-
1
-
-
79953776915
-
DNA double-strand break signaling and human disorders
-
Bohgaki, T., Bohgaki, M. & Hakem, R. DNA double-strand break signaling and human disorders. Genome Integr 1, 15 (2010).
-
(2010)
Genome Integr
, vol.1
, pp. 15
-
-
Bohgaki, T.1
Bohgaki, M.2
Hakem, R.3
-
2
-
-
84893262127
-
PARP inhibitors for anticancer therapy
-
Curtin, N. PARP inhibitors for anticancer therapy. Biochem Soc Trans 42, 82-8 (2014).
-
(2014)
Biochem Soc Trans
, vol.42
, pp. 82-88
-
-
Curtin, N.1
-
3
-
-
84891622264
-
Targeting DNA double-strand break signalling and repair: Recent advances in cancer therapy
-
Huhn, D., Bolck, H. A. & Sartori, A. A. Targeting DNA double-strand break signalling and repair: recent advances in cancer therapy. Swiss Med Wkly 143, w13837 (2013).
-
(2013)
Swiss Med Wkly
, vol.143
-
-
Huhn, D.1
Bolck, H.A.2
Sartori, A.A.3
-
4
-
-
84896717088
-
Is non-homologous end-joining really an inherently error-prone process?
-
Betermier, M., Bertrand, P. & Lopez, B. S. Is non-homologous end-joining really an inherently error-prone process? PLoS Genet 10, e1004086 (2014).
-
(2014)
PLoS Genet
, vol.10
-
-
Betermier, M.1
Bertrand, P.2
Lopez, B.S.3
-
5
-
-
34249931173
-
Fanconi anemia and DNA replication repair
-
Patel, K. J. & Joenje, H. Fanconi anemia and DNA replication repair. DNA Repair (Amst) 6, 885-90 (2007).
-
(2007)
DNA Repair (Amst)
, vol.6
, pp. 885-890
-
-
Patel, K.J.1
Joenje, H.2
-
6
-
-
84969127605
-
Helicases involved in the repair of DNA inter-strand crosslinks
-
Rogers C. M., v. K. K. & Bochman M. L. Helicases involved in the repair of DNA inter-strand crosslinks. OA Biology 22 (2014).
-
(2014)
OA Biology
, vol.22
-
-
Rogers, C.M.1
V, K.K.2
Bochman, M.L.3
-
7
-
-
84933073669
-
Ubiquitylation, neddylation and the DNA damage response
-
Brown, J. S. & Jackson, S. P. Ubiquitylation, neddylation and the DNA damage response. Open Biol 5, 150018 (2015).
-
(2015)
Open Biol
, vol.5
-
-
Brown, J.S.1
Jackson, S.P.2
-
8
-
-
29244489543
-
Fanconi anemia (cross)linked to DNA repair
-
Niedernhofer, L. J., Lalai, A. S. & Hoeijmakers, J. H. Fanconi anemia (cross)linked to DNA repair. Cell 123, 1191-8 (2005).
-
(2005)
Cell
, vol.123
, pp. 1191-1198
-
-
Niedernhofer, L.J.1
Lalai, A.S.2
Hoeijmakers, J.H.3
-
9
-
-
84863670930
-
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway
-
Kim, H. & D'Andrea, A. D. Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev 26, 1393-408 (2012).
-
(2012)
Genes Dev
, vol.26
, pp. 1393-1408
-
-
Kim, H.1
D'Andrea, A.D.2
-
10
-
-
84903779008
-
Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia
-
Lachaud, C. et al. Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia. J Cell Sci. 127, 2811-7 (2014).
-
(2014)
J Cell Sci
, vol.127
, pp. 2811-2817
-
-
Lachaud, C.1
-
11
-
-
57749112131
-
Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI
-
Alpi, A. F., Pace, P. E., Babu, M. M. & Patel, K. J. Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI. Mol Cell 32, 767-77 (2008).
-
(2008)
Mol Cell
, vol.32
, pp. 767-777
-
-
Alpi, A.F.1
Pace, P.E.2
Babu, M.M.3
Patel, K.J.4
-
12
-
-
77955290719
-
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair
-
Liu, T., Ghosal, G., Yuan, J., Chen, J. & Huang, J. FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science 329, 693-6 (2010).
-
(2010)
Science
, vol.329
, pp. 693-696
-
-
Liu, T.1
Ghosal, G.2
Yuan, J.3
Chen, J.4
Huang, J.5
-
13
-
-
77954286076
-
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair
-
Smogorzewska, A. et al. A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol Cell 39, 36-47 (2010).
-
(2010)
Mol Cell
, vol.39
, pp. 36-47
-
-
Smogorzewska, A.1
-
14
-
-
77954279611
-
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents
-
Kratz, K. et al. Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Cell 142, 77-88 (2010).
-
(2010)
Cell
, vol.142
, pp. 77-88
-
-
Kratz, K.1
-
15
-
-
77954274685
-
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2
-
MacKay, C. et al. Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell 142, 65-76 (2010).
