435-46. 15851485 10.1084/jem.20041964 2213193 F1000 Recommendation
    • (2005) J Exp Med , vol.201 , Issue.9 , pp. 1435-1446
    • Gautier, G.1    Humbert, M.2    Deauvieau, F.3
  • 41
    • 84872368414 scopus 로고    scopus 로고
    • Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5
    • 23154183, F1000 Recommendation
    • Koshiba R Yanai H Matsuda A: Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5. Biochem Biophys Res Commun. 2013;430(1):95-100. 23154183 10.1016/j.bbrc.2012.11.006 F1000 Recommendation
    • (2013) Biochem Biophys Res Commun , vol.430 , Issue.1 , pp. 95-100
    • Koshiba, R.1    Yanai, H.2    Matsuda, A.3
  • 42
    • 84862622032 scopus 로고    scopus 로고
    • Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses
    • 22610141, F1000 Recommendation
    • Negishi H Yanai H Nakajima A: Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses. Nat Immunol. 2012;13(7):659-66. 22610141 10.1038/ni.2307 F1000 Recommendation
    • (2012) Nat Immunol , vol.13 , Issue.7 , pp. 659-666
    • Negishi, H.1    Yanai, H.2    Nakajima, A.3
  • 43
    • 84936976977 scopus 로고    scopus 로고
    • A novel crosstalk between TLR4- and NOD2-mediated signaling in the regulation of intestinal inflammation
    • 26153766, 4495563
    • Kim H Zhao Q Zheng H: A novel crosstalk between TLR4- and NOD2-mediated signaling in the regulation of intestinal inflammation. Sci Rep. 2015;5: 12018. 26153766 10.1038/srep12018 4495563
    • (2015) Sci Rep , vol.5
    • Kim, H.1    Zhao, Q.2    Zheng, H.3
  • 44
    • 84859388578 scopus 로고    scopus 로고
    • Regulation of immune responses by mTOR
    • 22136167, 3616892
    • Powell JD Pollizzi KN Heikamp EB: Regulation of immune responses by mTOR. Annu Rev Immunol. 2012;30:39-68. 22136167 10.1146/annurev-immunol-020711-075024 3616892
    • (2012) Annu Rev Immunol , vol.30 , pp. 39-68
    • Powell, J.D.1    Pollizzi, K.N.2    Heikamp, E.B.3
  • 45
    • 84933522869 scopus 로고    scopus 로고
    • mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines
    • 26122641, F1000 Recommendation
    • He L Zang A Du M: mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines. Virol Sin. 2015;30(3):174-89. 26122641 10.1007/s12250-015-3606-3 F1000 Recommendation
    • (2015) Virol Sin , vol.30 , Issue.3 , pp. 174-189
    • He, L.1    Zang, A.2    Du, M.3
  • 46
    • 84930269016 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells
    • 25877925, F1000 Recommendation
    • Wei WC Liu CP Yang WC: Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells. J Leukoc Biol. 2015;97(6):1071-80. 25877925 10.1189/jlb.2A0414-206RR F1000 Recommendation
    • (2015) J Leukoc Biol , vol.97 , Issue.6 , pp. 1071-1080
    • Wei, W.C.1    Liu, C.P.2    Yang, W.C.3
  • 47
    • 0030891006 scopus 로고    scopus 로고
    • Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter
    • 9099678
    • Ma X Neurath M Gri G: Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter. J Biol Chem. 1997;272(16):10389-95. 9099678 10.1074/jbc.272.16.10389
    • (1997) J Biol Chem , vol.272 , Issue.16 , pp. 10389-10395
    • Ma, X.1    Neurath, M.2    Gri, G.3
  • 48
    • 0025335354 scopus 로고
    • Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI
    • 2161559
    • Moore KW Vieira P Fiorentino DF: Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science. 1990;248(4960):1230-4. 2161559 10.1126/science.2161559
    • (1990) Science , vol.248 , Issue.4960 , pp. 1230-1234
    • Moore, K.W.1    Vieira, P.2    Fiorentino, D.F.3
  • 49
    • 0024408824 scopus 로고
    • Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • 2531194, 2189521
    • Fiorentino DF Bond MW Mosmann TR: Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med. 1989;170(6):2081-95. 2531194 10.1084/jem.170.6.2081 2189521
    • (1989) J Exp Med , vol.170 , Issue.6 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 50
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • 11526392
    • Maloy KJ Powrie F: Regulatory T cells in the control of immune pathology. Nat Immunol. 2001;2(9):816-22. 11526392 10.1038/ni0901-816
    • (2001) Nat Immunol , vol.2 , Issue.9 , pp. 816-822
    • Maloy, K.J.1    Powrie, F.2
  • 51
    • 0035062021 scopus 로고    scopus 로고
    • Interleukin-10 and the interleukin-10 receptor
    • 11244051
    • Moore KW de Waal Malefyt R Coffman RL: Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683-765. 11244051 10.1146/annurev.immunol.19.1.683
    • (2001) Annu Rev Immunol , vol.19 , pp. 683-765
    • Moore, K.W.1    de Waal Malefyt, R.2    Coffman, R.L.3
  • 52
    • 0036795531 scopus 로고    scopus 로고
    • B cells regulate autoimmunity by provision of IL-10
    • 12244307, F1000 Recommendation
    • Fillatreau S Sweenie CH McGeachy MJ: B cells regulate autoimmunity by provision of IL-10. Nat Immunol. 2002;3(10):944-50. 12244307 10.1038/ni833 F1000 Recommendation
    • (2002) Nat Immunol , vol.3 , Issue.10 , pp. 944-950
    • Fillatreau, S.1    Sweenie, C.H.2    McGeachy, M.J.3
  • 53
    • 33746338535 scopus 로고    scopus 로고
    • Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
    • 16903904
    • Roncarolo MG Gregori S Battaglia M: Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev. 2006;212:28-50. 16903904 10.1111/j.0105-2896.2006.00420.x
    • (2006) Immunol Rev , vol.212 , pp. 28-50
    • Roncarolo, M.G.1    Gregori, S.2    Battaglia, M.3
  • 54
    • 34249678457 scopus 로고    scopus 로고
    • H1 cells control themselves by producing interleukin-10
    • 17525751
    • O'Garra A Vieira P: T H1 cells control themselves by producing interleukin-10. Nat Rev Immunol. 2007;7(6):425-8. 17525751 10.1038/nri2097
    • (2007) Nat Rev Immunol , vol.7 , Issue.6 , pp. 425-428
    • O'Garra, A.1    Vieira, P.2
  • 55
    • 33847165817 scopus 로고    scopus 로고
    • Interleukin-10 production by effector T cells: Th1 cells show self control
    • 17296790, 2118719
    • Trinchieri G: Interleukin-10 production by effector T cells: Th1 cells show self control. J Exp Med. 2007;204(2):239-43. 17296790 10.1084/jem.20070104 2118719
    • (2007) J Exp Med , vol.204 , Issue.2 , pp. 239-243
    • Trinchieri, G.1
  • 56
    • 55149111143 scopus 로고    scopus 로고
    • Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation
