IL-10 gene modified dendritic cells induced antigen-specific tolerance in experimental autoimmune myocarditis

Clinical Immunology

Volumn 121, Issue 1, 2006, Pages 63-73

  Yang, Shusen ^a   Li, Weimin ^a   Liu, Wei ^a   Gao, Cheng ^a   Zhou, Baoguo ^a   Li, Shaojun ^a   Li, Yue ^a   Kong, Yihui ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Dendritic cell; Experimental autoimmune myocarditis; Gene therapy; Immunotherapy; Interleukin 10

Indexed keywords

CARDIAC MYOSIN; CYTOKINE; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DNA MODIFICATION; DRUG EFFECT; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSFECTION; HEART FUNCTION; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; INFLAMMATORY INFILTRATE; LYMPHOCYTE PROLIFERATION; MALE; MYOCARDITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SPLEEN CELL; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ADOPTIVE TRANSFER; ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; BONE MARROW CELLS; CELLS, CULTURED; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; EPITOPES; IMMUNE TOLERANCE; INTERLEUKIN-10; MALE; MYOCARDITIS; RATS; RATS, INBRED LEW;

EID: 33748618698     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2006.06.009     Document Type: Article

References (33)

1. Liu W., Li W.M., and Sun N.L. HLA-DQA1,-DQB1 polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy in Hans of Northern China. Ann. Hum. Genet. 69 (2005) 382-388
2. Afanasyeva M., Georgakopoulos D., and Rose N.R. Autoimmune myocarditis: cellular mediators of cardiac dysfunction. Autoimmun. Rev. 3 7-8 (2004) 476-486
3. Li Y., Heuser J.S., Kosanke S.D., Hemric M., and Cunningham M.W. Cryptic epitope identified in rat and human cardiac myosin S2 region induces myocarditis in the Lewis rat. J. Immunol. 172 5 (2004) 3225-3234
4. Li W.M., Liu W., Gao C., and Zhou B.G. Immunoregulatory effects of atorvastatin on the experimental autoimmune myocarditis in Lewis rats. Immunol. Cell Biol. 84 (2006) 274-280
5. Liu W., Gao C., Zhou B.G., and Li W.M. Effects of adenovirus-mediated gene transfer of ICOSIg and CTLA4Ig fusion protein on experimental autoimmune myocarditis. Autoimmunity 39 2 (2006) 83-92
6. Haase C., Skak K., Michelsen B.K., and Markholst H. Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expressing CD154 on the pancreatic β-cells. Diabetes 53 (2004) 2588-2595
7. Kalinski P., Hilkens C.M.U., Wierenga E.A., and Kapsenberg M.L. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol. Today 20 12 (1999) 561-567
8. H2 and nonpolarized T cells. Nat. Immunol. 1 (2000) 311-316
9. Zhou X.H., Paulsson G., Stemme S., and Hansson G.K. Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice. J. Clin. Invest. 101 8 (1998) 1717-1725
10. Bayry J., Thirion M., Delignat S., Misra N., Lacroix-Desmazes S., Kazatchkine M.D., and Kaveri S.V. Dendritic cells and autoimmunity. Autoimmun. Rev. 3 (2004) 183-187
11. Eriksson U., Kurrer M.O., Sonderegger I., Iezzi G., Tafuri A., Hunziker L., Suzuki S., Bachmaier K., Bingisser R.M., Penninger J.M., and Kopf M. Activation of dendritic cells through the interleukin 1 receptor 1 Is critical for the induction of autoimmune myocarditis. J. Exp. Med. 197 3 (2003) 323-331
12. Steptoe R.J., Ritchie J.M., and Harrison L.C. Increased generation of dendritic cells from myeloid progenitors in autoimmune-prone nonobese diabetic mice. J. Immunol. 168 (2002) 5032-5041
13. Figdor C G., M de Vries I.J.M., Joost Lesterhuis W., and Melief C J.M. Dendritic cell immunotherapy: mapping the way. Nat. Med. 10 5 (2004) 475-480
