Bioavailability of anthocyanins and colonic polyphenol metabolites following consumption of aronia berry extract

Food Chemistry

Volumn 211, Issue , 2016, Pages 860-868

  Xie, Liyang ^a   Lee, Sang Gil ^a   Vance, Terrence M ^a   Wang, Ying ^a   Kim, Bohkyung ^a   Lee, Ji Young ^a   Chun, Ock K ^a   Bolling, Bradley W ^a,b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Anthocyanin; Aronia; Cyanidin; Ferulic acid; Metabolism; Pharmacokinetic; Polyphenol; UHPLC MS

Indexed keywords

BIOCHEMISTRY; BIOMOLECULES; BODY FLUIDS; FRUITS; METABOLISM; METABOLITES; PHARMACOKINETICS; PHYSIOLOGY; PLASMA (HUMAN);

ARONIA; CYANIDIN; FERULIC ACIDS; POLYPHENOLS; U-HPLC-MS;

ANTHOCYANINS;

3 (4 HYDROXYPHENYL)PROPIONIC ACID; 3,4 DIHYDROXYPHENYLACETIC ACID; ANTHOCYANIN; ARONIA BERRY EXTRACT; CAFFEIC ACID; CHLOROGENIC ACID; CYANIDIN 3 ARABINOSIDE; CYANIDIN 3 O GALACTOSIDE; CYANIDN 3 XYLOSIDE; DRUG METABOLITE; FERULIC ACID; HIPPURIC ACID; HYPERIN; ISOQUERCITRIN; NEOCHLOROGENIC ACID; PEONIDIN 3 O GALACTOSIDE; PLANT EXTRACT; POLYPHENOL; PROANTHOCYANIDIN; PROTOCATECHUIC ACID; QUERCETIN; RUTOSIDE; UNCLASSIFIED DRUG;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG URINE LEVEL; FEMALE; FOOD INTAKE; HUMAN; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; QUANTITATIVE ANALYSIS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; BIOAVAILABILITY; CHEMISTRY; CLINICAL TRIAL; COLON; EATING; FRUIT; METABOLISM; MIDDLE AGED; PHOTINIA; PHYSIOLOGY; PILOT STUDY; YOUNG ADULT;

ADULT; ANTHOCYANINS; BIOLOGICAL AVAILABILITY; COLON; EATING; FEMALE; FRUIT; HUMANS; MALE; MIDDLE AGED; PHOTINIA; PILOT PROJECTS; PLANT EXTRACTS; POLYPHENOLS; YOUNG ADULT;

EID: 84970974433     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2016.05.122     Document Type: Article

References (41)

