Polymorphisms in the UBC9 and PIAS3 genes of the SUMO-conjugating system and breast cancer risk

Breast Cancer Research and Treatment

Volumn 121, Issue 1, 2010, Pages 185-194

  Dünnebier, Thomas ^a   Bermejo, Justo Lorenzo ^b   Haas, Susanne ^c   Fischer, Hans Peter ^c   Pierl, Christiane B ^d   Justenhoven, Christina ^e,f   Brauch, Hiltrud ^e,f   Baisch, Christian ^g   Gilbert, Michael ^a   Harth, Volker ^d,g   Spickenheuer, Anne ^d   Rabstein, Sylvia ^d   Pesch, Beate ^d   Brüning, Thomas ^d   Ko, Yon Dschun ^g   Hamann, Ute ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d RUHR UNIVERSITY BOCHUM   (Germany)

^e DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^f UNIVERSITY OF TÜBINGEN   (Germany)

^g Johanniter Krankenhaus   (Germany)

Author keywords

Breast cancer risk; Multiple imputation; SUMOylation; Tumor grade; UBC9 and PIAS3 polymorphisms

Indexed keywords

PROTEIN INHIBITOR OF ACTIVATED STAT; PROTEIN INHIBITOR OF ACTIVATED STAT 3; SUMO PROTEIN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN CONJUGATING ENZYME 9; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER GRADING; CANCER RISK; CONTROLLED STUDY; FAMILY HISTORY; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HAPLOTYPES; HUMANS; MIDDLE AGED; MOLECULAR CHAPERONES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN INHIBITORS OF ACTIVATED STAT; RISK FACTORS; SUMO-1 PROTEIN; UBIQUITIN-CONJUGATING ENZYMES; YOUNG ADULT;

EID: 77951297101     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-009-0530-y     Document Type: Article

References (44)