    • 19161427, 2630587
    • Maynard CL Weaver CT: Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation. Immunol Rev. 2008;226:219-33. 19161427 10.1111/j.1600-065X.2008.00711.x 2630587
    • (2008) Immunol Rev , vol.226 , pp. 219-233
    • Maynard, C.L.1    Weaver, C.T.2
  • 57
    • 78049232715 scopus 로고    scopus 로고
    • Antigen-specific immunotherapy of autoimmune and allergic diseases
    • 20850958, 2977065
    • Sabatos-Peyton CA Verhagen J Wraith DC: Antigen-specific immunotherapy of autoimmune and allergic diseases. Curr Opin Immunol. 2010;22(5):609-15. 20850958 10.1016/j.coi.2010.08.006 2977065
    • (2010) Curr Opin Immunol , vol.22 , Issue.5 , pp. 609-615
    • Sabatos-Peyton, C.A.1    Verhagen, J.2    Wraith, D.C.3
  • 58
    • 84859385739 scopus 로고    scopus 로고
    • Immune regulatory function of B cells
    • 22224776
    • Mauri C Bosma A: Immune regulatory function of B cells. Annu Rev Immunol. 2012;30:221-41. 22224776 10.1146/annurev-immunol-020711-074934
    • (2012) Annu Rev Immunol , vol.30 , pp. 221-241
    • Mauri, C.1    Bosma, A.2
  • 59
    • 4043052238 scopus 로고    scopus 로고
    • Regulatory T cells and mechanisms of immune system control
    • 15286781
    • O'Garra A Vieira P: Regulatory T cells and mechanisms of immune system control. Nat Med. 2004;10(8):801-5. 15286781 10.1038/nm0804-801
    • (2004) Nat Med , vol.10 , Issue.8 , pp. 801-805
    • O'Garra, A.1    Vieira, P.2
  • 60
    • 0027441138 scopus 로고
    • Characterization of interleukin-10 receptors on human and mouse cells
    • 8407942
    • Tan JC Indelicato SR Narula SK: Characterization of interleukin-10 receptors on human and mouse cells. J Biol Chem. 1993;268(28):21053-9. 8407942
    • (1993) J Biol Chem , vol.268 , Issue.28 , pp. 21053-21059
    • Tan, J.C.1    Indelicato, S.R.2    Narula, S.K.3
  • 61
    • 0028350053 scopus 로고
    • Expression cloning and characterization of a human IL-10 receptor
    • 8120391
    • Liu Y Wei SH Ho AS: Expression cloning and characterization of a human IL-10 receptor. J Immunol. 1994;152(4):1821-9. 8120391
    • (1994) J Immunol , vol.152 , Issue.4 , pp. 1821-1829
    • Liu, Y.1    Wei, S.H.2    Ho, A.S.3
  • 62
    • 0030799157 scopus 로고    scopus 로고
    • Identification and functional characterization of a second chain of the interleukin-10 receptor complex
    • 9312047, 1170220
    • Kotenko SV Krause CD Izotova LS: Identification and functional characterization of a second chain of the interleukin-10 receptor complex. EMBO J. 1997;16(19):5894-903. 9312047 10.1093/emboj/16.19.5894 1170220
    • (1997) EMBO J , vol.16 , Issue.19 , pp. 5894-5903
    • Kotenko, S.V.1    Krause, C.D.2    Izotova, L.S.3
  • 63
    • 0032536530 scopus 로고    scopus 로고
    • The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor
    • 9463407, 2212143
    • Spencer SD Di Marco F Hooley J: The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J Exp Med. 1998;187(4):571-8. 9463407 10.1084/jem.187.4.571 2212143
    • (1998) J Exp Med , vol.187 , Issue.4 , pp. 571-578
    • Spencer, S.D.1    Di Marco, F.2    Hooley, J.3
  • 64
    • 0032779561 scopus 로고    scopus 로고
    • The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes
    • 10433356
    • Donnelly RP Dickensheets H Finbloom DS: The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. J Interferon Cytokine Res. 1999;19(6):563-73. 10433356 10.1089/107999099313695
    • (1999) J Interferon Cytokine Res , vol.19 , Issue.6 , pp. 563-573
    • Donnelly, R.P.1    Dickensheets, H.2    Finbloom, D.S.3
  • 65
    • 0030573991 scopus 로고    scopus 로고
    • IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes
    • 8830676
    • Wehinger J Gouilleux F Groner B: IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes. FEBS Lett. 1996;394(3):365-70. 8830676 10.1016/0014-5793(96)00990-8
    • (1996) FEBS Lett , vol.394 , Issue.3 , pp. 365-370
    • Wehinger, J.1    Gouilleux, F.2    Groner, B.3
  • 66
    • 0029981103 scopus 로고    scopus 로고
    • Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain
    • 8910398
    • Weber-Nordt RM Riley JK Greenlund AC: Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain. J Biol Chem. 1996;271(44):27954-61. 8910398 10.1074/jbc.271.44.27954
    • (1996) J Biol Chem , vol.271 , Issue.44 , pp. 27954-27961
    • Weber-Nordt, R.M.1    Riley, J.K.2    Greenlund, A.C.3
  • 67
    • 0033523019 scopus 로고    scopus 로고
    • Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action
    • 10347215
    • Riley JK Takeda K Akira S: Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action. J Biol Chem. 1999;274(23):16513-21. 10347215 10.1074/jbc.274.23.16513
    • (1999) J Biol Chem , vol.274 , Issue.23 , pp. 16513-16521
    • Riley, J.K.1    Takeda, K.2    Akira, S.3
  • 68
    • 9244237038 scopus 로고    scopus 로고
    • T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation
    • 15534372, 2211912, F1000 Recommendation
    • Roers A Siewe L Strittmatter E: T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med. 2004;200(10):1289-97. 15534372 10.1084/jem.20041789 2211912 F1000 Recommendation
    • (2004) J Exp Med , vol.200 , Issue.10 , pp. 1289-1297
    • Roers, A.1    Siewe, L.2    Strittmatter, E.3
  • 69
    • 33947692819 scopus 로고    scopus 로고
    • TLR-mediated innate immune recognition
    • 22228983, 3252746
    • Medzhitov R: TLR-mediated innate immune recognition. Semin Immunol. 2007;19(1):1-2. 22228983 10.1016/j.smim.2007.02.001 3252746
    • (2007) Semin Immunol , vol.19 , Issue.1 , pp. 1-2
    • Medzhitov, R.1
  • 70
    • 74549167783 scopus 로고    scopus 로고
    • Regulation of adaptive immunity by the innate immune system
    • 20075244, 3645875
    • Iwasaki A Medzhitov R: Regulation of adaptive immunity by the innate immune system. Science. 2010;327(5963):291-5. 20075244 10.1126/science.1183021 3645875
    • (2010) Science , vol.327 , Issue.5963 , pp. 291-295
    • Iwasaki, A.1    Medzhitov, R.2
  • 71
    • 0034651850 scopus 로고    scopus 로고
    • A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages
    • 10657644
    • Brightbill HD Plevy SE Modlin RL: A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages. J Immunol. 2000;164(4):1940-51. 10657644 10.4049/jimmunol.164.4.1940