-
(2010)
Cell
, vol.142
, pp. 65-76
-
-
MacKay, C.1
-
16
-
-
84862783021
-
Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint
-
Cremona, C. A. et al. Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint. Mol Cell 45, 422-32 (2012).
-
(2012)
Mol Cell
, vol.45
, pp. 422-432
-
-
Cremona, C.A.1
-
17
-
-
72449175818
-
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
-
Galanty, Y. et al. Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature 462, 935-9 (2009).
-
(2009)
Nature
, vol.462
, pp. 935-939
-
-
Galanty, Y.1
-
18
-
-
72449163470
-
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
-
Morris, J. R. et al. The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. Nature 462, 886-90 (2009).
-
(2009)
Nature
, vol.462
, pp. 886-890
-
-
Morris, J.R.1
-
19
-
-
84876886904
-
Regulation of DNA damage responses by ubiquitin and SUMO
-
Jackson, S. P. & Durocher, D. Regulation of DNA damage responses by ubiquitin and SUMO. Mol Cell 49, 795-807 (2013).
-
(2013)
Mol Cell
, vol.49
, pp. 795-807
-
-
Jackson, S.P.1
Durocher, D.2
-
20
-
-
68049103216
-
An additional role for SUMO in ubiquitin-mediated proteolysis
-
Geoffroy, M. C. & Hay, R. T. An additional role for SUMO in ubiquitin-mediated proteolysis. Nat Rev Mol Cell Biol 10, 564-8 (2009).
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 564-568
-
-
Geoffroy, M.C.1
Hay, R.T.2
-
21
-
-
77951297101
-
Polymorphisms in the UBC9 and PIAS3 genes of the SUMO-conjugating system and breast cancer risk
-
Dunnebier, T. et al. Polymorphisms in the UBC9 and PIAS3 genes of the SUMO-conjugating system and breast cancer risk. Breast Cancer Res Treat 121, 185-94 (2009).
-
(2009)
Breast Cancer Res Treat
, vol.121
, pp. 185-194
-
-
Dunnebier, T.1
-
22
-
-
33744783406
-
Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis
-
Kim, J. H. et al. Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis. Nat Cell Biol 8, 631-9 (2006).
-
(2006)
Nat Cell Biol
, vol.8
, pp. 631-639
-
-
Kim, J.H.1
-
23
-
-
84887850498
-
Sumoylation in gene regulation, human disease, and therapeutic action
-
Yang, X. J. & Chiang, C. M. Sumoylation in gene regulation, human disease, and therapeutic action. F1000Prime Rep. 5, 45 (2013).
-
(2013)
F1000Prime Rep.
, vol.5
, pp. 45
-
-
Yang, X.J.1
Chiang, C.M.2
-
24
-
-
43049093756
-
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
-
Tatham, M. H. et al. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol 10, 538-46 (2008).
-
(2008)
Nat Cell Biol
, vol.10
, pp. 538-546
-
-
Tatham, M.H.1
-
25
-
-
84861784690
-
SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage
-
Yin, Y. et al. SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage. Genes Dev 26, 1196-208 (2012).
-
(2012)
Genes Dev
, vol.26
, pp. 1196-1208
-
-
Yin, Y.1
-
26
-
-
84861765707
-
RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair
-
Galanty, Y., Belotserkovskaya, R., Coates, J. & Jackson, S. P. RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. Genes Dev 26, 1179-95 (2012).
-
(2012)
Genes Dev
, vol.26
, pp. 1179-1195
-
-
Galanty, Y.1
Belotserkovskaya, R.2
Coates, J.3
Jackson, S.P.4
-
27
-
-
84879008640
-
Ube2W conjugates ubiquitin to alpha-amino groups of protein N-termini
-
Tatham, M. H., Plechanovova, A., Jaffray, E. G., Salmen, H. & Hay, R. T. Ube2W conjugates ubiquitin to alpha-amino groups of protein N-termini. Biochem J 453, 137-45 (2013).
-
(2013)
Biochem J
, vol.453
, pp. 137-145
-
-
Tatham, M.H.1
Plechanovova, A.2
Jaffray, E.G.3
Salmen, H.4
Hay, R.T.5
-
28
-
-
84879597523
-
The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates
-
Scaglione, K. M. et al. The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates. J Biol Chem 288, 18784-8 (2013).
-
(2013)
J Biol Chem
, vol.288
, pp. 18784-18788
-
-
Scaglione, K.M.1
-
29
-
-
84938751194
-
TRIM5alpha requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription
-
Fletcher, A. J. et al. TRIM5alpha requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription. Embo J 34, 2078-95 (2015).
-
(2015)
Embo J
, vol.34
, pp. 2078-2095
-
-
Fletcher, A.J.1
-
30
-
-
84926328724
-
RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway
-
Xie, J. et al. RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway. J Clin Invest 125, 1523-32 (2015).
-
(2015)
J Clin Invest
, vol.125
, pp. 1523-1532
-
-
Xie, J.1
-
31
-
-
84920415516
-
Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage
-
Gibbs-Seymour, I. et al. Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage. Mol Cell 57, 150-64 (2015).
