High-throughput glycosylation analysis of therapeutic immunoglobulin G by capillary gel electrophoresis using a DNA analyzer

mAbs

Volumn 6, Issue 1, 2014, Pages 185-196

  Reusch, Dietmar ^a   Haberger, Markus ^a   Kailich, Tobias ^a   Heidenreich, Anna Katharina ^a   Kampe, Michael ^a   Bulau, Patrick ^a   Wuhrer, Manfred ^b,c  

^a ROCHE DIAGNOSTICS GMBH   (Germany)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

APTS labeling; Automation; DNA analyzer; HILIC UPLC; IgG glycosylation; LC MS; Monoclonal antibody (mAb); Multiplexed capillary electrophoresis

Indexed keywords

9 AMINOPYRENE 1,3,6 TRISULFONIC ACID; GLYCAN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; PROTEIN A; PYRENE DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ANALYZER; ARTICLE; AUTOMATION; COMPUTER PROGRAM; DNA ANALYZER; FERMENTATION; FLUORESCENCE; FUCOSYLATION; GEL ELECTROPHORESIS; GLYCOSYLATION; LASER INDUCED FLUORESCENCE; MASS SPECTROMETRY; MEASUREMENT REPEATABILITY; PROCESS DEVELOPMENT; PURIFICATION; QUANTITATIVE ANALYSIS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAFILTRATION;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CRICETINAE; CRICETULUS; ELECTROPHORESIS, CAPILLARY; FLUORESCENT DYES; GLYCOSYLATION; IMMUNOGLOBULIN G; POLYSACCHARIDES; PYRENES; SEQUENCE ANALYSIS, DNA; SOFTWARE;

EID: 84892577275     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.26712     Document Type: Article

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