    • (2000) J Immunol , vol.164 , Issue.4 , pp. 1940-1951
    • Brightbill, H.D.1    Plevy, S.E.2    Modlin, R.L.3
  • 72
    • 0037769043 scopus 로고    scopus 로고
    • Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages
    • 12847250
    • Liu YW Tseng HP Chen LC: Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages. J Immunol. 2003;171(2):821-8. 12847250 10.4049/jimmunol.171.2.821
    • (2003) J Immunol , vol.171 , Issue.2 , pp. 821-828
    • Liu, Y.W.1    Tseng, H.P.2    Chen, L.C.3
  • 73
    • 14844340837 scopus 로고    scopus 로고
    • The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages
    • 15749884, 2955976
    • Cao S Liu J Song L: The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages. J Immunol. 2005;174(6):3484-92. 15749884 10.4049/jimmunol.174.6.3484 2955976
    • (2005) J Immunol , vol.174 , Issue.6 , pp. 3484-3492
    • Cao, S.1    Liu, J.2    Song, L.3
  • 74
    • 33744783446 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced transcriptional activation of interleukin-10 is mediated by MAPK- and NF-kappaB-induced CCAAT/enhancer-binding protein delta in mouse macrophages
    • 16413748
    • Liu YW Chen CC Tseng HP: Lipopolysaccharide-induced transcriptional activation of interleukin-10 is mediated by MAPK- and NF-kappaB-induced CCAAT/enhancer-binding protein delta in mouse macrophages. Cell Signal. 2006;18(9):1492-500. 16413748 10.1016/j.cellsig.2005.12.001
    • (2006) Cell Signal , vol.18 , Issue.9 , pp. 1492-1500
    • Liu, Y.W.1    Chen, C.C.2    Tseng, H.P.3
  • 75
    • 50049086910 scopus 로고    scopus 로고
    • The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
    • 18690222, F1000 Recommendation
    • Ananieva O Darragh J Johansen C: The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol. 2008;9(9):1028-36. 18690222 10.1038/ni.1644 F1000 Recommendation
    • (2008) Nat Immunol , vol.9 , Issue.9 , pp. 1028-1036
    • Ananieva, O.1    Darragh, J.2    Johansen, C.3
  • 76
    • 84872197968 scopus 로고    scopus 로고
    • 2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway
    • 23241891, 3620524
    • 2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway. J Immunol. 2013;190(2):565-77. 23241891 10.4049/jimmunol.1202462 3620524
    • (2013) J Immunol , vol.190 , Issue.2 , pp. 565-577
    • MacKenzie, K.F.1    Clark, K.2    Naqvi, S.3
  • 77
    • 79953172892 scopus 로고    scopus 로고
    • 2 modulation of Toll-like receptor signaling in alveolar macrophages
    • 21247892, 3058957
    • Kim SH Serezani CH Okunishi K: Distinct protein kinase A anchoring proteins direct prostaglandin E 2 modulation of Toll-like receptor signaling in alveolar macrophages. J Biol Chem. 2011;286(11):8875-83. 21247892 10.1074/jbc.M110.187815 3058957
    • (2011) J Biol Chem , vol.286 , Issue.11 , pp. 8875-8883
    • Kim, S.H.1    Serezani, C.H.2    Okunishi, K.3
  • 78
    • 84866166941 scopus 로고    scopus 로고
    • Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback
    • 22904308, 3443740
    • Pattison MJ MacKenzie KF Arthur JS: Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback. J Immunol. 2012;189(6):2784-92. 22904308 10.4049/jimmunol.1200310 3443740
    • (2012) J Immunol , vol.189 , Issue.6 , pp. 2784-2792
    • Pattison, M.J.1    MacKenzie, K.F.2    Arthur, J.S.3
  • 79
    • 79251553145 scopus 로고    scopus 로고
    • TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells
    • 21149607
    • Sayi A Kohler E Toller IM: TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells. J Immunol. 2011;186(2):878-90. 21149607 10.4049/jimmunol.1002269
    • (2011) J Immunol , vol.186 , Issue.2 , pp. 878-890
    • Sayi, A.1    Kohler, E.2    Toller, I.M.3
  • 80
    • 79953892799 scopus 로고    scopus 로고
    • TLR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors
    • 20821041, 3064903
    • Agrawal S Gupta S: TLR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors. J Clin Immunol. 2011;31(1):89-98. 20821041 10.1007/s10875-010-9456-8 3064903
    • (2011) J Clin Immunol , vol.31 , Issue.1 , pp. 89-98
    • Agrawal, S.1    Gupta, S.2
  • 81
    • 17444374245 scopus 로고    scopus 로고
    • + B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs
    • 15845451
    • Sun CM Deriaud E Leclerc C: Upon TLR9 signaling, CD5 + B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs. Immunity. 2005;22(4):467-77. 15845451 10.1016/j.immuni.2005.02.008
    • (2005) Immunity , vol.22 , Issue.4 , pp. 467-477
    • Sun, C.M.1    Deriaud, E.2    Leclerc, C.3
  • 82
    • 9144232256 scopus 로고    scopus 로고
    • IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA
    • 14707068
    • Wagner M Poeck H Jahrsdoerfer B: IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA. J Immunol. 2004;172(2):954-63. 14707068 10.4049/jimmunol.172.2.954
    • (2004) J Immunol , vol.172 , Issue.2 , pp. 954-963
    • Wagner, M.1    Poeck, H.2    Jahrsdoerfer, B.3
  • 83
    • 33750840753 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase is required for TLR-induced IL-10 production
    • 17082638
    • Schmidt NW Thieu VT Mann BA: Bruton's tyrosine kinase is required for TLR-induced IL-10 production. J Immunol. 2006;177(10):7203-10. 17082638 10.4049/jimmunol.177.10.7203
    • (2006) J Immunol , vol.177 , Issue.10 , pp. 7203-7210
    • Schmidt, N.W.1    Thieu, V.T.2    Mann, B.A.3
  • 84
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • 20154735
    • Saraiva M O'Garra A: The regulation of IL-10 production by immune cells. Nat Rev Immunol. 2010;10(3):170-81. 20154735 10.1038/nri2711
    • (2010) Nat Rev Immunol , vol.10 , Issue.3 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 85
    • 84902505212 scopus 로고    scopus 로고
    • Transcriptional regulation of IL-10 and its cell-specific role in vivo
    • 24941159, F1000 Recommendation
    • MacKenzie KF Pattison MJ Arthur JS: Transcriptional regulation of IL-10 and its cell-specific role in vivo. Crit Rev Immunol. 2014;34(4):315-45. 24941159 10.1615/CritRevImmunol.2014010694 F1000 Recommendation
    • (2014) Crit Rev Immunol , vol.34 , Issue.4 , pp. 315-345
    • MacKenzie, K.F.1    Pattison, M.J.2    Arthur, J.S.3
  • 86
    • 0031454570 scopus 로고    scopus 로고