-
(2015)
Mol Cell
, vol.57
, pp. 150-164
-
-
Gibbs-Seymour, I.1
-
32
-
-
33746957852
-
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation
-
Machida, Y. J. et al. UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Mol Cell 23, 589-96 (2006).
-
(2006)
Mol Cell
, vol.23
, pp. 589-596
-
-
Machida, Y.J.1
-
33
-
-
37549072240
-
UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: A basis for the regulation of FANCD2 monoubiquitination
-
Alpi, A. et al. UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination. Mol Cell Biol 27, 8421-30 (2007).
-
(2007)
Mol Cell Biol
, vol.27
, pp. 8421-8430
-
-
Alpi, A.1
-
34
-
-
79952988534
-
UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2
-
Zhang, Y. et al. UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2. Mol Cells 31, 113-22 (2010).
-
(2010)
Mol Cells
, vol.31
, pp. 113-122
-
-
Zhang, Y.1
-
35
-
-
32844459257
-
Cloning, characterization and subcellular localization of a gene encoding a human Ubiquitin-conjugating enzyme (E2) homologous to the Arabidopsis thaliana UBC-16 gene product
-
Yin, G. et al. Cloning, characterization and subcellular localization of a gene encoding a human Ubiquitin-conjugating enzyme (E2) homologous to the Arabidopsis thaliana UBC-16 gene product. Front Biosci 11, 1500-7 (2006).
-
(2006)
Front Biosci
, vol.11
, pp. 1500-1507
-
-
Yin, G.1
-
36
-
-
84957565279
-
Loss of the Ubiquitin-conjugating Enzyme Ube2W results in susceptibility to early postnatal lethality and defects in skin, immune and male reproductive systems
-
Wang, B. et al. Loss of the Ubiquitin-conjugating Enzyme Ube2W results in susceptibility to early postnatal lethality and defects in skin, immune and male reproductive systems. J Biol Chem 291, 3030-42 (2015).
-
(2015)
J Biol Chem
, vol.291
, pp. 3030-3042
-
-
Wang, B.1
-
37
-
-
84945937533
-
Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair
-
Schmidt, C. K. et al. Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair. Nat Cell Biol 17, 1458-70 (2016).
-
(2016)
Nat Cell Biol
, vol.17
, pp. 1458-1470
-
-
Schmidt, C.K.1
-
38
-
-
34948848684
-
E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages
-
Christensen, D. E., Brzovic, P. S. & Klevit, R. E. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. Nat Struct Mol Biol 14, 941-8 (2007).
-
(2007)
Nat Struct Mol Biol
, vol.14
, pp. 941-948
-
-
Christensen, D.E.1
Brzovic, P.S.2
Klevit, R.E.3
-
39
-
-
77953879925
-
Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway
-
Pace, P. et al. Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. Science 329, 219-23 (2010).
-
(2010)
Science
, vol.329
, pp. 219-223
-
-
Pace, P.1
-
40
-
-
77954310242
-
Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia
-
Adamo, A. et al. Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Mol Cell 39, 25-35 (2010).
-
(2010)
Mol Cell
, vol.39
, pp. 25-35
-
-
Adamo, A.1
-
41
-
-
84938579589
-
A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination
-
Wang, A. T. et al. A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination. Mol Cell 59, 478-90 (2015).
-
(2015)
Mol Cell
, vol.59
, pp. 478-490
-
-
Wang, A.T.1
-
42
-
-
84927544290
-
Intrinsic disorder drives N-terminal ubiquitination by Ube2w
-
Vittal, V. et al. Intrinsic disorder drives N-terminal ubiquitination by Ube2w. Nat Chem Biol 11, 83-9 (2015).
-
(2015)
Nat Chem Biol
, vol.11
, pp. 83-89
-
-
Vittal, V.1
-
43
-
-
84946779981
-
Biochemical and structural characterization of a novel ubiquitin-conjugating enzyme E2 from Agrocybe aegeria reveals Ube2w family-specific properties
-
Qi, C. et al. Biochemical and structural characterization of a novel ubiquitin-conjugating enzyme E2 from Agrocybe aegeria reveals Ube2w family-specific properties. Sci. Rep. 5, 16056 (2015).
-
(2015)
Sci. Rep.
, vol.5
-
-
Qi, C.1
-
44
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-23 (2013).
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
-
45
-
-
84873734105
-
RNA-guided human genome engineering via Cas9
-
Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823-6 (2013).
-
(2013)
Science
, vol.339
, pp. 823-826
-
-
Mali, P.1
-
46
-
-
4344597147
-
The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair
-
Niedzwiedz, W. et al. The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. Mol Cell 15, 607-20 (2004).
-
(2004)
Mol Cell
, vol.15
, pp. 607-620
-
-
Niedzwiedz, W.1
-
47
-
-
26944499485
-
The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway
-
Mosedale, G. et al. The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway. Nat Struct Mol Biol 12, 763-71 (2005).
-
(2005)
Nat Struct Mol Biol
, vol.12
, pp. 763-771
-
-
Mosedale, G.1
|