14. Wallet M.A., Sen P., and Tisch R. Immunoregulation of dendritic cells. Clin. Med. Res. 3 (2005) 166-175
15. D'Orazio T.J., and Niederkorn J.Y. A novel role of TGF-β and IL-10 in the induction of immune privilege. J. Immunol. 160 (1988) 2089
16. Li L., Elliott J.F., and Mosmann T.R. IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivity. J. Immunol. 153 9 (1994) 3967-3978
17. Katsikis P.D., Chu C.Q., Brennan F.M., Maini R.N., and Feldmann M. Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J. Exp. Med. 179 (1994) 1517
18. Okura Y., Jee Y., and Matsumoto Y. Acquired thymic tolerance to autoimmune encephalomyelitis is associated with activation of peripheral IL-10-producing macrophages/dendritic cells. Int. Immunol. 15 3 (2003) 437-446
19. Zhu X.M., Lu C.Z., Xiao B.G., Qiao J., and Sun Y. An experimental study of dendritic cells-mediated immunotherapy against intracranial gliomas in rats. J. Neuro-Oncol. 74 (2005) 9-17
20. Inaba K., Inaba M., Romani N., Aya H., Deguchi M., Ikehara S., Muramatsu S., and Steinman R.M. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176 (1992) 1693
21. Liu W., Li W.M., Gao C., and Sun N.L. Effects of atorvastatin on the Th1/Th2 polarization of ongoing experimental autoimmune myocarditis in Lewis rats. J. Autoimmun. 25 4 (2005) 258-263
22. Azuma R.W., Suzuki J., Ogawa M., Futamatsu H., Koga N., Onai Y., Kosuge H., and Isobe M. HMG-CoA reductase inhibitor attenuates experimental autoimmune myocarditis through inhibition of T cell activation. Cardiovasc. Res. 64 (2004) 412-420
23. Levings M.K., Sangregorio R., Galbiati F., et al. IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J. Immunol. 166 (2001) 5530
24. Verdijk R.M., Mutis T., Esendam B., Kamp J., Melief Cee J.M., Brand A., and Goulmy E. Polyriboinosinic polyribocytidylic acid (poly (I:C)) induces stable maturation of functionally active human dendritic cells. J. Immunol. 163 (1999) 57-61
25. Feili-Harir M., Falkner D.H., and Morel P.A. Regulatory Th2 response induced following adoptive transfer of dendritic cells in prediabetic NOD mice. Eur. J. Immun. 32 7 (2002) 2021-2030
26. Hodapkar M.V., Steinman R.M., Krasovsky J., Munz C., and Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. 193 2 (2001) 233-238
27. Liblau R.S., Singer S.M., and McDevitt H.O. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16 (1995) 34-38
28. Lamb J.R., Skidmore B.J., Green N., Chiller J.M., and Feldmann M. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J. Exp. Med. 157 (1983) 1434
29. Jenkins M.K., and Schwartz R.H. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165 (1987) 302
30. Harding F.A., McArthur J.G., Gross J.A., Raulet D.H., and Allison J.P. CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356 (1992) 607
31. Assenmacher M., Löhning M., Scheffold A., Richter A., Miltenyi S., Schmitz J., and Radbruch A. Commitment of individual Th1-like lymphocytes to expression of IFN-γ versus IL-4 and IL-10: selective induction of IL-10 by sequential stimulation of naive Th cells with IL-12 and IL-4. The J. Immunol. 161 (1998) 2825-2832
32. Ozawa H., Ding W.H., Torii H., Hosoi J., Seiffert K., Campton K., Hackett N.R., Topf N., Crystal R.G., and Granstein R.D. Granulocyte-macrophage colony-stimulating factor gene transfer to dendritic cells or epidermal cells augments their antigen-presenting function including induction of anti-tumor immunity. J. Invest. Dermatol. 113 6 (1999) 999
33. Chorny A., Gonzalez-Rey E., Fernandez-Martin A., Pozo D., Ganea D., and Delgado M. Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders. Proc. Natl. Acad. Sci. 102 38 (2005) 13562-13567