Metabolic markers associated with high mannose glycan levels of therapeutic recombinant monoclonal antibodies

Journal of Biotechnology

Volumn 203, Issue , 2015, Pages 22-31

  Kang, Sohye ^a   Zhang, Zhongqi ^a   Richardson, Jason ^a   Shah, Bhavana ^a   Gupta, Shivani ^a   Huang, Chung Jr ^a   Qiu, Jinshu ^a   Le, Nicole ^a   Lin, Henry ^a,b   Bondarenko, Pavel V ^a  

^a AMGEN INC   (United States)

^b Boehringer Ingelheim   (United States)

Author keywords

Chinese hamster ovary; Copper; Glycosylation; High mannose; Metabolomics; Ornithine

Indexed keywords

AMINO ACIDS; CELL CULTURE; CELLS; COPPER; CYTOLOGY; GLYCOSYLATION; METABOLISM; MOBILE SECURITY; MONOCLONAL ANTIBODIES; PLANTS (BOTANY); POLYSACCHARIDES; SURFACE PLASMON RESONANCE;

CELLULAR REDOX REGULATION; CHINESE HAMSTER OVARY; EXTRACELLULAR METABOLITES; HIGH MANNOSE; METABOLOMICS; MRNA EXPRESSION LEVEL; ORNITHINE; RECOMBINANT MONOCLONAL ANTIBODY;

ANTIBODIES;

ARGINASE; ARGINASE 1; COPPER; CULTURE MEDIUM; GLYCAN; MANNOSE; MESSENGER RNA; MONOCLONAL ANTIBODY; ORNITHINE; POLYSACCHARIDE; RECOMBINANT PROTEIN; SPERMINE;

AMINO ACID METABOLISM; ANIMAL; ARTICLE; CHO CELL LINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; CRICETULUS; CULTURE MEDIUM; GENE EXPRESSION; GENETICS; HAMSTER; METABOLISM; METABOLOMICS; PRIORITY JOURNAL; VALIDATION STUDY;

ANIMALS; ANTIBODIES, MONOCLONAL; ARGINASE; CHO CELLS; COPPER; CRICETINAE; CRICETULUS; CULTURE MEDIA; GENETICS; MANNOSE; METABOLISM; METABOLOMICS; ORNITHINE; POLYSACCHARIDES; RECOMBINANT PROTEINS; RNA, MESSENGER; SPERMINE;

CRICETULUS GRISEUS;

EID: 84964284061     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2015.03.002     Document Type: Article

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