Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5

Biochemical and Biophysical Research Communications

Volumn 430, Issue 1, 2013, Pages 95-100

  Koshiba, Ryuji ^a,b   Yanai, Hideyuki ^a,b   Matsuda, Atsushi ^a   Goto, Ayana ^a,b   Nakajima, Akira ^a   Negishi, Hideo ^a,b   Nishio, Junko ^a,b   Smale, Stephen T ^c   Taniguchi, Tadatsugu ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Enhancer; Gene regulation; IL 12p40; IRFs; Promoter

Indexed keywords

DNA; INTERFERON REGULATORY FACTOR; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 5; INTERLEUKIN 12P40; OCTAMER TRANSCRIPTION FACTOR; RETINOIC ACID INDUCIBLE PROTEIN I; TOLL LIKE RECEPTOR;

ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; EMBRYO; ENHANCER REGION; GENE CONTROL; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

BASE SEQUENCE; ENHANCER ELEMENTS, GENETIC; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; INTERFERON REGULATORY FACTOR-3; INTERFERON REGULATORY FACTORS; INTERLEUKIN-12 SUBUNIT P40; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; TOLL-LIKE RECEPTORS;

EID: 84872368414     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.11.006     Document Type: Article

References (23)

1. Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
2. Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature 2007, 449:819-826.
3. Bonizzi G., Karin M. The two NF-κB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 2004, 25:280-288.
4. Dev A., Iyer S., Razani B., Cheng G. NF-κB and innate immunity. Curr. Top. Microbiol. Immunol. 2011, 349:115-143.
5. Tamura T., Yanai H., Savitsky D., Taniguchi T. The IRF family transcription factors in immunity and oncogenesis. Annu. Rev. Immunol. 2008, 26:535-584.
6. Kastelein R.A., Hunter C.A., Cua D.J. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu. Rev. Immunol. 2007, 25:221-242.
7. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 2003, 3:133-146.
8. O'Quinn D.B., Palmer M.T., Lee Y.K., Weaver C.T. Emergence of the Th17 pathway and its role in host defense. Adv. Immunol. 2008, 99:115-163.
9. Murphy T.L., Cleveland M.G., Kulesza P., Magram J., Murphy K.M. Regulation of interleukin 12 p40 expression through an NF-κB half-site. Mol. Cell Biol. 1995, 15:5258-5267.
10. Plevy S.E., Gemberling J.H., Hsu S., Dorner A.J., Smale S.T. Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and rel proteins. Mol. Cell Biol. 1997, 17:4572-4588.
11. Zhou L., Nazarian A.A., Xu J., Tantin D., Corcoran L.M., Smale S.T. An inducible enhancer required for Il12b promoter activity in an insulated chromatin environment. Mol. Cell Biol. 2007, 27:2698-2712.
12. Takaoka A., Yanai H., Kondo S., Duncan G., Negishi H., Mizutani T., Kano S., Honda K., Ohba Y., Mak T.W., Taniguchi T. Integral role of IRF-5 in the gene induction programme activated by toll-like receptors. Nature 2005, 434:243-249.
13. Negishi H., Yanai H., Nakajima A., Koshiba R., Atarashi K., Matsuda A., Matsuki K., Miki S., Doi T., Aderem A., Nishio J., Smale S.T., Honda K., Taniguchi T. Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses. Nat. Immunol. 2012, 13:659-666.
14. Mori M., Yoneyama M., Ito T., Takahashi K., Inagaki F., Fujita T. Identification of Ser-386 of interferon regulatory factor three as critical target for inducible phosphorylation that determines activation. J. Biol. Chem. 2004, 279:9698-9702.
15. Takahasi K., Horiuchi M., Fujii K., Nakamura S., Noda N.N., Yoneyama M., Fujita T., Inagaki F. Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change. Genes Cells 2010, 15:901-910.
16. Nguyen H., Hiscott J., Pitha P.M. The growing family of interferon regulatory factors. Cytokine Growth Factor Rev. 1997, 8:293-312.
17. Panne D., Maniatis T., Harrison S.C. An atomic model of the interferon-b enhanceosome. Cell 2007, 129:1111-1123.
18. Glass C.K., Holloway J.M., Devary O.V., Rosenfeld M.G. The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements. Cell 1988, 54:313-323.
19. Sakai D.D., Helms S., Carlstedt-Duke J., Gustafsson J.A., Rottman F.M., Yamamoto K.R. Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene. Genes Dev. 1988, 2:1144-1154.
20. Tan S., Richmond T.J. DNA binding-induced conformational change of the yeast transcriptional activator PRTF. Cell 1990, 62:367-377.
21. Fujita T., Nolan G.P., Ghosh S., Baltimore D. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κB. Genes Dev. 1992, 6:775-787.
22. Banchereau J., Pascual V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 2006, 25:383-392.
23. Trinchieri G. Type I interferon: friend or foe?. J. Exp. Med. 2010, 207:2053-2063.