Flavonoids and phenolic acids from cranberry juice are bioavailable and bioactive in healthy older adults

Food Chemistry

Volumn 168, Issue , 2015, Pages 233-240

  McKay, Diane L ^a   Chen, C Y Oliver ^a   Zampariello, Carly A ^a   Blumberg, Jeffrey B ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Antioxidant; Bioavailability; Cranberry; Flavonoids; Phenolics; Polyphenols; Proanthocyanidins

Indexed keywords

ANTIOXIDANTS; BIOCHEMISTRY; BODY FLUIDS; FRUIT JUICES; ORGANIC ACIDS;

BIOAVAILABILITY; CRANBERRY; PHENOLICS; POLYPHENOLS; PROANTHOCYANIDINS;

FLAVONOIDS;

ANTHOCYANIN; ANTIOXIDANT; BENZOIC ACID; CAFFEIC ACID; COUMARIC ACID; CREATININE; DIMER; EPICATECHIN; FERULIC ACID; FLAVONOID; FLAVONOL DERIVATIVE; GENTISIC ACID; ISORHAMNETIN; KAEMPFEROL; MYRICETIN; PHENOL DERIVATIVE; PHENOLIC ACID; PROANTHOCYANIDIN; PROTOCATECHUIC ACID; QUERCETIN; SALICYLIC ACID; SINAPIC ACID; UNCLASSIFIED DRUG; VANILLIC ACID; COPPER; DRUG METABOLITE; LOW DENSITY LIPOPROTEIN; PROANTHOCYANIDIN DERIVATIVE; HYDROXYBENZOIC ACID DERIVATIVE;

ANTIOXIDANT ACTIVITY; ARTICLE; CALORIE; CRANBERRY JUICE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; HUMAN; HUMAN EXPERIMENT; LOW CALORY DIET; NORMAL HUMAN; SINGLE DRUG DOSE; URINALYSIS; ADULT; AREA UNDER THE CURVE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG EXCRETION; FOOD INTAKE; MAXIMUM PLASMA CONCENTRATION; ORAC ASSAY; OXIDATION; PLASMA; TIME TO MAXIMUM PLASMA CONCENTRATION; URINE; AGED; BIOAVAILABILITY; CHEMISTRY; CRANBERRY; FEMALE; FRUIT AND VEGETABLE JUICE; MALE; METABOLISM; MIDDLE AGED;

VACCINIUM MACROCARPON;

AGED; ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; FEMALE; FLAVONOIDS; FRUIT AND VEGETABLE JUICES; HUMANS; HYDROXYBENZOATES; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; VACCINIUM MACROCARPON;

EID: 84904968388     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2014.07.062     Document Type: Article

References (42)

