Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia

Journal of Cell Science

Volumn 127, Issue 13, 2014, Pages 2811-2817

  Lachaud, Christophe ^a   Castor, Dennis ^a   Hain, Karolina ^a   Muñoz, Ivan ^a   Wilson, Jamie ^a   MacArtney, Thomas J ^a   Schindler, Detlev ^b   Rouse, John ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Fanconi anemia; FANCP; ICL; SLX4; Ubiquitin; UBZ

Indexed keywords

ALANINE; BRCA1 PROTEIN; FANCONI ANEMIA GROUP D2 PROTEIN; POLYUBIQUITIN; PROTEIN; RAD18 PROTEIN; RNF8 PROTEIN; SLX4 PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG; DNA; RECOMBINASE; SLX4 PROTEIN, HUMAN; SLX4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FANCONI ANEMIA; FIBROBLAST; HCT116 CELL LINE; HOLLIDAY JUNCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SISTER CHROMATID EXCHANGE; U2OS CELL LINE; UBIQUITINATION; ANIMAL; BINDING SITE; GENETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE;

ANIMALS; BINDING SITES; DNA; DNA REPAIR; FANCONI ANEMIA; HUMANS; MICE; PROTEIN STRUCTURE, TERTIARY; RECOMBINASES; UBIQUITIN;

EID: 84903779008     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.146167     Document Type: Article

References (19)

1. Aressy, B. and Greenberg, R. A. (2012). DNA damage: placing BRCA1 in the proper context. Curr. Biol. 22, R806-R808.
2. Castor, D., Nair, N., Declais, A. C., Lachaud, C., Toth, R., Macartney, T. J., Lilley, D. M., Arthur, J. S. and Rouse, J. (2013). Cooperative control of Holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 Nucleases. Mol. Cell 52, 221-233.
3. Fekairi, S., Scaglione, S., Chahwan, C., Taylor, E. R., Tissier, A., Coulon, S., Dong, M. Q., Ruse, C., Yates, J. R., III, Russell, P. et al. (2009). Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. Cell 138, 78-89.
4. Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M. S., Timmers, C., Hejna, J., Grompe, M. and D'Andrea, A. D. (2001). Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol. Cell 7, 249-262.
5. Geng, L., Huntoon, C. J. and Karnitz, L. M. (2010). RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network. J. Cell Biol. 191, 249-257.
6. Hofmann, K. (2009). Ubiquitin-binding domains and their role in the DNA damage response. DNA Repair (Amst.) 8, 544-556.
7. Kim, Y., Lach, F. P., Desetty, R., Hanenberg, H., Auerbach, A. D. and Smogorzewska, A. (2011). Mutations of the SLX4 gene in Fanconi anemia. Nat. Genet. 43, 142-146.
8. Leung, J. W., Wang, Y., Fong, K. W., Huen, M. S., Li, L. and Chen, J. (2012). Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proc. Natl. Acad. Sci. USA 109, 4491-4496.
9. Moldovan, G. L. and D'Andrea, A. D. (2009). How the fanconi anemia pathway guards the genome. Annu. Rev. Genet. 43, 223-249.
10. Muñoz, I. M., Hain, K., Déclais, A. C., Gardiner, M., Toh, G. W., Sanchez-Pulido, L., Heuckmann, J. M., Toth, R., Macartney, T., Eppink, B. et al. (2009). Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol. Cell 35, 116-127.
11. Song, I. Y., Palle, K., Gurkar, A., Tateishi, S., Kupfer, G. M. and Vaziri, C. (2010). Rad18-mediated translesion synthesis of bulky DNA adducts is coupled to activation of the Fanconi anemia DNA repair pathway. J. Biol. Chem. 285, 31525-31536.
12. Stoepker, C., Hain, K., Schuster, B., Hilhorst-Hofstee, Y., Rooimans, M. A., Steltenpool, J., Oostra, A. B., Eirich, K., Korthof, E. T., Nieuwint, A. W. et al. (2011). SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat. Genet. 43, 138-141.
13. Svendsen, J. M., Smogorzewska, A., Sowa, M. E., O'Connell, B. C., Gygi, S. P., Elledge, S. J. and Harper, J. W. (2009). Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell 138, 63-77.
14. Taniguchi, T., Garcia-Higuera, I., Andreassen, P. R., Gregory, R. C., Grompe, M. and D'Andrea, A. D. (2002). S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood 100, 2414-2420.
15. Thazhathveetil, A. K., Liu, S. T., Indig, F. E. and Seidman, M. M. (2007). Psoralen conjugates for visualization of genomic interstrand cross-links localized by laser photoactivation. Bioconjug. Chem. 18, 431-437.
16. Wilson, J. S., Tejera, A. M., Castor, D., Toth, R., Blasco, M. A. and Rouse, J. (2013). Localization-dependent and -independent roles of SLX4 in regulating telomeres. Cell Rep. 4, 853-860.
17. Wyatt, H. D., Sarbajna, S., Matos, J. and West, S. C. (2013). Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells. Mol. Cell 52, 234-247.
18. Yamamoto, K. N., Kobayashi, S., Tsuda, M., Kurumizaka, H., Takata, M., Kono, K., Jiricny, J., Takeda, S. and Hirota, K. (2011). Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proc. Natl. Acad. Sci. USA 108, 6492-6496.
19. Yan, Z., Guo, R., Paramasivam, M., Shen, W., Ling, C., Fox, D., III, Wang, Y., Oostra, A. B., Kuehl, J., Lee, D. Y. et al. (2012). A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. Mol. Cell 47, 61-75.