    • Immunosuppressive effects of apoptotic cells
    • 9389474
    • Voll RE Herrmann M Roth EA: Immunosuppressive effects of apoptotic cells. Nature. 1997;390(6658):350-1. 9389474 10.1038/37022
    • (1997) Nature , vol.390 , Issue.6658 , pp. 350-351
    • Voll, R.E.1    Herrmann, M.2    Roth, E.A.3
  • 87
    • 0027240219 scopus 로고
    • Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
    • 8102388, 2191152
    • D'Andrea A Aste-Amezaga M Valiante NM: Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med. 1993;178(3):1041-8. 8102388 10.1084/jem.178.3.1041 2191152
    • (1993) J Exp Med , vol.178 , Issue.3 , pp. 1041-1048
    • D'Andrea, A.1    Aste-Amezaga, M.2    Valiante, N.M.3
  • 88
    • 0032526338 scopus 로고    scopus 로고
    • Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10
    • 9637507
    • Aste-Amezaga M Ma X Sartori A: Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. J Immunol. 1998;160(12):5936-44. 9637507
    • (1998) J Immunol , vol.160 , Issue.12 , pp. 5936-5944
    • Aste-Amezaga, M.1    Ma, X.2    Sartori, A.3
  • 89
    • 79959558062 scopus 로고    scopus 로고
    • A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3
    • 21566115, 3123121
    • Smith AM Qualls JE O'Brien K: A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3. J Biol Chem. 2011;286(26):23582-90. 21566115 10.1074/jbc.M111.249235 3123121
    • (2011) J Biol Chem , vol.286 , Issue.26 , pp. 23582-23590
    • Smith, A.M.1    Qualls, J.E.2    O'Brien, K.3
  • 90
    • 84864799993 scopus 로고    scopus 로고
    • IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis
    • 22786766, 3411910, F1000 Recommendation
    • Kobayashi T Matsuoka K Sheikh SZ: IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis. J Immunol. 2012;189(4):1792-9. 22786766 10.4049/jimmunol.1200042 3411910 F1000 Recommendation
    • (2012) J Immunol , vol.189 , Issue.4 , pp. 1792-1799
    • Kobayashi, T.1    Matsuoka, K.2    Sheikh, S.Z.3
  • 91
    • 0037111372 scopus 로고    scopus 로고
    • Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma
    • 12421951
    • Cao S Liu J Chesi M: Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma. J Immunol. 2002;169(10):5715-25. 12421951 10.4049/jimmunol.169.10.5715
    • (2002) J Immunol , vol.169 , Issue.10 , pp. 5715-5725
    • Cao, S.1    Liu, J.2    Chesi, M.3
  • 92
    • 79951671510 scopus 로고    scopus 로고
    • H17 responses
    • 21240265, F1000 Recommendation
    • Krausgruber T Blazek K Smallie T: IRF5 promotes inflammatory macrophage polarization and T H1-T H17 responses. Nat Immunol. 2011;12(3):231-8. 21240265 10.1038/ni.1990 F1000 Recommendation
    • (2011) Nat Immunol , vol.12 , Issue.3 , pp. 231-238
    • Krausgruber, T.1    Blazek, K.2    Smallie, T.3
  • 93
    • 0036005890 scopus 로고    scopus 로고
    • Interleukin-12 in anti-tumor immunity and immunotherapy
    • 11900991
    • Colombo MP Trinchieri G: Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev. 2002;13(2):155-68. 11900991 10.1016/S1359-6101(01)00032-6
    • (2002) Cytokine Growth Factor Rev , vol.13 , Issue.2 , pp. 155-168
    • Colombo, M.P.1    Trinchieri, G.2
  • 94
    • 1642279609 scopus 로고    scopus 로고
    • Genome-wide analysis of molecular changes in IL-12-induced control of mammary carcinoma via IFN-gamma-independent mechanisms
    • 15034023, 2956987
    • Shi X Cao S Mitsuhashi M: Genome-wide analysis of molecular changes in IL-12-induced control of mammary carcinoma via IFN-gamma-independent mechanisms. J Immunol. 2004;172(7):4111-22. 15034023 10.4049/jimmunol.172.7.4111 2956987
    • (2004) J Immunol , vol.172 , Issue.7 , pp. 4111-4122
    • Shi, X.1    Cao, S.2    Mitsuhashi, M.3
  • 95
    • 67349218153 scopus 로고    scopus 로고
    • IL-12 delivered intratumorally by multilamellar liposomes reactivates memory T cells in human tumor microenvironments
    • 19395317, 2693480
    • Simpson-Abelson MR Purohit VS Pang WM: IL-12 delivered intratumorally by multilamellar liposomes reactivates memory T cells in human tumor microenvironments. Clin Immunol. 2009;132(1):71-82. 19395317 10.1016/j.clim.2009.03.516 2693480
    • (2009) Clin Immunol , vol.132 , Issue.1 , pp. 71-82
    • Simpson-Abelson, M.R.1    Purohit, V.S.2    Pang, W.M.3
  • 96
    • 77955509674 scopus 로고    scopus 로고
    • IL-12 enhances efficacy and shortens enrichment time in cytokine-induced killer cell immunotherapy
    • 20532883
    • Helms MW Prescher JA Cao YA: IL-12 enhances efficacy and shortens enrichment time in cytokine-induced killer cell immunotherapy. Cancer Immunol Immunother. 2010;59(9):1325-34. 20532883 10.1007/s00262-010-0860-y
    • (2010) Cancer Immunol Immunother , vol.59 , Issue.9 , pp. 1325-1334
    • Helms, M.W.1    Prescher, J.A.2    Cao, Y.A.3
  • 97
    • 18144447300 scopus 로고    scopus 로고
    • Subcutaneous sarcoidosis following hypophysectomy for pituitary microadenoma inducing Cushing's disease
    • 9802695
    • Marzano AV Gasparini G Caputo R: Subcutaneous sarcoidosis following hypophysectomy for pituitary microadenoma inducing Cushing's disease. Int J Dermatol. 1998;37(10):798. 9802695 10.1046/j.1365-4362.1998.00525.x
    • (1998) Int J Dermatol , vol.37 , Issue.10 , pp. 798
    • Marzano, A.V.1    Gasparini, G.2    Caputo, R.3
  • 98
    • 84902593667 scopus 로고    scopus 로고
    • Combination of interleukin-12 gene therapy, metronomic cyclophosphamide and DNA cancer vaccination directs all arms of the immune system towards tumor eradication
    • 24887014
    • Denies S Cicchelero L Van Audenhove I: Combination of interleukin-12 gene therapy, metronomic cyclophosphamide and DNA cancer vaccination directs all arms of the immune system towards tumor eradication. J Control Release. 2014;187:175-82. 24887014 10.1016/j.jconrel.2014.05.045
    • (2014) J Control Release , vol.187 , pp. 175-182
    • Denies, S.1    Cicchelero, L.2    Van Audenhove, I.3
  • 99
    • 84890846323 scopus 로고    scopus 로고
    • Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell-mediated glioma rejection
    • 24277150, 3865478
    • Vom Berg J Vrohlings M Haller S: Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell-mediated glioma rejection. J Exp Med. 2013;210(13):2803-11. 24277150 10.1084/jem.20130678 3865478