1. L. Battiston, A. Macagno, S. Passamonti, F. Micali, and G. Luigi Sottocasa Specific sequence-directed anti-bilitranslocase antibodies as a tool to detect potentially bilirubin-binding proteins in different tissues of the rat FEBS Letters 453 3 1999 351 355
2. M. Broncel, M. Koziróg, P. Duchnowicz, M. Koter-Michalapruk, J. Sikora, and J. Chojnowska-Jezierska Aronia melanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker levels in patients with metabolic syndrome Medical Science Monitor 16 1 2010 CR28 CR34
3. G. Cao, H.U. Muccitelli, C. Sánchez-Moreno, and R.L. Prior Anthocyanins are absorbed in glycated forms in elderly women: A pharmacokinetic study American Journal of Clinical Nutrition 73 5 2001 920 926
4. C. Czank, A. Cassidy, Q. Zhang, D.J. Morrison, T. Preston, and P.A. Kroon C.D. Kay Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: A 13C-tracer study American Journal of Clinical Nutrition 97 5 2013 995 1003
5. R.M. de Ferrars, C. Czank, Q. Zhang, N.P. Botting, P.A. Kroon, A. Cassidy, and C.D. Kay The pharmacokinetics of anthocyanins and their metabolites in humans British Journal of Pharmacology 171 13 2014 3268 3282
6. S. Déprez, C. Brezillon, S. Rabot, C. Philippe, I. Mila, C. Lapierre, and A. Scalbert Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids Journal of Nutrition 130 11 2000 2733 2738
7. M.A. El Mohsen, J. Marks, G. Kuhnle, K. Moore, E. Debnam, and S.K. Srai J.P. Spencer Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats British Journal of Nutrition 95 1 2006 51 58
8. I. Fernandes, V. de Freitas, C. Reis, and N. Mateus A new approach on the gastric absorption of anthocyanins Food & Function 3 5 2012 508 516
9. M.-P. Gonthier, J.L. Donovan, O. Texier, C. Felgines, C. Remesy, and A. Scalbert Metabolism of dietary procyanidins in rats Free Radical Biology and Medicine 35 8 2003 837 844
10. C.D. Kay Aspects of anthocyanin absorption, metabolism and pharmacokinetics in humans Nutrition Research Reviews 19 1 2006 137 146
11. C.D. Kay, G. Mazza, and B.J. Holub Anthocyanins exist in the circulation primarily as metabolites in adult men Journal of Nutrition 135 11 2005 2582 2588
12. C.D. Kay, G. Mazza, B.J. Holub, and J. Wang Anthocyanin metabolites in human urine and serum British Journal of Nutrition 91 6 2004 933 942
13. K. Keane, P. Bell, J. Lodge, C. Constantinou, S. Jenkinson, R. Bass, and G. Howatson Phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro European Journal of Nutrition 2015 1 11 [in press]
14. B. Kim, C.S. Ku, T.X. Pham, Y. Park, D.A. Martin, and L. Xie B.W. Bolling Aronia melanocarpa (chokeberry) polyphenol-rich extract improves antioxidant function and reduces total plasma cholesterol in apolipoprotein E knockout mice Nutrition Research 33 5 2013 406 413
15. M. Kujawska, E. Ignatowicz, M. Ewertowska, J. Oszmiański, and J. Jodynis-Liebert Protective effect of chokeberry on chemical-induced oxidative stress in rat Human & Experimental Toxicology 30 3 2011 199 208
16. G. Lappin, M. Rowland, and R.C. Garner The use of isotopes in the determination of absolute bioavailability of drugs in humans Expert Opinion on Drug Metabolism & Toxicology 2 3 2006 419 427
17. C. Manach, A. Scalbert, C. Morand, C. Rémésy, and L. Jiménez Polyphenols: Food sources and bioavailability American Journal of Clinical Nutrition 79 5 2004 727 747
18. C. Manach, G. Williamson, C. Morand, A. Scalbert, and C. Rémésy Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies American Journal of Clinical Nutrition 81 Suppl. 1 2005 230S 242S
19. D.L. McKay, C.Y.O. Chen, C.A. Zampariello, and J.B. Blumberg Flavonoids and phenolic acids from cranberry juice are bioavailable and bioactive in healthy older adults Food Chemistry 168 2015 233 240
20. T. Miyazawa, K. Nakagawa, M. Kudo, K. Muraishi, and K. Someya Direct intestinal absorption of red fruit anthocyanins, cyanidin-3-glucoside and cyanidin-3,5-diglucoside, into rats and humans Journal of Agricultural and Food Chemistry 47 3 1999 1083 1091
21. M. Monagas, M. Urpi-Sarda, F. Sánchez-Patán, R. Llorach, I. Garrido, and C. Gómez-Cordovés B. Bartolomé Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites Food & Function 1 3 2010 233 253
22. M. Naruszewicz, I. Łaniewska, B. Millo, and M. Dłużniewski Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infraction (MI) Atherosclerosis 194 2 2007 e179 e184