1. G. Aldini, K.J. Yeum, R.M. Russell, and N.I. Krinsky A method to measure the oxidizability of both the aqueous and lipid compartments of plasma Free Radical Biology and Medicine 31 9 2001 1043 1050 (Pubitemid 33000126)
2. I.C. Arts, and P.C. Hollman Polyphenols and disease risk in epidemiologic studies American Journal of Clinical Nutrition 81 1 Suppl 2005 317S 325S
3. I.F. Benzie, and J.J. Strain The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay Analytical Biochemistry 239 1 1996 70 76
4. G. Beretta, G. Aldini, R.M. Facino, R.M. Russell, N.I. Krinsky, and K.J. Yeum Total antioxidant performance: a validated fluorescence assay for the measurement of plasma oxidizability Analytical Biochemistry 354 2 2006 290 298
5. S. Caillet, J. Cote, J.F. Sylvain, and M. Lacroix Antimicrobial effects of fractions from cranberry products on the growth of seven pathogenic bacteria Food Control 23 2 2012 419 428
6. S. Caillet, G. Lorenzo, J. Cote, J.F. Sylvain, and M. Lacroix Free radical-scavenging properties and antioxidant activity of fractions from cranberry products Food and Nutrition Sciences 3 2012 337 347
7. C.Y. Chen, P.E. Milbury, K. Lapsley, and J.B. Blumberg Flavonoids from almond skins are bioavailable and act synergistically with vitamins C and E to enhance hamster and human LDL resistance to oxidation Journal of Nutrition 135 6 2005 1366 1373 (Pubitemid 40799597)
8. 13C-tracer study American Journal of Clinical Nutrition 97 5 2013 995 1003
9. D. Del Rio, G. Borges, and A. Crozier Berry flavonoids and phenolics: bioavailability and evidence of protective effects British Journal of Nutrition 104 3 Suppl 2010 S67 S90
10. S.J. Duthie, A.M. Jenkinson, A. Crozier, W. Mullen, L. Pirie, and J. Kyle et al. The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers European Journal of Nutrition 45 2 2006 113 122 (Pubitemid 43345204)
11. L. Hanske, W. Engst, G. Loh, S. Sczesny, M. Blaut, and A. Braune Contribution of gut bacteria to the metabolism of cyanidin 3-glucoside in human microbiota-associated rats British Journal of Nutrition 109 8 2013 1433 1441
12. R.R. Holt, S.A. Lazarus, M.C. Sullards, Q.Y. Zhu, D.D. Schramm, and J.F. Hammerstone et al. Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa American Journal of Clinical Nutrition 76 4 2002 798 804
13. A.B. Howell, H. Botto, C. Combescure, A.-B. Blanc-Potard, L. Gausa, and T. Matsumoto et al. Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study BMC Infectious Diseases 10 2010 94
14. D. Huang, B. Ou, M. Hampsch-Woodill, J.A. Flanagan, and R.L. Prior High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format Journal of Agricultural and Food Chemistry 50 16 2002 4437 4444 (Pubitemid 34823962)
15. W. Kalt, J.B. Blumberg, J.E. McDonald, M.R. Vinqvist-Tymchuk, S.A.E. Fillmore, and B.A. Graf et al. Identification of anthocyanins in the liver, brain and eye of blueberry-fed pigs Journal of Agricultural and Food Chemistry 56 3 2008 705 712 (Pubitemid 351300234)
16. C.D. Kay, G.J. Mazza, B.J. Holub, and J. Wang Anthocyanins in human urine and serum British Journal of Nutrition 91 6 2004 933 942
17. C.D. Kay, G.J. Mazza, and B.J. Holub Anthocyanins exist in the circulation primarily as metabolites in adult men Journal of Nutrition 135 11 2005 2582 2588 (Pubitemid 43156599)
18. T.H. Marczylo, D. Cooke, K. Brown, W.P. Steward, and A.J. Gescher Pharmacokinetics and metabolism of the putative cancer chemopreventive agent cyanidin-3-glucoside in mice Cancer Chemotherapy and Pharmacology 64 6 2009 1261 1268
19. D.L. McKay, and J.B. Blumberg Cranberries (Vaccinium macrocarpon) and cardiovascular disease risk factors Nutrition Reviews 65 11 2007 490 502 (Pubitemid 351804340)
20. P.E. Milbury, J.A. Vita, and J.B. Blumberg Anthocyanins are bioavailable in humans following an acute dose of cranberry juice Journal of Nutrition 140 6 2010 1099 1104
21. I.L. Nielsen, W.S. Chee, L. Poulsen, E. Offord-Cavin, S.E. Rasmussen, and H. Frederiksen et al. Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial Journal of Nutrition 136 2 2006 404 408 (Pubitemid 43228293)
22. R. Ohnishi, H. Ito, N. Kasajima, M. Kaneda, R. Kariyama, and H. Kumon et al. Urinary excretion of anthocyanins in humans after cranberry juice ingestion Bioscience Biotechnology and Biochemistry 70 7 2006 1681 1687 (Pubitemid 44124927)
23. K. Ou, S.S. Percival, T. Zou, C. Khoo, and L. Gu Transport of cranberry A-type procyanidin dimers, trimers, and tetramers across monolayers of human intestinal epithelial Caco-2 cells Journal of Agricultural and Food Chemistry 60 6 2012 1390 1396
