Trehalose alters subcellular trafficking and the metabolism of the Alzheimer-associated amyloid precursor protein

Journal of Biological Chemistry

Volumn 291, Issue 20, 2016, Pages 10528-10540

  Tien, Nguyen T ^a,b   Karaca, Ilker ^a   Tamboli, Irfan Y ^a,c   Walter, Jochen ^a  

^a UNIVERSITY OF BONN   (Germany)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; GLYCOPROTEINS; METABOLISM; NEURODEGENERATIVE DISEASES; PHYSIOLOGY;

AMYLOID PRECURSOR PROTEINS; AMYLOID-BETA PEPTIDES; BIOLOGICAL EXPERIMENTS; C-TERMINAL FRAGMENTS; PROTEOLYTIC ACTIVATION; SUBCELLULAR DISTRIBUTION; SUBCELLULAR TRAFFICKING; VESICULAR TRANSPORT;

PROTEINS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CATHEPSIN D; CELL PROTEIN; LC3 II PROTEIN; PROTEIN P62; TREHALOSE; UNCLASSIFIED DRUG; PEPTIDE FRAGMENT; SECRETASE; TARGET OF RAPAMYCIN KINASE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BIOACCUMULATION; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; CELL COMPARTMENTALIZATION; CELL VACUOLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOLOGY; ENDOCYTOSIS; ENDOSOME; ENZYME ACTIVATION; EXPERIMENTAL STUDY; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN SECRETION; PROTEIN TRANSPORT; ANIMAL; AUTOPHAGY; CELL FRACTIONATION; CELL LINE; DRUG EFFECT; HEK293 CELL LINE; HEP-G2 CELL LINE; METABOLISM;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; AUTOPHAGY; CELL LINE; HEK293 CELLS; HEP G2 CELLS; HUMANS; LYSOSOMES; MICE; PEPTIDE FRAGMENTS; PROTEIN TRANSPORT; PROTEOLYSIS; SUBCELLULAR FRACTIONS; TOR SERINE-THREONINE KINASES; TREHALOSE;

EID: 84969165518     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.719286     Document Type: Article

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