TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription

EMBO Journal

Volumn 34, Issue 15, 2015, Pages 2078-2095

  Fletcher, Adam J ^a,d   Christensen, Devin E ^b   Nelson, Chad ^b   Tan, Choon Ping ^a   Schaller, Torsten ^a,e   Lehner, Paul J ^c   Sundquist, Wesley I ^b   Towers, Greg J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^e GOETHE UNIVERSITY   (Germany)

Author keywords

restriction; TRIM5 ; Ube2N; Ube2W; ubiquitin

Indexed keywords

LYSINE; TRIPARTITE MOTIF PROTEIN 5; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E2W; UNCLASSIFIED DRUG; CARRIER PROTEIN; SMALL INTERFERING RNA; TRIM5 PROTEIN, HUMAN; UBE2W PROTEIN, HUMAN; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME;

AMINO ACID SEQUENCE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DNA SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; GEL FILTRATION CHROMATOGRAPHY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INNATE IMMUNITY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION; UBIQUITINATION; VIRUS GENOME; VIRUS INFECTIVITY; BIOLOGICAL MODEL; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; PHYSIOLOGY; RNA INTERFERENCE; SITE DIRECTED MUTAGENESIS;

MIRIDAE;

CARRIER PROTEINS; HEK293 CELLS; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; REVERSE TRANSCRIPTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES;

EID: 84938751194     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201490361     Document Type: Article

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