    • (2013) J Exp Med , vol.210 , Issue.13 , pp. 2803-2811
    • Vom Berg, J.1    Vrohlings, M.2    Haller, S.3
  • 100
    • 84893784833 scopus 로고    scopus 로고
    • Improving immunotherapy of hepatocellular carcinoma (HCC) using dendritic cells (DC) engineered to express IL-12 in vivo
    • 23998316
    • Vogt A Sievers E Lukacs-Kornek V: Improving immunotherapy of hepatocellular carcinoma (HCC) using dendritic cells (DC) engineered to express IL-12 in vivo. Liver Int. 2014;34(3):447-61. 23998316 10.1111/liv.12284
    • (2014) Liver Int , vol.34 , Issue.3 , pp. 447-461
    • Vogt, A.1    Sievers, E.2    Lukacs-Kornek, V.3
  • 101
    • 84886096502 scopus 로고    scopus 로고
    • Comparative antitumor effect among GM-CSF, IL-12 and GM-CSF+IL-12 genetically modified tumor cell vaccines
    • 23969885
    • Miguel A Herrero MJ Sendra L: Comparative antitumor effect among GM-CSF, IL-12 and GM-CSF+IL-12 genetically modified tumor cell vaccines. Cancer Gene Ther. 2013;20(10):576-81. 23969885 10.1038/cgt.2013.54
    • (2013) Cancer Gene Ther , vol.20 , Issue.10 , pp. 576-581
    • Miguel, A.1    Herrero, M.J.2    Sendra, L.3
  • 102
    • 84865171102 scopus 로고    scopus 로고
    • Local delivery of recombinant adenovirus expressing hepatitis B virus X protein and interleukin-12 results in antitumor effects via inhibition of hepatoma cell growth and intervention of tumor microenvironment
    • 22710287
    • He H Fan P Yin T: Local delivery of recombinant adenovirus expressing hepatitis B virus X protein and interleukin-12 results in antitumor effects via inhibition of hepatoma cell growth and intervention of tumor microenvironment. Int J Mol Med. 2012;30(3):599-605. 22710287 10.3892/ijmm.2012.1027
    • (2012) Int J Mol Med , vol.30 , Issue.3 , pp. 599-605
    • He, H.1    Fan, P.2    Yin, T.3
  • 103
    • 79957513833 scopus 로고    scopus 로고
    • Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12
    • 21515097
    • Malvicini M Ingolotti M Piccioni F: Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12. Mol Oncol. 2011;5(3):242-55. 21515097 10.1016/j.molonc.2011.03.007
    • (2011) Mol Oncol , vol.5 , Issue.3 , pp. 242-255
    • Malvicini, M.1    Ingolotti, M.2    Piccioni, F.3
  • 104
    • 77956280888 scopus 로고    scopus 로고
    • + T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts
    • 20647327, 2935308
    • Kerkar SP Muranski P Kaiser A: Tumor-specific CD8 + T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts. Cancer Res. 2010;70(17):6725-34. 20647327 10.1158/0008-5472.CAN-10-0735 2935308
    • (2010) Cancer Res , vol.70 , Issue.17 , pp. 6725-6734
    • Kerkar, S.P.1    Muranski, P.2    Kaiser, A.3
  • 105
    • 73149125743 scopus 로고    scopus 로고
    • A novel synergistic combination of cyclophosphamide and gene transfer of interleukin-12 eradicates colorectal carcinoma in mice
    • 19920110
    • Malvicini M Rizzo M Alaniz L: A novel synergistic combination of cyclophosphamide and gene transfer of interleukin-12 eradicates colorectal carcinoma in mice. Clin Cancer Res. 2009;15(23):7256-65. 19920110 10.1158/1078-0432.CCR-09-1861
    • (2009) Clin Cancer Res , vol.15 , Issue.23 , pp. 7256-7265
    • Malvicini, M.1    Rizzo, M.2    Alaniz, L.3
  • 106
    • 84861410440 scopus 로고    scopus 로고
    • Interleukin-12: clinical usage and molecular markers of cancer susceptibility
    • 22515181
    • Yuzhalin AE Kutikhin AG: Interleukin-12: clinical usage and molecular markers of cancer susceptibility. Growth Factors. 2012;30(3):176-91. 22515181 10.3109/08977194.2012.678843
    • (2012) Growth Factors , vol.30 , Issue.3 , pp. 176-191
    • Yuzhalin, A.E.1    Kutikhin, A.G.2
  • 107
    • 84897533766 scopus 로고    scopus 로고
    • CD19-CAR trials
    • 24667955, 3979594, F1000 Recommendation
    • Ramos CA Savoldo B Dotti G: CD19-CAR trials. Cancer J. 2014;20(2):112-8. 24667955 10.1097/PPO.0000000000000031 3979594 F1000 Recommendation
    • (2014) Cancer J , vol.20 , Issue.2 , pp. 112-118
    • Ramos, C.A.1    Savoldo, B.2    Dotti, G.3
  • 108
    • 80052257433 scopus 로고    scopus 로고
    • IL-12 release by engineered T cells expressing chimeric antigen receptors can effectively Muster an antigen-independent macrophage response on tumor cells that have shut down tumor antigen expression
    • 21742772, F1000 Recommendation
    • Chmielewski M Kopecky C Hombach AA: IL-12 release by engineered T cells expressing chimeric antigen receptors can effectively Muster an antigen-independent macrophage response on tumor cells that have shut down tumor antigen expression. Cancer Res. 2011;71(17):5697-706. 21742772 10.1158/0008-5472.CAN-11-0103 F1000 Recommendation
    • (2011) Cancer Res , vol.71 , Issue.17 , pp. 5697-5706
    • Chmielewski, M.1    Kopecky, C.2    Hombach, A.A.3
  • 109
    • 79953325686 scopus 로고    scopus 로고
    • Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment
    • 21285960, 3070103
    • Zhang L Kerkar SP Yu Z: Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment. Mol Ther. 2011;19(4):751-9. 21285960 10.1038/mt.2010.313 3070103
    • (2011) Mol Ther , vol.19 , Issue.4 , pp. 751-759
    • Zhang, L.1    Kerkar, S.P.2    Yu, Z.3
  • 110
    • 84861229798 scopus 로고    scopus 로고
    • Evaluation of γ-retroviral vectors that mediate the inducible expression of IL-12 for clinical application
    • 22576348, 3358728
    • Zhang L Feldman SA Zheng Z: Evaluation of γ-retroviral vectors that mediate the inducible expression of IL-12 for clinical application. J Immunother. 2012;35(5):430-9. 22576348 10.1097/CJI.0b013e31825898e8 3358728
    • (2012) J Immunother , vol.35 , Issue.5 , pp. 430-439
    • Zhang, L.1    Feldman, S.A.2    Zheng, Z.3
  • 111
    • 23244443617 scopus 로고    scopus 로고
    • - T cell activation in the presence of T regulatory cells
    • 16002658, F1000 Recommendation
    • King IL Segal BM: Cutting edge: IL-12 induces CD4 +CD25 - T cell activation in the presence of T regulatory cells. J Immunol. 2005;175(2):641-5. 16002658 10.4049/jimmunol.175.2.641 F1000 Recommendation
    • (2005) J Immunol , vol.175 , Issue.2 , pp. 641-645
    • King, I.L.1    Segal, B.M.2
  • 112
    • 70449532980 scopus 로고    scopus 로고