23. K. Ou, and L. Gu Absorption and metabolism of proanthocyanidins Journal of Functional Foods 7 2014 43 53
24. S. Passamonti, U. Vrhovsek, and F. Mattivi The interaction of anthocyanins with bilitranslocase Biochamical and Biophysical Research Communications 296 3 2002 631 636
25. R. Porȩba, A. Skoczyńska, P. Gaç, M. Porȩba, I. Jȩdrychowska, and A. Affelska-Jercha R. Andrzejak Drinking of chokeberry juice from the ecological farm Dziȩ cioŁowo and distensibility of brachial artery in men with mild hypercholesterolemia Annals of Agricultural and Environmental Medicine 16 2 2009 305 308
26. L.Y. Rios, M.-P. Gonthier, C. Rémésy, I. Mila, C. Lapierre, and S.A. Lazarus A. Scalbert Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects American Journal of Clinical Nutrition 77 4 2003 912 918
27. A. Skoczyńska, I. Jedrychowska, R. Poreba, A. Affelska-Jercha, B. Turczyn, A. Wojakowska, and R. Andrzejak Influence of chokeberry juice on arterial blood pressure and lipid parameters in men with mild hypercholesterolemia Pharmacological Reports 59 Suppl. 1 2007 177 182
28. A. Stalmach, C.A. Edwards, J.D. Wightman, and A. Crozier Colonic catabolism of dietary phenolic and polyphenolic compounds from Concord grape juice Food & Function 4 1 2013 52 62
29. E.E. Sterchi, P.R. Mills, J.A. Fransen, H.P. Hauri, M.J. Lentze, and H.Y. Naim J. Bond Biogenesis of intestinal lactase-phlorizin hydrolase in adults with lactose intolerance. Evidence for reduced biosynthesis and slowed-down maturation in enterocytes Journal of Clinical Investigation 86 4 1990 1329 1337
30. R. Taheri, B.A. Connolly, M.H. Brand, and B.W. Bolling Underutilized chokeberry (Aronia melanocarpa, Aronia arbutifolia, Aronia prunifolia) accessions are rich sources of anthocyanins, flavonoids, hydroxycinnamic acids, and proanthocyanidins Journal of Agricultural and Food Chemistry 61 36 2013 8581 8588
31. M. Urpi-Sarda, M. Monagas, N. Khan, R. Lamuela-Raventos, C. Santos-Buelga, and E. Sacanella C. Andres-Lacueva Epicatechin, procyanidins, and phenolic microbial metabolites after cocoa intake in humans and rats Analytical and Bioanalytical Chemistry 394 6 2009 1545 1556
32. S. Valcheva-Kuzmanova, K. Kuzmanov, S. Tsanova-Savova, V. Mihova, I. Krasnaliev, P. Borisova, and A. Belcheva Lipid-lowering effects of Aronia melanocarpa fruit juice in rats fed cholesterol-containing diets Journal of Food Biochemistry 31 5 2007 589 602
33. J. van Duynhoven, E.E. Vaughan, D.M. Jacobs, A.R. Kemperman, E.J.J. van Velzen, and G. Gross T. Van de Wiele Metabolic fate of polyphenols in the human superorganism Proceedings of the National Academy of Sciences 108 Suppl. 1 2011 4531 4538
34. P. Vitaglione, G. Donnarumma, A. Napolitano, F. Galvano, A. Gallo, L. Scalfi, and V. Fogliano Protocatechuic acid is the major human metabolite of cyanidin-glucosides Journal of Nutrition 137 9 2007 2043 2048
35. W. Wiczkowski, E. Romaszko, and M.K. Piskula Bioavailability of cyanidin glycosides from natural chokeberry (Aronia melanocarpa) juice with dietary-relevant dose of anthocyanins in humans Journal of Agricultural and Food Chemistry 58 23 2010 12130 12136
36. G. Woodward, P. Kroon, A. Cassidy, and C. Kay Anthocyanin stability and recovery: Implications for the analysis of clinical and experimental samples Journal of Agricultural and Food Chemistry 57 12 2009 5271 5278
37. X. Wu, G. Cao, and R.L. Prior Absorption and metabolism of anthocyanins in elderly women after consumption of elderberry or blueberry Journal of Nutrition 132 7 2002 1865 1871
38. X. Wu, H.E. Pittman, and R.L. Prior Pelargonidin is absorbed and metabolized differently than cyanidin after marionberry consumption in pigs Journal of Nutrition 134 10 2004 2603 2610
39. L. Xie, and B.W. Bolling Characterisation of stilbenes in California almonds (Prunus dulcis) by UHPLC-MS Food Chemistry 148 2014 300 306
40. R. Zamora-Ros, M. Rabassa, A. Cherubini, M. Urpí-Sardà, S. Bandinelli, L. Ferrucci, and C. Andres-Lacueva High concentrations of a urinary biomarker of polyphenol intake are associated with decreased mortality in older adults Journal of Nutrition 143 9 2013 1445 1450
41. K. Zhang, and Y. Zuo GC-MS determination of flavonoids and phenolic and benzoic acids in human plasma after consumption of cranberry juice Journal of Agricultural and Food Chemistry 52 2 2004 222 227