24. C.B. Pedersen, J. Kyle, A.M. Jenkinson, P.T. Gardner, D.B. McPhail, and G.G. Duthie Effects of blueberry and cranberry juice consumption on the plasma antioxidant capacity of healthy female volunteers European Journal of Clinical Nutrition 54 5 2000 405 408 (Pubitemid 30261391)
25. S. Roy, S. Kanna, H.M. Alessio, J. Vider, D. Bagchi, and M. Bagchi et al. Anti-angiogenic property of edible berries Free Radical Research 36 9 2002 1023 1031 (Pubitemid 34863649)
26. G. Ruel, S. Pomerleau, P. Couture, B. Lamarche, and C. Couillard Changes in plasma antioxidant capacity and oxidized low-density lipoprotein levels in men after short-term cranberry juice consumption Metabolism 54 7 2005 856 861 (Pubitemid 40827199)
27. G. Ruel, S. Pomerleau, P. Couture, S. Lemieux, B. Lamarche, and C. Couillard Low-calorie cranberry juice supplementation reduces plasma oxidized LDL and cell adhesion molecule concentrations in men British Journal of Nutrition 99 2 2008 352 359
28. A. Sano, J. Yamakoshi, S. Tokutake, K. Tobe, Y. Kubota, and M. Kikuchi Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract Bioscience Biotechnology and Biochemistry 67 5 2003 1140 1143 (Pubitemid 39251877)
29. F. Saura-Calixto, J. Pérez-Jiménez, S. Touriño, J. Serrano, E. Fuguet, and J.L. Torres et al. Proanthocyanidin metabolites associated with dietary fibre from in vitro colonic fermentation and proanthocyanidin metabolites in human plasma Molecular Nutrition & Food Research 54 7 2010 939 946
30. F.A. Tomas-Barberan, E. Cienfuegos-Jovellanos, A. Marín, B. Muguerza, A. Gil-Izquierdo, and B. Cerda et al. A new process to develop a cocoa powder with higher flavonoid monomer content and enhanced bioavailability in healthy humans Journal of Agricultural and Food Chemistry 55 10 2007 3926 3935 (Pubitemid 46867398)
31. M. Urpi-Sarda, M. Monagas, N. Khan, R.M. Lamuela-Raventos, C. Santos-Buelga, and E. Sacanella et al. Epicatechin, procyanidins, and phenolic microbial metabolites after cocoa intake in humans and rats Analytical and Bioanalytical Chemistry 394 6 2009 1545 1556
32. D.A. Vattem, H.D. Jang, R. Levin, and K. Shetty Synergism of cranberry phenolics with ellagic acid and rosmarinic acid for antimutagenic and DNA protection functions Journal of Food Biochemistry 30 1 2006 98 116
33. J.A. Vinson, X. Su, L. Zubik, and P. Bose Phenol antioxidant quantity and quality in foods: fruits Journal of Agricultural and Food Chemistry 49 11 2001 5315 5321 (Pubitemid 33089671)
34. J.A. Vinson, P. Bose, J. Proch, H. Al Kharrat, and N. Samman Cranberries and cranberry products: powerful in vitro, ex vivo, and in vivo sources of antioxidants Journal of Agricultural and Food Chemistry 56 14 2008 5884 5889
35. P. Vitaglione, G. Donnarumma, A. Napolitano, F. Galvano, A. Gallo, and L. Scalfi et al. Protocatechuic acid is the major human metabolite of cyanidin-glucosides Journal of Nutrition 137 9 2007 2043 2048 (Pubitemid 47367263)
36. K.D. Vu, H. Carlettini, J. Bouvet, J. Cote, G. Doyon, and J.-F. Sylvain et al. Effect of different cranberry extracts and juices during cranberry juice processing on the antiproliferative activity against two colon cancer cell lines Food Chemistry 132 2 2012 959 967
37. C. Wang, Y. Zuo, J.A. Vinson, and Y. Deng Absorption and excretion of cranberry-derived phenolics in humans Food Chemistry 132 3 2012 1420 1428
38. E.I. Weiss, A. Kozlovsky, D. Steinberg, R. Lev-Dor, and Bar Ness. Greenstein et al. A high molecular mass cranberry constituent reduces mutan streptococci level in saliva and inhibits in vitro adhesion to hydroxyapatite FEMS Microbiology Letters 232 1 2004 89 92 (Pubitemid 38328739)
39. T. Wilson, S.L. Meyers, A.P. Singh, P.J. Limburg, and N. Vorsa Favorable glycemic response of type 2 diabetics to low-calorie cranberry juice Journal of Food Science 73 9 2008 H241 H245
40. X. Wu, G. Cao, and R.L. Prior Absorption and metabolism of anthocyanins in elderly women after consumption of elderberry or blueberry Journal of Nutrition 132 7 2002 1865 1871 (Pubitemid 34742869)
41. K. Zhang, and Y. Zuo GC-MS determination of flavonoids and phenolic and benzoic acids in human plasma after consumption of cranberry juice Journal of Agricultural and Food Chemistry 52 2 2004 222 227
42. L. Zhang, J. Ma, K. Pan, V.L. Go, J. Chen, and W.C. You Efficacy of cranberry juice on Helicobacter pylori infection: a double-blind, randomized placebo-controlled trial Helicobacter 10 2 2005 139 145 (Pubitemid 40477023)