    • + Treg cell number and acquisition of effector cell phenotype during lethal infection
    • 19896394, 2814877, F1000 Recommendation
    • Oldenhove G Bouladoux N Wohlfert EA: Decrease of Foxp3 + Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity. 2009;31(5):772-86. 19896394 10.1016/j.immuni.2009.10.001 2814877 F1000 Recommendation
    • (2009) Immunity , vol.31 , Issue.5 , pp. 772-786
    • Oldenhove, G.1    Bouladoux, N.2    Wohlfert, E.A.3
  • 113
    • 79958130907 scopus 로고    scopus 로고
    • + T cells that inhibit colitis
    • 21419767, 3109200
    • Feng T Cao AT Weaver CT: Interleukin-12 converts Foxp3 + regulatory T cells to interferon-γ-producing Foxp3 + T cells that inhibit colitis. Gastroenterology. 2011;140(7):2031-43. 21419767 10.1053/j.gastro.2011.03.009 3109200
    • (2011) Gastroenterology , vol.140 , Issue.7 , pp. 2031-2043
    • Feng, T.1    Cao, A.T.2    Weaver, C.T.3
  • 114
    • 84866893829 scopus 로고    scopus 로고
    • Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-γ, IL-2 and IL-2R
    • 23029447, 3459844, F1000 Recommendation
    • Zhao J Zhao J Perlman S: Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-γ, IL-2 and IL-2R. PLoS One. 2012;7(9):e46241. 23029447 10.1371/journal.pone.0046241 3459844 F1000 Recommendation
    • (2012) PLoS One , vol.7 , Issue.9
    • Zhao, J.1    Zhao, J.2    Perlman, S.3
  • 115
    • 84055217292 scopus 로고    scopus 로고
    • IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors
    • 22056381, 3226001, F1000 Recommendation
    • Kerkar SP Goldszmid RS Muranski P: IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. J Clin Invest. 2011;121(12):4746-57. 22056381 10.1172/JCI58814 3226001 F1000 Recommendation
    • (2011) J Clin Invest , vol.121 , Issue.12 , pp. 4746-4757
    • Kerkar, S.P.1    Goldszmid, R.S.2    Muranski, P.3
  • 116
    • 32044452015 scopus 로고    scopus 로고
    • IL-12 reverses anergy to T cell receptor triggering in human lung tumor-associated memory T cells
    • 16271513
    • Broderick L Brooks SP Takita H: IL-12 reverses anergy to T cell receptor triggering in human lung tumor-associated memory T cells. Clin Immunol. 2006;118(2-3):159-69. 16271513 10.1016/j.clim.2005.09.008
    • (2006) Clin Immunol , vol.118 , Issue.2-3 , pp. 159-169
    • Broderick, L.1    Brooks, S.P.2    Takita, H.3
  • 117
    • 33750802413 scopus 로고    scopus 로고
    • + T effectors
    • 17082611
    • Kilinc MO Aulakh KS Nair RE: Reversing tumor immune suppression with intratumoral IL-12: activation of tumor-associated T effector/memory cells, induction of T suppressor apoptosis, and infiltration of CD8 + T effectors. J Immunol. 2006;177(10):6962-73. 17082611 10.4049/jimmunol.177.10.6962
    • (2006) J Immunol , vol.177 , Issue.10 , pp. 6962-6973
    • Kilinc, M.O.1    Aulakh, K.S.2    Nair, R.E.3
  • 118
    • 33846479526 scopus 로고    scopus 로고
    • IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo
    • 17237382, F1000 Recommendation
    • Watkins SK Egilmez NK Suttles J: IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo. J Immunol. 2007;178(3):1357-62. 17237382 10.4049/jimmunol.178.3.1357 F1000 Recommendation
    • (2007) J Immunol , vol.178 , Issue.3 , pp. 1357-1362
    • Watkins, S.K.1    Egilmez, N.K.2    Suttles, J.3
  • 119
    • 0037544148 scopus 로고    scopus 로고
    • Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function
    • 12732656, 2193970, F1000 Recommendation
    • Curtsinger JM Lins DC Mescher MF: Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function. J Exp Med. 2003;197(9):1141-51. 12732656 10.1084/jem.20021910 2193970 F1000 Recommendation
    • (2003) J Exp Med , vol.197 , Issue.9 , pp. 1141-1151
    • Curtsinger, J.M.1    Lins, D.C.2    Mescher, M.F.3
  • 120
    • 47249134619 scopus 로고    scopus 로고
    • Strategies for use of IL-10 or its antagonists in human disease
    • 18613832
    • O'Garra A Barrat FJ Castro AG: Strategies for use of IL-10 or its antagonists in human disease. Immunol Rev. 2008;223(1):114-31. 18613832 10.1111/j.1600-065X.2008.00635.x
    • (2008) Immunol Rev , vol.223 , Issue.1 , pp. 114-131
    • O'Garra, A.1    Barrat, F.J.2    Castro, A.G.3
  • 121
    • 84937813197 scopus 로고    scopus 로고
    • + IL-10-producing B cells in lupus-prone mice
    • 25973757, F1000 Recommendation
    • Baglaenko Y Manion KP Chang NH: Suppression of autoimmunity by CD5 + IL-10-producing B cells in lupus-prone mice. Genes Immun. 2015;16(5):311-20. 25973757 10.1038/gene.2015.17 F1000 Recommendation
    • (2015) Genes Immun , vol.16 , Issue.5 , pp. 311-320
    • Baglaenko, Y.1    Manion, K.P.2    Chang, N.H.3
  • 122
    • 20444371569 scopus 로고    scopus 로고
    • Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke
    • 15894335, F1000 Recommendation
    • Frenkel D Huang Z Maron R: Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke. J Neurol Sci. 2005;233(1-2):125-32. 15894335 10.1016/j.jns.2005.03.022 F1000 Recommendation
    • (2005) J Neurol Sci , vol.233 , Issue.1-2 , pp. 125-132
    • Frenkel, D.1    Huang, Z.2    Maron, R.3
  • 123
    • 18944379171 scopus 로고    scopus 로고
    • + regulatory T cells play a critical role in granulocyte-macrophage colony-stimulating factor-induced suppression of experimental autoimmune thyroiditis
    • 15905543, F1000 Recommendation
    • Gangi E Vasu C Cheatem D: IL-10-producing CD4 +CD25 + regulatory T cells play a critical role in granulocyte-macrophage colony-stimulating factor-induced suppression of experimental autoimmune thyroiditis. J Immunol. 2005;174(11):7006-13. 15905543 10.4049/jimmunol.174.11.7006 F1000 Recommendation
    • (2005) J Immunol , vol.174 , Issue.11 , pp. 7006-7013
    • Gangi, E.1    Vasu, C.2    Cheatem, D.3
  • 124
    • 77749322389 scopus 로고    scopus 로고
    • A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells
    • 20126401, 2814855, F1000 Recommendation
    • Lavasani S Dzhambazov B Nouri M: A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells. PLoS One. 2010;5(2):e9009. 20126401 10.1371/journal.pone.0009009 2814855 F1000 Recommendation
    • (2010) PLoS One , vol.5 , Issue.2 , pp. e9009
    • Lavasani, S.1    Dzhambazov, B.2    Nouri, M.3
  • 125
    • 54949141219 scopus 로고    scopus 로고
    • Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression
    • 18802481, 2542851, F1000 Recommendation
    • Matsushita T Yanaba K Bouaziz JD: Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest. 2008;118(10):3420-30. 18802481 10.1172/JCI36030 2542851 F1000 Recommendation
    • (2008) J Clin Invest , vol.118 , Issue.10 , pp. 3420-3430
    • Matsushita, T.1    Yanaba, K.2    Bouaziz, J.D.3
  • 126
    • 84861630486 scopus 로고    scopus 로고
    • IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation
    • 22538089, F1000 Recommendation
    • Yang M Deng J Liu Y: IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation. Am J Pathol. 2012;180(6):2375-85. 22538089 10.1016/j.ajpath.2012.03.010 F1000 Recommendation
    • (2012) Am J Pathol , vol.180 , Issue.6 , pp. 2375-2385
    • Yang, M.1    Deng, J.2    Liu, Y.3
  • 127
    • 33748618698 scopus 로고    scopus 로고
    • IL-10 gene modified dendritic cells induced antigen-specific tolerance in experimental autoimmune myocarditis
    • 16904381, F1000 Recommendation
    • Yang S Li W Liu W: IL-10 gene modified dendritic cells induced antigen-specific tolerance in experimental autoimmune myocarditis. Clin Immunol. 2006;121(1):63-73. 16904381 10.1016/j.clim.2006.06.009 F1000 Recommendation
    • (2006) Clin Immunol , vol.121 , Issue.1 , pp. 63-73
    • Yang, S.1    Li, W.2    Liu, W.3
  • 128
    • 67650224449 scopus 로고    scopus 로고
    • Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
    • 19592695
    • Brand S: Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut. 2009;58(8):1152-67. 19592695 10.1136/gut.2008.163667
    • (2009) Gut , vol.58 , Issue.8 , pp. 1152-1167
    • Brand, S.1
  • 129
    • 65249115914 scopus 로고    scopus 로고
    • A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
    • 19349988, 2928218, F1000 Recommendation
    • Noguchi E Homma Y Kang X: A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1. Nat Immunol. 2009;10(5):471-9. 19349988 10.1038/ni.1722 2928218 F1000 Recommendation
    • (2009) Nat Immunol , vol.10 , Issue.5 , pp. 471-479
    • Noguchi, E.1    Homma, Y.2    Kang, X.3
  • 130
    • 0028670487 scopus 로고
    • Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major
    • 7809149, 45554
    • Wang ZE Zheng S Corry DB: Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major. Proc Natl Acad Sci U S A. 1994;91(26):12932-6. 7809149 10.1073/pnas.91.26.12932 45554
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.26 , pp. 12932-6
    • Wang, Z.E.1    Zheng, S.2    Corry, D.B.3
  • 131
    • 0030895747 scopus 로고    scopus 로고
    • Intracellular antimicrobial activity in the absence of interferon-gamma: effect of interleukin-12 in experimental visceral leishmaniasis in interferon-gamma gene-disrupted mice
    • 9104810, 2196266
    • Taylor AP Murray HW: Intracellular antimicrobial activity in the absence of interferon-gamma: effect of interleukin-12 in experimental visceral leishmaniasis in interferon-gamma gene-disrupted mice. J Exp Med. 1997;185(7):1231-9. 9104810 10.1084/jem.185.7.1231 2196266
    • (1997) J Exp Med , vol.185 , Issue.7 , pp. 1231-1239
    • Taylor, A.P.1    Murray, H.W.2
  • 132
    • 0032490564 scopus 로고    scopus 로고
    • + T cells and Granulocyte/Macrophage colony-stimulating factor
    • 9653090, 2525540
    • Zilocchi C Stoppacciaro A Chiodoni C: Interferon gamma-independent rejection of interleukin 12-transduced carcinoma cells requires CD4 + T cells and Granulocyte/Macrophage colony-stimulating factor. J Exp Med. 1998;188(1):133-43. 9653090 10.1084/jem.188.1.133 2525540
    • (1998) J Exp Med , vol.188 , Issue.1 , pp. 133-143
    • Zilocchi, C.1    Stoppacciaro, A.2    Chiodoni, C.3
  • 133
    • 0033025430 scopus 로고    scopus 로고
    • Interleukin-12 enhances antifungal activity of human mononuclear phagocytes against Aspergillus fumigatus: implications for a gamma interferon-independent pathway
    • 10338518, 96619
    • Roilides E Tsaparidou S Kadiltsoglou I: Interleukin-12 enhances antifungal activity of human mononuclear phagocytes against Aspergillus fumigatus: implications for a gamma interferon-independent pathway. Infect Immun. 1999;67(6):3047-50. 10338518 96619
    • (1999) Infect Immun , vol.67 , Issue.6 , pp. 3047-3050
    • Roilides, E.1    Tsaparidou, S.2    Kadiltsoglou, I.3
  • 134
    • 0032708410 scopus 로고    scopus 로고
    • Interleukin-12 activates NK cells for IFN-gamma-dependent and NKT cells for IFN-gamma-independent antimetastatic activity
    • 10586121
    • Hafner M Falk W Echtenacher B: Interleukin-12 activates NK cells for IFN-gamma-dependent and NKT cells for IFN-gamma-independent antimetastatic activity. Eur Cytokine Netw. 1999;10(4):541-8. 10586121
    • (1999) Eur Cytokine Netw , vol.10 , Issue.4 , pp. 541-548
    • Hafner, M.1    Falk, W.2    Echtenacher, B.3
  • 135
    • 0035909925 scopus 로고    scopus 로고
    • Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway
    • 11748115
    • Afanasyeva M Wang Y Kaya Z: Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway. Circulation. 2001;104(25):3145-51. 11748115 10.1161/hc5001.100629
    • (2001) Circulation , vol.104 , Issue.25 , pp. 3145-3151
    • Afanasyeva, M.1    Wang, Y.2    Kaya, Z.3
  • 136
    • 2542434086 scopus 로고    scopus 로고
    • Gene expression analysis in Interleukin-12-induced suppression of mouse mammary carcinoma
    • 15122590, 2957898
    • Shi X Liu J Xiang Z: Gene expression analysis in Interleukin-12-induced suppression of mouse mammary carcinoma. Int J Cancer. 2004;110(4):570-8. 15122590 10.1002/ijc.20145 2957898
    • (2004) Int J Cancer , vol.110 , Issue.4 , pp. 570-578
    • Shi, X.1    Liu, J.2    Xiang, Z.3
  • 137
    • 0030584733 scopus 로고    scopus 로고
    • IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses
    • 8609396
    • Meyaard L Hovenkamp E Otto SA: IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses. J Immunol. 1996;156(8):2776-82. 8609396
    • (1996) J Immunol , vol.156 , Issue.8 , pp. 2776-2782
    • Meyaard, L.1    Hovenkamp, E.2    Otto, S.A.3
  • 138
    • 0037242365 scopus 로고    scopus 로고
    • Repeated administrations of interleukin (IL)-12 are associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma, tumor necrosis factor-alpha, IL-6, and IL-8 responses