1. R Geiss-Friedlander F Melchior 2007 Concepts in sumoylation: a decade on Nat Rev Mol Cell Biol 8 947 956 10.1038/nrm2293 1:CAS:528:DC%2BD2sXhtlCrsbrN 18000527 (Pubitemid 350176509)
2. S Muller C Hoege G Pyrowolakis S Jentsch 2001 SUMO, ubiquitin's mysterious cousin Nat Rev Mol Cell Biol 2 202 210 10.1038/35056591 1:CAS:528:DC%2BD3MXhvFOksrk%3D 11265250 (Pubitemid 33675745)
3. M Dasso 2008 Emerging roles of the SUMO pathway in mitosis Cell Div 3 5 10.1186/1747-1028-3-5 18218095 (Pubitemid 351385675)
4. RT Hay 2005 SUMO: a history of modification Mol Cell 18 1 12 10.1016/j.molcel.2005.03.012 1:CAS:528:DC%2BD2MXjt1Oit78%3D 15808504 (Pubitemid 40444643)
5. JS Seeler O Bischof K Nacerddine A Dejean 2007 SUMO, the three Rs and cancer Curr Top Microbiol Immunol 313 49 71 10.1007/978-3-540-34594-7-4 1:CAS:528:DC%2BD2sXjtlGrsLo%3D 17217038
6. M Gostissa A Hengstermann V Fogal P Sandy SE Schwarz M Scheffner G Del Sal 1999 Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1 EMBO J 18 6462 6471 10.1093/emboj/18.22.6462 1:CAS:528:DyaK1MXns1Ort78%3D 10562558 (Pubitemid 29533250)
7. S Muller M Berger F Lehembre JS Seeler Y Haupt A Dejean 2000 c-Jun and p53 activity is modulated by SUMO-1 modification J Biol Chem 275 13321 13329 10.1074/jbc.275.18.13321 1:CAS:528:DC%2BD3cXjtFyksLc%3D 10788439 (Pubitemid 30257389)
8. S Muller MJ Matunis A Dejean 1998 Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus EMBO J 17 61 70 10.1093/emboj/17.1.61 1:CAS:528:DyaK1cXnvVyjsA%3D%3D 9427741 (Pubitemid 28041048)
9. MS Rodriguez JM Desterro S Lain CA Midgley DP Lane RT Hay 1999 SUMO-1 modification activates the transcriptional response of p53 EMBO J 18 6455 6461 10.1093/emboj/18.22.6455 1:CAS:528:DyaK1MXns1Ort74%3D 10562557 (Pubitemid 29533249)
10. S Eladad TZ Ye P Hu M Leversha S Beresten MJ Matunis NA Ellis 2005 Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification Hum Mol Genet 14 1351 1365 10.1093/hmg/ddi145 1:CAS:528:DC%2BD2MXktFyqt7s%3D 15829507 (Pubitemid 40744493)
11. Y Kawabe M Seki T Seki WS Wang O Imamura Y Furuichi H Saitoh T Enomoto 2000 Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1 J Biol Chem 275 20963 20966 10.1074/jbc.C000273200 1:CAS:528:DC%2BD3cXkvFGjt7w%3D 10806190 (Pubitemid 30481783)
12. G Bossis CE Malnou R Farras E Andermarcher R Hipskind M Rodriguez D Schmidt S Muller I Jariel-Encontre M Piechaczyk 2005 Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation Mol Cell Biol 25 6964 6979 10.1128/MCB.25.16.6964-6979.2005 1:CAS:528:DC%2BD2MXhtVejsrbF 16055710 (Pubitemid 41105897)
13. DP Xirodimas J Chisholm JM Desterro DP Lane RT Hay 2002 P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2 FEBS Lett 528 207 211 10.1016/S0014-5793(02)03310-0 1:CAS:528:DC%2BD38Xnt1Klu78%3D 12297306 (Pubitemid 35258025)
14. YY Mo Y Yu E Theodosiou PL Rachel Ee WT Beck 2005 A role for Ubc9 in tumorigenesis Oncogene 24 2677 2683 10.1038/sj.onc.1208210 1:CAS:528: DC%2BD2MXjtFOkurs%3D 15735760 (Pubitemid 40593095)
15. J Cheng T Bawa P Lee L Gong ET Yeh 2006 Role of desumoylation in the development of prostate cancer Neoplasia 8 667 676 10.1593/neo.06445 1:CAS:528:DC%2BD28XhtVGltbnM 16925949 (Pubitemid 44379793)
16. L Wang S Banerjee 2004 Differential PIAS3 expression in human malignancy Oncol Rep 11 1319 1324 1:CAS:528:DC%2BD2cXkvVWht7c%3D 15138572
17. SJ Moschos AP Smith M Mandic C Athanassiou K Watson-Hurst DM Jukic HD Edington JM Kirkwood D Becker 2007 SAGE and antibody array analysis of melanoma-infiltrated lymph nodes: identification of Ubc9 as an important molecule in advanced-stage melanomas Oncogene 26 4216 4225 10.1038/sj.onc. 1210216 1:CAS:528:DC%2BD2sXmslSrtb8%3D 17297476 (Pubitemid 46975803)
18. F Wu S Zhu Y Ding WT Beck YY Mo 2009 MicroRNA-mediated regulation of Ubc9 expression in cancer cells Clin Cancer Res 15 1550 1557 10.1158/1078-0432.CCR- 08-0820 1:CAS:528:DC%2BD1MXisVWku7g%3D 19223510
19. MV Karamouzis PA Konstantinopoulos FA Badra AG Papavassiliou 2008 SUMO and estrogen receptors in breast cancer Breast Cancer Res Treat 107 195 210 10.1007/s10549-007-9552-5 1:CAS:528:DC%2BD2sXhsVarurrJ 17377839 (Pubitemid 50015940)
20. S Ali RC Coombes 2000 Estrogen receptor alpha in human breast cancer: occurrence and significance J Mammary Gland Biol Neoplasia 5 271 281 10.1023/A:1009594727358 14973389 (Pubitemid 32156528)
21. S Sentis M Le Romancer C Bianchin MC Rostan L Corbo 2005 Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity Mol Endocrinol 19 2671 2684 10.1210/me.2005-0042 1:CAS:528:DC%2BD2MXhtFyjsrbL 15961505 (Pubitemid 41577242)
22. A Chauchereau L Amazit M Quesne A Guiochon-Mantel E Milgrom 2003 Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1 J Biol Chem 278 12335 12343 10.1074/jbc.M207148200 1:CAS:528: DC%2BD3sXisVOnt7s%3D 12529333 (Pubitemid 36800217)
23. N Kotaja U Karvonen OA Janne JJ Palvimo 2002 The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1 J Biol Chem 277 30283 30288 10.1074/jbc.M204768200 1:CAS:528:DC%2BD38XmsVKhtrg%3D 12060666
24. H Wu L Sun Y Zhang Y Chen B Shi R Li Y Wang J Liang D Fan G Wu, et al. 2006 Coordinated regulation of AIB1 transcriptional activity by sumoylation and phosphorylation J Biol Chem 281 21848 21856 10.1074/jbc.M603772200 1:CAS:528:DC%2BD28XnsVOnu70%3D 16760465 (Pubitemid 44181888)
25. T Dunnebier JL Bermejo S Haas HP Fischer CB Pierl C Justenhoven H Brauch C Baisch M Gilbert V Harth, et al. 2009 Common variants in the UBC9 gene encoding the SUMO-conjugating enzyme are associated with breast tumor grade Int J Cancer 125 596 602 10.1002/ijc.24286 19358266
26. B Pesch Y Ko H Brauch U Hamann V Harth S Rabstein C Pierl HP Fischer C Baisch C Justenhoven, et al. 2005 Factors modifying the association between hormone-replacement therapy and breast cancer risk Eur J Epidemiol 20 699 711 10.1007/s10654-005-0032-0 16151884 (Pubitemid 41266867)
27. C Justenhoven U Hamann B Pesch V Harth S Rabstein C Baisch C Vollmert T Illig YD Ko T Bruning, et al. 2004 ERCC2 genotypes and a corresponding haplotype are linked with breast cancer risk in a German population Cancer Epidemiol Biomarkers Prev 13 2059 2064 1:CAS:528:DC%2BD2cXhtVOjsLvK 15598761
28. C Justenhoven CB Pierl S Haas HP Fischer C Baisch U Hamann V Harth B Pesch T Bruning C Vollmert, et al. 2008 The CYP1B1-1358-GG genotype is associated with estrogen receptor-negative breast cancer Breast Cancer Res Treat 111 171 177 10.1007/s10549-007-9762-x 1:CAS:528:DC%2BD1cXos1Wntrc%3D 17922187 (Pubitemid 352009231)
29. del Val C, Pelz O, Glatting K-H, Barta E, Hotz-Wagenblatt A (2009) PromoterSweep: a tool for identification of transcription factor binding sites. Theor Chem Acc (in press)
30. KA Frazer DG Ballinger DR Cox DA Hinds LL Stuve RA Gibbs JW Belmont A Boudreau P Hardenbol SM Leal, et al. 2007 A second generation human haplotype map of over 3.1 million SNPs Nature 449 851 861 10.1038/nature06258 1:CAS:528:DC%2BD2sXhtFOjt7jL 17943122 (Pubitemid 47598626)
31. V Ramensky P Bork S Sunyaev 2002 Human non-synonymous SNPs: server and survey Nucleic Acids Res 30 3894 3900 10.1093/nar/gkf493 1:CAS:528: DC%2BD38Xms1Klt7k%3D 12202775
32. PD Thomas MJ Campbell A Kejariwal H Mi B Karlak R Daverman K Diemer A Muruganujan A Narechania 2003 PANTHER: a library of protein families and subfamilies indexed by function Genome Res 13 2129 2141 10.1101/gr.772403 1:CAS:528:DC%2BD3sXnslKhtLw%3D 12952881 (Pubitemid 37161770)
33. Thomas PD, Kejariwal A, Guo N, Mi H, Campbell MJ, Muruganujan A, Lazareva-Ulitsky B (2006) Applications for protein sequence-function evolution data: mRNA/protein expression analysis and coding SNP scoring tools. Nucleic Acids Res 34(Web Server issue):W645-650
34. Westfall PH, Young SS (1993) Resampling-Based Multiple Testing. Wiley, New York
35. DJ Schaid CM Rowland DE Tines RM Jacobson GA Poland 2002 Score tests for association between traits and haplotypes when linkage phase is ambiguous Am J Hum Genet 70 425 434 10.1086/338688 11791212 (Pubitemid 34112296)
36. J Marchini B Howie S Myers G McVean P Donnelly 2007 A new multipoint method for genome-wide association studies by imputation of genotypes Nat Genet 39 906 913 10.1038/ng2088 1:CAS:528:DC%2BD2sXmvFKlsLY%3D 17572673 (Pubitemid 47014502)
37. AC Antoniou DF Easton 2003 Polygenic inheritance of breast cancer: implications for design of association studies Genet Epidemiol 25 190 202 10.1002/gepi.10261 14557987 (Pubitemid 37296594)
38. RJ Daniels JF Peden C Lloyd SW Horsley K Clark C Tufarelli L Kearney VJ Buckle NA Doggett J Flint, et al. 2001 Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 Hum Mol Genet 10 339 352 10.1093/hmg/10.4.339 1:STN:280:DC%2BD3Mzit1eitg%3D%3D 11157797
39. J Zhao 2007 Sumoylation regulates diverse biological processes Cell Mol Life Sci 64 3017 3033 10.1007/s00018-007-7137-4 1:CAS:528:DC%2BD2sXhsVOqur%2FL 17763827 (Pubitemid 351152231)
40. Q Shen IP Uray Y Li TI Krisko TE Strecker HT Kim PH Brown 2008 The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors Oncogene 27 366 377 10.1038/sj.onc.1210643 1:CAS:528: DC%2BD1cXksVKntA%3D%3D 17637753
41. KH Vousden DP Lane 2007 p53 in health and disease Nat Rev Mol Cell Biol 8 275 283 10.1038/nrm2147 1:CAS:528:DC%2BD2sXjtlygsr0%3D 17380161 (Pubitemid 46474662)
42. B Vogelstein D Lane AJ Levine 2000 Surfing the p53 network Nature 408 307 310 10.1038/35042675 1:CAS:528:DC%2BD3cXosVemtrY%3D 11099028
43. GG Chen Q Zeng GM Tse 2008 Estrogen and its receptors in cancer Med Res Rev 28 954 974 10.1002/med.20131 1:CAS:528:DC%2BD1cXhtlyjtb7J 18642351
44. W Yang W Paschen 2009 Gene expression and cell growth are modified by silencing SUMO2 and SUMO3 expression Biochem Biophys Res Commun 382 215 218 10.1016/j.bbrc.2009.03.013 1:CAS:528:DC%2BD1MXktF2ntL0%3D 19275883