    • 12538454
    • Portielje JE Lamers CH Kruit WH: Repeated administrations of interleukin (IL)-12 are associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma, tumor necrosis factor-alpha, IL-6, and IL-8 responses. Clin Cancer Res. 2003;9(1):76-83. 12538454
    • (2003) Clin Cancer Res , vol.9 , Issue.1 , pp. 76-83
    • Portielje, J.E.1    Lamers, C.H.2    Kruit, W.H.3
  • 139
    • 0029984051 scopus 로고    scopus 로고
    • Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10
    • 8676077, 2192598
    • Gerosa F Paganin C Peritt D: Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10. J Exp Med. 1996;183(6):2559-69. 8676077 10.1084/jem.183.6.2559 2192598
    • (1996) J Exp Med , vol.183 , Issue.6 , pp. 2559-2569
    • Gerosa, F.1    Paganin, C.2    Peritt, D.3
  • 140
    • 0035877107 scopus 로고    scopus 로고
    • IL-12 suppression during experimental endotoxin tolerance: dendritic cell loss and macrophage hyporesponsiveness
    • 11390504, F1000 Recommendation
    • Wysocka M Robertson S Riemann H: IL-12 suppression during experimental endotoxin tolerance: dendritic cell loss and macrophage hyporesponsiveness. J Immunol. 2001;166(12):7504-13. 11390504 10.4049/jimmunol.166.12.7504 F1000 Recommendation
    • (2001) J Immunol , vol.166 , Issue.12 , pp. 7504-7513
    • Wysocka, M.1    Robertson, S.2    Riemann, H.3
  • 141
    • 34250823515 scopus 로고    scopus 로고
    • Gene-specific control of inflammation by TLR-induced chromatin modifications
    • 17538624, F1000 Recommendation
    • Foster SL Hargreaves DC Medzhitov R: Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature. 2007;447(7147):972-8. 17538624 10.1038/nature05836 F1000 Recommendation
    • (2007) Nature , vol.447 , Issue.7147 , pp. 972-978
    • Foster, S.L.1    Hargreaves, D.C.2    Medzhitov, R.3
  • 142
    • 33748499140 scopus 로고    scopus 로고
    • Serum amyloid A is an endogenous ligand that differentially induces IL-12 and IL-23
    • 16951371, F1000 Recommendation
    • He R Shepard LW Chen J: Serum amyloid A is an endogenous ligand that differentially induces IL-12 and IL-23. J Immunol. 2006;177(6):4072-9. 16951371 10.4049/jimmunol.177.6.4072 F1000 Recommendation
    • (2006) J Immunol , vol.177 , Issue.6 , pp. 4072-4079
    • He, R.1    Shepard, L.W.2    Chen, J.3
  • 143
    • 33751230223 scopus 로고    scopus 로고
    • TLR-ligand stimulated interleukin-23 subunit expression and assembly is regulated differentially in murine plasmacytoid and myeloid dendritic cells
    • 17052755
    • Waibler Z Kalinke U Will J: TLR-ligand stimulated interleukin-23 subunit expression and assembly is regulated differentially in murine plasmacytoid and myeloid dendritic cells. Mol Immunol. 2007;44(7):1483-9. 17052755 10.1016/j.molimm.2006.09.001
    • (2007) Mol Immunol , vol.44 , Issue.7 , pp. 1483-1489
    • Waibler, Z.1    Kalinke, U.2    Will, J.3
  • 144
    • 0028967287 scopus 로고
    • Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist
    • 7843232
    • Gillessen S Carvajal D Ling P: Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur J Immunol. 1995;25(1):200-6. 7843232 10.1002/eji.1830250133
    • (1995) Eur J Immunol , vol.25 , Issue.1 , pp. 200-206
    • Gillessen, S.1    Carvajal, D.2    Ling, P.3
  • 145
    • 0028819316 scopus 로고
    • Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
    • 7527811
    • Ling P Gately MK Gubler U: Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J Immunol. 1995;154(1):116-27. 7527811
    • (1995) J Immunol , vol.154 , Issue.1 , pp. 116-127
    • Ling, P.1    Gately, M.K.2    Gubler, U.3
  • 146
    • 78649988840 scopus 로고    scopus 로고
    • Human breast tumor cells express IL-10 and IL-12p40 transcripts and proteins, but do not produce IL-12p70
    • 21055733
    • Heckel MC Wolfson A Slachta CA: Human breast tumor cells express IL-10 and IL-12p40 transcripts and proteins, but do not produce IL-12p70. Cell Immunol. 2011;266(2):143-53. 21055733 10.1016/j.cellimm.2010.09.010
    • (2011) Cell Immunol , vol.266 , Issue.2 , pp. 143-153
    • Heckel, M.C.1    Wolfson, A.2    Slachta, C.A.3
  • 147
    • 0031132212 scopus 로고    scopus 로고
    • In vivo production and function of IL-12 p40 homodimers
    • 9127002
    • Heinzel FP Hujer AM Ahmed FN: In vivo production and function of IL-12 p40 homodimers. J Immunol. 1997;158(9):4381-8. 9127002
    • (1997) J Immunol , vol.158 , Issue.9 , pp. 4381-4388
    • Heinzel, F.P.1    Hujer, A.M.2    Ahmed, F.N.3
  • 148
    • 0030817861 scopus 로고    scopus 로고
    • Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock
    • 9353058, 175679
    • Mattner F Ozmen L Podlaski FJ: Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock. Infect Immun. 1997;65(11):4734-7. 9353058 175679
    • (1997) Infect Immun , vol.65 , Issue.11 , pp. 4734-4737
    • Mattner, F.1    Ozmen, L.2    Podlaski, F.J.3
  • 149
    • 0031567892 scopus 로고    scopus 로고
    • + IFN-gamma-producing cells
    • 8992979
    • Piccotti JR Chan SY Li K: Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4 + and CD8 + IFN-gamma-producing cells. J Immunol. 1997;158(2):643-8. 8992979
    • (1997) J Immunol , vol.158 , Issue.2 , pp. 643-648
    • Piccotti, J.R.1    Chan, S.Y.2    Li, K.3
  • 150
    • 84858759305 scopus 로고    scopus 로고
    • Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
    • 22354001, 3359735
    • Pegram HJ Lee JC Hayman EG: Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood. 2012;119(18):4133-41. 22354001 10.1182/blood-2011-12-400044 3359735
    • (2012) Blood , vol.119 , Issue.18 , pp. 4133-4141
    • Pegram, H.J.1    Lee, J.C.2    Hayman, E.G.3
  • 151
    • 84954534981 scopus 로고    scopus 로고
    • IL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumors in vivo
    • 25949921, 4404840, F1000 Recommendation
    • Koneru M Purdon TJ Spriggs D: IL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumors in vivo. Oncoimmunology. 2015;4(3):e994446. 25949921 10.4161/2162402X.2014.994446 4404840 F1000 Recommendation
    • (2015) Oncoimmunology , vol.4 , Issue.3
    • Koneru, M.1    Purdon, T.J.2    Spriggs, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.